New insights into the antifibrotic effects of sorafenib on hepatic stellate cells and liver fibrosis

Journal of Hepatology

Volumn 53, Issue 1, 2010, Pages 132-144

  Wang, Yan ^a   Gao, Juncha ^a   Zhang, Di ^a   Zhang, Jian ^a   Ma, Junji ^a   Jiang, Huiqing ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Cell proliferation; Collagen; Hepatic stellate cell; Liver fibrosis; Sorafenib

Indexed keywords

CASPASE 3; COLLAGEN; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; FAS ANTIGEN; FAS LIGAND; HYDROXYPROLINE; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; S6 KINASE; SORAFENIB; TISSUE INHIBITOR OF METALLOPROTEINASE; BENZENESULFONIC ACID DERIVATIVE; CARBANILAMIDE DERIVATIVE; COLLAGEN TYPE 1; NICOTINAMIDE; PRIMER DNA; PROTEIN KINASE INHIBITOR; PYRIDINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL GROWTH; CELL PROLIFERATION; COLLAGEN DEGRADATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FIBROGENESIS; HEPATIC STELLATE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER; LIVER FIBROSIS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STELLATE CELL; ANALOGS AND DERIVATIVES; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CELL CYCLE; DRUG EFFECTS; GENETICS; LIVER CIRRHOSIS; METABOLISM; NUCLEOTIDE SEQUENCE; PATHOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; WISTAR RAT;

ANIMALS; APOPTOSIS; BASE SEQUENCE; BENZENESULFONATES; CASPASE 3; CELL CYCLE; CELL PROLIFERATION; CELLS, CULTURED; COLLAGEN TYPE I; DNA PRIMERS; DOWN-REGULATION; HEPATIC STELLATE CELLS; HUMANS; LIVER CIRRHOSIS; MALE; MAP KINASE SIGNALING SYSTEM; PROTEIN KINASE INHIBITORS; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; IN VITRO TECHNIQUES; NIACINAMIDE; PHENYLUREA COMPOUNDS;

EID: 77953552969     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2010.02.027     Document Type: Article

References (41)

1. Friedman S.L. Mechanisms of hepatic fibrogenesis. Gastroenterology 134 (2008) 1655-1669
2. Parola M., Marra F., and Pinzani M. Myofibroblast-like cells and liver fibrogenesis: emerging concepts in a rapidly moving scenario. Mol Aspects Med 29 (2008) 58-66
3. Fallowfield J.A., Mizuno M., Kendall T.J., Constandinou C.M., Benyon R.C., Duffield J.S., et al. Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis. J Immunol 178 (2007) 5288-5295
4. Yoshiji H., Kuriyama S., Yoshii J., Ikenaka Y., Noguchi R., Nakatani T., et al. Tissue inhibitor of metalloproteinases-1 attenuates spontaneous liver fibrosis resolution in the transgenic mouse. Hepatology 36 (2002) 850-860
5. Moreno M., and Bataller R. Cytokines and renin-angiotensin system signaling in hepatic fibrosis. Clin Liver Dis 12 (2008) 825-852 ix
6. Borkham-Kamphorst E., Kovalenko E., van Roeyen C.R., Gassler N., Bomble M., Ostendorf T., et al. Platelet-derived growth factor isoform expression in carbon tetrachloride-induced chronic liver injury. Lab Invest 88 (2008) 1090-1100
7. Gabele E., Reif S., Tsukada S., Bataller R., Yata Y., Morris T., et al. The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. J Biol Chem 280 (2005) 13374-13382
8. Borkham-Kamphorst E., Stoll D., Gressner A.M., and Weiskirchen R. Antisense strategy against PDGF B-chain proves effective in preventing experimental liver fibrogenesis. Biochem Biophys Res Commun 321 (2004) 413-423
9. Gentilini A., Lottini B., Brogi M., Caligiuri A., Cosmi L., Marra F., et al. Evaluation of intracellular signalling pathways in response to insulin-like growth factor I in apoptotic-resistant activated human hepatic stellate cells. Fibrogenesis Tissue Repair 2 (2009) 1
10. Wang Y., Jiang X.Y., Liu L., and Jiang H.Q. Phosphatidylinositol 3-kinase/Akt pathway regulates hepatic stellate cell apoptosis. World J Gastroenterol 14 (2008) 5186-5191
11. Wilhelm S.M., Adnane L., Newell P., Villanueva A., Llovet J.M., and Lynch M. Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling. Mol Cancer Ther 7 (2008) 3129-3140
12. Plastaras J.P., Kim S.H., Liu Y.Y., Dicker D.T., Dorsey J.F., McDonough J., et al. Cell cycle dependent and schedule-dependent antitumor effects of sorafenib combined with radiation. Cancer Res 67 (2007) 9443-9454
13. Delgado J.S., Mustafi R., Yee J., Cerda S., Chumsangsri A., Dougherty U., et al. Sorafenib triggers antiproliferative and pro-apoptotic signals in human esophageal adenocarcinoma cells. Dig Dis Sci 53 (2008) 3055-3064
14. Tugues S., Fernandez-Varo G., Munoz-Luque J., Ros J., Arroyo V., Rodes J., et al. Antiangiogenic treatment with sunitinib ameliorates inflammatory infiltrate, fibrosis, and portal pressure in cirrhotic rats. Hepatology 46 (2007) 1919-1926
15. Mejias M., Garcia-Pras E., Tiani C., Miquel R., Bosch J., and Fernandez M. Beneficial effects of sorafenib on splanchnic, intrahepatic, and portocollateral circulations in portal hypertensive and cirrhotic rats. Hepatology 49 (2009) 1245-1256
16. Zhang X.L., Liu J.M., Yang C.C., Zheng Y.L., Liu L., Wang Z.K., et al. Dynamic expression of extracellular signal-regulated kinase in rat liver tissue during hepatic fibrogenesis. World J Gastroenterol 12 (2006) 6376-6381
17. Ma J., Li F., Liu L., Cui D., Wu X., Jiang X., et al. Raf kinase inhibitor protein inhibits cell proliferation but promotes cell migration in rat hepatic stellate cells. Liver Int 29 (2009) 567-574
18. Xu L., Hui A.Y., Albanis E., Arthur M.J., O'Byrne S.M., Blaner W.S., et al. Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis. Gut 54 (2005) 142-151
19. Wang G.J., Huang Y.J., Chen D.H., and Lin Y.L. Ganoderma lucidum extract attenuates the proliferation of hepatic stellate cells by blocking the PDGF receptor. Phytother Res 23 (2009) 833-839
20. Borkham-Kamphorst E., Herrmann J., Stoll D., Treptau J., Gressner A.M., and Weiskirchen R. Dominant-negative soluble PDGF-beta receptor inhibits hepatic stellate cell activation and attenuates liver fibrosis. Lab Invest 84 (2004) 766-777
21. Park M.A., Zhang G., Martin A.P., Hamed H., Mitchell C., Hylemon P.B., et al. Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation. Cancer Biol Ther 7 (2008) 1648-1662
22. Elsharkawy A.M., Oakley F., and Mann D.A. The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis. Apoptosis 10 (2005) 927-939
23. Jin Y.L., Enzan H., Kuroda N., Hayashi Y., Nakayama H., Zhang Y.H., et al. Tissue remodeling following submassive hemorrhagic necrosis in rat livers induced by an intraperitoneal injection of dimethylnitrosamine. Virchows Arch 442 (2003) 39-47
24. Yu J., Wu C.W., Hui A.Y., Cheng A.S., Go M.Y., Chu E.S., et al. Elucidation of the role of COX-2 in liver fibrogenesis using transgenic mice. Biochem Biophys Res Commun 372 (2008) 571-577
25. Huynh H, Ngo VC, Koong HN, Poon D, Choo SP, Thng CH, et al. Sorafenib and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma. J Cell Mol Med 2009 [Epub ahead of print].
26. Huynh H., Lee J.W., Chow P.K., Ngo V.C., Lew G.B., Lam I.W., et al. Sorafenib induces growth suppression in mouse models of gastrointestinal stromal tumor. Mol Cancer Ther 8 (2009) 152-159
27. Ulivi P., Arienti C., Amadori D., Fabbri F., Carloni S., Tesei A., et al. Role of RAF/MEK/ERK pathway, p-STAT-3 and Mcl-1 in sorafenib activity in human pancreatic cancer cell lines. J Cell Physiol 220 (2009) 214-221
28. Jiang M.D., Zheng S.M., Xu H., Zeng W.Z., Zhang Y., Sun H.P., et al. An experimental study of extracellular signal-regulated kinase and its interventional treatments in hepatic fibrosis. Hepatobiliary Pancreat Dis Int 7 (2008) 51-57
29. Jane E.P., Premkumar D.R., and Pollack I.F. Coadministration of sorafenib with rottlerin potently inhibits cell proliferation and migration in human malignant glioma cells. J Pharmacol Exp Ther 319 (2006) 1070-1080
30. Chor J.S., Yu J., Chan K.K., Go Y.Y., and Sung J.J. Stephania tetrandra prevents and regresses liver fibrosis induced by carbon tetrachloride in rats. J Gastroenterol Hepatol 24 (2009) 853-859
31. Wright M.C., Issa R., Smart D.E., Trim N., Murray G.I., Primrose J.N., et al. Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats. Gastroenterology 121 (2001) 685-698
32. Iredale J.P., Benyon R.C., Pickering J., McCullen M., Northrop M., Pawley S., et al. Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. J Clin Invest 102 (1998) 538-549
33. Novo E., Marra F., Zamara E., Valfre di Bonzo L., Monitillo L., Cannito S., et al. Overexpression of Bcl-2 by activated human hepatic stellate cells: resistance to apoptosis as a mechanism of progressive hepatic fibrogenesis in humans. Gut 55 (2006) 1174-1182
34. Kurosu T., Ohki M., Wu N., Kagechika H., and Miura O. Sorafenib induces apoptosis specifically in cells expressing BCR/ABL by inhibiting its kinase activity to activate the intrinsic mitochondrial pathway. Cancer Res 69 (2009) 3927-3936
35. Walker T., Mitchell C., Park M.A., Yacoub A., Graf M., Rahmani M., et al. Sorafenib and vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms. Mol Pharmacol 7 (2009) 342-355
36. Wang X.Z., Zhang S.J., Chen Y.X., Chen Z.X., Huang Y.H., and Zhang L.J. Effects of platelet-derived growth factor and interleukin-10 on Fas/Fas-ligand and Bcl-2/Bax mRNA expression in rat hepatic stellate cells in vitro. World J Gastroenterol 10 (2004) 2706-2710
37. Priya S., and Sudhakaran P.R. Cell survival, activation and apoptosis of hepatic stellate cells: modulation by extracellular matrix proteins. Hepatol Res 38 (2008) 1221-1232
38. Paik Y.H., Kim J.K., Lee J.I., Kang S.H., Kim D.Y., Ahn S.H., et al. Celecoxib induces hepatic stellate cell apoptosis through inhibition of Akt activation and suppresses hepatic fibrosis in rats. Gut 58 (2009) 1517-1527
39. Yu C., Friday B.B., Lai J.P., Yang L., Sarkaria J., Kay N.E., et al. Cytotoxic synergy between the multikinase inhibitor sorafenib and the proteasome inhibitor bortezomib in vitro: induction of apoptosis through Akt and c-Jun NH2-terminal kinase pathways. Mol Cancer Ther 5 (2006) 2378-2387
40. Marra F., Arrighi M.C., Fazi M., Caligiuri A., Pinzani M., Romanelli R.G., et al. Extracellular signal-regulated kinase activation differentially regulates platelet-derived growth factor's actions in hepatic stellate cells, and is induced by in vivo liver injury in the rat. Hepatology 30 (1999) 951-958
41. Zheng S.M., Jiang M.D., Zeng W.Z., Xu H., Wang Y.X., Ma H.D., et al. Effects of extracellular signal-regulated kinase on rat cultured hepatic stellate cells stimulated by acetaldehyde. J Dig Dis 8 (2007) 148-153