Butein inhibits ethanol-induced activation of liver stellate cells through TGF-β, NFκB, p38, and JNK signaling pathways and inhibition of oxidative stress

Journal of Gastroenterology

Volumn 48, Issue 2, 2013, Pages 222-237

  Szuster Ciesielska, Agnieszka ^a   Mizerska Dudka, Magdalena ^a   Daniluk, Jadwiga ^b   Kandefer Szerszeń, Martyna ^a  

^a MARIA CURIE SK ODOWSKA UNIVERSITY   (Poland)

^b MEDICAL UNIVERSITY OF LUBLIN   (Poland)

Author keywords

Butein; Cytokines; Hepatic stellate cells; HepG2; MAPK; NF B

Indexed keywords

ACETALDEHYDE; ALCOHOL; ALPHA SMOOTH MUSCLE ACTIN; BUTEIN; CELL MARKER; COLLAGENASE 3; GELATINASE A; I KAPPA B KINASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PROCOLLAGEN; PROCOLLAGEN C PROTEINASE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; ACTIN; ANTIOXIDANT; CHALCONE DERIVATIVE; COLLAGEN TYPE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; SMOOTH MUSCLE ACTIN, RAT;

ALCOHOL INTOXICATION; ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL DENSITY; CELL MIGRATION; CELL STRAIN HEPG2; CELL VIABILITY; COCULTURE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE EXPRESSION; HEPATOMA CELL; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; LIVER CELL; LIVER FIBROSIS; LIVER STELLATE CELL; NONHUMAN; OXIDATIVE STRESS; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CELL DEATH; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; METABOLISM; METHODOLOGY; PHYSIOLOGY; STELLATE CELL;

ACETALDEHYDE; ACTINS; ANIMALS; ANTIOXIDANTS; CELL DEATH; CELLS, CULTURED; CHALCONES; COCULTURE TECHNIQUES; COLLAGEN TYPE I; DRUG EVALUATION, PRECLINICAL; ETHANOL; HEP G2 CELLS; HEPATIC STELLATE CELLS; HUMANS; MAP KINASE KINASE 4; NF-KAPPA B; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

MLCS; MLOWN;

EID: 84880983644     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-012-0619-7     Document Type: Article

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