Fibrogenesis. I. New insights into hepatic stellate cell activation: The simple becomes complex

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 279, Issue 1 42-1, 2000, Pages

  Eng, Francis J ^a   Friedman, Scott L ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Extracellular matrix; Hepatic fibrosis; Receptors; Signaling; Transcription

Indexed keywords

MEMBRANE RECEPTOR; TRANSCRIPTION FACTOR;

ARTICLE; AUTOCRINE EFFECT; CELL ACTIVATION; CELL FATE; EXTRACELLULAR MATRIX; FIBROGENESIS; GENETIC TRANSCRIPTION; LIVER FIBROSIS; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STELLATE CELL;

EID: 0033853732     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.2000.279.1.g7     Document Type: Article

References (30)

1. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
2. Coordinated induction of VEGF receptors in mesenchymal cell types during rat hepatic wound healing
3. Hypoxic stimulation of vascular endothelial growth factor expression in activated rat hepatic stellate cells
4. Tyrosine phosphorylation of focal adhesion kinase by PDGF is dependent on ras in human hepatic stellate cells
5. Persistent activation of nuclear factor-κB in cultured rat hepatic stellate cells involves the induction of potentially novel Rel-like factors and prolonged changes in the expression of IκB family proteins
6. Molecular regulation of hepatic fibrosis; An integrated cellular response to tissue injury
7. Peroxisome proliferator-activated receptor γ transcriptional regulation is involved in platelet-derived growth factor-induced proliferation of human hepatic stellate cells
8. Role of NF-κB in the antiproliferative effect of endothelin-1 and tumor necrosis factor-α in human hepatic stellate cells. Involvement of cyclooxygenase-2
9. Atrial natriuretic peptide antagonizes endothelin-induced calcium increase and cell contraction in cultured human hepatic stellate cells
10. Cytokines induce NF-κB in activated but not in quiescent rat hepatic stellate cells
11. Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors
12. Expression of variant fibronectins in wound healing: Cellular source and biological activity of the EIIIA segment in rat hepatic fibrogenesis
13. Expression and regulation of cell adhesion molecules by hepatic stellate cells (HSC) of rat liver: Involvement of HSC in recruitment of inflammatory cells during hepatic tissue repair
14. Rat liver myofibroblasts and hepatic stellate cells: Different cell populations of the fibroblast lineage with fibrogenic potential
15. Zf9 (KLF6) regulates cell proliferation and apoptosis in activated stellate cells and NIH3T3 cells (Abstract)
16. Liver fibrogenesis and the role of hepatic stellate cells: New insights and prospects for therapy
17. Platelet-derived growth factor-BB and thrombin generate positive and negative signals for human hepatic stellate cell proliferation. Role of a prostaglandin/cyclic AMP pathway and cross-talk with endothelin receptors
18. Growth inhibitory properties of endothelin-1 in activated human hepatic stellate cells: A cyclic adenosine monophosphate-mediated pathway. Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B receptors
19. Extracellular signal-regulated kinase activation differentially regulates platelet-derived growth factor's actions in hepatic stellate cells, and is induced by in vivo liver injury in the rat
20. Ligands of peroxisome-proliferator activated receptor gamma modulate profibrogenic and proinflammatory actions of hepatic stellate cells
21. Phosphatidylinositol 3-kinase is required for platelet-derived growth factor's actions on hepatic stellate cells
22. Inhibition of hepatic stellate cell contraction during activation in vitro by vascular endothelial growth factor in association with upregulation of FLT tyrosine kinase receptor family, FLT-1
23. Signal transduction in hepatic stellate cells
24. Endothelin i is overexpressed in human cirrhotic liver and exerts multiple effects on activated hepatic stellate cells
25. Chronic blockade of endothelin receptors in cirrhotic rats: Hepatic and hemodynamic effects
26. Zf9, a Kruppel-like transcription factor upregulated in vivo during early hepatic fibrosis
27. NF-κB inhibits expression of the α1(I) collagen gene
28. An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors
29. Identification and characterization of a fibroblast marker: FSP1
30. Biological effects of C-type natriuretic peptide in human myofibroblastic hepatic stellate cells