Targeted silencing of TRPM7 ion channel induces replicative senescence and produces enhanced cytotoxicity with gemcitabine in pancreatic adenocarcinoma

Cancer Letters

Volumn 318, Issue 1, 2012, Pages 99-105

  Yee, Nelson S ^a,b,c,d,e   Zhou, Weiqiang ^d,e,g   Lee, Minsun ^d,e   Yee, Rosemary K ^f  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b PENN STATE CANCER INSTITUTE   (United States)

^c PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^d UNIVERSITY OF IOWA   (United States)

^e UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

^f PENNSYLVANIA STATE UNIVERSITY   (United States)

^g SHENYANG MEDICAL COLLEGE   (China)

Author keywords

Ion channel; Pancreatic cancer; Replicative senescence; Transient receptor potential; TRPM7

Indexed keywords

GEMCITABINE; MESSENGER RNA; TRANSIENT RECEPTOR POTENTIAL CHANNEL M7;

ARTICLE; CANCER CELL; CELL AGING; CELL SURVIVAL; CONTROLLED STUDY; CYCLIN DEPENDENT KINASE INHIBITOR 2A GENE; DRUG CYTOTOXICITY; DRUG POTENTIATION; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; PROTEIN FUNCTION; RNA INTERFERENCE; WERNER SYNDROME PROTEIN GENE;

ADENOCARCINOMA; ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; BLOTTING, WESTERN; CELL AGING; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DEOXYCYTIDINE; EXODEOXYRIBONUCLEASES; HUMANS; PANCREATIC NEOPLASMS; REAL-TIME POLYMERASE CHAIN REACTION; RECQ HELICASES; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING;

EID: 84862832728     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2011.12.007     Document Type: Article

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