Inhibition of TRPM7 channels prevents proliferation and differentiation of human lung fibroblasts

Inflammation Research

Volumn 62, Issue 11, 2013, Pages 961-970

  Yu, Mingzhe ^a   Huang, Cheng ^a   Huang, Yan ^a   Wu, Xiaoqin ^a   Li, Xiaohui ^a   Li, Jun ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Human lung fibroblasts; PI3K Akt pathway; Pulmonary fibrosis; Transient receptor potential melastatin 7

Indexed keywords

2 AMINOETHOXYDIPHENYLBORANE; ALPHA SMOOTH MUSCLE ACTIN; BETA ACTIN; COLLAGEN TYPE 1; GANGLIOSIDE GD3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA1; TRANSIENT RECEPTOR POTENTIAL CHANNEL M7;

ARTICLE; CELL DEDIFFERENTIATION; CELL PROLIFERATION; CELL STRAIN; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EX VIVO STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG FIBROBLAST; NUCLEOTIDE SEQUENCE; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING;

CELL CYCLE; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; FIBROBLASTS; GENE SILENCING; HUMANS; LUNG; MCF-7 CELLS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RNA, SMALL INTERFERING; TRANSFORMING GROWTH FACTOR BETA1; TRPM CATION CHANNELS;

EID: 84888202682     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-013-0653-9     Document Type: Article

References (44)

1. Datta A, Scotton, CJ Chambers, RC. Novel therapeutic approaches for pulmonary fibrosis. Br J Pharmacol. 2011;163:141-72.
2. Coker RK, Laurent GJ. Pulmonary fibrosis: cytokines in the balance. Eur Respir J. 1998;11:1218-21.
3. El-Chemaly S, Pacheco-Rodriguez, G, Ikeda, Y, Malide, D Moss, J. Lymphatics in idiopathic pulmonary fibrosis: new insights into an old disease. Lymphat Res Biol. 2009;7:197-203.
4. Scotton CJ, Chambers RC. Molecular targets in pulmonary fibrosis: the myofibroblast in focus. Chest. 2007;132:1311-21.
5. Guo W, Shan, B, Klingsberg, RC, Qin, X Lasky, JA. Abrogation of TGF-beta1-induced fibroblast-myofibroblast differentiation by histone deacetylase inhibition. Am J Physiol Lung Cell Mol Physiol. 2009;297:L864-70.
6. Hetzel M, Bachem, M, Anders, D, Trischler, G Faehling, M. Different effects of growth factors on proliferation and matrix production of normal and fibrotic human lung fibroblasts. Lung. 183:225-37.
7. 2+ wave and enhances gene expression in human pulmonary fibroblast. Am J Respir Cell Mol Biol. 2012;46:757-64.
8. Yue L, Xie, J Nattel, S. Molecular determinants of cardiac fibroblast electrical function and therapeutic implications for atrial fibrillation. Cardiovasc Res. 2011;89:744-53.
9. Guilbert A, Gautier M, Dhennin-Duthille I, et al. Evidence that TRPM7 is required for breast cancer cell proliferation. Am J Physiol Cell Physiol. 2009;297:C493-502.
10. 2+ signals confer fibrogenesis in human atrial fibrillation. Circ Res. 2010;106:992-1003.
11. Kim BJ, Park EJ, Lee JH, et al. Suppression of transient receptor potential melastatin 7 channel induces cell death in gastric cancer. Cancer Sci. 2008;99:2502-9.
12. Wertz IE, Dixit VM. Characterization of calcium release-activated apoptosis of LNCaP prostate cancer cells. J Biol Chem. 2000;275:11470-7.
13. Runnels LW, Yue, L Clapham, DE. TRP-PLIK, a bifunctional protein with kinase and ion channel activities. Science. 2001;291:1043-7.
14. Karashima Y, Hoka S. TRP channels as novel cellular sensors. Fukuoka Igaku Zasshi. 2011;102:48-55.
15. Tian SL, Jiang, H Shi, J. TRPM7: a membrane protein with ion channel and kinase activities. Sheng Li Ke Xue Jin Zhan. 2009;40:253-7.
16. Nadler MJ, Hermosura MC, Inabe K, et al. LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability. Nature. 2001;411:590-5.
17. Chen JP, Luan Y, You CX, et al. TRPM7 regulates the migration of human nasopharyngeal carcinoma cell by mediating Ca(2+) influx. Cell Calcium. 2010;47:425-32.
18. Wykes RC, Lee M, Duffy SM, et al. Functional transient receptor potential melastatin 7 channels are critical for human mast cell survival. J Immunol. 2007;179:4045-52.
19. Liu H, Li J, Huang Y, Huang C. Inhibition of transient receptor potential melastain 7 channel increases HSCs apoptosis induced by TRAIL. Life Sci. 2012;90:612-8.
20. Bin G, Fen QY, Hua LX, et al. Dysfunction of myocardial sarcoplasmic reticulum in rats with myocardial calcification. Life Sci. 2005;77:966-79.
21. Oh GS, Pae HO, Lee BS, et al. Hydrogen sulfide inhibits nitric oxide production and nuclear factor-kappaB via heme oxygenase-1 expression in RAW264.7 macrophages stimulated with lipopolysaccharide. Free Radic Biol Med. 2006;41:106-19.
22. Kurihara R, Yamaoka K, Sawamukai N, et al. C5a promotes migration, proliferation, and vessel formation in endothelial cells. Inflamm Res. 2010;59:659-66.
23. Hardie WD, Hagood JS, Dave V, et al. Signaling pathways in the epithelial origins of pulmonary fibrosis. Cell Cycle. 2010;9:2769-76.
24. Conte E, Fruciano M, Fagone E, et al. Inhibition of PI3K prevents the proliferation and differentiation of human lung fibroblasts into myofibroblasts: the role of class I P110 isoforms. PLoS ONE. 2011;6:e24663.
25. Liu X, Li F, Sun SQ, et al. Fibroblast-specific expression of AC6 enhances beta-adrenergic and prostacyclin signaling and blunts bleomycin-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2010;298:L819-29.
26. Fang LP, Lin Q, Tang CS, Liu XM. Hydrogen sulfide suppresses migration, proliferation and myofibroblast transdifferentiation of human lung fibroblasts. Pulm Pharmacol Ther. 2009;22:554-61.
27. Tarantal AF, Chen H, Shi TT, et al. Overexpression of transforming growth factor-beta1 in fetal monkey lung results in prenatal pulmonary fibrosis. Eur Respir J. 2010;36:907-14.
28. Dooley S, ten Dijke P. TGF-beta in progression of liver disease. Cell Tissue Res. 2012;347:245-56.
29. Mackinnon AC, Gibbons MA, Farnworth SL, et al. Regulation of transforming growth factor-beta1-driven lung fibrosis by galectin-3. Am J Respir Crit Care Med. 2012;185:537-46.
30. Gauldie J, Kolb M, Sime PJ. A new direction in the pathogenesis of idiopathic pulmonary fibrosis? Respir Res. 2002;3:1.
31. Nathan N, Thouvenin G, Fauroux B, Corvol H, Clement A. Interstitial lung disease: physiopathology in the context of lung growth. Paediatr Respir Rev. 2011;12:216-22.
32. Strieter RM, Mehrad B. New mechanisms of pulmonary fibrosis. Chest. 2009;136:1364-70.
33. Monteilh-Zoller MK, Hermosura MC, Nadler MJ, et al. TRPM7 provides an ion channel mechanism for cellular entry of trace metal ions. J Gen Physiol. 2003;121:49-60.
34. Sahmoun AE, Singh BB. Does a higher ratio of serum calcium to magnesium increase the risk for postmenopausal breast cancer? Med Hypotheses. 2010;75:315-8.
35. 2+/calmodulin-sensitive TRPM7-like current in hepatoma and hepatocytes. Am J Physiol Gastrointest Liver Physiol. 2009;297:G687-94.
36. Zhao L, Wang Y, Sun N, et al. Electroacupuncture regulates TRPM7 expression through the trkA/PI3K pathway after cerebral ischemia-reperfusion in rats. Life Sci. 2007;81:1211-22.
37. Cheng H, Feng JM, Figueiredo ML, et al. Transient receptor potential melastatin type 7 channel is critical for the survival of bone marrow derived mesenchymal stem cells. Stem Cells Dev. 2010;19:1393-403.
38. 2+ entry pathway in human retinoblastoma cells. J Pharmacol Sci. 2004;95:403-19.
39. Jiang J, Li MH, Inoue K, et al. Transient receptor potential melastatin 7-like current in human head and neck carcinoma cells: role in cell proliferation. Cancer Res. 2007;67:10929-38.
40. Abed E, Moreau R. Importance of melastatin-like transient receptor potential 7 and magnesium in the stimulation of osteoblast proliferation and migration by platelet-derived growth factor. Am J Physiol Cell Physiol. 2009;297:C360-8.
41. Carracedo A, Pandolfi PP. The PTEN-PI3K pathway: of feedbacks and cross-talks. Oncogene. 2008;27:5527-41.
42. Lu Y, Azad N, Wang L, et al. Phosphatidylinositol-3-kinase/akt regulates bleomycin-induced fibroblast proliferation and collagen production. Am J Respir Cell Mol Biol. 2010;42:432-41.
43. Cantley LC. The phosphoinositide 3-kinase pathway. Science. 2002;296:1655-7.
44. Sahni J, Scharenberg AM. TRPM7 ion channels are required for sustained phosphoinositide 3-kinase signaling in lymphocytes. Cell Metab. 2008;8:84-93.