Prevention of in vitro hepatic stellate cells activation by the adenosine derivative compound IFC305

Biochemical Pharmacology

Volumn 80, Issue 11, 2010, Pages 1690-1699

  Velasco Loyden, Gabriela ^a   Pérez Carreón, Julio Isael ^b   Agüero, José Fernando Cabello ^a   Romero, Pilar Cabrales ^a   Vidrio Gómez, Susana ^a   Martínez Pérez, Lidia ^a   Yáñez Maldonado, Lucia ^a   Hernández Muñoz, Rolando ^a   Macías Silva, Marina ^a   de Sánchez, Victoria Chagoya ^a  

^a INSTITUTO DE FISIOLOGÍA CELULAR   (Mexico)

^b INSTITUTO NACIONAL DE MEDICINA GENÓMICA   (Mexico)

Author keywords

Adenosine; Cell differentiation; Cell proliferation; Fibrosis; Hepatic stellate cells; Liver

Indexed keywords

ADENOSINE DERIVATIVE; ADENOSINE KINASE; ADENOSINE PHOSPHATE; ADENOSINE RECEPTOR; ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN; COLLAGEN ALPHA1; COLLAGENASE 3; FAT DROPLET; IFC 305; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PYRIMIDINE RIBONUCLEOSIDE; RHO FACTOR; RIBONUCLEOSIDE; SMAD7 PROTEIN; UNCLASSIFIED DRUG; URIDINE; ADENOSINE; ADENOSINE 2-AMINOSUCCINIC ACID-2-(6-AMINO-9H-PURIN-9-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL; GROWTH INHIBITOR;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL GROWTH; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; IN VITRO STUDY; LIVER CELL; LIVER FIBROSIS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RAT; SIGNAL TRANSDUCTION; STELLATE CELL; UPREGULATION; ANALOGS AND DERIVATIVES; ANIMAL; CELL CULTURE; COMPARATIVE STUDY; DRUG EFFECTS; METABOLISM; PHYSIOLOGY; WISTAR RAT;

ADENOSINE; ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; GROWTH INHIBITORS; HEPATIC STELLATE CELLS; MALE; RATS; RATS, WISTAR; UP-REGULATION;

EID: 77957913431     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2010.08.017     Document Type: Article

References (53)

1. Friedman S.L. Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev 2008, 88:125-172.
2. Zimmermann H. Extracellular metabolism of ATP and other nucleotides. Naunyn Schmiedebergs Arch Pharmacol 2000, 362:299-309.
3. Fredholm B.B. Adenosine, an endogenous distress signal, modulates tissue damage and repair. Cell Death Differ 2007, 14:1315-1323.
4. Hardie D.G. AMPK: a key regulator of energy balance in the single cell and the whole organism. Int J Obes (Lond) 2008, 32(Suppl. 4):S7-S12.
5. Snyder F.F., Seegmiller J.E. The adenosine-like effect of exogenous cyclic AMP upon nucleotide and PP-ribose-P concentrations of cultured human lymphoblasts. FEBS Lett 1976, 66:102-106.
6. Weisman G.A., Lustig K.D., Lane E., Huang N.N., Belzer I., Friedberg I. Growth inhibition of transformed mouse fibroblasts by adenine nucleotides occurs via generation of extracellular adenosine. J Biol Chem 1988, 263:12367-12372.
7. Seetulsingh-Goorah S.P. Mechanisms of adenosine-induced cytotoxicity and their clinical and physiological implications. Biofactors 2006, 27:213-230.
8. Hernandez-Munoz R., Glender W., Diaz-Munoz M., Adolfo J., Garcia-Sainz J.A., Chagoya de Sanchez V. Effects of adenosine on liver cell damage induced by carbon tetrachloride. Biochem Pharmacol 1984, 33:2599-2604.
9. Hernandez-Munoz R., Diaz-Munoz M., Suarez J., Chagoya de Sanchez V. Adenosine partially prevents cirrhosis induced by carbon tetrachloride in rats. Hepatology 1990, 12:242-248.
10. Hernandez-Munoz R., Diaz-Munoz M., Chagoya de Sanchez V. Effects of adenosine administration on the function and membrane composition of liver mitochondria in carbon tetrachloride-induced cirrhosis. Arch Biochem Biophys 1992, 294:160-167.
11. Hernandez-Munoz R., Diaz-Munoz M., Chagoya de Sanchez V. Possible role of cell redox state on collagen metabolism in carbon tetrachloride-induced cirrhosis as evidenced by adenosine administration to rats. Biochim Biophys Acta 1994, 1200:93-99.
12. Chagoya de Sanchez V., Hernandez-Munoz R., Yanez L., Vidrio S., Diaz-Munoz M. Possible mechanism of adenosine protection in carbon tetrachloride acute hepatotoxicity. Role of adenosine by-products and glutathione peroxidase. J Biochem Toxicol 1995, 10:41-50.
13. Hernandez-Munoz R., Diaz-Munoz M., Suarez-Cuenca J.A., Trejo-Solis C., Lopez V., Sanchez-Sevilla L., et al. Adenosine reverses a preestablished CCl4-induced micronodular cirrhosis through enhancing collagenolytic activity and stimulating hepatocyte cell proliferation in rats. Hepatology 2001, 34:677-687.
14. Perez-Carreon J.I., Martinez-Perez L., Loredo M.L., Yanez-Maldonado L., Velasco-Loyden G., Vidrio-Gomez S., et al. An adenosine derivative compound, IFC305, reverses fibrosis and alters gene expression in a pre-established CCl(4)-induced rat cirrhosis. Int J Biochem Cell Biol 2010, 42:287-296.
15. Yassuda Filho P., Bracht A., Ishii-Iwamoto E.L., Lousano S.H., Bracht L., Kelmer-Bracht A.M. The urea cycle in the liver of arthritic rats. Mol Cell Biochem 2003, 243:97-106.
16. Schafer S., Zerbe O., Gressner A.M. The synthesis of proteoglycans in fat-storing cells of rat liver. Hepatology 1987, 7:680-687.
17. Murata T., Arii S., Nakamura T., Mori A., Kaido T., Furuyama H., et al. Inhibitory effect of Y-27632, a ROCK inhibitor, on progression of rat liver fibrosis in association with inactivation of hepatic stellate cells. J Hepatol 2001, 35:474-481.
18. Higashi N., Kohjima M., Fukushima M., Ohta S., Kotoh K., Enjoji M., et al. Epigallocatechin-3-gallate, a green-tea polyphenol, suppresses Rho signaling in TWNT-4 human hepatic stellate cells. J Lab Clin Med 2005, 145:316-322.
19. Yee H.F. Rho directs activation-associated changes in rat hepatic stellate cell morphology via regulation of the actin cytoskeleton. Hepatology 1998, 28:843-850.
20. Sohail M.A., Hashmi A.Z., Hakim W., Watanabe A., Zipprich A., Groszmann R.J., et al. Adenosine induces loss of actin stress fibers and inhibits contraction in hepatic stellate cells via Rho inhibition. Hepatology 2009, 49:185-194.
21. Pinzani M., Gesualdo L., Sabbah G.M., Abboud H.E. Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells. J Clin Invest 1989, 84:1786-1793.
22. Marra F., Gentilini A., Pinzani M., Choudhury G.G., Parola M., Herbst H., et al. Phosphatidylinositol 3-kinase is required for platelet-derived growth factor's actions on hepatic stellate cells. Gastroenterology 1997, 112:1297-1306.
23. Pinzani M. PDGF and signal transduction in hepatic stellate cells. Front Biosci 2002, 7:d1720-d1726.
24. Gabele E., Reif S., Tsukada S., Bataller R., Yata Y., Morris T., et al. The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. J Biol Chem 2005, 280:13374-13382.
25. Bridle K.R., Li L., O'Neill R., Britton R.S., Bacon B.R. Coordinate activation of intracellular signaling pathways by insulin-like growth factor-1 and platelet-derived growth factor in rat hepatic stellate cells. J Lab Clin Med 2006, 147:234-241.
26. Pastor-Anglada M., Cano-Soldado P., Errasti-Murugarren E., Casado F.J. SLC28 genes and concentrative nucleoside transporter (CNT) proteins. Xenobiotica 2008, 38:972-994.
27. Molina-Arcas M., Trigueros-Motos L., Casado F.J., Pastor-Anglada M. Physiological and pharmacological roles of nucleoside transporter proteins. Nucleos Nucleot Nucl Acids 2008, 27:769-778.
28. Hardie D.G. The AMP-activated protein kinase pathway-new players upstream and downstream. J Cell Sci 2004, 117:5479-5487.
29. Ohkubo S., Nagata K., Nakahata N. Adenosine uptake-dependent C6 cell growth inhibition. Eur J Pharmacol 2007, 577:35-43.
30. Schaefer B., Rivas-Estilla A.M., Meraz-Cruz N., Reyes-Romero M.A., Hernandez-Nazara Z.H., Dominguez-Rosales J.A., et al. Reciprocal modulation of matrix metalloproteinase-13 and type I collagen genes in rat hepatic stellate cells. Am J Pathol 2003, 162:1771-1780.
31. Tsukada S., Parsons C.J., Rippe R.A. Mechanisms of liver fibrosis. Clin Chim Acta 2006, 364:33-60.
32. Chen Y.W., Li D.G., Wu J.X., Lu H.M. Tetrandrine inhibits activation of rat hepatic stellate cells stimulated by transforming growth factor-beta in vitro via up-regulation of Smad 7. J Ethnopharmacol 2005, 100:299-305.
33. Dooley S., Hamzavi J., Breitkopf K., Wiercinska E., Said H.M., Lorenzen J., et al. Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats. Gastroenterology 2003, 125:178-191.
34. Miyahara T., Schrum L., Rippe R., Xiong S., Yee H.F., Motomura K., et al. Peroxisome proliferator-activated receptors and hepatic stellate cell activation. J Biol Chem 2000, 275:35715-35722.
35. Hazra S., Xiong S., Wang J., Rippe R.A., Krishna V., Chatterjee K., et al. Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cells. J Biol Chem 2004, 279:11392-11401.
36. Guo Y.T., Leng X.S., Li T., Peng J.R., Song S.H., Xiong L.F., et al. Effect of ligand of peroxisome proliferator-activated receptor gamma on the biological characters of hepatic stellate cells. World J Gastroenterol 2005, 11:4735-4739.
37. Neuschwander-Tetri B.A., Brunt E.M., Wehmeier K.R., Oliver D., Bacon B.R. Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-gamma ligand rosiglitazone. Hepatology 2003, 38:1008-1017.
38. Belfort R., Harrison S.A., Brown K., Darland C., Finch J., Hardies J., et al. A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. N Engl J Med 2006, 355:2297-2307.
39. Chagoya de Sanchez V., Hernandez-Munoz R., Sanchez L., Vidrio S., Yanez L., Suarez J. Twenty-four-hour changes of S-adenosylmethionine, S-adenosylhomocysteine adenosine and their metabolizing enzymes in rat liver; possible physiological significance in phospholipid methylation. Int J Biochem 1991, 23:1439-1443.
40. Tada S., Iwamoto H., Nakamuta M., Sugimoto R., Enjoji M., Nakashima Y., et al. A selective ROCK inhibitor, Y27632, prevents dimethylnitrosamine-induced hepatic fibrosis in rats. J Hepatol 2001, 34:529-536.
41. Hashmi A.Z., Hakim W., Kruglov E.A., Watanabe A., Watkins W., Dranoff J.A., et al. Adenosine inhibits cytosolic calcium signals and chemotaxis in hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol 2007, 292:G395-G401.
42. Che J., Chan E.S., Cronstein B.N. Adenosine A2A receptor occupancy stimulates collagen expression by hepatic stellate cells via pathways involving protein kinase A, Src, and extracellular signal-regulated kinases 1/2 signaling cascade or p38 mitogen-activated protein kinase signaling pathway. Mol Pharmacol 2007, 72:1626-1636.
43. Pinzani M., Marra F., Carloni V. Signal transduction in hepatic stellate cells. Liver 1998, 18:2-13.
44. Wong L., Yamasaki G., Johnson R.J., Friedman S.L. Induction of beta-platelet-derived growth factor receptor in rat hepatic lipocytes during cellular activation in vivo and in culture. J Clin Invest 1994, 94:1563-1569.
45. Weber J.D., Raben D.M., Phillips P.J., Baldassare J.J. Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase. Biochem J 1997, 326(Pt 1):61-68.
46. Roberts E.C., Shapiro P.S., Nahreini T.S., Pages G., Pouyssegur J., Ahn N.G. Distinct cell cycle timing requirements for extracellular signal-regulated kinase and phosphoinositide 3-kinase signaling pathways in somatic cell mitosis. Mol Cell Biol 2002, 22:7226-7241.
47. Adachi M., Brenner D.A. High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase. Hepatology 2008, 47:677-685.
48. Caligiuri A., Bertolani C., Guerra C.T., Aleffi S., Galastri S., Trappoliere M., et al. Adenosine monophosphate-activated protein kinase modulates the activated phenotype of hepatic stellate cells. Hepatology 2008, 47:668-676.
49. Danks M.K., Scholar E.M. Regulation of phosphoribosylpyrophosphate synthetase by endogenous purine and pyrimidine compounds and synthetic analogs in normal and leukemic white blood cells. Biochem Pharmacol 1982, 31:1687-1691.
50. van der Kraan P.M., van Zandvoort P.M., De Abreu R.A., van Baal J.M., Bakkeren J.A. Inhibition of lymphoid cell growth by adenine ribonucleotide accumulation. The role of phosphoribosylpyrophosphate-depletion induced pyrimidine starvation. Biochim Biophys Acta 1987, 927:213-221.
51. Huang M., Graves L.M. De novo synthesis of pyrimidine nucleotides; emerging interfaces with signal transduction pathways. Cell Mol Life Sci 2003, 60:321-336.
52. Yang D., Yaguchi T., Yamamoto H., Nishizaki T. Intracellularly transported adenosine induces apoptosis in HuH-7 human hepatoma cells by downregulating c-FLIP expression causing caspase-3/-8 activation. Biochem Pharmacol 2007, 73:1665-1675.
53. Saitoh M., Nagai K., Nakagawa K., Yamamura T., Yamamoto S., Nishizaki T. Adenosine induces apoptosis in the human gastric cancer cells via an intrinsic pathway relevant to activation of AMP-activated protein kinase. Biochem Pharmacol 2004, 67:2005-2011.