Inhibition of the ANT(2″)-Ia resistance enzyme and rescue of aminoglycoside antibiotic activity by synthetic α-hydroxytropolones

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 21, 2014, Pages 4943-4947

  Hirsch, Danielle R ^a,b   Cox, Georgina ^c   D'Erasmo, Michael P ^a,b   Shakya, Tushar ^c   Meck, Christine ^a,b   Mohd, Noushad ^a   Wright, Gerard D ^c   Murelli, Ryan P ^a,b  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b CITY UNIVERSITY OF NEW YORK   (United States)

^c MCMASTER UNIVERSITY   (Canada)

Author keywords

Aminoglycoside 2 O nucleotidyltransferase; Aminoglycosides; Bacterial; Gentamicin; Resistance; Hydroxytropolones

Indexed keywords

ALPHA HYDROXYTROPOLONE; AMINOGLYCOSIDE 2" 4 NUCLEOTIDYLTRANSFERASE; AMINOGLYCOSIDE ANTIBIOTIC AGENT; GENTAMICIN; TROPOLONE DERIVATIVE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; GENTAMICIN 2''-NUCLEOTIDYLTRANSFERASE; NUCLEOTIDYLTRANSFERASE; TROPOLONE;

ANTIBIOTIC RESISTANCE; ANTIMICROBIAL ACTIVITY; ARTICLE; CYCLOADDITION; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; ESCHERICHIA COLI; NONHUMAN; RING OPENING; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; METABOLISM;

ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; GENTAMICINS; MODELS, CHEMICAL; MOLECULAR STRUCTURE; NUCLEOTIDYLTRANSFERASES; TROPOLONE;

EID: 84908007681     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.09.037     Document Type: Article

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