메뉴 건너뛰기




Volumn 26, Issue 4, 2014, Pages 577-590

Gene body methylation can alter gene expression and is a therapeutic target in cancer

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; DNA METHYLTRANSFERASE 3B;

EID: 84907997839     PISSN: 15356108     EISSN: 18783686     Source Type: Journal    
DOI: 10.1016/j.ccr.2014.07.028     Document Type: Article
Times cited : (878)

References (62)
  • 1
    • 70349333201 scopus 로고    scopus 로고
    • Nucleosomes are well positioned in exons and carry characteristic histone modifications
    • Andersson R., Enroth S., Rada-Iglesias A., Wadelius C., Komorowski J. Nucleosomes are well positioned in exons and carry characteristic histone modifications. Genome Res. 2009, 19:1732-1741.
    • (2009) Genome Res. , vol.19 , pp. 1732-1741
    • Andersson, R.1    Enroth, S.2    Rada-Iglesias, A.3    Wadelius, C.4    Komorowski, J.5
  • 2
    • 84877574817 scopus 로고    scopus 로고
    • The future of epigenetic therapy in solid tumours-lessons from the past
    • Azad N., Zahnow C.A., Rudin C.M., Baylin S.B. The future of epigenetic therapy in solid tumours-lessons from the past. Nat. Rev. Clin. Oncol. 2013, 10:256-266.
    • (2013) Nat. Rev. Clin. Oncol. , vol.10 , pp. 256-266
    • Azad, N.1    Zahnow, C.A.2    Rudin, C.M.3    Baylin, S.B.4
  • 3
    • 84869064386 scopus 로고    scopus 로고
    • Epigenetic targeting therapies to overcome chemotherapy resistance
    • Balch C., Nephew K.P. Epigenetic targeting therapies to overcome chemotherapy resistance. Adv. Exp. Med. Biol. 2013, 754:285-311.
    • (2013) Adv. Exp. Med. Biol. , vol.754 , pp. 285-311
    • Balch, C.1    Nephew, K.P.2
  • 4
    • 80053144962 scopus 로고    scopus 로고
    • A decade of exploring the cancer epigenome - biological and translational implications
    • Baylin S.B., Jones P.A. A decade of exploring the cancer epigenome - biological and translational implications. Nat. Rev. Cancer 2011, 11:726-734.
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 726-734
    • Baylin, S.B.1    Jones, P.A.2
  • 6
    • 84865790047 scopus 로고    scopus 로고
    • An integrated encyclopedia of DNA elements in the human genome
    • ENCODE Project Consortium
    • Bernstein B.E., Birney E., Dunham I., Green E.D., Gunter C., Snyder M. An integrated encyclopedia of DNA elements in the human genome. Nature 2012, 489:57-74. ENCODE Project Consortium.
    • (2012) Nature , vol.489 , pp. 57-74
    • Bernstein, B.E.1    Birney, E.2    Dunham, I.3    Green, E.D.4    Gunter, C.5    Snyder, M.6
  • 7
    • 84877752572 scopus 로고    scopus 로고
    • Stalling the engine of resistance: targeting cancer metabolism to overcome therapeutic resistance
    • Butler E.B., Zhao Y., Muñoz-Pinedo C., Lu J., Tan M. Stalling the engine of resistance: targeting cancer metabolism to overcome therapeutic resistance. Cancer Res. 2013, 73:2709-2717.
    • (2013) Cancer Res. , vol.73 , pp. 2709-2717
    • Butler, E.B.1    Zhao, Y.2    Muñoz-Pinedo, C.3    Lu, J.4    Tan, M.5
  • 8
    • 84868122260 scopus 로고    scopus 로고
    • Deposition of histone variant H2A.Z within gene bodies regulates responsive genes
    • Coleman-Derr D., Zilberman D. Deposition of histone variant H2A.Z within gene bodies regulates responsive genes. PLoS Genet. 2012, 8:e1002988.
    • (2012) PLoS Genet. , vol.8 , pp. e1002988
    • Coleman-Derr, D.1    Zilberman, D.2
  • 9
    • 84859171807 scopus 로고    scopus 로고
    • MYC on the path to cancer
    • Dang C.V. MYC on the path to cancer. Cell 2012, 149:22-35.
    • (2012) Cell , vol.149 , pp. 22-35
    • Dang, C.V.1
  • 13
    • 33748998743 scopus 로고    scopus 로고
    • Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival
    • Egger G., Jeong S., Escobar S.G., Cortez C.C., Li T.W., Saito Y., Yoo C.B., Jones P.A., Liang G. Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival. Proc. Natl. Acad. Sci. USA 2006, 103:14080-14085.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 14080-14085
    • Egger, G.1    Jeong, S.2    Escobar, S.G.3    Cortez, C.C.4    Li, T.W.5    Saito, Y.6    Yoo, C.B.7    Jones, P.A.8    Liang, G.9
  • 15
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 16
    • 33847304609 scopus 로고    scopus 로고
    • Gene body-specific methylation on the active X chromosome
    • Hellman A., Chess A. Gene body-specific methylation on the active X chromosome. Science 2007, 315:1141-1143.
    • (2007) Science , vol.315 , pp. 1141-1143
    • Hellman, A.1    Chess, A.2
  • 17
    • 85027954125 scopus 로고    scopus 로고
    • DNA methylation profiling in the clinic: applications and challenges
    • Heyn H., Esteller M. DNA methylation profiling in the clinic: applications and challenges. Nat. Rev. Genet. 2012, 13:679-692.
    • (2012) Nat. Rev. Genet. , vol.13 , pp. 679-692
    • Heyn, H.1    Esteller, M.2
  • 18
    • 84863986133 scopus 로고    scopus 로고
    • Functions of DNA methylation: islands, start sites, gene bodies and beyond
    • Jones P.A. Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat. Rev. Genet. 2012, 13:484-492.
    • (2012) Nat. Rev. Genet. , vol.13 , pp. 484-492
    • Jones, P.A.1
  • 19
    • 0018860957 scopus 로고
    • Cellular differentiation, cytidine analogs and DNA methylation
    • Jones P.A., Taylor S.M. Cellular differentiation, cytidine analogs and DNA methylation. Cell 1980, 20:85-93.
    • (1980) Cell , vol.20 , pp. 85-93
    • Jones, P.A.1    Taylor, S.M.2
  • 20
    • 70350046301 scopus 로고    scopus 로고
    • Rethinking how DNA methylation patterns are maintained
    • Jones P.A., Liang G. Rethinking how DNA methylation patterns are maintained. Nat. Rev. Genet. 2009, 10:805-811.
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 805-811
    • Jones, P.A.1    Liang, G.2
  • 22
    • 77955459115 scopus 로고    scopus 로고
    • Long-term stability of demethylation after transient exposure to 5-aza-2'-deoxycytidine correlates with sustained RNA polymerase II occupancy
    • Kagey J.D., Kapoor-Vazirani P., McCabe M.T., Powell D.R., Vertino P.M. Long-term stability of demethylation after transient exposure to 5-aza-2'-deoxycytidine correlates with sustained RNA polymerase II occupancy. Mol. Cancer Res. 2010, 8:1048-1059.
    • (2010) Mol. Cancer Res. , vol.8 , pp. 1048-1059
    • Kagey, J.D.1    Kapoor-Vazirani, P.2    McCabe, M.T.3    Powell, D.R.4    Vertino, P.M.5
  • 24
  • 25
    • 77956931047 scopus 로고    scopus 로고
    • H2A.Z maintenance during mitosis reveals nucleosome shifting on mitotically silenced genes
    • Kelly T.K., Miranda T.B., Liang G., Berman B.P., Lin J.C., Tanay A., Jones P.A. H2A.Z maintenance during mitosis reveals nucleosome shifting on mitotically silenced genes. Mol. Cell 2010, 39:901-911.
    • (2010) Mol. Cell , vol.39 , pp. 901-911
    • Kelly, T.K.1    Miranda, T.B.2    Liang, G.3    Berman, B.P.4    Lin, J.C.5    Tanay, A.6    Jones, P.A.7
  • 26
    • 84870552401 scopus 로고    scopus 로고
    • Genome-wide mapping of nucleosome positioning and DNA methylation within individual DNA molecules
    • Kelly T.K., Liu Y., Lay F.D., Liang G., Berman B.P., Jones P.A. Genome-wide mapping of nucleosome positioning and DNA methylation within individual DNA molecules. Genome Res. 2012, 22:2497-2506.
    • (2012) Genome Res. , vol.22 , pp. 2497-2506
    • Kelly, T.K.1    Liu, Y.2    Lay, F.D.3    Liang, G.4    Berman, B.P.5    Jones, P.A.6
  • 29
    • 84871539869 scopus 로고    scopus 로고
    • Foxa2 and H2A.Z mediate nucleosome depletion during embryonic stem cell differentiation
    • Li Z., Gadue P., Chen K., Jiao Y., Tuteja G., Schug J., Li W., Kaestner K.H. Foxa2 and H2A.Z mediate nucleosome depletion during embryonic stem cell differentiation. Cell 2012, 151:1608-1616.
    • (2012) Cell , vol.151 , pp. 1608-1616
    • Li, Z.1    Gadue, P.2    Chen, K.3    Jiao, Y.4    Tuteja, G.5    Schug, J.6    Li, W.7    Kaestner, K.H.8
  • 44
    • 79952258043 scopus 로고    scopus 로고
    • Nucleosomes containing methylated DNA stabilize DNA methyltransferases 3A/3B and ensure faithful epigenetic inheritance
    • Sharma S., De Carvalho D.D., Jeong S., Jones P.A., Liang G. Nucleosomes containing methylated DNA stabilize DNA methyltransferases 3A/3B and ensure faithful epigenetic inheritance. PLoS Genet. 2011, 7:e1001286.
    • (2011) PLoS Genet. , vol.7 , pp. e1001286
    • Sharma, S.1    De Carvalho, D.D.2    Jeong, S.3    Jones, P.A.4    Liang, G.5
  • 46
    • 0018581647 scopus 로고
    • Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine
    • Taylor S.M., Jones P.A. Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine. Cell 1979, 17:771-779.
    • (1979) Cell , vol.17 , pp. 771-779
    • Taylor, S.M.1    Jones, P.A.2
  • 48
    • 84863337757 scopus 로고    scopus 로고
    • Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells
    • Tsai H.C., Li H., Van Neste L., Cai Y., Robert C., Rassool F.V., Shin J.J., Harbom K.M., Beaty R., Pappou E., et al. Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells. Cancer Cell 2012, 21:430-446.
    • (2012) Cancer Cell , vol.21 , pp. 430-446
    • Tsai, H.C.1    Li, H.2    Van Neste, L.3    Cai, Y.4    Robert, C.5    Rassool, F.V.6    Shin, J.J.7    Harbom, K.M.8    Beaty, R.9    Pappou, E.10
  • 51
    • 84856120332 scopus 로고    scopus 로고
    • Understanding the language of Lys36 methylation at histone H3
    • Wagner E.J., Carpenter P.B. Understanding the language of Lys36 methylation at histone H3. Nat. Rev. Mol. Cell Biol. 2012, 13:115-126.
    • (2012) Nat. Rev. Mol. Cell Biol. , vol.13 , pp. 115-126
    • Wagner, E.J.1    Carpenter, P.B.2
  • 52
    • 84858604270 scopus 로고    scopus 로고
    • Metabolic reprogramming: a cancer hallmark even warburg did not anticipate
    • Ward P.S., Thompson C.B. Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer Cell 2012, 21:297-308.
    • (2012) Cancer Cell , vol.21 , pp. 297-308
    • Ward, P.S.1    Thompson, C.B.2
  • 54
    • 77954182362 scopus 로고    scopus 로고
    • ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking
    • Wilkerson M.D., Hayes D.N. ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking. Bioinformatics 2010, 26:1572-1573.
    • (2010) Bioinformatics , vol.26 , pp. 1572-1573
    • Wilkerson, M.D.1    Hayes, D.N.2
  • 59
    • 84885834757 scopus 로고    scopus 로고
    • Epigenetic aspects of MDS and its molecular targeted therapy
    • Yamazaki J., Issa J.P. Epigenetic aspects of MDS and its molecular targeted therapy. Int. J. Hematol. 2013, 97:175-182.
    • (2013) Int. J. Hematol. , vol.97 , pp. 175-182
    • Yamazaki, J.1    Issa, J.P.2
  • 60
    • 84859261580 scopus 로고    scopus 로고
    • Gene reactivation by 5-aza-2'-deoxycytidine-induced demethylation requires SRCAP-mediated H2A.Z insertion to establish nucleosome depleted regions
    • Yang X., Noushmehr H., Han H., Andreu-Vieyra C., Liang G., Jones P.A. Gene reactivation by 5-aza-2'-deoxycytidine-induced demethylation requires SRCAP-mediated H2A.Z insertion to establish nucleosome depleted regions. PLoS Genet. 2012, 8:e1002604.
    • (2012) PLoS Genet. , vol.8 , pp. e1002604
    • Yang, X.1    Noushmehr, H.2    Han, H.3    Andreu-Vieyra, C.4    Liang, G.5    Jones, P.A.6
  • 61
    • 77952355762 scopus 로고    scopus 로고
    • Genome-wide evolutionary analysis of eukaryotic DNA methylation
    • Zemach A., McDaniel I.E., Silva P., Zilberman D. Genome-wide evolutionary analysis of eukaryotic DNA methylation. Science 2010, 328:916-919.
    • (2010) Science , vol.328 , pp. 916-919
    • Zemach, A.1    McDaniel, I.E.2    Silva, P.3    Zilberman, D.4
  • 62
    • 55549141877 scopus 로고    scopus 로고
    • Histone H2A.Z and DNA methylation are mutually antagonistic chromatin marks
    • Zilberman D., Coleman-Derr D., Ballinger T., Henikoff S. Histone H2A.Z and DNA methylation are mutually antagonistic chromatin marks. Nature 2008, 456:125-129.
    • (2008) Nature , vol.456 , pp. 125-129
    • Zilberman, D.1    Coleman-Derr, D.2    Ballinger, T.3    Henikoff, S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.