PAX6 methylation and ectopic expression in human tumor cells

International Journal of Cancer

Volumn 87, Issue 2, 2000, Pages 179-185

  Salem, Carol E ^a   Markl, Isabel D C ^b   Bender, Christina M ^b   Gonzales, Felicidad A ^b   Jones, Peter A ^a,b   Liang, Gangning ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BLADDER CANCER; CANCER CELL CULTURE; CANCER GENETICS; COLON CANCER; DNA DETERMINATION; DNA METHYLATION; EXON; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN LOCALIZATION; TISSUE DISTRIBUTION;

ANTIMETABOLITES, ANTINEOPLASTIC; AZACITIDINE; BLOTTING, WESTERN; COLONIC NEOPLASMS; CPG ISLANDS; DNA METHYLATION; DNA-BINDING PROTEINS; EXONS; EYE PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; HOMEODOMAIN PROTEINS; HUMANS; PAIRED BOX TRANSCRIPTION FACTORS; PROMOTER REGIONS (GENETICS); REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED; URINARY BLADDER NEOPLASMS;

EID: 0034662306     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0215(20000715)87:2<179::AID-IJC4>3.0.CO;2-X     Document Type: Article

References (22)

1. BENDER, C.M., PAO, M.M. and JONES, P.A., Inhibition of DNA methylation by 5-aza-2'-deoxycytidine suppresses the growth of human tumor cell lines. Cancer Res., 58, 95-101 (1998).
2. CHALEPAKIS, G., WIJNHOLDS, J., GIESE, P., SCHACHNER, M. and GRUSS, P., Characterization of Pax-6 and Hoxa-1 binding to the promoter region of the neural cell adhesion molecule L1. DNA Cell Biol., 13, 891-900 (1994).
3. GONZALEZ-ZULUETA, M., BENDER, C.M., YANG, A.S., NGUYEN, T., BEART, R.W., VAN TORNOUT, J.M. and JONES, P.A., Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res., 55, 4531-4535 (1995).
4. GONZALGO, M.L., HAYASHIDA, T., BENDER, C.M., PAO, M.M., TSAI, Y.C., GONZALES, F.A., NGUYEN, H.D., NGUYEN, T.T. and JONES, P.A., The role of DNA methylation in expression of the p19/p16 locus in human bladder cancer cell lines. Cancer Res., 58, 1245-1252 (1998).
5. GONZALGO, M.L. and JONES, P.A., Rapid quantitation of methylation differences at specific sites using methylation-sensitive single nucleotide primer extension (Ms-SNuPE). Nucleic Acids Res., 25, 2529-2531 (1997).
6. GONZALGO, M.L., LIANG, G., SPRUCK III, C.H., ZINGG, J.M., RIDEOUT III, W.M. and JONES, P.A., Identification and characterization of differentially methylated regions of genomic DNA by methylation-sensitive arbitrarily primed PCR. Cancer Res., 57, 594-599 (1997).
7. ISSA, J.P., BAYLIN, S.B. and BELINSKY, S.A., Methylation of the estrogen receptor CpG island in lung tumors is related to the specific type of carcinogen exposure. Cancer Res., 56, 3655-3658 (1996).
8. JONES, P.A. and TAYLOR, S.M., Cellular differentiation, cytidine analogs and DNA methylation. Cell, 20, 85-93 (1980).
9. JONES, P.A., WOLKOWICZ, M.J., RIDEOUT, W.M.D., GONZALES, F.A., MARZIASZ, C.M., COETZEE, G.A. and TAPSCOTT, S.J., De novo methylation of the MyoD1 CpG island during the establishment of immortal cell lines. Proc. Nat. Acad. Sci. (Wash.), 87, 6117-6121 (1990).
10. KOZMIK, Z., CZERNY, T. and BUSSLINGER, M., Alternatively spliced insertions in the paired domain restrict the DNA sequence specificity of Pax6 and Pax8. Embo J., 16, 6793-6803 (1997).
11. LIANG, G., SALEM, C.E., YU, M.C., NGUYEN, H.D., GONZALES, F.A., NGUYEN, T.T., NICHOLS, P.W. and JONES, P.A., DNA methylation differences associated with tumor tissues identified by genome scanning analysis. Genomics, 53, 260-268 (1998).
12. MANSOURI, A., HALLONET, M. and GRUSS, P., Pax genes and their roles in cell differentiation and development. Curr. Opin. cell. Biol., 8, 851-857 (1996).
13. MAULBECKER, C.C. and GRUSS, P., The oncogenic potential of Pax genes. Embo J., 12, 2361-237 (1993).
14. PROSSER, J. and VAN HEYNINGEN, V., PAX6 mutations reviewed. Hum. Mutal., 11, 93-108 (1998).
15. SANDER, M., NEUBUSER, A., KALAMARAS, J., EE, H.C., MARTIN, G.R. and GERMAN, M.S., Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development. Genes Dev., 11, 1662-1673 (1997).
16. STOYKOVA, A., GOTZ, M., GRUSS, P. and PRICE, J., Pax6-dependent regulation of adhesive patterning, R-cadherin expression and boundary formation in developing forebrain. Development, 124, 3765-3777 (1997).
17. STUART, E.T., KIOUSSI, C., and GRUSS, P., Mammalian PAX genes. Ann. Rev. Genet., 27, 219-236 (1993).
18. STUART, E.T. and GRUSS, P., PAX genes: what's new in developmental biology and CANCER? Hum Mol Genet, 4, 1717-1720 (1995).
19. TAKAGI, H., TAJIMA, S. and ASANO, A., Overexpression of DNA methyltransferase in myoblast cells accelerates myotube formation. Eur. J. Biochem., 231, 282-291 (1995).
20. TOYOTA, M., AHUJA, N., OHE-TOYOTA, M., HERMAN, J.G., BAYLIN, S.B. and ISSA, J.P., CpG island methylator phenotype in colorectal cancer. Proc. Nat. Acad. Sci. (Wash.), 96, 8681-8686 (1999).
21. WUTZ, A., SMRZKA, O.W., SCHWEIFER, N., SCHELLANDER, K., WAGNER, E.F. and BARLOW, D.P., Imprinted expression of the 1gf2r gene depends on an intronic CpG island [see comments]. Nature (Lond.), 389, 745-749 (1997).
22. XU, Z.P. and SAUNDERS, G.F., Transcriptional regulation of the human PAX6 gene promoter. J. Biol. Chem., 272, 3430-3436 (1997).