Trafficking dynamics of glycosylated pannexin1 proteins

Cell Communication and Adhesion

Volumn 15, Issue 1-2, 2008, Pages 119-132

  Boassa, Daniela ^a   Qiu, Feng ^c   Dahl, Gerhard ^c   Sosinsky, Gina ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Connexins; Gap junctions; Hemichannel; Innexins; Pannexins

Indexed keywords

BREFELDIN A; GAP JUNCTION PROTEIN; GLYCOPEPTIDASE; GLYCOSYLATED PROTEIN; MUTANT PROTEIN; MYC PROTEIN; OLIGOMER; PANNEXIN 1; TUNICAMYCIN;

ANIMAL CELL; ARTICLE; CELL SURFACE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DEGLYCOSYLATION; GOLGI COMPLEX; HUMAN; HUMAN CELL; MUTANT; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; RAT; TRANSPORT KINETICS; WILD TYPE; XENOPUS;

AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; CONNEXINS; DOGS; FOLLOW-UP STUDIES; GAP JUNCTIONS; GLYCOSYLATION; HUMANS; KINETICS; NERVE TISSUE PROTEINS; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RATS;

MAMMALIA; RATTUS;

EID: 42649085323     PISSN: 15419061     EISSN: 15435180     Source Type: Journal    
DOI: 10.1080/15419060802013885     Document Type: Article

References (36)

1. Bao, L., Locovei, S. and Dahl, G. (2004) Pannexin membrane channels are mechanosensitive conduits for ATP. 572, pp. 65-68.
2. Bao, L., Samuels, S., Locovei, S., Macagno, E. R., Muller, K. J. and Dahl, G. (2007) Innexins form two types of channels. 581, pp. 5703-5708.
3. Boassa, D., Ambrosi, C., Qiu, F., Dahl, G., Gaietta, G. and Sosinsky, G. (2007) Pannexin1 channels contain a glycosylation site that targets the hexamer to the plasma membrane. 282, pp. 31733-31743.
4. Bruzzone, R., Hormuzdi, S. G., Barbe, M. T., Herb, A. and Monyer, H. (2003) Pannexins, a family of gap junction proteins expressed in brain. 100, pp. 13644-13649.
5. Bukauskas, F. F., Jordan, K., Bukauskiene, A., Bennett, M. V., Lampe, P. D., Laird, D. W. and Verselis, V. K. (2000) Clustering of connexin 43-enhanced green fluorescent protein gap junction channels and functional coupling in living cells. 97, pp. 2556-2561.
6. Contreras, J. E., Saez, J. C., Bukauskas, F. F. and Bennett, M. V. (2003) Gating and regulation of connexin 43 (Cx43). hemichannels. 100, pp. 11388-11393.
7. Dahl, G. (1992) The Xenopus oocyte cell-cell channel assay for functional analysis of gap junction proteins. pp. 143-165. IRL, Oxford, UK
8. Dahl, G. and Locovei, S. (2006) Pannexin: To gap or not to gap, is that a question?. 58, pp. 409-419.
9. Gaietta, G., Deerinck, T. J., Adams, S. R., Bouwer, J., Tour, O., Laird, D. W., Sosinsky, G. E., Tsien, R. Y. and Ellisman, M. H. (2002) Multicolor and electron microscopic imaging of connexin trafficking. 296, pp. 503-507.
10. Gerido, D. A. and White, T. W. (2004) Connexin disorders of the ear, skin, and lens. 1662, pp. 159-170.
11. Huang, Y., Grinspan, J. B., Abrams, C. K. and Scherer, S. S. (2007) Pannexin1 is expressed by neurons and glia but does not form functional gap junctions. 55, pp. 46-56.
12. Hunter, A. W., Barker, R. J., Zhu, C. and Gourdie, R. G. (2005) Zonula occludens-1 alters connexin43 gap junction size and organization by influencing channel accretion. 16, pp. 5686-5698.
13. Jordan, K., Solan, J. L., Dominguez, M., Sia, M., Hand, A., Lampe, P. D. and Laird, D. W. (1999) Trafficking, assembly, and function of a connexin43-green fluorescent protein chimera in live mammalian cells. 10, pp. 2033-2050.
14. Khanna, R., Myers, M. P., Laine, M. and Papazian, D. M. (2001) Glycosylation increases potassium channel stability and surface expression in mammalian cells. 276, pp. 34028-34034.
15. Laird, D. W. (2006) Life cycle of connexins in health and disease. 394, pp. 527-543.
16. Laird, D. W., Castillo, M. and Kasprzak, L. (1995) Gap junction turnover, intracellular trafficking, and phosphorylation of connexin43 in brefeldin A-treated rat mammary tumor cells. 131, pp. 1193-1203.
17. Levine, E., Werner, R. and Dahl, G. (1991) Cell-cell channel formation and lectins. 261, p. C1025.
18. Lippincott-Schwartz, J., Yuan, L., Tipper, C., Amherdt, M., Orci, L. and Klausner, R. D. (1991) Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic. 67, pp. 601-616.
19. Lippincott-Schwartz, J., Yuan, L. C., Bonifacino, J. S. and Klausner, R. D. (1989) Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: Evidence for membrane cycling from Golgi to ER. 56, pp. 801-813.
20. Litvin, O., Tiunova, A., Connell-Alberts, Y., Panchin, Y. and Baranova, A. (2006) What is hidden in the pannexin treasure trove: The sneak peek and the guesswork. 10, pp. 613-634.
21. Locovei, S., Bao, L. and Dahl, G. (2006) Pannexin 1 in erythrocytes: function without a gap. 103, pp. 7655-7659.
22. Locovei, S., Scemes, E., Qiu, F., Spray, D. C. and Dahl, G. (2007) Pannexin1 is part of the pore forming unit of the P2X(7) receptor death complex. 581, pp. 483-488.
23. Martin, B. R., Giepmans, B. N., Adams, S. R. and Tsien, R. Y. (2005) Mammalian cell-based optimization of the biarsenical-binding tetracysteine motif for improved fluorescence and affinity. 23, pp. 1308-1314.
24. Musil, L. S. and Goodenough, D. A. (1993) Multisubunit assembly of an integral plasma membrane channel protein, gap junction connexin43, occurs after exit from the ER. 74, pp. 1065-1077.
25. Musil, L. S., Le, A. C., VanSlyke, J. K. and Roberts, L. M. (2000) Regulation of connexin degradation as a mechanism to increase gap junction assembly and function. 275, pp. 25207-25215.
26. Panchin, Y. V. (2005) Evolution of gap junction proteins - the pannexin alternative. 208, pp. 1415-1419.
27. Pelegrin, P. and Surprenant, A. (2006) Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor. 25, pp. 5071-5082.
28. Pelegrin, P. and Surprenant, A. (2007) Pannexin-1 couples to maitotoxin-and nigericin-induced interleukin-1beta release through a dye uptake-independent pathway. 282, pp. 2386-2394.
29. Penuela, S., Bhalla, R., Gong, X. Q., Cowan, K. N., Celetti, S. J., Cowan, B. J., Bai, D., Shao, Q. and Laird, D. W. (2007) Pannexin 1 and pannexin 3 are glycoproteins that exhibit many distinct characteristics from the connexin family of gap junction proteins. 120, pp. 3772-3783.
30. Petrecca, K., Atanasiu, R., Akhavan, A. and Shrier, A. (1999) N-linked glycosylation sites determine HERG channel surface membrane expression. 515, pp. 41-48.
31. Sosinsky, G. E., Solan, J. L., Gaietta, G. M., Ngan, L., Lee, G. J., Mackey, M. R. and Lampe, P. D. (2007) The C-terminus of connexin43 adopts different conformations in the Golgi and gap junction as detected with structure specific antibodies. 408, pp. 375-385.
32. Spray, D. C., Harris, A. L. and Bennett, M. V. (1981) Equilibrium properties of a voltage-dependent junctional conductance. 77, pp. 77-93.
33. Towbin, H., Staehelin, T. and Gordon, J. (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications. 76, pp. 4350-4354.
34. Vanden Abeele, F, Bidaux, G., Gordienko, D., Beck, B., Panchin, Y. V., Baranova, A. V., Ivanov, D. V., Skryma, R. and Prevarskaya, N. (2006) Functional implications of calcium permeability of the channel formed by pannexin 1. 174, pp. 535-546.
35. Wang, Y., Mehta, P. P. and Rose, B. (1995) Inhibition of glycosylation induces formation of open connexin-43 cell-to-cell channels and phosphorylation and triton X-100 insolubility of connexin-43. 270, pp. 26581-26585.
36. Watanabe, I., Zhu, J., Recio-Pinto, E. and Thornhill, W. B. (2004) Glycosylation affects the protein stability and cell surface expression of Kv1.4 but Not Kv1.1 potassium channels. A pore region determinant dictates the effect of glycosylation on trafficking. 279, pp. 8879-8885.