메뉴 건너뛰기




Volumn 144, Issue 2, 2014, Pages 192-201

Epilepsy, energy deficiency and new therapeutic approaches including diet

Author keywords

Epilepsy; Glucose; GLUT1 deficiency; Ketogenic diet; Metabolism

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; CREATINE; DEOXYGLUCOSE; GLUCOSE; GLUCOSE TRANSPORTER 1; GLUTAMIC ACID; LACTIC ACID; POLYUNSATURATED FATTY ACID; PURINERGIC RECEPTOR; ADENOSINE TRIPHOSPHATASE; GLUCOSE TRANSPORTER;

EID: 84907891697     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2014.06.001     Document Type: Review
Times cited : (32)

References (122)
  • 3
    • 84902482488 scopus 로고    scopus 로고
    • Alternating hemiplegia of childhood and rapid-onset dystonia parkinsonism are allelic disorders due to ATP1A3 gene mutations
    • A. Alexoudi, and S.A. Schneider Alternating hemiplegia of childhood and rapid-onset dystonia parkinsonism are allelic disorders due to ATP1A3 gene mutations Movement Disorders 27 2012 1494
    • (2012) Movement Disorders , vol.27 , pp. 1494
    • Alexoudi, A.1    Schneider, S.A.2
  • 4
    • 0037098856 scopus 로고    scopus 로고
    • Activation of presynaptic P2X7-like receptors depresses mossy fiber-CA3 synaptic transmission through p38 mitogen-activated protein kinase
    • J.N. Armstrong, T.B. Brust, R.G. Lewis, and B.A. MacVicar Activation of presynaptic P2X7-like receptors depresses mossy fiber-CA3 synaptic transmission through p38 mitogen-activated protein kinase Journal of Neuroscience 22 2002 5938 5945
    • (2002) Journal of Neuroscience , vol.22 , pp. 5938-5945
    • Armstrong, J.N.1    Brust, T.B.2    Lewis, R.G.3    Macvicar, B.A.4
  • 5
  • 8
    • 84864081369 scopus 로고    scopus 로고
    • Fatty acid oxidation and epilepsy
    • S. Auvin Fatty acid oxidation and epilepsy Epilepsy Research 100 2012 224 228
    • (2012) Epilepsy Research , vol.100 , pp. 224-228
    • Auvin, S.1
  • 9
    • 55249116379 scopus 로고    scopus 로고
    • Status epilepticus induces a particular microglial activation state characterized by enhanced purinergic signaling
    • E. Avignone, L. Ulmann, F. Levavasseur, F. Rassendren, and E. Audinat Status epilepticus induces a particular microglial activation state characterized by enhanced purinergic signaling The Journal of Neuroscience 28 2008 9133 9144
    • (2008) The Journal of Neuroscience , vol.28 , pp. 9133-9144
    • Avignone, E.1    Ulmann, L.2    Levavasseur, F.3    Rassendren, F.4    Audinat, E.5
  • 10
    • 84876705126 scopus 로고    scopus 로고
    • Cortical excitability changes correlate with fluctuations in glucose levels in patients with epilepsy
    • R.A. Badawy, S.J. Vogrin, A. Lai, and M.J. Cook Cortical excitability changes correlate with fluctuations in glucose levels in patients with epilepsy Epilepsy and Behavior 27 2013 455 460
    • (2013) Epilepsy and Behavior , vol.27 , pp. 455-460
    • Badawy, R.A.1    Vogrin, S.J.2    Lai, A.3    Cook, M.J.4
  • 11
    • 33745016252 scopus 로고    scopus 로고
    • Arginine:glycine amidinotransferase (AGAT) deficiency in a newborn: Early treatment can prevent phenotypic expression of the disease
    • R. Battini, M.G. Alessandri, V. Leuzzi, F. Moro, M. Tosetti, and M.C. Bianchi Arginine:glycine amidinotransferase (AGAT) deficiency in a newborn: early treatment can prevent phenotypic expression of the disease The Journal of Pediatrics 148 2006 828 830
    • (2006) The Journal of Pediatrics , vol.148 , pp. 828-830
    • Battini, R.1    Alessandri, M.G.2    Leuzzi, V.3    Moro, F.4    Tosetti, M.5    Bianchi, M.C.6
  • 12
    • 81555228426 scopus 로고    scopus 로고
    • The CBS domain: A protein module with an emerging prominent role in regulation
    • A.A. Baykov, H.K. Tuominen, and R. Lahti The CBS domain: a protein module with an emerging prominent role in regulation ACS Chemical Biology 6 2011 1156 1163
    • (2011) ACS Chemical Biology , vol.6 , pp. 1156-1163
    • Baykov, A.A.1    Tuominen, H.K.2    Lahti, R.3
  • 13
    • 72249098744 scopus 로고    scopus 로고
    • Astrocyte-neuron interactions: Implications for epilepsy
    • E.E. Benarroch Astrocyte-neuron interactions: implications for epilepsy Neurology 73 2009 1323 1327
    • (2009) Neurology , vol.73 , pp. 1323-1327
    • Benarroch, E.E.1
  • 14
    • 77950857874 scopus 로고    scopus 로고
    • Revised terminology and concepts for organization of seizures and epilepsies: Report of the ILAE Commission on Classification and Terminology, 2005-2009
    • A.T. Berg, S.F. Berkovic, M.J. Brodie, J. Buchhalter, J.H. Cross, and W. van Emde Boas Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009 Epilepsia 51 2010 676 685
    • (2010) Epilepsia , vol.51 , pp. 676-685
    • Berg, A.T.1    Berkovic, S.F.2    Brodie, M.J.3    Buchhalter, J.4    Cross, J.H.5    Van Emde Boas, W.6
  • 16
    • 84865703692 scopus 로고    scopus 로고
    • Mitochondrial diseases and epilepsy
    • L.A. Bindoff, and B.A. Engelsen Mitochondrial diseases and epilepsy Epilepsia 53 Suppl. 4 2012 92 97
    • (2012) Epilepsia , vol.53 , Issue.SUPPL. 4 , pp. 92-97
    • Bindoff, L.A.1    Engelsen, B.A.2
  • 18
    • 84870288653 scopus 로고    scopus 로고
    • Adenosine augmentation therapy
    • J.L. Noebels, M. Avoli, M.A. Rogawski, R.W. Olsen, A.V. Delgado-Escueta, 4th ed. Oxford University Press Bethesda (MD)
    • D. Boison Adenosine augmentation therapy J.L. Noebels, M. Avoli, M.A. Rogawski, R.W. Olsen, A.V. Delgado-Escueta, Jasper's Basic Mechanisms of the Epilepsies 4th ed. 2012 Oxford University Press Bethesda (MD)
    • (2012) Jasper's Basic Mechanisms of the Epilepsies
    • Boison, D.1
  • 19
    • 84864090873 scopus 로고    scopus 로고
    • Triheptanoin - A medium chain triglyceride with odd chain fatty acids: A new anaplerotic anticonvulsant treatment?
    • K. Borges, and U. Sonnewald Triheptanoin - a medium chain triglyceride with odd chain fatty acids: a new anaplerotic anticonvulsant treatment? Epilepsy Research 100 2012 239 244
    • (2012) Epilepsy Research , vol.100 , pp. 239-244
    • Borges, K.1    Sonnewald, U.2
  • 20
    • 33846250398 scopus 로고    scopus 로고
    • Anticonvulsant mechanisms of the ketogenic diet
    • K.J. Bough, and J.M. Rho Anticonvulsant mechanisms of the ketogenic diet Epilepsia 48 2007 43 58
    • (2007) Epilepsia , vol.48 , pp. 43-58
    • Bough, K.J.1    Rho, J.M.2
  • 22
    • 0035098030 scopus 로고    scopus 로고
    • Irreversible brain creatine deficiency with elevated serum and urine creatine: A creatine transporter defect?
    • K.M. Cecil, G.S. Salomons, W.S. Ball Jr., B. Wong, G. Chuck, and N.M. Verhoeven Irreversible brain creatine deficiency with elevated serum and urine creatine: a creatine transporter defect? Annals of Neurology 49 2001 401 404
    • (2001) Annals of Neurology , vol.49 , pp. 401-404
    • Cecil, K.M.1    Salomons, G.S.2    Ball, W.S.3    Wong, B.4    Chuck, G.5    Verhoeven, N.M.6
  • 24
    • 84861319459 scopus 로고    scopus 로고
    • Long-term follow-up of children treated with the modified Atkins diet
    • W. Chen, and E.H. Kossoff Long-term follow-up of children treated with the modified Atkins diet Journal of Child Neurology 27 2012 754 758
    • (2012) Journal of Child Neurology , vol.27 , pp. 754-758
    • Chen, W.1    Kossoff, E.H.2
  • 25
    • 84862321615 scopus 로고    scopus 로고
    • Astrocytic regulation of glutamate homeostasis in epilepsy
    • D.A. Coulter, and T. Eid Astrocytic regulation of glutamate homeostasis in epilepsy Glia 60 2012 1215 1226
    • (2012) Glia , vol.60 , pp. 1215-1226
    • Coulter, D.A.1    Eid, T.2
  • 26
    • 0036584661 scopus 로고    scopus 로고
    • Childhood absence epilepsy: Genes, channels, neurons and networks
    • V. Crunelli, and N. Leresche Childhood absence epilepsy: genes, channels, neurons and networks Nature Reviews Neuroscience 3 2002 371 382
    • (2002) Nature Reviews Neuroscience , vol.3 , pp. 371-382
    • Crunelli, V.1    Leresche, N.2
  • 28
    • 33847288873 scopus 로고    scopus 로고
    • Plasma phospholipid fatty acids are influenced by a ketogenic diet enriched with n-3 fatty acids in children with epilepsy
    • M. Dahlin, L. Hjelte, S. Nilsson, and P. Amark Plasma phospholipid fatty acids are influenced by a ketogenic diet enriched with n-3 fatty acids in children with epilepsy Epilepsy Research 73 2007 199 207
    • (2007) Epilepsy Research , vol.73 , pp. 199-207
    • Dahlin, M.1    Hjelte, L.2    Nilsson, S.3    Amark, P.4
  • 30
    • 0037312922 scopus 로고    scopus 로고
    • Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump alpha2 subunit associated with familial hemiplegic migraine type 2
    • M. De Fusco, R. Marconi, L. Silvestri, L. Atorino, L. Rampoldi, and L. Morgante Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump alpha2 subunit associated with familial hemiplegic migraine type 2 Nature Genetics 33 2003 192 196
    • (2003) Nature Genetics , vol.33 , pp. 192-196
    • De Fusco, M.1    Marconi, R.2    Silvestri, L.3    Atorino, L.4    Rampoldi, L.5    Morgante, L.6
  • 31
    • 0025819954 scopus 로고
    • Defective glucose transport across the blood-brain barrier as a cause of persistent hypoglycorrhachia, seizures, and developmental delay
    • D.C. De Vivo, R.R. Trifiletti, R.I. Jacobson, G.M. Ronen, R.A. Behmand, and S.I. Harik Defective glucose transport across the blood-brain barrier as a cause of persistent hypoglycorrhachia, seizures, and developmental delay The New England Journal of Medicine 325 1991 703 709
    • (1991) The New England Journal of Medicine , vol.325 , pp. 703-709
    • De Vivo, D.C.1    Trifiletti, R.R.2    Jacobson, R.I.3    Ronen, G.M.4    Behmand, R.A.5    Harik, S.I.6
  • 33
    • 84860301890 scopus 로고    scopus 로고
    • Epilepsy in children - When should we think neurometabolic disease?
    • R. Dhamija, M.C. Patterson, and E.C. Wirrell Epilepsy in children - when should we think neurometabolic disease? Journal of Child Neurology 27 2012 663 671
    • (2012) Journal of Child Neurology , vol.27 , pp. 663-671
    • Dhamija, R.1    Patterson, M.C.2    Wirrell, E.C.3
  • 35
    • 35448989687 scopus 로고    scopus 로고
    • Conditional knock-out of Kir4.1 leads to glial membrane depolarization, inhibition of potassium and glutamate uptake, and enhanced short-term synaptic potentiation
    • B. Djukic, K.B. Casper, B.D. Philpot, L.S. Chin, and K.D. McCarthy Conditional knock-out of Kir4.1 leads to glial membrane depolarization, inhibition of potassium and glutamate uptake, and enhanced short-term synaptic potentiation The Journal of Neuroscience 27 2007 11354 11365
    • (2007) The Journal of Neuroscience , vol.27 , pp. 11354-11365
    • Djukic, B.1    Casper, K.B.2    Philpot, B.D.3    Chin, L.S.4    McCarthy, K.D.5
  • 36
    • 0022361353 scopus 로고
    • Is adenosine an endogenous anticonvulsant?
    • M. Dragunow, G.V. Goddard, and R. Laverty Is adenosine an endogenous anticonvulsant? Epilepsia 26 1985 480 487
    • (1985) Epilepsia , vol.26 , pp. 480-487
    • Dragunow, M.1    Goddard, G.V.2    Laverty, R.3
  • 37
    • 0030875738 scopus 로고    scopus 로고
    • Adenine nucleotides undergo rapid, quantitative conversion to adenosine in the extracellular space in rat hippocampus
    • T.V. Dunwiddie, L. Diao, and W.R. Proctor Adenine nucleotides undergo rapid, quantitative conversion to adenosine in the extracellular space in rat hippocampus The Journal of Neuroscience 17 1997 7673 7682
    • (1997) The Journal of Neuroscience , vol.17 , pp. 7673-7682
    • Dunwiddie, T.V.1    Diao, L.2    Proctor, W.R.3
  • 38
  • 40
    • 0027397989 scopus 로고
    • Glucose deprivation results in a lactate preventable increase in adenosine and depression of synaptic transmission in rat hippocampal slices
    • J.C. Fowler Glucose deprivation results in a lactate preventable increase in adenosine and depression of synaptic transmission in rat hippocampal slices Journal of Neurochemistry 60 1993 572 576
    • (1993) Journal of Neurochemistry , vol.60 , pp. 572-576
    • Fowler, J.C.1
  • 41
    • 0037465771 scopus 로고    scopus 로고
    • Elevated polyunsaturated fatty acids in blood serum obtained from children on the ketogenic diet
    • D.D. Fraser, S. Whiting, R.D. Andrew, E.A. Macdonald, K. Musa-Veloso, and S.C. Cunnane Elevated polyunsaturated fatty acids in blood serum obtained from children on the ketogenic diet Neurology 60 2003 1026 1029
    • (2003) Neurology , vol.60 , pp. 1026-1029
    • Fraser, D.D.1    Whiting, S.2    Andrew, R.D.3    Macdonald, E.A.4    Musa-Veloso, K.5    Cunnane, S.C.6
  • 45
    • 33750443292 scopus 로고    scopus 로고
    • 2-Deoxy-d-glucose reduces epilepsy progression by NRSF-CtBP-dependent metabolic regulation of chromatin structure
    • M. Garriga-Canut, B. Schoenike, R. Qazi, K. Bergendahl, T.J. Daley, and R.M. Pfender 2-Deoxy-d-glucose reduces epilepsy progression by NRSF-CtBP-dependent metabolic regulation of chromatin structure Nature Neuroscience 9 2006 1382 1387
    • (2006) Nature Neuroscience , vol.9 , pp. 1382-1387
    • Garriga-Canut, M.1    Schoenike, B.2    Qazi, R.3    Bergendahl, K.4    Daley, T.J.5    Pfender, R.M.6
  • 46
    • 80053903167 scopus 로고    scopus 로고
    • Astrocyte-neuron lactate shuttle may boost more ATP supply to the neuron under hypoxic conditions - In silico study supported by in vitro expression data
    • S. Genc, I.A. Kurnaz, and M. Ozilgen Astrocyte-neuron lactate shuttle may boost more ATP supply to the neuron under hypoxic conditions - in silico study supported by in vitro expression data BMC Systems Biology 5 2011 162
    • (2011) BMC Systems Biology , vol.5 , pp. 162
    • Genc, S.1    Kurnaz, I.A.2    Ozilgen, M.3
  • 47
    • 17444384164 scopus 로고    scopus 로고
    • Glucose transporter 1, distribution in the brain and in neural disorders: Its relationship with transport of neuroactive drugs through the blood-brain barrier
    • X. Guo, M. Geng, and G. Du Glucose transporter 1, distribution in the brain and in neural disorders: its relationship with transport of neuroactive drugs through the blood-brain barrier Biochemical Genetics 43 2005 175 187
    • (2005) Biochemical Genetics , vol.43 , pp. 175-187
    • Guo, X.1    Geng, M.2    Du, G.3
  • 48
    • 80052805065 scopus 로고    scopus 로고
    • Evidence that compromised K+ spatial buffering contributes to the epileptogenic effect of mutations in the human Kir4.1 gene (KCNJ10)
    • N.N. Haj-Yasein, V. Jensen, G.F. Vindedal, G.A. Gundersen, A. Klungland, and O.P. Ottersen Evidence that compromised K+ spatial buffering contributes to the epileptogenic effect of mutations in the human Kir4.1 gene (KCNJ10) Glia 59 2011 1635 1642
    • (2011) Glia , vol.59 , pp. 1635-1642
    • Haj-Yasein, N.N.1    Jensen, V.2    Vindedal, G.F.3    Gundersen, G.A.4    Klungland, A.5    Ottersen, O.P.6
  • 50
    • 0344091562 scopus 로고    scopus 로고
    • Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies
    • K. Haug, M. Warnstedt, A.K. Alekov, T. Sander, A. Ramirez, and B. Poser Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies Nature Genetics 33 2003 527 532
    • (2003) Nature Genetics , vol.33 , pp. 527-532
    • Haug, K.1    Warnstedt, M.2    Alekov, A.K.3    Sander, T.4    Ramirez, A.5    Poser, B.6
  • 51
    • 0030317076 scopus 로고    scopus 로고
    • Descriptive epidemiology of epilepsy: Contributions of population-based studies from Rochester, Minnesota
    • W.A. Hauser, J.F. Annegers, and W.A. Rocca Descriptive epidemiology of epilepsy: contributions of population-based studies from Rochester, Minnesota Mayo Clinic Proceedings 71 1996 576 586
    • (1996) Mayo Clinic Proceedings , vol.71 , pp. 576-586
    • Hauser, W.A.1    Annegers, J.F.2    Rocca, W.A.3
  • 53
    • 80052553383 scopus 로고    scopus 로고
    • Neuron-restrictive silencer factor is not required for the antiepileptic effect of the ketogenic diet
    • X.L. Hu, X. Cheng, J. Fei, and Z.Q. Xiong Neuron-restrictive silencer factor is not required for the antiepileptic effect of the ketogenic diet Epilepsia 52 2011 1609 1616
    • (2011) Epilepsia , vol.52 , pp. 1609-1616
    • Hu, X.L.1    Cheng, X.2    Fei, J.3    Xiong, Z.Q.4
  • 54
    • 84861881239 scopus 로고    scopus 로고
    • Lactate effectively covers energy demands during neuronal network activity in neonatal hippocampal slices
    • A. Ivanov, M. Mukhtarov, P. Bregestovski, and Y. Zilberter Lactate effectively covers energy demands during neuronal network activity in neonatal hippocampal slices Frontiers in Neuroenergetics 3 2011 2
    • (2011) Frontiers in Neuroenergetics , vol.3 , pp. 2
    • Ivanov, A.1    Mukhtarov, M.2    Bregestovski, P.3    Zilberter, Y.4
  • 55
    • 84890533352 scopus 로고    scopus 로고
    • Higher transport and metabolism of glucose in astrocytes compared with neurons: A multiphoton study of hippocampal and cerebellar tissue slices
    • P. Jakoby, E. Schmidt, I. Ruminot, R. Gutierrez, L.F. Barros, and J.W. Deitmer Higher transport and metabolism of glucose in astrocytes compared with neurons: a multiphoton study of hippocampal and cerebellar tissue slices Cerebral Cortex 24 1 2014 222 231
    • (2014) Cerebral Cortex , vol.24 , Issue.1 , pp. 222-231
    • Jakoby, P.1    Schmidt, E.2    Ruminot, I.3    Gutierrez, R.4    Barros, L.F.5    Deitmer, J.W.6
  • 56
    • 23844500344 scopus 로고    scopus 로고
    • Mutation in the glutamate transporter EAAT1 causes episodic ataxia, hemiplegia, and seizures
    • J.C. Jen, J. Wan, T.P. Palos, B.D. Howard, and R.W. Baloh Mutation in the glutamate transporter EAAT1 causes episodic ataxia, hemiplegia, and seizures Neurology 65 2005 529 534
    • (2005) Neurology , vol.65 , pp. 529-534
    • Jen, J.C.1    Wan, J.2    Palos, T.P.3    Howard, B.D.4    Baloh, R.W.5
  • 58
    • 33846212708 scopus 로고    scopus 로고
    • Safe and effective use of the ketogenic diet in children with epilepsy and mitochondrial respiratory chain complex defects
    • H.C. Kang, Y.M. Lee, H.D. Kim, J.S. Lee, and A. Slama Safe and effective use of the ketogenic diet in children with epilepsy and mitochondrial respiratory chain complex defects Epilepsia 48 2007 82 88
    • (2007) Epilepsia , vol.48 , pp. 82-88
    • Kang, H.C.1    Lee, Y.M.2    Kim, H.D.3    Lee, J.S.4    Slama, A.5
  • 59
    • 84872133600 scopus 로고    scopus 로고
    • Triheptanoin reduces seizure susceptibility in a syndrome-specific mouse model of generalized epilepsy
    • T.H. Kim, K. Borges, S. Petrou, and C.A. Reid Triheptanoin reduces seizure susceptibility in a syndrome-specific mouse model of generalized epilepsy Epilepsy Research 103 2013 101 105
    • (2013) Epilepsy Research , vol.103 , pp. 101-105
    • Kim, T.H.1    Borges, K.2    Petrou, S.3    Reid, C.A.4
  • 60
    • 84890805572 scopus 로고    scopus 로고
    • Low glycaemic index diet reduces seizure susceptibility in a syndrome-specific mouse model of generalized epilepsy
    • T.H. Kim, S. Petrou, and C.A. Reid Low glycaemic index diet reduces seizure susceptibility in a syndrome-specific mouse model of generalized epilepsy Epilepsy Research 108 2014 139 143
    • (2014) Epilepsy Research , vol.108 , pp. 139-143
    • Kim, T.H.1    Petrou, S.2    Reid, C.A.3
  • 61
    • 9344266325 scopus 로고    scopus 로고
    • Potassium buffering in the central nervous system
    • P. Kofuji, and E.A. Newman Potassium buffering in the central nervous system Neuroscience 129 2004 1045 1056
    • (2004) Neuroscience , vol.129 , pp. 1045-1056
    • Kofuji, P.1    Newman, E.A.2
  • 62
    • 84855573842 scopus 로고    scopus 로고
    • Beneficial effect of pyruvate therapy on Leigh syndrome due to a novel mutation in PDH E1alpha gene
    • Y. Koga, N. Povalko, K. Katayama, N. Kakimoto, T. Matsuishi, and E. Naito Beneficial effect of pyruvate therapy on Leigh syndrome due to a novel mutation in PDH E1alpha gene Brain Dev 34 2012 87 91
    • (2012) Brain Dev , vol.34 , pp. 87-91
    • Koga, Y.1    Povalko, N.2    Katayama, K.3    Kakimoto, N.4    Matsuishi, T.5    Naito, E.6
  • 63
    • 0347364663 scopus 로고    scopus 로고
    • Efficacy of the Atkins diet as therapy for intractable epilepsy
    • E.H. Kossoff, G.L. Krauss, J.R. McGrogan, and J.M. Freeman Efficacy of the Atkins diet as therapy for intractable epilepsy Neurology 61 2003 1789 1791
    • (2003) Neurology , vol.61 , pp. 1789-1791
    • Kossoff, E.H.1    Krauss, G.L.2    McGrogan, J.R.3    Freeman, J.M.4
  • 64
    • 84875255103 scopus 로고    scopus 로고
    • Energy depletion in seizures: Anaplerosis as a strategy for future therapies
    • S. Kovac, A.Y. Abramov, and M.C. Walker Energy depletion in seizures: anaplerosis as a strategy for future therapies Neuropharmacology 69 2013 96 104
    • (2013) Neuropharmacology , vol.69 , pp. 96-104
    • Kovac, S.1    Abramov, A.Y.2    Walker, M.C.3
  • 65
    • 33846862901 scopus 로고    scopus 로고
    • Downregulation of Kir4.1 inward rectifying potassium channel subunits by RNAi impairs potassium transfer and glutamate uptake by cultured cortical astrocytes
    • Y.V. Kucheryavykh, L.Y. Kucheryavykh, C.G. Nichols, H.M. Maldonado, K. Baksi, and A. Reichenbach Downregulation of Kir4.1 inward rectifying potassium channel subunits by RNAi impairs potassium transfer and glutamate uptake by cultured cortical astrocytes Glia 55 2007 274 281
    • (2007) Glia , vol.55 , pp. 274-281
    • Kucheryavykh, Y.V.1    Kucheryavykh, L.Y.2    Nichols, C.G.3    Maldonado, H.M.4    Baksi, K.5    Reichenbach, A.6
  • 66
    • 84857920108 scopus 로고    scopus 로고
    • Low glycemic index treatment for epilepsy in tuberous sclerosis complex
    • A.M. Larson, H.H. Pfeifer, and E.A. Thiele Low glycemic index treatment for epilepsy in tuberous sclerosis complex Epilepsy Research 99 2012 180 182
    • (2012) Epilepsy Research , vol.99 , pp. 180-182
    • Larson, A.M.1    Pfeifer, H.H.2    Thiele, E.A.3
  • 67
    • 43349098636 scopus 로고    scopus 로고
    • Mitochondrial respiratory chain defects: Underlying etiology in various epileptic conditions
    • Y.M. Lee, H.C. Kang, J.S. Lee, S.H. Kim, E.Y. Kim, and S.K. Lee Mitochondrial respiratory chain defects: underlying etiology in various epileptic conditions Epilepsia 49 2008 685 690
    • (2008) Epilepsia , vol.49 , pp. 685-690
    • Lee, Y.M.1    Kang, H.C.2    Lee, J.S.3    Kim, S.H.4    Kim, E.Y.5    Lee, S.K.6
  • 68
    • 77950286198 scopus 로고    scopus 로고
    • Glucose transporter-1 deficiency syndrome: The expanding clinical and genetic spectrum of a treatable disorder
    • W.G. Leen, J. Klepper, M.M. Verbeek, M. Leferink, T. Hofste, and B.G. van Engelen Glucose transporter-1 deficiency syndrome: the expanding clinical and genetic spectrum of a treatable disorder Brain 133 Pt 3 2010 655 670
    • (2010) Brain , vol.133 , pp. 655-670
    • Leen, W.G.1    Klepper, J.2    Verbeek, M.M.3    Leferink, M.4    Hofste, T.5    Van Engelen, B.G.6
  • 69
    • 84873411672 scopus 로고    scopus 로고
    • Inborn errors of creatine metabolism and epilepsy
    • V. Leuzzi, M. Mastrangelo, R. Battini, and G. Cioni Inborn errors of creatine metabolism and epilepsy Epilepsia 54 2013 217 227
    • (2013) Epilepsia , vol.54 , pp. 217-227
    • Leuzzi, V.1    Mastrangelo, M.2    Battini, R.3    Cioni, G.4
  • 71
    • 33748203626 scopus 로고    scopus 로고
    • Dynamic regulation of synaptic GABA release by the glutamate-glutamine cycle in hippocampal area CA1
    • S.L. Liang, G.C. Carlson, and D.A. Coulter Dynamic regulation of synaptic GABA release by the glutamate-glutamine cycle in hippocampal area CA1 The Journal of Neuroscience 26 2006 8537 8548
    • (2006) The Journal of Neuroscience , vol.26 , pp. 8537-8548
    • Liang, S.L.1    Carlson, G.C.2    Coulter, D.A.3
  • 73
    • 84883352727 scopus 로고    scopus 로고
    • Medium-chain triglyceride ketogenic diet, an effective treatment for drug-resistant epilepsy and a comparison with other ketogenic diets
    • Y.M. Liu, and H.S. Wang Medium-chain triglyceride ketogenic diet, an effective treatment for drug-resistant epilepsy and a comparison with other ketogenic diets Biomedical Journal 36 2013 9 15
    • (2013) Biomedical Journal , vol.36 , pp. 9-15
    • Liu, Y.M.1    Wang, H.S.2
  • 74
    • 0025323079 scopus 로고
    • Survey of seizure disorders in the French southwest. I. Incidence of epileptic syndromes
    • J. Loiseau, P. Loiseau, M. Guyot, B. Duche, J.F. Dartigues, and B. Aublet Survey of seizure disorders in the French southwest. I. Incidence of epileptic syndromes Epilepsia 31 1990 391 396
    • (1990) Epilepsia , vol.31 , pp. 391-396
    • Loiseau, J.1    Loiseau, P.2    Guyot, M.3    Duche, B.4    Dartigues, J.F.5    Aublet, B.6
  • 76
    • 84871718480 scopus 로고    scopus 로고
    • The ketogenic diet: Metabolic influences on brain excitability and epilepsy
    • A. Lutas, and G. Yellen The ketogenic diet: metabolic influences on brain excitability and epilepsy Trends in Neurosciences 36 2013 32 40
    • (2013) Trends in Neurosciences , vol.36 , pp. 32-40
    • Lutas, A.1    Yellen, G.2
  • 77
    • 34147189503 scopus 로고    scopus 로고
    • Ketogenic diet metabolites reduce firing in central neurons by opening K(ATP) channels
    • W. Ma, J. Berg, and G. Yellen Ketogenic diet metabolites reduce firing in central neurons by opening K(ATP) channels The Journal of Neuroscience 27 2007 3618 3625
    • (2007) The Journal of Neuroscience , vol.27 , pp. 3618-3625
    • Ma, W.1    Berg, J.2    Yellen, G.3
  • 78
    • 0021828468 scopus 로고
    • Hypoglycemia: Causes, neurological manifestations, and outcome
    • R. Malouf, and J.C. Brust Hypoglycemia: causes, neurological manifestations, and outcome Annals of Neurology 17 1985 421 430
    • (1985) Annals of Neurology , vol.17 , pp. 421-430
    • Malouf, R.1    Brust, J.C.2
  • 80
    • 84869095296 scopus 로고    scopus 로고
    • Mechanisms of ketogenic diet action
    • J.L. Noebels, M. Avoli, M.A. Rogawski, R.W. Olsen, A.V. Delgado-Escueta, 4th ed. Oxford University Press Bethesda (MD)
    • S.A. Masino, and J.M. Rho Mechanisms of ketogenic diet action J.L. Noebels, M. Avoli, M.A. Rogawski, R.W. Olsen, A.V. Delgado-Escueta, Jasper's Basic Mechanisms of the Epilepsies 4th ed. 2012 Oxford University Press Bethesda (MD)
    • (2012) Jasper's Basic Mechanisms of the Epilepsies
    • Masino, S.A.1    Rho, J.M.2
  • 81
    • 0025954861 scopus 로고
    • Immunofluorescent localization of three Na, K-ATPase isozymes in the rat central nervous system: Both neurons and glia can express more than one Na, K-ATPase
    • K.M. McGrail, J.M. Phillips, and K.J. Sweadner Immunofluorescent localization of three Na, K-ATPase isozymes in the rat central nervous system: both neurons and glia can express more than one Na, K-ATPase The Journal of Neuroscience 11 1991 381 391
    • (1991) The Journal of Neuroscience , vol.11 , pp. 381-391
    • McGrail, K.M.1    Phillips, J.M.2    Sweadner, K.J.3
  • 84
    • 64849087753 scopus 로고    scopus 로고
    • The P2X7 receptor drives microglial activation and proliferation: A trophic role for P2X7R pore
    • M. Monif, C.A. Reid, K.L. Powell, M.L. Smart, and D.A. Williams The P2X7 receptor drives microglial activation and proliferation: a trophic role for P2X7R pore The Journal of Neuroscience 29 2009 3781 3791
    • (2009) The Journal of Neuroscience , vol.29 , pp. 3781-3791
    • Monif, M.1    Reid, C.A.2    Powell, K.L.3    Smart, M.L.4    Williams, D.A.5
  • 86
    • 77955363549 scopus 로고    scopus 로고
    • Absence epilepsies with widely variable onset are a key feature of familial GLUT1 deficiency
    • S.A. Mullen, A. Suls, P. De Jonghe, S.F. Berkovic, and I.E. Scheffer Absence epilepsies with widely variable onset are a key feature of familial GLUT1 deficiency Neurology 75 2010 432 440
    • (2010) Neurology , vol.75 , pp. 432-440
    • Mullen, S.A.1    Suls, A.2    De Jonghe, P.3    Berkovic, S.F.4    Scheffer, I.E.5
  • 87
    • 65549104388 scopus 로고    scopus 로고
    • Efficacy, safety, and tolerability of the low glycemic index treatment in pediatric epilepsy
    • D.A. Muzykewicz, D.A. Lyczkowski, N. Memon, K.D. Conant, H.H. Pfeifer, and E.A. Thiele Efficacy, safety, and tolerability of the low glycemic index treatment in pediatric epilepsy Epilepsia 50 2009 1118 1126
    • (2009) Epilepsia , vol.50 , pp. 1118-1126
    • Muzykewicz, D.A.1    Lyczkowski, D.A.2    Memon, N.3    Conant, K.D.4    Pfeifer, H.H.5    Thiele, E.A.6
  • 89
    • 7944234789 scopus 로고    scopus 로고
    • Functional evaluation of human ClC-2 chloride channel mutations associated with idiopathic generalized epilepsies
    • M.I. Niemeyer, Y.R. Yusef, I. Cornejo, C.A. Flores, F.V. Sepulveda, and L.P. Cid Functional evaluation of human ClC-2 chloride channel mutations associated with idiopathic generalized epilepsies Physiological Genomics 19 2004 74 83
    • (2004) Physiological Genomics , vol.19 , pp. 74-83
    • Niemeyer, M.I.1    Yusef, Y.R.2    Cornejo, I.3    Flores, C.A.4    Sepulveda, F.V.5    Cid, L.P.6
  • 90
    • 34547823399 scopus 로고    scopus 로고
    • Activity-dependent regulation of energy metabolism by astrocytes: An update
    • L. Pellerin, A.K. Bouzier-Sore, A. Aubert, S. Serres, M. Merle, and R. Costalat Activity-dependent regulation of energy metabolism by astrocytes: an update Glia 55 2007 1251 1262
    • (2007) Glia , vol.55 , pp. 1251-1262
    • Pellerin, L.1    Bouzier-Sore, A.K.2    Aubert, A.3    Serres, S.4    Merle, M.5    Costalat, R.6
  • 92
    • 0028350477 scopus 로고
    • Structural requirements for charged lipid molecules to directly increase or suppress K+ channel activity in smooth muscle cells. Effects of fatty acids, lysophosphatidate, acyl coenzyme A and sphingosine
    • S. Petrou, R.W. Ordway, J.A. Hamilton, J.V. Walsh Jr., and J.J. Singer Structural requirements for charged lipid molecules to directly increase or suppress K+ channel activity in smooth muscle cells. Effects of fatty acids, lysophosphatidate, acyl coenzyme A and sphingosine The Journal of General Physiology 103 1994 471 486
    • (1994) The Journal of General Physiology , vol.103 , pp. 471-486
    • Petrou, S.1    Ordway, R.W.2    Hamilton, J.A.3    Walsh, J.V.4    Singer, J.J.5
  • 93
    • 55349104803 scopus 로고    scopus 로고
    • Low glycemic index treatment: Implementation and new insights into efficacy
    • H.H. Pfeifer, D.A. Lyczkowski, and E.A. Thiele Low glycemic index treatment: implementation and new insights into efficacy Epilepsia 49 Suppl. 8 2008 42 45
    • (2008) Epilepsia , vol.49 , Issue.SUPPL. 8 , pp. 42-45
    • Pfeifer, H.H.1    Lyczkowski, D.A.2    Thiele, E.A.3
  • 94
    • 33645078170 scopus 로고    scopus 로고
    • Low-glycemic-index treatment: A liberalized ketogenic diet for treatment of intractable epilepsy
    • H.H. Pfeifer, and E.A. Thiele Low-glycemic-index treatment: a liberalized ketogenic diet for treatment of intractable epilepsy Neurology 65 2005 1810 1812
    • (2005) Neurology , vol.65 , pp. 1810-1812
    • Pfeifer, H.H.1    Thiele, E.A.2
  • 95
    • 84866054022 scopus 로고    scopus 로고
    • Glucose transporter type i deficiency syndrome: Epilepsy phenotypes and outcomes
    • A.W. Pong, B.R. Geary, K.M. Engelstad, A. Natarajan, H. Yang, and D.C. De Vivo Glucose transporter type I deficiency syndrome: epilepsy phenotypes and outcomes Epilepsia 53 2012 1503 1510
    • (2012) Epilepsia , vol.53 , pp. 1503-1510
    • Pong, A.W.1    Geary, B.R.2    Engelstad, K.M.3    Natarajan, A.4    Yang, H.5    De Vivo, D.C.6
  • 96
    • 58149250333 scopus 로고    scopus 로고
    • Anticonvulsant effects of linolenic acid are unrelated to brain phospholipid cell membrane compositions
    • N. Porta, B. Bourgois, C. Galabert, C. Lecointe, P. Cappy, and R. Bordet Anticonvulsant effects of linolenic acid are unrelated to brain phospholipid cell membrane compositions Epilepsia 50 2009 65 71
    • (2009) Epilepsia , vol.50 , pp. 65-71
    • Porta, N.1    Bourgois, B.2    Galabert, C.3    Lecointe, C.4    Cappy, P.5    Bordet, R.6
  • 98
    • 78651330010 scopus 로고    scopus 로고
    • Low blood glucose precipitates spike-and-wave activity in genetically predisposed animals
    • C.A. Reid, T.H. Kim, S.F. Berkovic, and S. Petrou Low blood glucose precipitates spike-and-wave activity in genetically predisposed animals Epilepsia 52 2011 115 120
    • (2011) Epilepsia , vol.52 , pp. 115-120
    • Reid, C.A.1    Kim, T.H.2    Berkovic, S.F.3    Petrou, S.4
  • 99
    • 84876254766 scopus 로고    scopus 로고
    • Multiple molecular mechanisms for a single GABAA mutation in epilepsy
    • C.A. Reid, T. Kim, A.M. Phillips, J. Low, S.F. Berkovic, and B. Luscher Multiple molecular mechanisms for a single GABAA mutation in epilepsy Neurology 80 2013 1003 1008
    • (2013) Neurology , vol.80 , pp. 1003-1008
    • Reid, C.A.1    Kim, T.2    Phillips, A.M.3    Low, J.4    Berkovic, S.F.5    Luscher, B.6
  • 100
    • 0036071008 scopus 로고    scopus 로고
    • Treatment of cardiomyopathy and rhabdomyolysis in long-chain fat oxidation disorders using an anaplerotic odd-chain triglyceride
    • C.R. Roe, L. Sweetman, D.S. Roe, F. David, and H. Brunengraber Treatment of cardiomyopathy and rhabdomyolysis in long-chain fat oxidation disorders using an anaplerotic odd-chain triglyceride The Journal of Clinical Investigation 110 2002 259 269
    • (2002) The Journal of Clinical Investigation , vol.110 , pp. 259-269
    • Roe, C.R.1    Sweetman, L.2    Roe, D.S.3    David, F.4    Brunengraber, H.5
  • 101
    • 50549093513 scopus 로고    scopus 로고
    • Carnitine palmitoyltransferase II deficiency: Successful anaplerotic diet therapy
    • C.R. Roe, B.Z. Yang, H. Brunengraber, D.S. Roe, M. Wallace, and B.K. Garritson Carnitine palmitoyltransferase II deficiency: successful anaplerotic diet therapy Neurology 71 2008 260 264
    • (2008) Neurology , vol.71 , pp. 260-264
    • Roe, C.R.1    Yang, B.Z.2    Brunengraber, H.3    Roe, D.S.4    Wallace, M.5    Garritson, B.K.6
  • 102
    • 0014939901 scopus 로고
    • Brain adenosine triphosphate: Decreased concentration precedes convulsions
    • A.P. Sanders, R.S. Kramer, B. Woodhall, and W.D. Currie Brain adenosine triphosphate: decreased concentration precedes convulsions Science 169 1970 206 208
    • (1970) Science , vol.169 , pp. 206-208
    • Sanders, A.P.1    Kramer, R.S.2    Woodhall, B.3    Currie, W.D.4
  • 103
    • 9144268527 scopus 로고    scopus 로고
    • Ketogenic treatment reduces deleted mitochondrial DNAs in cultured human cells
    • S. Santra, R.W. Gilkerson, M. Davidson, and E.A. Schon Ketogenic treatment reduces deleted mitochondrial DNAs in cultured human cells Annals of Neurology 56 2004 662 669
    • (2004) Annals of Neurology , vol.56 , pp. 662-669
    • Santra, S.1    Gilkerson, R.W.2    Davidson, M.3    Schon, E.A.4
  • 104
    • 33644800768 scopus 로고    scopus 로고
    • Neonatal epilepsy syndromes and generalized epilepsy with febrile seizures plus (GEFS+)
    • I.E. Scheffer, L.A. Harkin, L.M. Dibbens, J.C. Mulley, and S.F. Berkovic Neonatal epilepsy syndromes and generalized epilepsy with febrile seizures plus (GEFS+) Epilepsia 46 Suppl. 10 2005 41 47
    • (2005) Epilepsia , vol.46 , Issue.SUPPL. 10 , pp. 41-47
    • Scheffer, I.E.1    Harkin, L.A.2    Dibbens, L.M.3    Mulley, J.C.4    Berkovic, S.F.5
  • 106
    • 29144469081 scopus 로고    scopus 로고
    • Lactate: The ultimate cerebral oxidative energy substrate?
    • A. Schurr Lactate: the ultimate cerebral oxidative energy substrate? Journal of Cerebral Blood Flow and Metabolism 26 2006 142 152
    • (2006) Journal of Cerebral Blood Flow and Metabolism , vol.26 , pp. 142-152
    • Schurr, A.1
  • 108
    • 0032953159 scopus 로고    scopus 로고
    • Generalized epilepsy with febrile seizures plus: A common childhood-onset genetic epilepsy syndrome
    • R. Singh, I.E. Scheffer, K. Crossland, and S.F. Berkovic Generalized epilepsy with febrile seizures plus: a common childhood-onset genetic epilepsy syndrome Annals of Neurology 45 1999 75 81
    • (1999) Annals of Neurology , vol.45 , pp. 75-81
    • Singh, R.1    Scheffer, I.E.2    Crossland, K.3    Berkovic, S.F.4
  • 110
    • 84885349589 scopus 로고    scopus 로고
    • Astrocyte dysfunction in epilepsy
    • J.L. Noebels, M. Avoli, M.A. Rogawski, R.W. Olsen, A.V. Delgado-Escueta, 4th ed. Oxford University Press Bethesda (MD)
    • C. Steinhauser, and G. Seifert Astrocyte dysfunction in epilepsy J.L. Noebels, M. Avoli, M.A. Rogawski, R.W. Olsen, A.V. Delgado-Escueta, Jasper's Basic Mechanisms of the Epilepsies 4th ed. 2012 Oxford University Press Bethesda (MD)
    • (2012) Jasper's Basic Mechanisms of the Epilepsies
    • Steinhauser, C.1    Seifert, G.2
  • 116
    • 0036899553 scopus 로고    scopus 로고
    • Mechanisms of neuronal hyperexcitability caused by partial inhibition of Na+-K+-ATPases in the rat CA1 hippocampal region
    • C. Vaillend, S.E. Mason, M.F. Cuttle, and B.E. Alger Mechanisms of neuronal hyperexcitability caused by partial inhibition of Na+-K+-ATPases in the rat CA1 hippocampal region Journal of Neurophysiology 88 2002 2963 2978
    • (2002) Journal of Neurophysiology , vol.88 , pp. 2963-2978
    • Vaillend, C.1    Mason, S.E.2    Cuttle, M.F.3    Alger, B.E.4
  • 118
    • 0031238676 scopus 로고    scopus 로고
    • Glucose transporter proteins in brain: Delivery of glucose to neurons and glia
    • S.J. Vannucci, F. Maher, and I.A. Simpson Glucose transporter proteins in brain: delivery of glucose to neurons and glia Glia 21 1997 2 21
    • (1997) Glia , vol.21 , pp. 2-21
    • Vannucci, S.J.1    Maher, F.2    Simpson, I.A.3
  • 119
    • 77957790307 scopus 로고    scopus 로고
    • Anticonvulsant effects of a triheptanoin diet in two mouse chronic seizure models
    • S. Willis, J. Stoll, L. Sweetman, and K. Borges Anticonvulsant effects of a triheptanoin diet in two mouse chronic seizure models Neurobiology of Disease 40 2010 565 572
    • (2010) Neurobiology of Disease , vol.40 , pp. 565-572
    • Willis, S.1    Stoll, J.2    Sweetman, L.3    Borges, K.4
  • 120
    • 84876194901 scopus 로고    scopus 로고
    • The antiepileptic effect of the glycolytic inhibitor 2-deoxy-d-glucose is mediated by upregulation of K(ATP) channel subunits Kir6.1 and Kir6.2
    • H. Yang, R. Guo, J. Wu, Y. Peng, D. Xie, and W. Zheng The antiepileptic effect of the glycolytic inhibitor 2-deoxy-d-glucose is mediated by upregulation of K(ATP) channel subunits Kir6.1 and Kir6.2 Neurochemical Research 38 2013 677 685
    • (2013) Neurochemical Research , vol.38 , pp. 677-685
    • Yang, H.1    Guo, R.2    Wu, J.3    Peng, Y.4    Xie, D.5    Zheng, W.6
  • 121
    • 0028316790 scopus 로고
    • Essential fatty acid preparation (SR-3) raises the seizure threshold in rats
    • S. Yehuda, R.L. Carasso, and D.I. Mostofsky Essential fatty acid preparation (SR-3) raises the seizure threshold in rats European Journal of Pharmacology 254 1994 193 198
    • (1994) European Journal of Pharmacology , vol.254 , pp. 193-198
    • Yehuda, S.1    Carasso, R.L.2    Mostofsky, D.I.3
  • 122
    • 0027270365 scopus 로고
    • Adenosine release is a major cause of failure of synaptic transmission during hypoglycaemia in rat hippocampal slices
    • P.J. Zhu, and K. Krnjevic Adenosine release is a major cause of failure of synaptic transmission during hypoglycaemia in rat hippocampal slices Neuroscience Letters 155 1993 128 131
    • (1993) Neuroscience Letters , vol.155 , pp. 128-131
    • Zhu, P.J.1    Krnjevic, K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.