The antiepileptic effect of the glycolytic inhibitor 2-deoxy-d-glucose is mediated by upregulation of KATP channel subunits Kir6.1 and Kir6.2

Neurochemical Research

Volumn 38, Issue 4, 2013, Pages 677-685

  Yang, Heng ^a   Guo, Ren ^a   Wu, Jiongxing ^a   Peng, Yufeng ^a   Xie, Dujie ^a   Zheng, Wen ^a   Huang, Xian ^a   Liu, Ding ^a   Liu, Wei ^a   Huang, Lihua ^a   Song, Zhi ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

2 DG; Epilepsy; Kir6.1; Kir6.2; Pilocarpine

Indexed keywords

DEOXYGLUCOSE; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.1; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; MESSENGER RNA; PILOCARPINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; BEHAVIOR; CONTROLLED STUDY; CONVULSION; DRUG MEGADOSE; EPILEPTIC STATE; HIPPOCAMPUS; LOW DRUG DOSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

ANIMALS; ANTICONVULSANTS; DEOXYGLUCOSE; GLYCOLYSIS; HIPPOCAMPUS; KATP CHANNELS; MALE; MICE; MICE, INBRED C57BL; PILOCARPINE; POTASSIUM CHANNELS, INWARDLY RECTIFYING; STATUS EPILEPTICUS; UP-REGULATION;

MUS;

EID: 84876194901     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-012-0958-z     Document Type: Article

References (42)

1. Scharfman HE (2007) The neurobiology of epilepsy. Curr Neurol Neurosci Rep 7:348-354 (Pubitemid 47098457)
2. Birbeck G, Chomba E, Atadzhanov M, Mbewe E, Haworth A (2007) The social and economic impact of epilepsy in Zambia: a cross-sectional study. Lancet Neurol 6:39-44 (Pubitemid 44880258)
3. Berg AT (2006) Defining intractable epilepsy. Adv Neurol 97:5-10
4. Holmes GL, Zhao Q (2008) Choosing the correct antiepileptic drugs: from animal studies to the clinic. Pediatr Neurol 38:151-162 (Pubitemid 351221224)
5. White HS (2003) Preclinical development of antiepileptic drugs: past, present, and future directions. Epilepsia Suppl 7:2-8 (Pubitemid 37100022)
6. Stables JP, Bertram EH, White HS, Coulter DA, Dichter MA, Jacobs MP, Loscher W, Lowenstein DH, Moshe SL, Noebels JL, Davis M (2002) Models for epilepsy and epileptogenesis: report from the NIH workshop, Bethesda, Maryland. Epilepsia 43:1410-1420 (Pubitemid 35365001)
7. Stafstrom CE, Roopra A, Sutula TP (2008) Seizure suppression via glycolysis inhibition with 2-deoxy-d-glucose (2-DG). Epilepsia 49:97-100
8. Gasior M, Yankura J, Hartman AL, French A, Rogawski MA (2010) Anticonvulsant and proconvulsant actions of 2-deoxy-d-glucose. Epilepsia 51:1385-1394
9. Stafstrom CE, Ockuly JC, Murphree L, Valley MT, Roopra A, Sutula TP (2009) Anticonvulsant and antiepileptic actions of 2-deoxy-d-glucose in epilepsy models. Ann Neurol 65:435-447
10. Barton ME, Klein BD, Wolf HH, White HS (2001) Pharmacological characterization of the 6 Hz psychomotor seizure model of partial epilepsy. Epilepsy Res 47:217-227 (Pubitemid 34008465)
11. Lian XY, Khan FA, Stringer JL (2007) Fructose-1,6-bisphosphate has anticonvulsant activity in models of acute seizures in adult rats. J Neurosci 27:12007-12011 (Pubitemid 350072086)
12. Garriga-Canut M, Schoenike B, Qazi R, Bergendahl K, Daley TJ, Pfender RM, Morrison JF, Ockuly J, Stafstrom C, Sutula T, Roopra A (2006) 2-Deoxy-d-glucose reduces epilepsy progression by NRSF-CtBP-dependent metabolic regulation of chromatin structure. Nat Neurosci 9:1382-1387 (Pubitemid 44646210)
13. Kimmich GA, Randles J (1976) 2-Deoxyglucose transport by intestinal epithelial cells isolated from chick. J Membrane Biol 27:363-379
14. Sols A, Crane RK (1954) Substrate specificity of brain hexokinase. J Biol Chem 210:581-595
15. Bissonnette P, Gagné H, Blais A, Berteloot A (1996) 2-Deoxyglucose transport and metabolism in Caco-2 cells. Am J Physiol 270:G153-G162
16. Chen W, Gueron M (1992) The inhibition of bovine heart hexokinase by 2-deoxy-d-glucose-6-phosphate: characterization by 31P NMR and metabolic implications. Biochimie 74:867-873
17. Yamada K, Ji JJ, Yuan H, Miki T, Sato S, Horimoto N, Shimizu T, Seino S, Inagaki N (2001) Protective role of ATP-sensitive potassium channels in hypoxia-induced generalized seizure. Science 292:1543-1546 (Pubitemid 32493422)
18. Hernández-Sánchez C, Basile AS, Fedorova I, Arima H, Stannard B, Fernandez AM, Ito Y, LeRoith D (2001) Mice transgenically overexpressing sulfonylurea receptor 1 in forebrain resist seizure induction and excitotoxic neuron death. Proc Natl Acad Sci USA 98:3549-3554 (Pubitemid 32220882)
19. Ma W, Berg J, Yellen G (2007) Ketogenic diet metabolites reduce firing in central neurons by opening K(ATP) channels. J Neurosci 27:3618-3625 (Pubitemid 46557685)
20. Mercer RW, Dunham PB (1981) Membrane-bound ATP fuels the Na/K pump. Studies on membrane-bound glycolytic enzymes on inside-out vesicles from human red cell membranes. J Gen Physiol 78:547-568 (Pubitemid 12247662)
21. Avanzi RD, Cavarsan CF, Santos JG, Hamani C, Mello LE, Covolan L (2010) Basal dendrites are present in newly born dentate granule cells of young but not aged pilocarpine-treated chronic epileptic rats. Neuroscience 27:687-691
22. Covolan L, Mello LE (2006) Assessment of the progressive nature of cell damage in the pilocarpine model of epilepsy. Braz J Med Biol Res 39:915-924 (Pubitemid 44111060)
23. Bough KJ, Gudi K, Han FT, Rathod AH, Eagles DA (2002) An anticonvulsant profile of the ketogenic diet in the rat. Epilepsy Res 50:313-325 (Pubitemid 35015215)
24. Lian XY, Stringer JL (2004) Inhibition of aconitase in astrocytes increases the sensitivity to chemical convulsants. Epilepsy Res 60:41-52 (Pubitemid 38981760)
25. Cavalheiro EA, Leite JP, Bortolotto ZA, Turski WA, Ikonomidou C, Turski L (1991) Long-term effects of pilocarpine in rats: structural damage of the brain triggers kindling and spontaneous recurrent seizures. Epilepsia 32:778-782
26. Cavalheiro EA, Fernandes MJ, Turski L, Naffah-Mazzacoratti MG (1994) Spontaneous recurrent seizures in rats: amino acid and monoamine determination in the hippocampus. Epilepsia 35:1-11 (Pubitemid 24074459)
27. Mello LE, Cavalheiro EA, Tan AM, Kupfer WR, Pretorius JK, Babb TL, Finch DM (1993) Circuit mechanisms of seizures in the pilocarpine model of chronic epilepsy: cell loss and mossy fiber sprouting. Epilepsia 34:985-995 (Pubitemid 24004233)
28. Cao X, Xiao H, Zhang Y, Zou L, Chu Y, Chu X (2010) 1, 5-Dicaffeoylquinic acid-mediated glutathione synthesis through activation of Nrf2 protects against OGD/reperfusion-induced oxidative stress in astrocytes. Brain Res 1347:142-148
29. Zawar C, Plant TD, Schirra C, Konnerth A, Neumcke B (1999) Cell-type specific expression of ATP-sensitive potassium channels in the rat hippocampus. J Physiol 514:327-341 (Pubitemid 29055963)
30. Zhou M, Tanaka O, Suzuki M, Sekiguchi M, Takata K, Kawahara K, Abe H (2002) Localization of pore-forming subunit of the ATP-sensitive K(+)-channel, Kir6.2, in rat brain neurons and glial cells. Brain Res Mol Brain Res 101:23-32 (Pubitemid 34465557)
31. Liss B, Bruns R, Roeper J (1999) Alternative sulfonylurea receptor expression defines metabolic sensitivity of K-ATP channels in dopaminergic midbrain neurons. EMBO J 18:833-846 (Pubitemid 29082263)
32. Clement JP, Kunjilwar K, Gonzalez G, Schwanstecher M, Panten U, Aguilar-Bryan L, Bryan J (1997) Association and stoichiometry of K(ATP) channel Subunits. Neuron 18:827-838 (Pubitemid 27232792)
33. Liss B, Roeper J (2001) Molecular physiology of neuronal K-ATP channels (review). Mol Membr Biol 18:117-127 (Pubitemid 32666791)
34. Soundarapandian MM, Wu D, Zhong X, Petralia RS, Peng L, Tu W, Lu Y (2007) Expression of functional Kir6.1 channels regulates glutamate release at CA3 synapses in generation of epileptic form of seizures. J Neurochem 103:1982-1988 (Pubitemid 350126614)
35. + channel, in the model of hippocampus-generating partial seizures in rats. Eur J Pharmacol 311:37-44 (Pubitemid 26298497)
36. + channel openers decrease seizures in genetically epileptic rats. Eur J Pharmacol 167:181-183 (Pubitemid 19213721)
37. Jiang KW, Gao F, Shui QX, Yu ZS, Xia ZZ (2004) Effect of diazoxide on regulation of vesicular and plasma membrane GABA transporter genes and proteins in hippocampus of rats subjected to picrotoxin-induced kindling. Neurosci Res 50:319-329 (Pubitemid 39370899)
38. Ghasemi M, Shafaroodi H, Karimollah AR, Gholipour T, Nezami BG, Ebrahimi F, Dehpour AR (2010) ATP-sensitive potassium channels contribute to the time-dependent alteration in the pentylenetetrazole-induced seizure threshold in diabetic mice. Seizure 19:53-58
39. Jiang K, Shui Q, Xia Z, Yu Z (2004) Changes in the gene and protein expression of K(ATP) channel subunits in the hippocampus of rats subjected to picrotoxin-induced kindling. Brain Res Mol Brain Res 128:83-89 (Pubitemid 39158883)
40. + channel subunits, Kir6.2 and SUR1 mRNA expressions in DG region is different from those in CA1-3 regions of chronic epilepsy induced by picrotoxin in rats. Neuropathology 27:531-538 (Pubitemid 350045679)
41. Palizvan MR, Fathollahi Y, Semnanian S, Hajezadeh S, Mirnajafizadh J (2001) Differential effects of pentylenetetrazol-kindling on long-term potentiation of population excitatory postsynaptic potentials and population spikes in the CA1 region of rat hippocampus. Brain Res 898:82-90 (Pubitemid 32274195)
42. Curia G, Longo D, Biagini G, Jones RS, Avoli M (2008) The pilocarpine model of temporal lobe epilepsy. J Neurosci Methods 172:143-157