Fatty acid oxidation and epilepsy

Epilepsy Research

Volumn 100, Issue 3, 2012, Pages 224-228

  Auvin, Stéphane ^a,b,c  

^a INSERM   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c HÔPITAL ROBERT DEBRÉ   (France)

Author keywords

Epilepsy; Ketogenic diet; Polyunsaturated fatty acids

Indexed keywords

ACETYLSALICYLIC ACID; CYCLOOXYGENASE 2 INHIBITOR; FISH OIL; ICOSAPENTAENOIC ACID; NAPROXEN; NIMESULIDE; OMEGA 3 FATTY ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PLACEBO; POLYUNSATURATED FATTY ACID; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; ROFECOXIB;

ANTICONVULSANT ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CENTRAL NERVOUS SYSTEM; CONVULSION; DIET SUPPLEMENTATION; DIETARY INTAKE; ENZYME ACTIVITY; EPILEPSY; FATTY ACID OXIDATION; HUMAN; KETOGENIC DIET; NERVE CELL MEMBRANE; NONHUMAN; NUTRITIONAL ASSESSMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SEIZURE; TREATMENT RESPONSE;

DIET, CARBOHYDRATE-RESTRICTED; EPILEPSY; FATTY ACIDS, UNSATURATED; HUMANS; KETOGENIC DIET; LIPID METABOLISM; OXIDATION-REDUCTION;

EID: 84864081369     PISSN: 09201211     EISSN: 18726844     Source Type: Journal    
DOI: 10.1016/j.eplepsyres.2011.05.022     Document Type: Article

References (36)

1. Blondeau N., Widmann C., Lazdunski M., Heurteaux C. Polyunsaturated fatty acids induce ischemic and epileptic tolerance. Neuroscience 2002, 109:231-241.
2. Bromfield E., Dworetzky B., Hurwitz S., Eluri Z., Lane L., Replansky S., Mostofsky D. A randomized trial of polyunsaturated fatty acids for refractory epilepsy. Epilepsy Behav. 2008, 12:187-190.
3. Dahlin M., Hjelte L., Nilsson S., Amark P. Plasma phospholipid fatty acids are influenced by a ketogenic diet enriched with n-3 fatty acids in children with epilepsy. Epilepsy Res. 2007, 73:199-207.
4. DeGiorgio C.M., Miller P., Meymandi S., Gorndein J.A. n-3 fatty acids (fish oil) for epilepsy, cardiac risk factors, and risk of SUDEP: clues from a pilot, double-blind, exploratory study. Epilepsy Behav. 2008, 13:681-684.
5. Dhir A., Naidu P.S., Kulkarni S.K. Effect of cyclooxygenase inhibitors on pentylenetetrazol (PTZ)-induced convulsions: possible mechanism of action. Prog. Neuropsychopharmacol. Biol. Psychiatry 2006, 30:1478-1485.
6. Feunekes G.I., Van Staveren W.A., De Vries J.H., Burema J., Hautvast J.G. Relative and biomarker-based validity of a food-frequency questionnaire estimating intake of fats and cholesterol. Am. J. Clin. Nutr. 1993, 58:489-496.
7. Fraser D.D., Whiting S., Andrew R.D., Macdonald E.A., Musa-Veloso K., Cunnane S.C. Elevated polyunsaturated fatty acids in blood serum obtained from children on the ketogenic diet. Neurology 2003, 60:1026-1029.
8. Haag M. Essential fatty acids and the brain. Can. J. Psychiatry 2003, 48:195-203.
9. Healy D.A., Wallace F.A., Miles E.A., Calder P.C., Newsholm P. Effect of low-to-moderate amounts of dietary fish oil on neutrophil lipid composition and function. Lipids 2000, 35:763-768.
10. Kersten S., Mandard S., Escher P., Gonzalez F.J., Tafuri S., Desvergne B., Wahli W. The peroxisome proliferator-activated receptor alpha regulates amino acid metabolism. FASEB J. 2001, 15:1971-1978.
11. Kossoff E.H., Dorward J.L., Turner Z., Pyzik P.L. Prospective study of the modified atkins diet in combination with a ketogenic liquid supplement during the initial month. J. Child Neurol. 2010, 26:147-151.
12. Lauritzen I., Blondeau N., Heurteaux C., Widmann C., Romey G., Lazdunski M. Polyunsaturated fatty acids are potent neuroprotectors. EMBO J. 2000, 19:1784-1793.
13. Lin Q., Ruuska S.E., Shaw N.S., Dong D., Noy N. Ligand selectivity of the peroxisome proliferator-activated receptor alpha. Biochemistry 1999, 38:185-190.
14. Maurois P., Rocchi S., Pages N., Bac P., Stables J.P., Gressens P., Vamecq J. The PPARgamma agonist FMOC-l-leucine protects both mature and immature brain. Biomed. Pharmacother. 2008, 62:259-263.
15. Porta N., Bourgois B., Galabert C., Lecointe C., Cappy P., Bordet R., Vallee L., Auvin S. Anticonvulsant effects of linolenic acid are unrelated to brain phospholipid cell membrane compositions. Epilepsia 2009, 50:65-71.
16. Porta N., Vallee L., Boutry E., Fontaine M., Dessein A.F., Joriot S., Cuisset J.M., Cuvellier J.C., Auvin S. Comparison of seizure reduction and serum fatty acid levels after receiving the ketogenic and modified Atkins diet. Seizure 2009, 18:359-364.
17. Porta N., Vallee L., Lecointe C., Bouchaert E., Staels B., Bordet R., Auvin S. Fenofibrate, a peroxisome proliferator-activated receptor-alpha agonist, exerts anticonvulsive properties. Epilepsia 2009, 50:943-948.
18. Rabinovitz S., Mostofsky D.I., Yehuda S. Anticonvulsant efficiency, behavioral performance and cortisol levels: a comparison of carbamazepine (CBZ) and a fatty acid compound (SR-3). Psychoneuroendocrinology 2004, 29:113-124.
19. Rees D., Miles E.A., Banerjee T., Wells S.J., Roynette C.E., Wahle K.W., Calder P.C. Dose-related effects of eicosapentaenoic acid on innate immune function in healthy humans: a comparison of young and older men. Am. J. Clin. Nutr. 2006, 83:331-342.
20. Sampath H., Ntambi J.M. Polyunsaturated fatty acid regulation of genes of lipid metabolism. Annu. Rev. Nutr. 2005, 25:317-340.
21. Schlanger S., Shinitzky M., Yam D. Diet enriched with omega-3 fatty acids alleviates convulsion symptoms in epilepsy patients. Epilepsia 2002, 43:103-104.
22. Schmidt E.B., Skou H.A., Christensen J.H., Dyerberg J. N-3 fatty acids from fish and coronary artery disease: implications for public health. Public Health Nutr. 2000, 3:91-98.
23. Shafiq N., Malhotra S., Pandhi P. Anticonvulsant action of celecoxib (alone and in combination with sub-threshold dose of phenytoin) in electroshock induced convulsion. Methods Find. Exp. Clin. Pharmacol. 2003, 25:87-90.
24. Smith S.A. Peroxisome proliferator-activated receptors and the regulation of mammalian lipid metabolism. Biochem. Soc. Trans. 2002, 30:1086-1090.
25. Taha A.Y., Alizadeh S., Zeng Q.H., Filo E., McPherson J.P., Burnham W.M. Assessing the metabolic and toxic effects of anticonvulsant doses of polyunsaturated fatty acids on the liver in rats. J. Toxicol. Environ. Health A 2009, 72:1191-1200.
26. Taha A.Y., Burnham W.M., Auvin S. Polyunsaturated fatty acids and epilepsy. Epilepsia 2010, 51:1348-1358.
27. Taha A.Y., Filo E., Ma D.W., McIntyre B.W. Dose-dependent anticonvulsant effects of linoleic and alpha-linolenic polyunsaturated fatty acids on pentylenetetrazol induced seizures in rats. Epilepsia 2009, 50:72-82.
28. Taha A.Y., Huot P.S., Reza-Lopez S., Prayitno N.R., Kang J.X., Burnham W.M., Ma D.W. Seizure resistance in fat-1 transgenic mice endogenously synthesizing high levels of omega-3 polyunsaturated fatty acids. J Neurochem. 2008, 105:380-388.
29. Taha A.Y., Baghiu B.M., Lui R., Nylen K., Ma D.W., Burnham W.M. Lack of benefit of linoleic and alpha-linolenic polyunsaturated fatty acids on seizure latency, duration, severity or incidence in rats. Epilepsy Res. 2006, 71:40-46.
30. Umhau J.C., Zhou W., Carson R.E., Rapoport S.I., Polozova A., Demar J., Hussein N., Bhattacharjee A.K., Ma K., Esposito G., Majchrzak S., Herscovitch P., Eckelman W.C., Kurdziel K.A., Salem N. Imaging incorporation of circulating docosahexaenoic acid into the human brain using positron emission tomography. J. Lipid Res. 2008, 50:1259-1268.
31. Vezzani A., Granata T. Brain inflammation in epilepsy: experimental and clinical evidence. Epilepsia 2005, 46:1724-1743.
32. Vezzani A., Moneta D., Conti M., Richichi C., Ravizza T., De Luigi A., De Simoni M.G., Sperk G., Andell-Jonsson S., Lundkvist J., Iverfeldt K., Bartfai T. Powerful anticonvulsant action of IL-1 receptor antagonist on intracerebral injection and astrocytic overexpression in mice. Proc. Natl. Acad. Sci. U. S. A. 2000, 1153(97):4-11539.
33. Voskuyl R.A., Vreugdenhil M., Kang J.X., Leaf A. Anticonvulsant effect of polyunsaturated fatty acids in rats, using the cortical stimulation model. Eur J Pharmacol. 1998, 341:145-152.
34. Willis S., Samala R., Rosenberger T.A., Borges K. Eicosapentaenoic and docosahexaenoic acids are not anticonvulsant or neuroprotective in acute mouse seizure models. Epilepsia 2009, 50:138-142.
35. Yehuda S., Carasso R.L., Mostofsky D.I. Essential fatty acid preparation (SR-3) raises the seizure threshold in rats. Eur J Pharmacol. 1994, 254:193-198.
36. Yuen A.W., Sander J.W., Fluegel D., Patsalos P.N., Bell G.S., Johnson T., Koepp M.J. Omega-3 fatty acid supplementation in patients with chronic epilepsy: a randomized trial. Epilepsy Behav. 2005, 7:253-258.