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Volumn 60, Issue 8, 2012, Pages 1215-1226

Astrocytic regulation of glutamate homeostasis in epilepsy

Author keywords

Astrocytes; Epilepsy; Glutamate; Glutamine; Metabolism

Indexed keywords

GLUTAMIC ACID; GLUTAMINE;

EID: 84862321615     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.22341     Document Type: Review
Times cited : (244)

References (149)
  • 1
    • 0031562362 scopus 로고    scopus 로고
    • Expression of glial glutamate transporters GLT-1 and GLAST is unchanged in the hippocampus in fully kindled rats
    • Akbar MT, Torp R, Danbolt NC, Levy LM, Meldrum BS, Ottersen OP. 1997. Expression of glial glutamate transporters GLT-1 and GLAST is unchanged in the hippocampus in fully kindled rats. Neuroscience 78: 351-359.
    • (1997) Neuroscience , vol.78 , pp. 351-359
    • Akbar, M.T.1    Torp, R.2    Danbolt, N.C.3    Levy, L.M.4    Meldrum, B.S.5    Ottersen, O.P.6
  • 2
    • 77954363488 scopus 로고    scopus 로고
    • Mechanisms of oxidative glutamate toxicity: The glutamate/cystine antiporter system xc- as a neuroprotective drug target
    • Albrecht P, Lewerenz J, Dittmer S, Noack R, Maher P, Methner A. 2010. Mechanisms of oxidative glutamate toxicity: The glutamate/cystine antiporter system xc- as a neuroprotective drug target. CNS Neurol Disord Drug Targets 9: 373-382.
    • (2010) CNS Neurol Disord Drug Targets , vol.9 , pp. 373-382
    • Albrecht, P.1    Lewerenz, J.2    Dittmer, S.3    Noack, R.4    Maher, P.5    Methner, A.6
  • 4
    • 27144466742 scopus 로고    scopus 로고
    • Hippocampal CA1 circuitry dynamically gates direct cortical inputs preferentially at theta frequencies
    • Ang CW, Carlson GC, Coulter DA. 2005. Hippocampal CA1 circuitry dynamically gates direct cortical inputs preferentially at theta frequencies. J Neurosci 25: 9567-9580.
    • (2005) J Neurosci , vol.25 , pp. 9567-9580
    • Ang, C.W.1    Carlson, G.C.2    Coulter, D.A.3
  • 5
    • 33751109475 scopus 로고    scopus 로고
    • Massive and specific dysregulation of direct cortical input to the hippocampus in temporal lobe epilepsy
    • Ang CW, Carlson GC, Coulter DA. 2006. Massive and specific dysregulation of direct cortical input to the hippocampus in temporal lobe epilepsy. J Neurosci 26: 11850-11856.
    • (2006) J Neurosci , vol.26 , pp. 11850-11856
    • Ang, C.W.1    Carlson, G.C.2    Coulter, D.A.3
  • 6
    • 0034651087 scopus 로고    scopus 로고
    • SNARE protein-dependent glutamate release from astrocytes
    • Araque A, Li N, Doyle RT, Haydon PG. 2000. SNARE protein-dependent glutamate release from astrocytes. J Neurosci 20: 666-673.
    • (2000) J Neurosci , vol.20 , pp. 666-673
    • Araque, A.1    Li, N.2    Doyle, R.T.3    Haydon, P.G.4
  • 7
    • 0028291438 scopus 로고
    • Glia and neurons in dialogue
    • Attwell D. 1994. Glia and neurons in dialogue. Nature 369: 707-708.
    • (1994) Nature , vol.369 , pp. 707-708
    • Attwell, D.1
  • 9
    • 0025779184 scopus 로고
    • GABA synthesis in brain slices is dependent on glutamine produced in astrocytes
    • Battaglioli G, Martin DL. 1991. GABA synthesis in brain slices is dependent on glutamine produced in astrocytes. Neurochem Res 16: 151-156.
    • (1991) Neurochem Res , vol.16 , pp. 151-156
    • Battaglioli, G.1    Martin, D.L.2
  • 10
    • 0032102185 scopus 로고    scopus 로고
    • Expression of c-jun, junB, c-fos, fra-1 and fra-2 mRNA in the rat brain following seizure activity and axotomy
    • Beer J, Mielke K, Zipp M, Zimmermann M, Herdegen T. 1998. Expression of c-jun, junB, c-fos, fra-1 and fra-2 mRNA in the rat brain following seizure activity and axotomy. Brain Res 794: 255-266.
    • (1998) Brain Res , vol.794 , pp. 255-266
    • Beer, J.1    Mielke, K.2    Zipp, M.3    Zimmermann, M.4    Herdegen, T.5
  • 11
    • 0032211134 scopus 로고    scopus 로고
    • The localization of the brain-specific inorganic phosphate transporter suggests a specific presynaptic role in glutamatergic transmission
    • Bellocchio EE, Hu H, Pohorille A, Chan J, Pickel VM, Edwards RH. 1998. The localization of the brain-specific inorganic phosphate transporter suggests a specific presynaptic role in glutamatergic transmission. J Neurosci 18: 8648-8659.
    • (1998) J Neurosci , vol.18 , pp. 8648-8659
    • Bellocchio, E.E.1    Hu, H.2    Pohorille, A.3    Chan, J.4    Pickel, V.M.5    Edwards, R.H.6
  • 12
    • 0021921141 scopus 로고
    • Limbic seizure and brain damage produced by kainic acid: Mechanisms and relevance to human temporal lobe epilepsy
    • Ben-Ari Y. 1985. Limbic seizure and brain damage produced by kainic acid: Mechanisms and relevance to human temporal lobe epilepsy. Neuroscience 14: 375-403.
    • (1985) Neuroscience , vol.14 , pp. 375-403
    • Ben-Ari, Y.1
  • 13
    • 0016746875 scopus 로고
    • Metabolism of amino acids and ammonia in rat brain cortex slices in vitro: A possible role of ammonia in brain function
    • Benjamin AM, Quastel JH. 1975. Metabolism of amino acids and ammonia in rat brain cortex slices in vitro: A possible role of ammonia in brain function. J Neurochem 25: 197-206.
    • (1975) J Neurochem , vol.25 , pp. 197-206
    • Benjamin, A.M.1    Quastel, J.H.2
  • 14
    • 33846910806 scopus 로고    scopus 로고
    • Is lactate food for neurons? Comparison of monocarboxylate transporter subtypes in brain and muscle
    • Bergersen LH. 2007. Is lactate food for neurons? Comparison of monocarboxylate transporter subtypes in brain and muscle. Neuroscience 145: 11-19.
    • (2007) Neuroscience , vol.145 , pp. 11-19
    • Bergersen, L.H.1
  • 16
    • 58149235281 scopus 로고    scopus 로고
    • Glutamine synthetase becomes nitrated and its activity is reduced during repetitive seizure activity in the pentylentetrazole model of epilepsy
    • Bidmon HJ, Gorg B, Palomero-Gallagher N, Schleicher A, Haussinger D, Speckmann EJ, Zilles K. 2008. Glutamine synthetase becomes nitrated and its activity is reduced during repetitive seizure activity in the pentylentetrazole model of epilepsy. Epilepsia 49: 1733-1748.
    • (2008) Epilepsia , vol.49 , pp. 1733-1748
    • Bidmon, H.J.1    Gorg, B.2    Palomero-Gallagher, N.3    Schleicher, A.4    Haussinger, D.5    Speckmann, E.J.6    Zilles, K.7
  • 17
    • 0001716661 scopus 로고
    • De l'épilepsie considérée dans ses rapports avec l'aliénation mentale. Recherche sur la nature et le siége de ces deux maladies
    • Bouchet C. 1825. De l'épilepsie considérée dans ses rapports avec l'aliénation mentale. Recherche sur la nature et le siége de ces deux maladies. Arch Gén Méd 9: 510-42.
    • (1825) Arch Gén Méd , vol.9 , pp. 510-542
    • Bouchet, C.1
  • 18
    • 55349119933 scopus 로고    scopus 로고
    • Energy metabolism as part of the anticonvulsant mechanism of the ketogenic diet
    • Bough K. 2008. Energy metabolism as part of the anticonvulsant mechanism of the ketogenic diet. Epilepsia 49(Suppl 8): 91-93.
    • (2008) Epilepsia , vol.49 , Issue.SUPPL. 8 , pp. 91-93
    • Bough, K.1
  • 19
    • 0031720906 scopus 로고    scopus 로고
    • Selective changes in single cell GABA(A) receptor subunit expression and function in temporal lobe epilepsy
    • Brooks-Kayal AR, Shumate MD, Jin H, Rikhter TY, Coulter DA. 1998. Selective changes in single cell GABA(A) receptor subunit expression and function in temporal lobe epilepsy. Nat Med 4: 1166-1172.
    • (1998) Nat Med , vol.4 , pp. 1166-1172
    • Brooks-Kayal, A.R.1    Shumate, M.D.2    Jin, H.3    Rikhter, T.Y.4    Coulter, D.A.5
  • 21
    • 70449381077 scopus 로고    scopus 로고
    • Maintenance of thalamic epileptiform activity depends on the astrocytic glutamate-glutamine cycle
    • Bryant AS, Li B, Beenhakker MP, Huguenard JR. 2009. Maintenance of thalamic epileptiform activity depends on the astrocytic glutamate-glutamine cycle. J Neurophysiol 102: 2880-2888.
    • (2009) J Neurophysiol , vol.102 , pp. 2880-2888
    • Bryant, A.S.1    Li, B.2    Beenhakker, M.P.3    Huguenard, J.R.4
  • 23
    • 77956231926 scopus 로고    scopus 로고
    • Altered glial-neuronal crosstalk: Cornerstone in the pathogenesis of hepatic encephalopathy
    • Butterworth RF. 2010. Altered glial-neuronal crosstalk: Cornerstone in the pathogenesis of hepatic encephalopathy. Neurochem Int 57: 383-388.
    • (2010) Neurochem Int , vol.57 , pp. 383-388
    • Butterworth, R.F.1
  • 27
    • 0037193463 scopus 로고    scopus 로고
    • The glutamine commute: Take the N line and transfer to the A
    • Chaudhry FA, Reimer RJ, Edwards RH. 2002. The glutamine commute: Take the N line and transfer to the A. J Cell Biol 157: 349-355.
    • (2002) J Cell Biol , vol.157 , pp. 349-355
    • Chaudhry, F.A.1    Reimer, R.J.2    Edwards, R.H.3
  • 29
    • 7944220701 scopus 로고    scopus 로고
    • Mesial temporal lobe epilepsy: A proton magnetic resonance spectroscopy study and a histopathological analysis
    • Cohen-Gadol AA, Pan JW, Kim JH, Spencer DD, Hetherington HH. 2004. Mesial temporal lobe epilepsy: A proton magnetic resonance spectroscopy study and a histopathological analysis. J Neurosurg 101: 613-620.
    • (2004) J Neurosurg , vol.101 , pp. 613-620
    • Cohen-Gadol, A.A.1    Pan, J.W.2    Kim, J.H.3    Spencer, D.D.4    Hetherington, H.H.5
  • 30
    • 0037680161 scopus 로고    scopus 로고
    • Dentate granule cell GABA(A) receptors in epileptic hippocampus: Enhanced synaptic efficacy and altered pharmacology
    • Cohen AS, Lin DD, Quirk GL, Coulter DA. 2003. Dentate granule cell GABA(A) receptors in epileptic hippocampus: Enhanced synaptic efficacy and altered pharmacology. Eur J Neurosci 17: 1607-1616.
    • (2003) Eur J Neurosci , vol.17 , pp. 1607-1616
    • Cohen, A.S.1    Lin, D.D.2    Quirk, G.L.3    Coulter, D.A.4
  • 31
    • 0035202121 scopus 로고    scopus 로고
    • Epilepsy-associated plasticity in gamma-aminobutyric acid receptor expression, function, and inhibitory synaptic properties
    • Coulter DA. 2001. Epilepsy-associated plasticity in gamma-aminobutyric acid receptor expression, function, and inhibitory synaptic properties. Int Rev Neurobiol 45: 237-252.
    • (2001) Int Rev Neurobiol , vol.45 , pp. 237-252
    • Coulter, D.A.1
  • 32
    • 0035001341 scopus 로고    scopus 로고
    • Glutamate uptake
    • Danbolt NC. 2001. Glutamate uptake. Prog Neurobiol 65: 1-105.
    • (2001) Prog Neurobiol , vol.65 , pp. 1-105
    • Danbolt, N.C.1
  • 33
    • 0038666143 scopus 로고    scopus 로고
    • A retrospective analysis of hippocampal pathology in human temporal lobe epilepsy: Evidence for distinctive patient subcategories
    • de Lanerolle NC, Kim JH, Williamson A, Spencer SS, Zaveri HP, Eid T, Spencer DD. 2003. A retrospective analysis of hippocampal pathology in human temporal lobe epilepsy: Evidence for distinctive patient subcategories. Epilepsia 44: 677-687.
    • (2003) Epilepsia , vol.44 , pp. 677-687
    • de Lanerolle, N.C.1    Kim, J.H.2    Williamson, A.3    Spencer, S.S.4    Zaveri, H.P.5    Eid, T.6    Spencer, D.D.7
  • 34
    • 0017641188 scopus 로고
    • Comparative studies on glutamate metabolism in synpatic and non-synaptic rat brain mitochondria
    • Dennis SC, Lai JC, Clark JB. 1977. Comparative studies on glutamate metabolism in synpatic and non-synaptic rat brain mitochondria. Biochem J 164: 727-736.
    • (1977) Biochem J , vol.164 , pp. 727-736
    • Dennis, S.C.1    Lai, J.C.2    Clark, J.B.3
  • 35
    • 0035657611 scopus 로고    scopus 로고
    • Disruption of inhibition in area CA1 of the hippocampus in a rat model of temporal lobe epilepsy
    • Denslow MJ, Eid T, Du F, Schwarcz R, Lothman EW, Steward O. 2001. Disruption of inhibition in area CA1 of the hippocampus in a rat model of temporal lobe epilepsy. J Neurophysiol 86: 2231-2245.
    • (2001) J Neurophysiol , vol.86 , pp. 2231-2245
    • Denslow, M.J.1    Eid, T.2    Du, F.3    Schwarcz, R.4    Lothman, E.W.5    Steward, O.6
  • 36
    • 0027760968 scopus 로고
    • Preferential neuronal loss in layer III of the entorhinal cortex in patients with temporal lobe epilepsy
    • Du F, Whetsell WOJr, Abou-Khalil B, Blumenkopf B, Lothman EW, Schwarcz R. 1993. Preferential neuronal loss in layer III of the entorhinal cortex in patients with temporal lobe epilepsy. Epilepsy Res 16: 223-233.
    • (1993) Epilepsy Res , vol.16 , pp. 223-233
    • Du, F.1    Whetsell Jr., W.O.2    Abou-Khalil, B.3    Blumenkopf, B.4    Lothman, E.W.5    Schwarcz, R.6
  • 37
    • 0027262604 scopus 로고
    • Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain
    • During MJ, Spencer DD. 1993. Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain. Lancet 341: 1607-1610.
    • (1993) Lancet , vol.341 , pp. 1607-1610
    • During, M.J.1    Spencer, D.D.2
  • 40
    • 38449093605 scopus 로고    scopus 로고
    • Glutamate and astrocytes-Key players in human mesial temporal lobe epilepsy?
    • Eid T, Williamson A, Lee TS, Petroff OA, de Lanerolle NC. 2008b. Glutamate and astrocytes-Key players in human mesial temporal lobe epilepsy? Epilepsia 49(Suppl 2): 42-52.
    • (2008) Epilepsia , vol.49 , Issue.SUPPL. 2 , pp. 42-52
    • Eid, T.1    Williamson, A.2    Lee, T.S.3    Petroff, O.A.4    de Lanerolle, N.C.5
  • 41
    • 0029042341 scopus 로고
    • The perforant path projection to hippocampal area CA1 in the rat hippocampal-entorhinal cortex combined slice
    • Empson RM, Heinemann U. 1995. The perforant path projection to hippocampal area CA1 in the rat hippocampal-entorhinal cortex combined slice. J Physiol 484(Pt 3): 707-720.
    • (1995) J Physiol , vol.484 , Issue.PART 3 , pp. 707-720
    • Empson, R.M.1    Heinemann, U.2
  • 42
    • 77952421764 scopus 로고    scopus 로고
    • Neurotransmitter transporters expressed in glial cells as regulators of synapse function
    • Eulenburg V, Gomeza J. 2010. Neurotransmitter transporters expressed in glial cells as regulators of synapse function. Brain Res Rev 63: 103-112.
    • (2010) Brain Res Rev , vol.63 , pp. 103-112
    • Eulenburg, V.1    Gomeza, J.2
  • 43
    • 0014472954 scopus 로고
    • Glycogen, ammonia and related metabolities in the brain during seizures evoked by methionine sulphoximine
    • Folbergrova J, Passonneau JV, Lowry OH, Schulz DW. 1969. Glycogen, ammonia and related metabolities in the brain during seizures evoked by methionine sulphoximine. J Neurochem 16: 191-203.
    • (1969) J Neurochem , vol.16 , pp. 191-203
    • Folbergrova, J.1    Passonneau, J.V.2    Lowry, O.H.3    Schulz, D.W.4
  • 44
    • 0021330769 scopus 로고
    • Glutamate: A neurotransmitter in mammalian brain
    • Fonnum F. 1984. Glutamate: A neurotransmitter in mammalian brain. J Neurochem 42: 1-11.
    • (1984) J Neurochem , vol.42 , pp. 1-11
    • Fonnum, F.1
  • 47
    • 34548225352 scopus 로고    scopus 로고
    • Glutamine uptake by System A transporters maintains neurotransmitter GABA synthesis and inhibitory synaptic transmission
    • Fricke MN, Jones-Davis DM, Mathews GC. 2007. Glutamine uptake by System A transporters maintains neurotransmitter GABA synthesis and inhibitory synaptic transmission. J Neurochem 102: 1895-1904.
    • (2007) J Neurochem , vol.102 , pp. 1895-1904
    • Fricke, M.N.1    Jones-Davis, D.M.2    Mathews, G.C.3
  • 48
    • 0030944370 scopus 로고    scopus 로고
    • Differential epilepsy-associated alterations in postsynaptic GABA(A) receptor function in dentate granule and CA1 neurons
    • Gibbs JWIII, Shumate MD, Coulter DA. 1997. Differential epilepsy-associated alterations in postsynaptic GABA(A) receptor function in dentate granule and CA1 neurons. J Neurophysiol 77: 1924-1938.
    • (1997) J Neurophysiol , vol.77 , pp. 1924-1938
    • Gibbs III, J.W.1    Shumate, M.D.2    Coulter, D.A.3
  • 49
    • 0002545867 scopus 로고
    • Mesial temporal sclerosis: Historical background and an overview from a modern perspective
    • Luders H, editor. New York: Raven Press
    • Gloor P. 1991. Mesial temporal sclerosis: Historical background and an overview from a modern perspective. In: Luders H, editor. Epilepsy surgery. New York: Raven Press. pp 689-703.
    • (1991) Epilepsy surgery , pp. 689-703
    • Gloor, P.1
  • 51
    • 0033569442 scopus 로고    scopus 로고
    • The proton-linked monocarboxylate transporter (MCT) family: Structure, function and regulation
    • Halestrap AP, Price NT. 1999. The proton-linked monocarboxylate transporter (MCT) family: Structure, function and regulation. Biochem J 343: 281-299.
    • (1999) Biochem J , vol.343 , pp. 281-299
    • Halestrap, A.P.1    Price, N.T.2
  • 52
    • 77949841510 scopus 로고    scopus 로고
    • Do astrocytes really exocytose neurotransmitters?
    • Hamilton NB, Attwell D. 2010. Do astrocytes really exocytose neurotransmitters? Nat Rev Neurosci 11: 227-238.
    • (2010) Nat Rev Neurosci , vol.11 , pp. 227-238
    • Hamilton, N.B.1    Attwell, D.2
  • 53
    • 0029059287 scopus 로고
    • Regional brain glutamate transport in rats at normal and raised concentrations of circulating glutamate
    • Hawkins RA, DeJoseph MR, Hawkins PA. 1995. Regional brain glutamate transport in rats at normal and raised concentrations of circulating glutamate. Cell Tissue Res 281: 207-214.
    • (1995) Cell Tissue Res , vol.281 , pp. 207-214
    • Hawkins, R.A.1    DeJoseph, M.R.2    Hawkins, P.A.3
  • 55
    • 0031688871 scopus 로고    scopus 로고
    • Interleukin-1 beta and tumor necrosis factor-alpha suppress dexamethasone induction of glutamine synthetase in primary mouse astrocytes
    • Huang TL, O'Banion MK. 1998. Interleukin-1 beta and tumor necrosis factor-alpha suppress dexamethasone induction of glutamine synthetase in primary mouse astrocytes. J Neurochem 71: 1436-1442.
    • (1998) J Neurochem , vol.71 , pp. 1436-1442
    • Huang, T.L.1    O'Banion, M.K.2
  • 56
    • 0017143254 scopus 로고
    • Ketonemia and seizures: Metabolic and anticonvulsant effects of two ketogenic diets in childhood epilepsy
    • Huttenlocher PR. 1976. Ketonemia and seizures: Metabolic and anticonvulsant effects of two ketogenic diets in childhood epilepsy. Pediatr Res 10: 536-540.
    • (1976) Pediatr Res , vol.10 , pp. 536-540
    • Huttenlocher, P.R.1
  • 57
    • 0034161522 scopus 로고    scopus 로고
    • Imaging extracellular waves of glutamate during calcium signaling in cultured astrocytes
    • Innocenti B, Parpura V, Haydon PG. 2000. Imaging extracellular waves of glutamate during calcium signaling in cultured astrocytes. J Neurosci 20: 1800-1808.
    • (2000) J Neurosci , vol.20 , pp. 1800-1808
    • Innocenti, B.1    Parpura, V.2    Haydon, P.G.3
  • 58
    • 38449112392 scopus 로고    scopus 로고
    • Astrocytic function and its alteration in the epileptic brain
    • Jabs R, Seifert G, Steinhauser C. 2008. Astrocytic function and its alteration in the epileptic brain. Epilepsia 49(Suppl 2): 3-12.
    • (2008) Epilepsia , vol.49 , Issue.SUPPL. 2 , pp. 3-12
    • Jabs, R.1    Seifert, G.2    Steinhauser, C.3
  • 59
    • 0028945649 scopus 로고
    • Effect of dibutyryl cyclic AMP and dexamethasone on glutamine synthetase gene expression in rat astrocytes in culture
    • Jackson MJ, Zielke HR, Max SR. 1995. Effect of dibutyryl cyclic AMP and dexamethasone on glutamine synthetase gene expression in rat astrocytes in culture. Neurochem Res 20: 201-207.
    • (1995) Neurochem Res , vol.20 , pp. 201-207
    • Jackson, M.J.1    Zielke, H.R.2    Max, S.R.3
  • 61
    • 0037386577 scopus 로고    scopus 로고
    • Demonstration of functional coupling between gamma-aminobutyric acid (GABA) synthesis and vesicular GABA transport into synaptic vesicles
    • Jin H, Wu H, Osterhaus G, Wei J, Davis K, Sha D, Floor E, Hsu CC, Kopke RD, Wu JY. 2003. Demonstration of functional coupling between gamma-aminobutyric acid (GABA) synthesis and vesicular GABA transport into synaptic vesicles. Proc Natl Acad Sci USA 100: 4293-4298.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 4293-4298
    • Jin, H.1    Wu, H.2    Osterhaus, G.3    Wei, J.4    Davis, K.5    Sha, D.6    Floor, E.7    Hsu, C.C.8    Kopke, R.D.9    Wu, J.Y.10
  • 62
    • 34548178798 scopus 로고    scopus 로고
    • Excitatory synaptic transmission persists independently of the glutamate-glutamine cycle
    • Kam K, Nicoll R. 2007. Excitatory synaptic transmission persists independently of the glutamate-glutamine cycle. J Neurosci 27: 9192-9200.
    • (2007) J Neurosci , vol.27 , pp. 9192-9200
    • Kam, K.1    Nicoll, R.2
  • 63
    • 67650741991 scopus 로고    scopus 로고
    • Ammonium-evoked alterations in intracellular sodium and pH reduce glial glutamate transport activity
    • Kelly T, Kafitz KW, Roderigo C, Rose CR. 2009. Ammonium-evoked alterations in intracellular sodium and pH reduce glial glutamate transport activity. Glia 57: 921-934.
    • (2009) Glia , vol.57 , pp. 921-934
    • Kelly, T.1    Kafitz, K.W.2    Roderigo, C.3    Rose, C.R.4
  • 65
    • 0025425558 scopus 로고
    • Swelling-induced release of glutamate, aspartate, and taurine from astrocyte cultures
    • Kimelberg HK, Goderie SK, Higman S, Pang S, Waniewski RA. 1990. Swelling-induced release of glutamate, aspartate, and taurine from astrocyte cultures. J Neurosci 10: 1583-1591.
    • (1990) J Neurosci , vol.10 , pp. 1583-1591
    • Kimelberg, H.K.1    Goderie, S.K.2    Higman, S.3    Pang, S.4    Waniewski, R.A.5
  • 66
    • 0028932763 scopus 로고
    • Astrocytic swelling due to hypotonic or high K+ medium causes inhibition of glutamate and aspartate uptake and increases their release
    • Kimelberg HK, Rutledge E, Goderie S, Charniga C. 1995. Astrocytic swelling due to hypotonic or high K+ medium causes inhibition of glutamate and aspartate uptake and increases their release. J Cereb Blood Flow Metab 15: 409-416.
    • (1995) J Cereb Blood Flow Metab , vol.15 , pp. 409-416
    • Kimelberg, H.K.1    Rutledge, E.2    Goderie, S.3    Charniga, C.4
  • 67
    • 0034968240 scopus 로고    scopus 로고
    • Basic fibroblast growth factor: A potential inhibitor of glutamine synthetase expression in injured neural tissue
    • Kruchkova Y, Ben-Dror I, Herschkovitz A, David M, Yayon A, Vardimon L. 2001. Basic fibroblast growth factor: A potential inhibitor of glutamine synthetase expression in injured neural tissue. J Neurochem 77: 1641-1649.
    • (2001) J Neurochem , vol.77 , pp. 1641-1649
    • Kruchkova, Y.1    Ben-Dror, I.2    Herschkovitz, A.3    David, M.4    Yayon, A.5    Vardimon, L.6
  • 68
    • 0035577281 scopus 로고    scopus 로고
    • Kinetics and localization of phosphate activated glutaminase
    • Kvamme E, Roberg B, Torgner IA. 2001. Kinetics and localization of phosphate activated glutaminase. J Neurosci Res 66: 951-958.
    • (2001) J Neurosci Res , vol.66 , pp. 951-958
    • Kvamme, E.1    Roberg, B.2    Torgner, I.A.3
  • 69
    • 0141485079 scopus 로고
    • Amino acid and protein metabolism of the brain. IV. The metabolism of glutamic acid
    • Lajtha A, Berl S, Waelsch H. 1959. Amino acid and protein metabolism of the brain. IV. The metabolism of glutamic acid. J Neurochem 3: 322-332.
    • (1959) J Neurochem , vol.3 , pp. 322-332
    • Lajtha, A.1    Berl, S.2    Waelsch, H.3
  • 70
    • 0035052469 scopus 로고    scopus 로고
    • Enhanced neuronal protection from oxidative stress by coculture with glutamic acid decarboxylase-expressing astrocytes
    • Lamigeon C, Bellier JP, Sacchettoni S, Rujano M, Jacquemont B. 2001. Enhanced neuronal protection from oxidative stress by coculture with glutamic acid decarboxylase-expressing astrocytes. J Neurochem 77: 598-606.
    • (2001) J Neurochem , vol.77 , pp. 598-606
    • Lamigeon, C.1    Bellier, J.P.2    Sacchettoni, S.3    Rujano, M.4    Jacquemont, B.5
  • 74
    • 0035106634 scopus 로고    scopus 로고
    • Diet-induced ketosis increases monocarboxylate transporter (MCT1) levels in rat brain
    • Leino RL, Gerhart DZ, Duelli R, Enerson BE, Drewes LR. 2001. Diet-induced ketosis increases monocarboxylate transporter (MCT1) levels in rat brain. Neurochem Int 38: 519-527.
    • (2001) Neurochem Int , vol.38 , pp. 519-527
    • Leino, R.L.1    Gerhart, D.Z.2    Duelli, R.3    Enerson, B.E.4    Drewes, L.R.5
  • 75
    • 79955660794 scopus 로고    scopus 로고
    • Synthesis of neurotransmitter GABA via the neuronal tricarboxylic acid cycle is elevated in rats with liver cirrhosis consistent with a high GABAergic tone in chronic hepatic encephalopathy
    • Leke R, Bak LK, Iversen P, Sorensen M, Keiding S, Vilstrup H, Ott P, Portela LV, Schousboe A, Waagepetersen HS. 2011. Synthesis of neurotransmitter GABA via the neuronal tricarboxylic acid cycle is elevated in rats with liver cirrhosis consistent with a high GABAergic tone in chronic hepatic encephalopathy. J Neurochem 117: 824-832.
    • (2011) J Neurochem , vol.117 , pp. 824-832
    • Leke, R.1    Bak, L.K.2    Iversen, P.3    Sorensen, M.4    Keiding, S.5    Vilstrup, H.6    Ott, P.7    Portela, L.V.8    Schousboe, A.9    Waagepetersen, H.S.10
  • 76
    • 33748203626 scopus 로고    scopus 로고
    • Dynamic regulation of synaptic GABA release by the glutamate-glutamine cycle in hippocampal area CA1
    • Liang SL, Carlson GC, Coulter DA. 2006. Dynamic regulation of synaptic GABA release by the glutamate-glutamine cycle in hippocampal area CA1. J Neurosci 26: 8537-8548.
    • (2006) J Neurosci , vol.26 , pp. 8537-8548
    • Liang, S.L.1    Carlson, G.C.2    Coulter, D.A.3
  • 77
    • 0343416851 scopus 로고    scopus 로고
    • Basic fibroblast growth factor-induced seizures in rats
    • Liu Z, Holmes GL. 1997. Basic fibroblast growth factor-induced seizures in rats. Neurosci Lett 233: 85-88.
    • (1997) Neurosci Lett , vol.233 , pp. 85-88
    • Liu, Z.1    Holmes, G.L.2
  • 80
    • 0027763898 scopus 로고
    • Neurotransmitters regulate energy metabolism in astrocytes: Implications for metabolic trafficking between neural cells
    • Magistretti PJ, Sorg O, Yu N, Martin J-L, Pellerin L. 1993. Neurotransmitters regulate energy metabolism in astrocytes: Implications for metabolic trafficking between neural cells. Dev Neurosci 15: 306-312.
    • (1993) Dev Neurosci , vol.15 , pp. 306-312
    • Magistretti, P.J.1    Sorg, O.2    Yu, N.3    Martin, J.-L.4    Pellerin, L.5
  • 82
    • 0017579832 scopus 로고
    • Glutamine synthetase: Glial localization in brain
    • Martinez-Hernandez A, Bell KP, Norenberg MD. 1977. Glutamine synthetase: Glial localization in brain. Science 195: 1356-1358.
    • (1977) Science , vol.195 , pp. 1356-1358
    • Martinez-Hernandez, A.1    Bell, K.P.2    Norenberg, M.D.3
  • 84
    • 0037444545 scopus 로고    scopus 로고
    • Neuronal glutamate uptake Contributes to GABA synthesis and inhibitory synaptic strength
    • Mathews GC, Diamond JS. 2003. Neuronal glutamate uptake Contributes to GABA synthesis and inhibitory synaptic strength. J Neurosci 23: 2040-2048.
    • (2003) J Neurosci , vol.23 , pp. 2040-2048
    • Mathews, G.C.1    Diamond, J.S.2
  • 85
    • 0026007064 scopus 로고
    • Excitotoxicity and epileptic brain damage
    • Meldrum B. 1991. Excitotoxicity and epileptic brain damage. Epilepsy Res 10: 55-61.
    • (1991) Epilepsy Res , vol.10 , pp. 55-61
    • Meldrum, B.1
  • 86
    • 0022616299 scopus 로고
    • Cell damage in epilepsy and the role of calcium in cytotoxicity
    • Meldrum BS. 1986. Cell damage in epilepsy and the role of calcium in cytotoxicity. Adv Neurol 44: 849-855.
    • (1986) Adv Neurol , vol.44 , pp. 849-855
    • Meldrum, B.S.1
  • 87
    • 0030939042 scopus 로고    scopus 로고
    • Alterations in glutamate transporter protein levels in kindling-induced epilepsy
    • Miller HP, Levey AI, Rothstein JD, Tzingounis AV, Conn PJ. 1997. Alterations in glutamate transporter protein levels in kindling-induced epilepsy. J Neurochem 68: 1564-1570.
    • (1997) J Neurochem , vol.68 , pp. 1564-1570
    • Miller, H.P.1    Levey, A.I.2    Rothstein, J.D.3    Tzingounis, A.V.4    Conn, P.J.5
  • 88
    • 19444376784 scopus 로고    scopus 로고
    • Cerebral ketone body metabolism
    • Morris AA. 2005. Cerebral ketone body metabolism. J Inherit Metab Dis 28: 109-121.
    • (2005) J Inherit Metab Dis , vol.28 , pp. 109-121
    • Morris, A.A.1
  • 89
    • 0018848558 scopus 로고
    • Kainic acid neurotoxicity toward the hippocampal formation: Dependence on specific excitatory pathways
    • Nadler J, Cuthbertson G. 1980. Kainic acid neurotoxicity toward the hippocampal formation: Dependence on specific excitatory pathways. Brain Res 195: 47-56.
    • (1980) Brain Res , vol.195 , pp. 47-56
    • Nadler, J.1    Cuthbertson, G.2
  • 90
    • 79960887452 scopus 로고    scopus 로고
    • Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model: Mechanism for deficient glutamatergic transmission?
    • Olabarria M, Noristani HN, Verkhratsky A, Rodriguez JJ. 2011. Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model: Mechanism for deficient glutamatergic transmission? Mol Neurodegener 6: 55.
    • (2011) Mol Neurodegener , vol.6 , pp. 55
    • Olabarria, M.1    Noristani, H.N.2    Verkhratsky, A.3    Rodriguez, J.J.4
  • 91
    • 0022566936 scopus 로고
    • Excitotoxic mechanims of epileptic brain damage
    • Delgado-Escueta AV, Ward AA Jr, Woodbury DM, Porter RJ, editors. New York: Raven Press
    • Olney JW, Collins RC, Sloviter RS. 1986. Excitotoxic mechanims of epileptic brain damage. In: Delgado-Escueta AV, Ward AAJr, Woodbury DM, Porter RJ, editors. Advances in neurology. New York: Raven Press. pp 857-877.
    • (1986) Advances in neurology , pp. 857-877
    • Olney, J.W.1    Collins, R.C.2    Sloviter, R.S.3
  • 94
    • 0032531028 scopus 로고    scopus 로고
    • Anion currents and predicted glutamate flux through a neuronal glutamate transporter
    • Otis TS, Jahr CE. 1998. Anion currents and predicted glutamate flux through a neuronal glutamate transporter. J Neurosci 18: 7099-7110.
    • (1998) J Neurosci , vol.18 , pp. 7099-7110
    • Otis, T.S.1    Jahr, C.E.2
  • 96
    • 65249091454 scopus 로고    scopus 로고
    • Epilepsy and cognitive impairments in Alzheimer disease
    • Palop JJ, Mucke L. 2009. Epilepsy and cognitive impairments in Alzheimer disease. Arch Neurol 66: 435-440.
    • (2009) Arch Neurol , vol.66 , pp. 435-440
    • Palop, J.J.1    Mucke, L.2
  • 97
    • 0033142036 scopus 로고    scopus 로고
    • Ketosis and epilepsy: 31P spectroscopic imaging at 4.1 T
    • Pan JW, Bebin EM, Chu WJ, Hetherington HP. 1999. Ketosis and epilepsy: 31P spectroscopic imaging at 4.1 T. Epilepsia 40: 703-707.
    • (1999) Epilepsia , vol.40 , pp. 703-707
    • Pan, J.W.1    Bebin, E.M.2    Chu, W.J.3    Hetherington, H.P.4
  • 98
    • 80052814456 scopus 로고    scopus 로고
    • Redistribution of astrocytic glutamine synthetase in the hippocampus of chronic epileptic rats
    • Papageorgiou IE, Gabriel S, Fetani AF, Kann O, Heinemann U. 2011. Redistribution of astrocytic glutamine synthetase in the hippocampus of chronic epileptic rats. Glia 59: 1706-1718.
    • (2011) Glia , vol.59 , pp. 1706-1718
    • Papageorgiou, I.E.1    Gabriel, S.2    Fetani, A.F.3    Kann, O.4    Heinemann, U.5
  • 100
    • 20344398223 scopus 로고    scopus 로고
    • Astrocyte activation and reactive gliosis
    • Pekny M, Nilsson M. 2005. Astrocyte activation and reactive gliosis. Glia 50: 427-434.
    • (2005) Glia , vol.50 , pp. 427-434
    • Pekny, M.1    Nilsson, M.2
  • 101
    • 12244262261 scopus 로고    scopus 로고
    • Cellular and subcellular distribution of monocarboxylate transporters in cultured brain cells and in the adult brain
    • Pellerin L, Bergersen LH, Halestrap AP, Pierre K. 2005. Cellular and subcellular distribution of monocarboxylate transporters in cultured brain cells and in the adult brain. J Neurosci Res 79: 55-64.
    • (2005) J Neurosci Res , vol.79 , pp. 55-64
    • Pellerin, L.1    Bergersen, L.H.2    Halestrap, A.P.3    Pierre, K.4
  • 104
    • 38449117883 scopus 로고    scopus 로고
    • Interictal extracellular glutamate concentrations are increased in hippocampal sclerosis
    • Petroff OA, Cavus I, Kim JH, Spencer DD. 2004. Interictal extracellular glutamate concentrations are increased in hippocampal sclerosis. Ann Neurol 56: S43.
    • (2004) Ann Neurol , vol.56
    • Petroff, O.A.1    Cavus, I.2    Kim, J.H.3    Spencer, D.D.4
  • 105
    • 0038813918 scopus 로고    scopus 로고
    • N-acetyl-aspartate, total creatine, and myo-inositol in the epileptogenic human hippocampus
    • Petroff OA, Errante LD, Kim JH, Spencer DD. 2003. N-acetyl-aspartate, total creatine, and myo-inositol in the epileptogenic human hippocampus. Neurology 60: 1646-1651.
    • (2003) Neurology , vol.60 , pp. 1646-1651
    • Petroff, O.A.1    Errante, L.D.2    Kim, J.H.3    Spencer, D.D.4
  • 107
    • 0031761692 scopus 로고    scopus 로고
    • Uniqueness and redundancy in GABA production
    • Pinal CS, Tobin AJ. 1998. Uniqueness and redundancy in GABA production. Perspect Dev Neurobiol 5: 109-118.
    • (1998) Perspect Dev Neurobiol , vol.5 , pp. 109-118
    • Pinal, C.S.1    Tobin, A.J.2
  • 109
    • 27544434764 scopus 로고    scopus 로고
    • Glucose transport to the brain: A systems model
    • Qutub AA, Hunt CA. 2005. Glucose transport to the brain: A systems model. Brain Res Brain Res Rev 49: 595-617.
    • (2005) Brain Res Brain Res Rev , vol.49 , pp. 595-617
    • Qutub, A.A.1    Hunt, C.A.2
  • 110
    • 0037390782 scopus 로고    scopus 로고
    • Inhibition of glutamine transport depletes glutamate and GABA neurotransmitter pools: Further evidence for metabolic compartmentation
    • Rae C, Hare N, Bubb WA, McEwan SR, Broer A, McQuillan JA, Balcar VJ, Conigrave AD, Broer S. 2003. Inhibition of glutamine transport depletes glutamate and GABA neurotransmitter pools: Further evidence for metabolic compartmentation. J Neurochem 85: 503-514.
    • (2003) J Neurochem , vol.85 , pp. 503-514
    • Rae, C.1    Hare, N.2    Bubb, W.A.3    McEwan, S.R.4    Broer, A.5    McQuillan, J.A.6    Balcar, V.J.7    Conigrave, A.D.8    Broer, S.9
  • 111
    • 0029845978 scopus 로고    scopus 로고
    • Long-lasting reduction of inhibitory function and gamma-aminobutyric acid type A receptor subunit mRNA expression in a model of temporal lobe epilepsy
    • Rice A, Rafiq A, Shapiro SM, Jakoi ER, Coulter DA, DeLorenzo RJ. 1996. Long-lasting reduction of inhibitory function and gamma-aminobutyric acid type A receptor subunit mRNA expression in a model of temporal lobe epilepsy. Proc Natl Acad Sci USA 93: 9665-9669.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 9665-9669
    • Rice, A.1    Rafiq, A.2    Shapiro, S.M.3    Jakoi, E.R.4    Coulter, D.A.5    DeLorenzo, R.J.6
  • 112
    • 0024996068 scopus 로고
    • Advanced Alzheimer's disease is a risk factor for late-onset seizures
    • Romanelli MF, Morris JC, Ashkin K, Coben LA. 1990. Advanced Alzheimer's disease is a risk factor for late-onset seizures. Arch Neurol 47: 847-850.
    • (1990) Arch Neurol , vol.47 , pp. 847-850
    • Romanelli, M.F.1    Morris, J.C.2    Ashkin, K.3    Coben, L.A.4
  • 114
    • 0032079863 scopus 로고    scopus 로고
    • Extrasynaptic glutamate diffusion in the hippocampus: Ultrastructural constraints, uptake, and receptor activation
    • Rusakov DA, Kullmann DM. 1998. Extrasynaptic glutamate diffusion in the hippocampus: Ultrastructural constraints, uptake, and receptor activation. J Neurosci 18: 3158-3170.
    • (1998) J Neurosci , vol.18 , pp. 3158-3170
    • Rusakov, D.A.1    Kullmann, D.M.2
  • 115
    • 63849107992 scopus 로고    scopus 로고
    • Glutamine induces epileptiform discharges in superficial layers of the medial entorhinal cortex from pilocarpine-treated chronic epileptic rats in vitro
    • Sandow N, Zahn RK, Gabriel S, Heinemann U, Lehmann TN. 2009. Glutamine induces epileptiform discharges in superficial layers of the medial entorhinal cortex from pilocarpine-treated chronic epileptic rats in vitro. Epilepsia 50: 849-858.
    • (2009) Epilepsia , vol.50 , pp. 849-858
    • Sandow, N.1    Zahn, R.K.2    Gabriel, S.3    Heinemann, U.4    Lehmann, T.N.5
  • 116
    • 79952234841 scopus 로고    scopus 로고
    • TNFalpha controls glutamatergic gliotransmission in the hippocampal dentate gyrus
    • Santello M, Bezzi P, Volterra A. 2011. TNFalpha controls glutamatergic gliotransmission in the hippocampal dentate gyrus. Neuron 69: 988-1001.
    • (2011) Neuron , vol.69 , pp. 988-1001
    • Santello, M.1    Bezzi, P.2    Volterra, A.3
  • 117
    • 0019347565 scopus 로고
    • Transport and metabolism of glutamate and GABA in neurons are glial cells
    • Schousboe A. 1981. Transport and metabolism of glutamate and GABA in neurons are glial cells. Int Rev Neurobiol 22: 1-45.
    • (1981) Int Rev Neurobiol , vol.22 , pp. 1-45
    • Schousboe, A.1
  • 118
    • 0024541972 scopus 로고
    • Metabolic effects of three ketogenic diets in the treatment of severe epilepsy
    • Schwartz RM, Boyes S, Aynsley-Green A. 1989. Metabolic effects of three ketogenic diets in the treatment of severe epilepsy. Dev Med Child Neurol 31: 152-160.
    • (1989) Dev Med Child Neurol , vol.31 , pp. 152-160
    • Schwartz, R.M.1    Boyes, S.2    Aynsley-Green, A.3
  • 120
    • 33644519960 scopus 로고    scopus 로고
    • Astrocyte dysfunction in neurological disorders: A molecular perspective
    • Seifert G, Schilling K, Steinhauser C. 2006. Astrocyte dysfunction in neurological disorders: A molecular perspective. Nat Rev Neurosci 7: 194-206.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 194-206
    • Seifert, G.1    Schilling, K.2    Steinhauser, C.3
  • 122
    • 0021988603 scopus 로고
    • Pyruvate carboxylase: An astrocyte-specific enzyme implicated in the replenishment of amino acid neurotransmitter pools
    • Shank RP, Bennett GS, Freytag SO, Campbell GL. 1985. Pyruvate carboxylase: An astrocyte-specific enzyme implicated in the replenishment of amino acid neurotransmitter pools. Brain Res 329: 364-367.
    • (1985) Brain Res , vol.329 , pp. 364-367
    • Shank, R.P.1    Bennett, G.S.2    Freytag, S.O.3    Campbell, G.L.4
  • 123
    • 0033582705 scopus 로고    scopus 로고
    • Changes in expression of neuronal and glial glutamate transporters in rat hippocampus following kainate-induced seizure activity
    • Simantov R, Crispino M, Hoe W, Broutman G, Tocco G, Rothstein JD, Baudry M. 1999. Changes in expression of neuronal and glial glutamate transporters in rat hippocampus following kainate-induced seizure activity. Brain Res Mol Brain Res 65: 112-123.
    • (1999) Brain Res Mol Brain Res , vol.65 , pp. 112-123
    • Simantov, R.1    Crispino, M.2    Hoe, W.3    Broutman, G.4    Tocco, G.5    Rothstein, J.D.6    Baudry, M.7
  • 124
    • 0034098766 scopus 로고    scopus 로고
    • Transport of glutamate and other amino acids at the blood-brain barrier
    • Smith QR. 2000. Transport of glutamate and other amino acids at the blood-brain barrier. J Nutr 130: 1016S-22S.
    • (2000) J Nutr , vol.130
    • Smith, Q.R.1
  • 126
    • 0029025299 scopus 로고
    • Brief history of cortico-hippocampal time with a special reference to the direct entorhinal input to CA1
    • Soltesz I. 1995. Brief history of cortico-hippocampal time with a special reference to the direct entorhinal input to CA1. Hippocampus 5: 120-124.
    • (1995) Hippocampus , vol.5 , pp. 120-124
    • Soltesz, I.1
  • 127
    • 34250548773 scopus 로고
    • Erkrankung des Ammonshorns als aetiologisches Moment der Epilepsie
    • Sommer W. 1880. Erkrankung des Ammonshorns als aetiologisches Moment der Epilepsie. Arch Psychiatr Nervenkr 10: 631-675.
    • (1880) Arch Psychiatr Nervenkr , vol.10 , pp. 631-675
    • Sommer, W.1
  • 128
    • 0036208029 scopus 로고    scopus 로고
    • Neural networks in human epilepsy: Evidence of and implications for treatment
    • Spencer SS. 2002. Neural networks in human epilepsy: Evidence of and implications for treatment. Epilepsia 43: 219-227.
    • (2002) Epilepsia , vol.43 , pp. 219-227
    • Spencer, S.S.1
  • 129
    • 0028124255 scopus 로고
    • Entorhinal-hippocampal interactions in medial temporal lobe epilepsy
    • Spencer SS, Spencer DD. 1994. Entorhinal-hippocampal interactions in medial temporal lobe epilepsy. Epilepsia 35: 721-727.
    • (1994) Epilepsia , vol.35 , pp. 721-727
    • Spencer, S.S.1    Spencer, D.D.2
  • 130
  • 131
    • 0033053566 scopus 로고    scopus 로고
    • Developmental regulation of glutamate transporters and glutamine synthetase activity in astrocyte cultures differentiated in vitro
    • Stanimirovic DB, Ball R, Small DL, Muruganandam A. 1999. Developmental regulation of glutamate transporters and glutamine synthetase activity in astrocyte cultures differentiated in vitro. Int J Dev Neurosci 17: 173-184.
    • (1999) Int J Dev Neurosci , vol.17 , pp. 173-184
    • Stanimirovic, D.B.1    Ball, R.2    Small, D.L.3    Muruganandam, A.4
  • 133
    • 0014881983 scopus 로고
    • Pig brain glutaminase: Purification and identification of different enzyme forms
    • Svenneby G. 1970. Pig brain glutaminase: Purification and identification of different enzyme forms. J Neurochem 17: 1591-1599.
    • (1970) J Neurochem , vol.17 , pp. 1591-1599
    • Svenneby, G.1
  • 134
    • 0036668641 scopus 로고    scopus 로고
    • Molecular cloning and functional characterization of human vesicular glutamate transporter 3
    • Takamori S, Malherbe P, Broger C, Jahn R. 2002. Molecular cloning and functional characterization of human vesicular glutamate transporter 3. EMBO Rep 3: 798-803.
    • (2002) EMBO Rep , vol.3 , pp. 798-803
    • Takamori, S.1    Malherbe, P.2    Broger, C.3    Jahn, R.4
  • 136
    • 75349093906 scopus 로고    scopus 로고
    • Glutamine is required for persistent epileptiform activity in the disinhibited neocortical brain slice
    • Tani H, Dulla CG, Huguenard JR, Reimer RJ. 2010. Glutamine is required for persistent epileptiform activity in the disinhibited neocortical brain slice. J Neurosci 30: 1288-1300.
    • (2010) J Neurosci , vol.30 , pp. 1288-1300
    • Tani, H.1    Dulla, C.G.2    Huguenard, J.R.3    Reimer, R.J.4
  • 138
    • 36348975209 scopus 로고    scopus 로고
    • Glutamate transporters: Confining runaway excitation by shaping synaptic transmission
    • Tzingounis AV, Wadiche JI. 2007. Glutamate transporters: Confining runaway excitation by shaping synaptic transmission. Nat Rev Neurosci 8: 935-947.
    • (2007) Nat Rev Neurosci , vol.8 , pp. 935-947
    • Tzingounis, A.V.1    Wadiche, J.I.2
  • 139
    • 0015071185 scopus 로고
    • A stimulation study of brain compartments. Metabolism of glutamate and related substances in mouse brain
    • van den Berg CJ, Garfinkel D. 1971. A stimulation study of brain compartments. Metabolism of glutamate and related substances in mouse brain. Biochem J 123: 211-218.
    • (1971) Biochem J , vol.123 , pp. 211-218
    • van den Berg, C.J.1    Garfinkel, D.2
  • 141
    • 2542525380 scopus 로고    scopus 로고
    • Brain edema in acute liver failure. A window to the pathogenesis of hepatic encephalopathy
    • Vaquero J, Chung C, Blei AT. 2003. Brain edema in acute liver failure. A window to the pathogenesis of hepatic encephalopathy. Ann Hepatol 2: 12-22.
    • (2003) Ann Hepatol , vol.2 , pp. 12-22
    • Vaquero, J.1    Chung, C.2    Blei, A.T.3
  • 143
    • 0032842197 scopus 로고    scopus 로고
    • The GABA paradox: Multiple roles as metabolite, neurotransmitter, and neurodifferentiative agent
    • Waagepetersen HS, Sonnewald U, Schousboe A. 1999. The GABA paradox: Multiple roles as metabolite, neurotransmitter, and neurodifferentiative agent. J Neurochem 73: 1335-1342.
    • (1999) J Neurochem , vol.73 , pp. 1335-1342
    • Waagepetersen, H.S.1    Sonnewald, U.2    Schousboe, A.3
  • 144
    • 71549141314 scopus 로고    scopus 로고
    • The development of recurrent seizures after continuous intrahippocampal infusion of methionine sulfoximine in rats: A video-intracranial electroencephalographic study
    • Wang Y, Zaveri HP, Lee TS, Eid T. 2009. The development of recurrent seizures after continuous intrahippocampal infusion of methionine sulfoximine in rats: A video-intracranial electroencephalographic study. Exp Neurol 220: 293-302.
    • (2009) Exp Neurol , vol.220 , pp. 293-302
    • Wang, Y.1    Zaveri, H.P.2    Lee, T.S.3    Eid, T.4
  • 145
    • 0032873812 scopus 로고    scopus 로고
    • Amygdala-kindled and pentylenetetrazole-induced seizures in glutamate transporter GLAST-deficient mice
    • Watanabe T, Morimoto K, Hirao T, Suwaki H, Watase K, Tanaka K. 1999. Amygdala-kindled and pentylenetetrazole-induced seizures in glutamate transporter GLAST-deficient mice. Brain Res 845: 92-96.
    • (1999) Brain Res , vol.845 , pp. 92-96
    • Watanabe, T.1    Morimoto, K.2    Hirao, T.3    Suwaki, H.4    Watase, K.5    Tanaka, K.6
  • 146
    • 18744364729 scopus 로고    scopus 로고
    • Correlations between granule cell physiology and bioenergetics in human temporal lobe epilepsy
    • Williamson A, Patrylo PR, Pan J, Spencer DD, Hetherington H. 2005. Correlations between granule cell physiology and bioenergetics in human temporal lobe epilepsy. Brain 128: 1199-1208.
    • (2005) Brain , vol.128 , pp. 1199-1208
    • Williamson, A.1    Patrylo, P.R.2    Pan, J.3    Spencer, D.D.4    Hetherington, H.5
  • 147
    • 22044453122 scopus 로고    scopus 로고
    • Entorhinal cortex entrains epileptiform activity in CA1 in pilocarpine-treated rats
    • Wozny C, Gabriel S, Jandova K, Schulze K, Heinemann U, Behr J. 2005. Entorhinal cortex entrains epileptiform activity in CA1 in pilocarpine-treated rats. Neurobiol Dis 19: 451-460.
    • (2005) Neurobiol Dis , vol.19 , pp. 451-460
    • Wozny, C.1    Gabriel, S.2    Jandova, K.3    Schulze, K.4    Heinemann, U.5    Behr, J.6
  • 148
    • 80053902399 scopus 로고    scopus 로고
    • Attenuation of inhibitory synaptic transmission by glial dysfunction in rat thalamus
    • Yang S, Cox CL. 2011. Attenuation of inhibitory synaptic transmission by glial dysfunction in rat thalamus. Synapse 65: 1298-1308.
    • (2011) Synapse , vol.65 , pp. 1298-1308
    • Yang, S.1    Cox, C.L.2


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