Fucosylated chondroitin sulfates from the body wall of the sea cucumber Holothuria forskali: Conformation, selectin binding, and biological activity

Journal of Biological Chemistry

Volumn 289, Issue 41, 2014, Pages 28284-28298

  Panagos, Charalampos G ^a   Thomson, Derek S ^b   Moss, Claire ^b   Hughes, Adam D ^b   Kelly, Maeve S ^b   Liu, Yan ^c   Chai, Wengang ^c   Venkatasamy, Radhakrishnan ^d   Spina, Domenico ^d   Page, Clive P ^d   Hogwood, John ^e   Woods, Robert J ^f,g   Mulloy, Barbara ^c,d   Bavington, Charlie D ^b   Uhrín, Dušan ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b SCOTTISH MARINE INSTITUTE   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d KING'S COLLEGE LONDON   (United Kingdom)

^e NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

^f UNIVERSITY OF GEORGIA   (United States)

^g NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

BIOACTIVITY; ENDOTHELIAL CELLS; HYDROGELS; MOLECULAR DYNAMICS; OLIGOSACCHARIDES; PATHOLOGY; POLYSACCHARIDES;

ANTICOAGULANT ACTIVITIES; ANTICOAGULANT PROPERTIES; CHONDROITIN SULFATES; HEPARIN COFACTOR II; HUMAN NEUTROPHIL ELASTASE; MOLECULAR DYNAMICS SIMULATIONS; NEUTROPHIL INFILTRATION; THERAPEUTIC INTERVENTION;

SULFUR COMPOUNDS;

CHONDROITIN SULFATE; COPPER ION; DEXTRAN SULFATE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; HEPARIN COFACTOR II; L SELECTIN; LEUKOCYTE ELASTASE; OLIGOSACCHARIDE; PADGEM PROTEIN; POLYSACCHARIDE; PREKALLIKREIN; SELECTIN; FENTON'S REAGENT; FUCOSYLATED CHONDROITIN SULFATE; HYDROGEN PEROXIDE; IRON; LEUKOCYTE ELASTASE INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BIOLOGICAL ACTIVITY; BLOOD GROUP; CATALYSIS; CELL MIGRATION; CYTOTOXICITY; DEPOLARIZATION; ENDOTHELIUM CELL; ENZYME ACTIVITY; EXPERIMENTAL PERITONITIS; FENTON REACTION; FUCOSYLATION; HOLOTHURIA; HOLOTHURIA FORSKALI; IN VITRO STUDY; MALE; METASTASIS; MICROARRAY ANALYSIS; MOLECULAR DYNAMICS; MOUSE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SEA CUCUMBER; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG EFFECTS; IMMUNE SYSTEM DISEASES; ISOLATION AND PURIFICATION; LEUKOCYTE DISORDERS; METABOLISM; MOLECULAR GENETICS; OXIDATION REDUCTION REACTION; PATHOLOGY; PERITONITIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARBOHYDRATE CONFORMATION; CHONDROITIN SULFATES; HYDROGEN PEROXIDE; IMMUNE SYSTEM DISEASES; IRON; L-SELECTIN; LEUKOCYTE DISORDERS; LEUKOCYTE ELASTASE; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEUTROPHIL INFILTRATION; NEUTROPHILS; OXIDATION-REDUCTION; P-SELECTIN; PERITONITIS; PROTEINASE INHIBITORY PROTEINS, SECRETORY; SEA CUCUMBERS;

EID: 84907831149     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.572297     Document Type: Article

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