Antithrombotic activity of a fucosylated chondroitin sulphate from echinoderm: Sulphated fucose branches on the polysaccharide account for its antithrombotic action

British Journal of Haematology

Volumn 101, Issue 4, 1998, Pages 647-652

  Mourão, Paulo A S ^a   Guimarães, Marco A M ^a,b   Mulloy, Barbara ^c   Thomas, Stephen ^c   Gray, Elaine ^c  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

Author keywords

Anticoagulant activity; Antithrombotic action; Chondroitin sulphate; Glycosaminoglycans; Sulphated fucans; Thrombosis

Indexed keywords

CHONDROITIN SULFATE; FUCOSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICOAGULATION; ARTICLE; BLEEDING TIME; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; ECHINODERM; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; RABBIT; THROMBOSIS;

ANIMALS; ANTICOAGULANTS; BLEEDING TIME; BLOOD COAGULATION; CHONDROITIN SULFATES; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBRINOLYTIC AGENTS; FUCOSE; INJECTIONS, INTRAVENOUS; POLYSACCHARIDES; RABBITS; SEA CUCUMBERS; THROMBOSIS;

EID: 0031831742     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1998.00769.x     Document Type: Article

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