The dendritic cell-specific C-type lectin DC-SIGN is a receptor for Schistosoma mansoni egg antigens and recognizes the glycan antigen Lewis x

Glycobiology

Volumn 13, Issue 6, 2003, Pages 471-478

  van Die, Irma ^a   van Vliet, Sandra J ^a   Nyame, A Kwame ^b   Cummings, Richard D ^b   Bank, Christine M C ^a   Appelmelk, Ben ^a   Geijtenbeek, Teunis B H ^a   van Kooyk, Yvette ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

Author keywords

Adhesion; Carbohydrate interaction; Dendritic cells; Glycosylation; Schistosomiasis

Indexed keywords

AMINO ACID; CARBOHYDRATE; CARBOHYDRATE ANTIGEN; FUCOSE; GLYCAN DERIVATIVE; GLYCOPROTEIN GP 120; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 3; LECTIN; LYMPHOCYTE ANTIGEN RECEPTOR; MANNOSE; MONOCLONAL ANTIBODY; MONOSACCHARIDE; OLIGOSACCHARIDE; SIALYL LEWIS X ANTIGEN; VALINE;

ANTIGEN BINDING; ANTIGEN RECOGNITION; ARTICLE; BINDING AFFINITY; CELL ADHESION; CELL ASSAY; CELL SPECIFICITY; CONJUGATION; CONTROLLED STUDY; DATA ANALYSIS; DENDRITIC CELL; GENE MUTATION; HELICOBACTER PYLORI; HOST RESISTANCE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; INFECTION RESISTANCE; MOLECULAR RECOGNITION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SCHISTOSOMA; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS; SITE DIRECTED MUTAGENESIS; SOLID;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD15; ANTIGENS, HELMINTH; CARBOHYDRATE CONFORMATION; CELL ADHESION MOLECULES; DENDRITIC CELLS; HIV ENVELOPE PROTEIN GP120; HUMANS; LECTINS, C-TYPE; LIGANDS; MOLECULAR SEQUENCE DATA; OVUM; PROTEIN BINDING; RECEPTORS, CELL SURFACE; SCHISTOSOMA MANSONI;

BACTERIA (MICROORGANISMS); HELICOBACTER PYLORI; HUMAN IMMUNODEFICIENCY VIRUS; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS MANSONI; TREMATODA;

EID: 0037942767     PISSN: 09596658     EISSN: None     Source Type: Journal    
DOI: 10.1093/glycob/cwg052     Document Type: Article

References (49)

1. Araujo, M.I., Dejesus, A.R., Bacellar, O., Sabin, E., Pearce, E., and Carvalho, E.M. (1996) Evidence of a T helper type 2 activation in human schistosomiasis. Eur. J. Immunol., 26, 1399-1403.
2. Blackwell, J.M., Ezekowitz, R.A.B., Roberts, M.B., Channon, J.Y., Sim, R.B., and Gordon, S. (1985) Macrophage complement and lectin-like receptors bind Leishmania in absence of serum. J. Exp. Med., 162, 324.
3. Cummings, R.D. and Nyame, A.K. (1996) Glycobiology of schistosomiasis. FASEB J., 10, 838-848.
4. Cummings, R.D. and Nyame, A.K. (1999) Schistosome glycoconjugates. Biochim. Biophys. Acta, 1455, 363-374.
5. Curtis, B.M., Scharnowske, S., and Watson, A.J. (1992) Sequence and expression of a membrane-associated C-type lectin that exhibits CD4-independent binding of human immunodeficiency virus envelope glycoprotein gp120. Proc. Natl Acad. Sci. USA, 89, 8356-8360.
6. Drickamer, K. (1999) C-type lectin-like domains. Curr. Opinion Struct. Biol., 9, 585-590.
7. Eberl, M., Langermans, J.A.M., Vervenne, R.A., Nyame, K.A., Cummings, R.D., Thomas, A.W., Coulson, P.S., and Wilson, R.A. (2002) Antibodies to glycans dominate the host response to schistosome larvae and eggs: is their role protective or subversive? J. Infect. Dis., 183, 1238-1247.
8. Elridi, R., Velupillai, P., and Harn, D.A. (1996) Regulation of schistosome egg granuloma formation - host-soluble L-selectin enters tissue-trapped eggs and binds to carbohydrate antigens on surface membranes of miracidia. Infect. Immun., 64, 4700-4705.
9. Engering, A., Geijtenbeek, T.B.H., van Vliet, S.J., Wijers, M., van Liempt, E., Demaurex, N., Lanzavecchia, A., Fransen, J., Figdor, C.G., Piguet, V., and van Kooyk, Y. (2002) The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells. J. Immunol., 168, 2118-2126.
10. Ezekowitz, R.A.B., Sastry, K., Bailly, P., and Warner, A. (1990) Molecular characterization of the human macrophage mannose receptor: demonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cells. J. Exp. Med., 172, 1785-1794.
11. Fawcett, J., Holness, C.L., Needham, L.A., Turley, H., Gatter, K.C., Mason, D.Y., and Simmons, D.L. (1992) Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes. Nature, 360, 481-484.
12. Feinberg, H., Mitchell, D.A., Drickamer, K., and Weis, W.I. (2001) Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR. Science, 294, 2163-2166.
13. Figdor, C.G., van Kooyk, Y., and Adema, G.J. (2002) C-type lectin receptors on dendritic cells and langerhans cells. Nature Rev. Immunol., 2, 77-84.
14. Funatsu, O., Sato, T., Kotovuori, P., Gahmberg, C.G., Ikekita, M., and Furukawa, K. (2001) Structural study of N-linked oligosaccharides of human intercellular adhesion molecule-3 (CD50). Eur. J. Biochem., 268, 1020-1029.
15. Geijtenbeek, T.B.H., van Kooyk, Y., van Vliet, S.J., Renes, M.H., Raymakers, R.A.P., and Figdor, C.G. (1999) High frequency of adhesion defects in B-Lineage acute lymphoblastic leukemia. Blood, 94, 754-764.
16. Geijtenbeek, T.B.H., Kwon, D.S., Torensma, R., van Vliet, S.J., van Duijnhoven, G.C.F., Middel, J., Cornelissen, I.L.M.H.A., Nottet, H.S.L.M., KewalRamani, V.N., Littman, D.R., and others. (2000a) DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T-cells. Cell, 100, 587-597.
17. Geijtenbeek, T.B.H., Krooshoop, D.J.E.B., Bleijs, D.A., van Vliet, S.J., van Duijnhoven, G.C.F., Grabovsky, V., Alon, R., Figdor, C.G., and van Kooyk, Y. (2000b) DC-SIGN-ICAM-2 interaction mediates dendritic cell trafficking. Nature Immunol., 1, 353-357.
18. Geijtenbeek, T.B.H., Torensma, R., van Vliet, S.J., van Duijnhoven, G.C.F., Adema, G.J., van Kooyk, Y., and Figdor, C.G. (2000c) Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses. Cell, 100, 575-585.
19. Geijtenbeek, T.B.H., van Duijnhoven, G.C.F., van Vliet, S.J., Krieger, E., Vriend, G., Figdor, C.G., and van Kooyk, Y. (2002) Identification of different binding sites in the dendritic cell-specific receptor DC-SIGN for intercellular adhesion molecule 3 and HIV-1. J. Biol. Chem., 277, 11314-11320.
20. Geyer, H., Holschbach, C., Hunsmann, G., and Schneider, J. (1988) Carbohydrates of human immunodeficiency virus. Structures of oligosaccharides linked to the envelope glycoprotein 120. J. Biol. Chem., 263, 11760-11767.
21. Grinnell, B.W., Hermann, R.B., and Yan, S.B. (1994) Human protein C inhibits selectin-mediated cell adhesion: role of unique fucosylated oligosaccharides. Glycobiology, 4, 221-225.
22. Grzych, J.M., Pearce, E., Cheever, A., Caulada, Z.A., Caspar, P., Heiny, S., Lewis, F., and Sher, A. (1991) Egg deposition is the major stimulus for the production of Th2 cytokines in murine Schistosomiasis mansoni. J. Immunol., 146, 1322-1327.
23. x structure in a nematode. Glycobiology, 10, 223-229.
24. Jacobs, W., Deelder, A.M., and Van Marck, E. (1999) Schistosomal granuloma modulation. II. Specific immunogenic carbohydrates can modulate schistosome-egg-antigen-induced hepatic granuloma formation. Parasitol. Res., 85, 14-18.
25. Jankovic, D., Liu, Z., and Gause, W.C. (2002) Th1- and Th2-cell commitment during infectious disease: asymmetry in divergent pathways. Trends Immunol., 22, 450-457.
26. Khoo, K.-H., Sarda, S., Xu, X., Caulfield, J.P., McNeil, M.R., Homans, S.W., Morris, H.R., and Dell, A. (1995) A unique multifucosylated -3GalNAc β1-4GlcNAcβ1-3Galα1- motif constitutes the repeating unit of the complex O-glycans derived from the cercarial glycocalyx of Schistosoma mansoni. J. Biol. Chem., 270, 17114-17123.
27. Khoo, K.-H., Chatterjee, D., Caulfield, J.P., Morris, H.R., and Dell, A. (1997) Structural mapping of the glycans from the egg glycoproteins of Schistosoma mansoni and Schistosoma japonicum - identification of novel core structures and terminal sequences. Glycobiology, 7, 663-677.
28. Khoo, K.H., Huang, H.H., and Lee, K.M. (2001) Characteristic structural features of schistosome cercarial N-glycans: expression of Lewis x and core xylosylation. Glycobiology, 11, 149-163.
29. MacDonald, A.S., Straw, A.D., Bauman, B., and Pearce, E.J. (2001) CD8-dendritic cell activation status plays an integral role in influencing Th2 response development. J. Immunol., 167, 1982-1988.
30. Mitchell, D.A., Fadden, A.J., and Drickamer, K. (2001) A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligands. J. Biol. Chem., 276, 28939-28945.
31. x determinants on myeloid cells. Exp. Parasitol., 82, 191-200.
32. Nyame, A.K., Pilcher, J.B., Tsang, V.C.W., and Cummings, R.D. (1997) Rodents infected with Schistosoma mansoni produce cytolytic IgG and IgM antibodies to the Lewis x antigen. Glycobiology, 7, 207-215.
33. x expression in other trematodes and nematodes. Glycobiology, 8, 615-624.
34. Nyame, A.K., Leppanen, A.M., Debose-Boyd, R., and Cummings, R.D. (1999) Mice infected with Schistosoma mansoni generate antibodies to LacdiNAc (GalNAcβ1,4GlcNAc) determinants. Glycobiology, 9, 1029-1035.
35. Nyame, K.A., Leppanen, A., Bogitsh, B.J., and Cummings, R.D. (2000) Antibody responses to the fucosylated LacdiNAc glycan antigen in Schistosoma mansoni-infected mice and expression of the glycan among schistosomes. Exp. Parasitol., 96, 202-212.
36. Nyame, A.K., Yoshino, T.P., and Cummings, R.D. (2002) Differential expression of LDN, LDNF and Lewis x glycan antigens in intramolluscan stages of Schistosoma mansoni. J. Parasitol., 88, 890-897.
37. Okano, M., Satoskar, A.R., Nishizaki, K., and Harn, D.A. Jr. (2001) Lacto-N-fucopentaose III found on Schistosoma mansoni egg antigens functions as adjuvant for proteins by inducing Th2-type response. J. Immunol., 167, 442-450.
38. Pearce, E.J., Caspar, P., Grzych, J.M., Lewis, F.A., and Sher, A. (1991) Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni. J. Exp. Med., 173, 159-166.
39. Ross, A.G.P., Bartley, P.B., Sleigh, A.C., Olds, G.R., Li, Y., Williams, G.M., and McManus, D.P. (2002) Schistosomiasis. N. Engl. J. Med., 346, 1212-1220.
40. Sallusto, F. and Lanzavecchia, A. (1994) Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J. Exp. Med., 179, 1109-1118.
41. Srivatsan, J., Smith, D.F., and Cummings, R.D. (1992) The human blood fluke Schistosoma mansoni synthesizes glycoproteins containing the Lewis x antigen. J. Biol. Chem., 267, 20196-20203.
42. Terrazas, L.I., Walsh, K.L., Piskorska, D., McGuire, E., and Harn, D.A. Jr. (2001) The schistosome oligosaccharide lacto-N-neotetraose expands Gr1+ cells that secrete anti-inflammatory cytokines and inhibit proliferation of naive CD4+ cells: a potential mechanism for immune polarization in helminth infections. J. Immunol., 167, 5294-5303.
43. Van Dam, G.J., Bergwerff, A.A., Thomas-Oates, J.E., Rotmans, J.P., Kamerling, J.P., Vliegenthart, J.F.G., and Deelder, A.M. (1994) The immunologically reactive O-linked polysaccharide chains derived from circulating cathodic antigen isolated from the human blood fluke Schistosoma mansoni have Lewis x as repeating unit. Eur. J. Biochem., 225, 467-482.
44. Van Dam, G.J., Claas, F.H.J., Yazdanbakhsh, M., Kruize, Y.C.M., Van Keulen, A.C.I., Ferreira, S.T.M.F., Rotmans, J.P., and Deelder, A.M. (1996) Schistosoma mansoni excretory circulating cathodic antigen shares Lewis-x epitopes with a human granulocyte surface antigen and evokes host antibodies mediating complement-dependent lysis of granulocytes. Blood, 88, 4246-4251.
45. x, LacdiNAc, GalNAcβ1-4(Fucα1-3GlcNAc, and GalNAcβ1-4(Fucα1-2Fucα1-3)GlcNAc carbohydrate epitopes: detection with monoclonal antibodies that are characterized by enzymatically synthesized neoglycoproteins. Glycobiology, 10, 601-609.
46. Van Remoortere, A., Van Dam, G.J., Hokke, C.H., Van den Eijnden, D.H., Van Die, I., and Deelder, A.M. (2001) Profiles of immunoglobulin M (IgM) and IgG antibodies against defined carbohydrate epitopes in sera of Schistosoma-infected individuals determined by surface plasmon resonance. Infect. Immun., 69, 2396-2401.
47. + T-cell subsets. Proc. Natl Acad. Sci. USA, 91, 18-22.
48. x-containing oligosaccharide attenuates schistosome egg antigen-induced immune depression in human schistosomiasis. Human Immunol., 61, 225-232.
49. Wuhrer, M., Dennis, R.D., Doenhoff, M.J., Lochnit, G., and Geyer, R. (2000) Schistosoma mansoni cercarial glycolipids are dominated by Lewis x and pseudo-Lewis Y structures. Glycobiology, 10, 89-101.