Structural and energetic effects of a2A adenosine receptor mutations on agonist and antagonist binding

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Keränen, Henrik ^a   Gutiérrez de Terán, Hugo ^a   Åqvist, Johan ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A2A RECEPTOR; ADENOSINE A2A RECEPTOR AGONIST; ADENOSINE A2A RECEPTOR ANTAGONIST; ADENOSINE A2 RECEPTOR AGONIST; ADENOSINE A2 RECEPTOR ANTAGONIST; LIGAND; MUTANT PROTEIN; TRIAZINE DERIVATIVE; TRIAZOLE DERIVATIVE;

ARTICLE; COMPUTER SIMULATION; CRYSTAL STRUCTURE; DRUG RECEPTOR BINDING; LIGAND BINDING; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; POINT MUTATION; SITE DIRECTED MUTAGENESIS; BINDING SITE; CHEMISTRY; GENETICS; HUMAN; METABOLISM; MUTATION; THERMODYNAMICS;

ADENOSINE A2 RECEPTOR AGONISTS; ADENOSINE A2 RECEPTOR ANTAGONISTS; ADENOSINE-5'-(N-ETHYLCARBOXAMIDE); BINDING SITES; HUMANS; LIGANDS; MUTANT PROTEINS; MUTATION; RECEPTOR, ADENOSINE A2A; THERMODYNAMICS; TRIAZINES; TRIAZOLES;

EID: 84907828144     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0108492     Document Type: Article

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