The roles of computational chemistry in the ligand design of G protein-coupled receptors: How far have we come and what should we expect?

Future Medicinal Chemistry

Volumn 6, Issue 3, 2014, Pages 251-254

  Gutiérrez De Terán, Hugo ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Allosteric modulation; Chemogenomics; Computational chemistry; G protein coupled receptors; Virtual screening

Indexed keywords

ALPHA 2A ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; DOPAMINE 3 RECEPTOR; G PROTEIN COUPLED RECEPTOR; LIGAND; SEROTONIN 1A AGONIST;

ALLOSTERISM; BIOCHEMISTRY; CHEMICAL DATABASE; COMPUTATIONAL CHEMISTRY; COMPUTER AIDED DESIGN; COMPUTER MODEL; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SCREENING; HUMAN; LIGAND BINDING; MOLECULAR DYNAMICS; MOLECULAR EVOLUTION; MOLECULAR INTERACTION; MOLECULAR LIBRARY; POLYPHARMACOLOGY; PRIORITY JOURNAL; RECEPTOR AFFINITY; REVIEW; SITE DIRECTED MUTAGENESIS; STRUCTURE BASED VIRTUAL SCREENING; X RAY CRYSTALLOGRAPHY;

COMPUTATIONAL BIOLOGY; DRUG DESIGN; HUMANS; LIGANDS; PROTEIN CONFORMATION; RECEPTORS, G-PROTEIN-COUPLED;

EID: 84895453561     PISSN: 17568919     EISSN: 17568927     Source Type: Journal    
DOI: 10.4155/fmc.13.209     Document Type: Review

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