A Target Repurposing Approach Identifies N-myristoyltransferase as a New Candidate Drug Target in Filarial Nematodes

PLoS Neglected Tropical Diseases

Volumn 8, Issue 9, 2014, Pages

  Galvin, Brendan D ^a   Li, Zhiru ^a   Villemaine, Estelle ^a   Poole, Catherine B ^a   Chapman, Melissa S ^a   Pollastri, Michael P ^b   Wyatt, Paul G ^c   Carlow, Clotilde K S ^a  

^a NEW ENGLAND BIOLABS   (United States)

^b NORTHEASTERN UNIVERSITY   (United States)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN N MYRISTOYLTRANSFERASE; PROTEIN N MYRISTOYLTRANSFERASE INHIBITOR; ACYLTRANSFERASE; GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE;

ADULT; ARTICLE; BIOINFORMATICS; BRUGIA MALAYI; CAENORHABDITIS ELEGANS; DRUG REPOSITIONING; DRUG TARGETING; ENZYME ACTIVITY; ENZYME KINETICS; FEMALE; FILARIASIS; GENE; GENE DELETION; GENOME ANALYSIS; IC50; LYMPHATIC FILARIASIS; MALE; MICROFILARIA (NEMATODE LARVA); MYRISTYLATION; NEMATODE; NONHUMAN; ONCHOCERCIASIS; PARASITE VIABILITY; PHENOTYPE; PHYLOGENY; PROTEIN ANALYSIS; PROTEIN FUNCTION; REVERSE TRANSCRIPTION; RNA INTERFERENCE; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; STRUCTURAL HOMOLOGY; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOLOGY; CHEMISTRY; DRUG DELIVERY SYSTEM; ENZYMOLOGY; ISOLATION AND PURIFICATION; MOLECULARLY TARGETED THERAPY;

ACYLTRANSFERASES; ANIMALS; BRUGIA MALAYI; CAENORHABDITIS ELEGANS; COMPUTATIONAL BIOLOGY; DRUG DELIVERY SYSTEMS; MOLECULAR TARGETED THERAPY;

EID: 84907584616     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0003145     Document Type: Article

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