Molecules incorporating a benzothiazole core scaffold inhibit the N-myristoyltransferase of Plasmodium falciparum

Biochemical Journal

Volumn 408, Issue 2, 2007, Pages 173-180

  Bowyer, Paul W ^a,b,e   Gunaratne, Ruwani S ^c,f   Grainger, Munira ^c   Withers Martinez, Chrislaine ^c   Wickramsinghe, Sasala R ^b   Tate, Edward W ^b   Leatherbarrow, Robin J ^b   Brown, Katherine A ^b   Holder, Anthony A ^c   Smith, Deborah F ^a,b,d  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^d UNIVERSITY OF YORK   (United Kingdom)

^e STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

Benzothiazole; Codon optimization; Inhibition; N myristoylation; Plasmodium falciparum; Scintillation proximity assay (SPA)

Indexed keywords

BENZOTHIAZOLE CORES; CODON OPTIMIZATION; PLASMODIUM FALCIPARUM; SCINTILLATION PROXIMITY ASSAY (SPA);

BIOASSAY; ENZYME INHIBITION; ESCHERICHIA COLI; OPTIMIZATION; PURIFICATION;

COLLOIDS;

ANTIMALARIAL AGENT; BENZOTHIAZOLE; CP 005240; CP 014553; CP 144568; PROTEIN N MYRISTOYLTRANSFERASE; UK 145974; UK 362799; UK 370309; UK 370485; UK 370509; UK 370624; UK 370709; UK 370710; UK 370713; UNCLASSIFIED DRUG;

ARTICLE; DRUG STRUCTURE; ESCHERICHIA COLI; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; NONHUMAN; PARASITEMIA; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION;

ACYLTRANSFERASES; ANIMALS; ANTIMALARIALS; BENZOTHIAZOLES; ENZYME INHIBITORS; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; RECOMBINANT PROTEINS;

ESCHERICHIA COLI; PLASMODIUM FALCIPARUM;

EID: 36749030760     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20070692     Document Type: Article

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