New chemotypes for wALADin1-like inhibitors of delta-aminolevulinic acid dehydratase from Wolbachia endobacteria

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 20, 2013, Pages 5558-5562

  Lentz, Christian S ^a,b   Stumpfe, Dagmar ^b   Bajorath, Juergen ^b   Famulok, Michael ^b   Hoerauf, Achim ^a   Pfarr, Kenneth M ^a  

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

Brugia malayi; Delta aminolevulinic acid dehydratase; Heme biosynthesis; wALADin; Wolbachia

Indexed keywords

ANTIFILARIAL AGENT; BENZIMIDAZOLE DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; LYASE INHIBITOR; PD 620; PD 636; PD 637; PD 638; PD 639; PD 640; PD 641; PD 642; PD 643; PD 644; PORPHOBILINOGEN SYNTHASE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; WALADIN1 LIKE INHIBITOR;

ARTICLE; CHEMICAL STRUCTURE; ENZYME ACTIVITY; HUMAN; IC 50; INTRACELLULAR BACTERIUM; NONHUMAN; PHYSICAL CHEMISTRY; STRUCTURE ACTIVITY RELATION; WOLBACHIA;

BRUGIA MALAYI; ENDOBACTERIA; NEMATODA; WOLBACHIA;

BRUGIA MALAYI; DELTA-AMINOLEVULINIC ACID DEHYDRATASE; HEME BIOSYNTHESIS; WALADIN; WOLBACHIA;

ANIMALS; BENZIMIDAZOLES; BRUGIA MALAYI; ENZYME INHIBITORS; FILARICIDES; KINETICS; PORPHOBILINOGEN SYNTHASE; PROTEIN BINDING; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES; WOLBACHIA;

EID: 84884283539     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.08.052     Document Type: Article

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