Altitudeomics: Rapid hemoglobin mass alterations with early acclimatization to and de-acclimatization from 5260 m in healthy humans

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Ryan, Benjamin J ^a   Wachsmuth, Nadine B ^b   Schmidt, Walter F ^b   Byrnes, William C ^a   Julian, Colleen G ^c   Lovering, Andrew T ^d   Subudhi, Andrew W ^c,e   Roach, Robert C ^c  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF BAYREUTH   (Germany)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF OREGON   (United States)

^e UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; FERRITIN; HEMOGLOBIN;

ADULT; ALTITUDE ACCLIMATIZATION; ARTICLE; BLOOD VOLUME; CELL DESTRUCTION; CONTROLLED STUDY; ERYTHROCYTE; ERYTHROPOIESIS; FEMALE; FERRITIN BLOOD LEVEL; HEMATOCRIT; HEMATOLOGICAL PARAMETERS; HEMOGLOBIN BLOOD LEVEL; HEMOGLOBIN DETERMINATION; HEMOGLOBIN MASS; HUMAN; HUMAN EXPERIMENT; LONG TERM EXPOSURE; MALE; NORMAL HUMAN; SEA LEVEL; ACCLIMATIZATION; ALTITUDE; PHYSIOLOGY; YOUNG ADULT;

ACCLIMATIZATION; ALTITUDE; ERYTHROPOIESIS; FEMALE; HEMOGLOBINS; HUMANS; MALE; YOUNG ADULT;

EID: 84907546069     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0108788     Document Type: Article

References (66)

1. Eckardt K-U, Boutellier U, Kurtz A, Schopen M, Koller EA, et al. (1989) Rate of erythropoietin formation in humans in response to acute hypobaric hypoxia. J Appl Physiol 66:1785-1788.
2. Sawka MN, Convertino VA, Eichner ER, Schnieder SM, Young AJ (2000) Blood volume: importance and adaptations to exercise training, environmental stresses, and trauma/sickness. Med Sci Sports Exerc 32:332-348.
3. Grover RF, Bärtsch P (2001) Blood. In: High Altitude: An Exploration of Human Adaptation, edited by Hornbein TF, Schoene RB. New York & Basel: M. Dekker, Inc.
4. Robach P, Recalcati S, Girelli D, Gelfi C, Aachmann-Andersen NJ, et al. (2009) Alterations of systemic and muscle iron metabolism in human subjects treated with low-dose recombinant erythropoietin. Blood 113:6707-6715.
5. Olsen NV, Aachmann-Andersen N-J, Oturai P, Munch-Andersen T, Bornø A, et al. (2011) Erythropoietin down-regulates proximal renal tubular reabsorption and causes a fall in glomerular filtration rate in humans. J Physiol 589:1273-1281.
6. Durussel J, Daskalaki E, Anderson M, Chatterji T, Wondimu DH, et al. (2013) Haemoglobin mass and running time trial performance after recombinant human erythropoietin administration in trained men. PLoS ONE 8(2):e56151.
7. Reynafarje C, Lozano R, Valdivieso J (1959) The polycythemia of high altitudes: iron metabolism and related aspects. Blood 14:433-455.
8. Pugh LGCE (1964) Blood volume and haemoglobin concentration at altitudes above 18, 000 ft (5500 m). J Physiol 170:344-354.
9. Sawka MN, Young AJ, Rock PB, Lyons TP, Boushel R, et al. (1996) Altitude acclimatization and blood volume: effects of exogenous erythrocyte volume expansion. J Appl Physiol 81:636-642.
10. Grover RF, Selland MA, McCullough RG, Dahms TE, Wolfel EE, et al. (1998) β-Adrenergic blockade does not prevent polycythemia or decrease in plasma volume in men at 4300 m altitude. Eur J Appl Physiol 77:264-270.
11. Wolfel EE, Groves BM, Brooks GA, Butterfield GE, Mazzeo RS, et al. (1991) Oxygen transport during steady-state submaximal exercise in chronic hypoxia. J Appl Physiol 70:1129-1136.
12. Reeves JT, Zamudio S, Dahms TE, Asmus I, Braun B, et al. (2001) Erythropoiesis in women during 11 days at 4, 300 m is not affected by menstrual cycle phase. J Appl Physiol 91:2579-2586.
13. Garvican L, Martin D, Quod M, Stephens B, Sassi A, et al. (2012) Time course of the hemoglobin mass response to natural altitude training in elite endurance cyclists. Scand J Med Sci Sports 22:95-103.
14. Wachsmuth NB, Vôlzke C, Prommer N, Schmidt-Trucksäss A, Frese F, et al. (2013) The effects of classic altitude training on hemoglobin mass in swimmers. Eur J Appl Physiol 113:1199-1211.
15. Wachsmuth NB, Kley M, Spielvogel H, Aughey RJ, Gore CJ, et al. (2013) Changes in blood gas transport of altitude native soccer players near sea-level and sea-level native soccer players at altitude (ISA3600). Br J Sports Med 47, i93-i99.
16. Rasmussen P, Siebenmann C, Díaz V, Lundby C (2013) Red cell volume expansion at altitude: a meta-analysis and Monte Carlo simulation. Med Sci Sports Exerc 45:1767-1772.
17. Gore CJ, Sharpe K, Garvican-Lewis LA, Saunders PU, Humberstone CE, et al. (2013) Altitude training and haemoglobin mass from the optimised carbon monoxide rebreathing method determined by a meta-analysis. Br J Sports Med 47:i31-i39.
18. Milledge JS, Cotes PM (1985) Serum erythropoietin in humans at high altitude and its relation to plasma renin. J Appl Physiol 59:360-364.
19. Richalet J-P, Souberbielle J-C, Antezana A-M, Déchaux M, Le Trong J-L, et al. (1994) Control of erythropoiesis in humans during prolonged exposure to the altitude of 6, 542 m. Am J Physiol Regul Integr Comp Physiol 266:R756-R764.
20. Lundby C, Achman-Andersen NJ, Thomsen JJ, Norgaard AM, Robach P (2008) Testing for recombinant human erythropoietin in urine: problems associated with current anti-doping testing. J Appl Physiol 105:417-419.
21. Rice L, Ruiz W, Driscoll T, Whitley CE, Tapia R, et al. (2001) Neocytolysis on descent from altitude: a newly recognized mechanism for the control of red cell mass. Ann Intern Med 134:652-656.
22. Subudhi AW, Bourdillon N, Bucher J, Davis C, Elliott JE, et al. (2014) AltitudeOmics: the integrative physiology of human acclimatization to hypobaric hypoxia and its retention upon reascent. PLoS ONE 9(3):e92191.
23. Imoberdorf R, Garlick PJ, McNurlan MA, Casella GA, Peheim E, et al. (2001) Enhanced synthesis of albumin and fibrinogen at high altitude. J Appl Physiol 90:528-537.
24. Loeppky JA, Roach RC, Maes D, Hinghofer-Szalkay H, Roessler A, et al. (2004) Role of hypobaria in fluid balance response to hypoxia. High Alt Med Biol 6:60-71.
25. Poulsen TD, Klausen T, Richalet J-P, Kanstrup I-L, Fogh-Andersen N, et al. (1998) Plasma volume in acute hypoxia: comparison of a carbon monoxide rebreathing method and dye dilution with Evans' blue. Eur J Appl Physiol 77:457-461.
26. 2 max during prolonged high-altitude exposure. J Appl Physiol 89:29-37.
27. Robach P, Lafforgue E, Olsen NV, Déchaux M, Fouqueray B, et al. (2002) Recovery of plasma volume after 1 week of exposure at 4, 350 m. Pflugers Arch-Eur J Physiol 444:821-828.
28. Smith TG, Robbins PA, Ratcliffe PJ (2008) The human side of hypoxiainducible factor. Br J Haematology 141:325-334.
29. Talbot NP, Smith TG, Privat C, Nickol AH, Rivera-Ch M, et al. (2011) Intravenous iron supplementation may protect against acute mountain sickness: a randomized, double-blinded, placebo-controlled trial. High Alt Med Biol 12:265-269.
30. Schmidt W, Prommer N (2005) The optimised CO-rebreathing method: a new tool to determine total haemoglobin mass routinely. Eur J Appl Physiol 95:486-495.
31. Prommer N, Schmidt W (2007) Loss of CO from the intravascular bed and its impact on the optimised CO-rebreathing method. Eur J Appl Physiol 100:383-391.
32. Ryan BJ, Brothers MD, Nelson JL, Doan BK, Zupan MF, et al. (2011) Influence of carbon monoxide leaks on the measurement error of total haemoglobin mass. Scand J Clin Lab Invest 71:523-528.
33. Hütler M, Beneke R, Littschwager A, Bôning D (2001) Fraction of carboxyhaemoglobin depends on oxygen saturation of haemoglobin. Scand J - Clin Lab Invest 61:83-88.
34. Gough CE, Sharpe K, Ashenden MJ, Anson JM, Saunders PU, et al. (2011) Quality control technique to reduce the variability of longitudinal measurement of hemoglobin mass. Scand J Med Sci Sports 21:e365-e371.
35. Hopkins WG (2000) Measures of reliability in sports medicine and science. Sports Med 30:1-15.
36. Eastwood A, Hopkins WG, Bourdon PC, Withers RT, Gore CJ (2008) Stability of hemoglobin mass over 100 days in active men. J Appl Physiol 104:982-985.
37. Prommer N, Sottas P-E, Schoch C, Schumacher YO, Schmidt W (2008) Total hemoglobin mass-a new parameter to detect blood doping? Med Sci Sports Exerc 40:2112-2118.
38. Chaplin H, Mollison PL, Vetter H (1953) The body/venous hematocrit ratio: its constancy over a wide hematocrit range. J Clin Invest 32:1309-1316.
39. Gore CJ, Hopkins WG, Burge CM (2005) Errors of measurement for blood volume parameters: a meta-analysis. J Appl Physiol 99:1745-58.
40. Abbrecht PH, Littell JK (1972) Plasma erythropoietin in men and mice during acclimatization to different altitudes. J Appl Physiol 32:54-58.
41. Robach P, Fulla Y, Westerterp KR, Richalet J-P (2004) Comparative response of EPO and soluble transferring receptor at high altitude. Med Sci Sports Exerc 36:1493-1498.
42. Jelkmann W (2011) Regulation of erythropoietin production. J Physiol 589:1251-1258.
43. Haase VH (2013) Regulation of erythropoiesis by hypoxia-inducible factors. Blood Reviews 27:41-53.
44. Robach P, Cairo G, Gelfi C, Bernuzzi F, Pilegaard H, et al. (2007) Strong iron demand during hypoxia-induced erythropoiesis is associated with downregulation of iron-related proteins and myoglobin in human skeletal muscle. Blood 109:4724-4731.
45. Bôning D, Rojas J, Serrato M, Ulloa C, Coy L, et al. (2001) Hemoglobin mass and peak oxygen uptake in untrained and trained residents of moderate altitude. Int J Sports Med 22:572-578.
46. Bôning D, Cristancho E, Serrato M, Reyes O, Mora M, et al. (2004) Hemoglobin mass and peak oxygen uptake in untrained and trained female altitude residents. Int J Sports Med 25:561-568.
47. Christancho E, Reyes O, Serrato M, Mora MM, Rojas JA, et al. (2007) Arterial oxygen saturation and hemoglobin mass in postmenopausal untrained and trained altitude residents. High Alt Med Biol 8:296-306.
48. Stray-Gundersen J, Alexander C, Hochstein A, deLemos D, Levine BD (1992) Failure of red cell volume to increase to altitude exposure in iron deficient runners (Abstract). Med Sci Sports Exerc 24:S90.
49. Mairbäurl H, Schobersberger W, Oelz O, Bärtsch P, Eckardt KU, et al. (1990) Unchanged in vivo P50 at high altitude despite decreased erythrocyte age and elevated 2, 3, -diphosphoglycerate. J Appl Physiol 68:1186-1194.
50. Goetze O, Schmitt J, Spliethoff K, Theurl I, Weiss G, et al. (2013) Adaptation of iron transport and metabolism to acute high-altitude hypoxia in mountaineers. Hepatology 58:2153-2162.
51. Bôning D, Maassen N, Jochum J, Steinacker J, Halder A, et al. (1997) Aftereffects of a high altitude expedition on blood. Int J Sports Med. 18:179-185.
52. León-Velarde F, Maggiorini M, Reeves JT, Aldashev A, Asmus I, et al. (2005) Consensus statement on chronic and subacute mountain sickness. High Alt Med Biol 6:147-157.
53. Finch CA, Harker LA, Cook JD (1977) Kinetics of the formed elements of human blood. Blood 50:699-707.
54. Alfrey CP, Udden MM, Leach-Huntoon C, Driscoll T, Pickett MH (1996) Control of red blood cell mass in spaceflight. J Appl Physiol 81:98-104.
55. Alfrey CP, Rice L, Udden MM, Driscoll TB (1997) Neocytolysis: physiological down-regulator of red-cell mass. Lancet 349:1389-1390.
56. Rice L, Alfrey CP (2005) The negative regulation of red cell mass by neocytolysis: physiologic and pathophysiologic manifestations. Cell Physiol Biochem 15:245-250.
57. Risso A, Cianna A, Achilli C, Antonutto G, Minetti G (2014) Neocytolysis: none, one or many? A reappraisal and future perspectives. Front Physiol 5:54.
58. Reljic D, Hässler E, Jost J, Friedmann-Bette B (2013) Rapid weight loss and the body fluid balance and hemoglobin mass of elite amateur boxers. J Athletic Training 48:109-117.
59. 2 max at high altitude. J Appl Physiol 81:252-259.
60. Pandolf KB, Young AJ, Sawka MN, Kenney JL, Sharp MW, et al. (1998) Does erythrocyte infusion improve 3.2 km run performance at high altitude? Eur J Appl Physiol 79:1-6.
61. 2 max depends on the severity of arterial hypoxemia. PLoS ONE 3(8):e2996.
62. 2 max and cardiovascular function in lowlanders acclimatised to 5260 m. J Physiol 545:715-728.
63. Eastwood A, Bourdon PC, Snowden KR, Gore CJ (2012) Detraining decreases Hbmass of triathletes. Int J Sports Med 33:253-257.
64. Schumacher YO, Ahlgrim C, Pottgiesser T (2008) Evaluation of anthropometrical reference parameters for hemoglobin mass in endurance athletes. J Sports Med Phys Fitness 48:509-514.
65. Miller ME, Cronkite EP, Garcia JF (1982) Plasma levels of immunoreactive erythropoietin after acute blood loss in man. Br J Haematol 52:545-549.
66. Pottgiesser T, Specker W, Umhau M, Dickhuth H-H, Roecker K, et al. (2009) Recovery of hemoglobin mass after blood donation. Transfusion 48:1390-1397.