Haemoglobin Mass and Running Time Trial Performance after Recombinant Human Erythropoietin Administration in Trained Men

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Durussel, Jérôme ^a   Daskalaki, Evangelia ^b   Anderson, Martin ^a   Chatterji, Tushar ^a   Wondimu, Diresibachew H ^a,c   Padmanabhan, Neal ^a   Patel, Rajan K ^a   McClure, John D ^a   Pitsiladis, Yannis P ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^c ADDIS ABABA UNIVERSITY   (Ethiopia)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON MONOXIDE; HEMOGLOBIN; RECOMBINANT ERYTHROPOIETIN;

ADULT; ARTICLE; CONTROLLED STUDY; FIELD STUDY; HEMATOLOGICAL PARAMETERS; HEMOGLOBIN MASS; HUMAN; HUMAN EXPERIMENT; MALE; MOTOR PERFORMANCE; MUSCLE TRAINING; NORMAL HUMAN; OXYGEN CONSUMPTION; PROCESS OPTIMIZATION; REBREATHING; RESPONSE TIME; RUNNING;

ADULT; ANALYSIS OF VARIANCE; BLOOD PRESSURE; BLOOD VOLUME; CARBOXYHEMOGLOBIN; DRUG ADMINISTRATION SCHEDULE; ERYTHROPOIETIN; HEART RATE; HEMATOCRIT; HEMOGLOBINS; HUMANS; INJECTIONS, SUBCUTANEOUS; MALE; OXYGEN CONSUMPTION; PHYSICAL ENDURANCE; RECOMBINANT PROTEINS; RUNNING; TIME FACTORS; YOUNG ADULT;

EID: 84873936500     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0056151     Document Type: Article

References (47)

1. Jelkmann W, (2011) Regulation of erythropoietin production. J Physiol 589: 1251-1258.
2. Lundby C, Thomsen JJ, Boushel R, Koskolou M, Warberg J, et al. (2007) Erythropoietin treatment elevates haemoglobin concentration by increasing red cell volume and depressing plasma volume. J Physiol 578: 309-314.
3. Olsen NV, Aachmann-Andersen NJ, Oturai P, Munch-Andersen T, Borno A, et al. (2011) Erythropoietin down-regulates proximal renal tubular reabsorption and causes a fall in glomerular filtration rate in humans. J Physiol 589: 1273-1281.
4. Lundby C, Olsen NV, (2011) Effects of recombinant human erythropoietin in normal humans. J Physiol 589: 1265-1271.
5. Franco RS, (2009) The measurement and importance of red cell survival. Am J Hematol 84: 109-114.
6. Rice L, Ruiz W, Driscoll T, Whitley CE, Tapia R, et al. (2001) Neocytolysis on descent from altitude: a newly recognized mechanism for the control of red cell mass. Ann Intern Med 134: 652-656.
7. Rice L, Alfrey CP, (2005) The negative regulation of red cell mass by neocytolysis: physiologic and pathophysiologic manifestations. Cell Physiol Biochem 15: 245-250.
8. Chang CC, Chen Y, Modi K, Awar O, Alfrey C, et al. (2009) Changes of red blood cell surface markers in a blood doping model of neocytolysis. J Investig Med 57: 650-654.
9. Alfrey CP, Rice L, Udden MM, Driscoll TB, (1997) Neocytolysis: physiological down-regulator of red-cell mass. Lancet 349: 1389-1390.
10. Schmidt W, Prommer N, (2005) The optimised CO-rebreathing method: a new tool to determine total haemoglobin mass routinely. Eur J Appl Physiol 95: 486-495.
11. Durussel J, Ross R, Raj Kodi P, Daskalaki E, Pantazis T, et al. (2011) Precision of the optimized carbon monoxide rebreathing method to determine total haemoglobin mass and blood volume. Eur J Sport Sci.
12. Noakes TD, (2008) Testing for maximum oxygen consumption has produced a brainless model of human exercise performance. Br J Sports Med 42: 551-555.
13. Shephard RJ, (2009) Is the measurement of maximal oxygen intake passe? Br J Sports Med 43: 83-85.
14. Costill DL, Thomason H, Roberts E, (1973) Fractional utilization of the aerobic capacity during distance running. Med Sci Sports 5: 248-252.
15. Levine BD, Stray-Gundersen J, (1992) A practical approach to altitude training: where to live and train for optimal performance enhancement. International journal of sports medicine 13Suppl 1: S209-212.
16. Thomsen JJ, Rentsch RL, Robach P, Calbet JA, Boushel R, et al. (2007) Prolonged administration of recombinant human erythropoietin increases submaximal performance more than maximal aerobic capacity. Eur J Appl Physiol 101: 481-486.
17. Noakes TD, (2008) Mechanism by which rHuEPO improves submaximal exercise performance. Eur J Appl Physiol 103: 485.
18. Millet GP, Roels B, Schmitt L, Woorons X, Richalet JP, (2010) Combining hypoxic methods for peak performance. Sports medicine 40: 1-25.
19. Laursen PB, Francis GT, Abbiss CR, Newton MJ, Nosaka K, (2007) Reliability of time-to-exhaustion versus time-trial running tests in runners. Med Sci Sports Exerc 39: 1374-1379.
20. Ahlgrim C, Pottgiesser T, Robinson N, Sottas PE, Ruecker G, et al. (2010) Are 10 min of seating enough to guarantee stable haemoglobin and haematocrit readings for the athlete's biological passport? Int J Lab Hematol 32: 1-6.
21. Kirkeberg JM, Dalleck LC, Kamphoff CS, Pettitt RW, (2011) Validity of 3 protocols for verifying VO2 max. Int J Sports Med 32: 266-270.
22. Pettitt RW, Clark IE, Ebner SM, Sedgeman DT, Murray SR (2012) Gas Exchange Threshold and VO2max Testing for Athletes: An Update. J Strength Cond Res.
23. Russell G, Gore CJ, Ashenden MJ, Parisotto R, Hahn AG, (2002) Effects of prolonged low doses of recombinant human erythropoietin during submaximal and maximal exercise. Eur J Appl Physiol 86: 442-449.
24. Audran M, Gareau R, Matecki S, Durand F, Chenard C, et al. (1999) Effects of erythropoietin administration in training athletes and possible indirect detection in doping control. Med Sci Sports Exerc 31: 639-645.
25. Birkeland KI, Stray-Gundersen J, Hemmersbach P, Hallen J, Haug E, et al. (2000) Effect of rhEPO administration on serum levels of sTfR and cycling performance. Med Sci Sports Exerc 32: 1238-1243.
26. Berglund B, Ekblom B, (1991) Effect of recombinant human erythropoietin treatment on blood pressure and some haematological parameters in healthy men. J Intern Med 229: 125-130.
27. Wilkerson DP, Rittweger J, Berger NJ, Naish PF, Jones AM, (2005) Influence of recombinant human erythropoietin treatment on pulmonary O2 uptake kinetics during exercise in humans. J Physiol 568: 639-652.
28. Parisotto R, Gore CJ, Emslie KR, Ashenden MJ, Brugnara C, et al. (2000) A novel method utilising markers of altered erythropoiesis for the detection of recombinant human erythropoietin abuse in athletes. Haematologica 85: 564-572.
29. Connes P, Perrey S, Varray A, Prefaut C, Caillaud C, (2003) Faster oxygen uptake kinetics at the onset of submaximal cycling exercise following 4 weeks recombinant human erythropoietin (r-HuEPO) treatment. Pflugers Arch 447: 231-238.
30. Mujika I, Padilla S, (2001) Physiological and performance characteristics of male professional road cyclists. Sports Med 31: 479-487.
31. Lucia A, Hoyos J, Perez M, Santalla A, Chicharro JL, (2002) Inverse relationship between VO2max and economy/efficiency in world-class cyclists. Med Sci Sports Exerc 34: 2079-2084.
32. Brien AJ, Simon TL, (1987) The effects of red blood cell infusion on 10-km race time. JAMA 257: 2761-2765.
33. Boning D, Maassen N, Pries A (2008) No proof for augmented arterial oxygen content as only factor influencing exercise capacity after Epo doping. J Appl Physiol 105: 1988; author reply 1989.
34. Boning D, Maassen N, Pries A, (2011) The hematocrit paradox-how does blood doping really work? Int J Sports Med 32: 242-246.
35. Ninot G, Connes P, Caillaud C, (2006) Effects of recombinant human erythropoietin injections on physical self in endurance athletes. J Sports Sci 24: 383-391.
36. Miskowiak K, Inkster B, Selvaraj S, Wise R, Goodwin GM, et al. (2008) Erythropoietin improves mood and modulates the cognitive and neural processing of emotion 3 days post administration. Neuropsychopharmacology 33: 611-618.
37. Jelkmann W, Depping R, Metzen E (2009) Nonhematopoietic effects of erythropoiesis-stimulating agents. In: Elliott SG, Foote M, Molineux G, editors. Erythropoietin, Erythropoietic Factores, and Erythropoiesis. Basel: Birkhäuser. 299-317.
38. Brines M, Cerami A, (2005) Emerging biological roles for erythropoietin in the nervous system. Nat Rev Neurosci 6: 484-494.
39. Ehrenreich H, Bartels C, Sargin D, Stawicki S, Krampe H, (2008) Recombinant human erythropoietin in the treatment of human brain disease: focus on cognition. J Ren Nutr 18: 146-153.
40. Lundby C, Robach P, Boushel R, Thomsen JJ, Rasmussen P, et al. (2008) Does recombinant human Epo increase exercise capacity by means other than augmenting oxygen transport? J Appl Physiol 105: 581-587.
41. Rasmussen P, Foged EM, Krogh-Madsen R, Nielsen J, Nielsen TR, et al. (2010) Effects of erythropoietin administration on cerebral metabolism and exercise capacity in men. J Appl Physiol 109: 476-483.
42. Heinicke K, Wolfarth B, Winchenbach P, Biermann B, Schmid A, et al. (2001) Blood volume and hemoglobin mass in elite athletes of different disciplines. Int J Sports Med 22: 504-512.
43. Morkeberg J, Sharpe K, Belhage B, Damsgaard R, Schmidt W, et al. (2009) Detecting autologous blood transfusions: a comparison of three passport approaches and four blood markers. Scand J Med Sci Sports: 1-9.
44. Banfi G, (2008) Reticulocytes in sports medicine. Sports Med 38: 187-211.
45. Belcher JD, Beckman JD, Balla G, Balla J, Vercellotti G, (2010) Heme degradation and vascular injury. Antioxid Redox Signal 12: 233-248.
46. Ryter SW, Otterbein LE, (2004) Carbon monoxide in biology and medicine. Bioessays 26: 270-280.
47. Engel RR, Rodkey FL, Krill CE Jr, (1971) Carboxyhemoglobin levels as an index of hemolysis. Pediatrics 47: 723-730.