Time course of the hemoglobin mass response to natural altitude training in elite endurance cyclists

Scandinavian Journal of Medicine and Science in Sports

Volumn 22, Issue 1, 2012, Pages 95-103

  Garvican, L ^a,b   Martin, D ^a   Quod, M ^a   Stephens, B ^a   Sassi, A ^c   Gore, C ^a,b  

^a AUSTRALIAN INSTITUTE OF SPORT   (Australia)

^b FLINDERS UNIVERSITY   (Australia)

^c Mapei Sport Research Center   (Italy)

Author keywords

Carbon monoxide rebreathing; Competitive road cycling; Erythropoiesis; Hematology; Live high:train low; Neocytolysis

Indexed keywords

ERYTHROPOIETIN; FERRITIN; HEMOGLOBIN; TRANSFERRIN RECEPTOR;

ADULT; ALTITUDE; ARTICLE; BICYCLE; BLOOD; ERYTHROCYTE COUNT; EXERCISE; HUMAN; METABOLISM; PHYSIOLOGY; RETICULOCYTE; TIME;

ADULT; ALTITUDE; BICYCLING; ERYTHROCYTE COUNT; ERYTHROPOIETIN; EXERCISE; FERRITINS; HEMOGLOBINS; HUMANS; RECEPTORS, TRANSFERRIN; RETICULOCYTES; TIME FACTORS; YOUNG ADULT;

EID: 84855829420     PISSN: 09057188     EISSN: 16000838     Source Type: Journal    
DOI: 10.1111/j.1600-0838.2010.01145.x     Document Type: Article

References (27)

1. Alfrey CP, Udden MM, Leach-Huntoon C, Driscoll T, Pickett MH. Control of red blood cell mass in spaceflight. J Appl Physiol 1996: 81: 98-104.
2. Banfi G. Reticulocytes in sports medicine. Sports Med 2008: 38: 187-211.
3. Berglund B. High-altitude training. Aspects of haematological adaptation. Sports Med 1992: 14: 289-303.
4. Brugniaux JV, Schmitt L, Robach P, Nicolet G, Fouillot JP, Moutereau S, Lasne F, Pialoux V, Saas P, Chorvot MC, Cornolo J, Olsen NV, Richalet JP. Eighteen days of "living high, training low" stimulate erythropoiesis and enhance aerobic performance in elite middle-distance runners. J Appl Physiol 2006: 100: 203-211.
5. Clark SA, Quod MJ, Clark MA, Martin DT, Saunders PU, Gore CJ. Time course of haemoglobin mass during 21 days live high: train low simulated altitude. Eur J Appl Physiol 2009: 106: 399-406.
6. Eastwood A, Hopkins WG, Bourdon PC, Withers RT, Gore CJ. Stability of hemoglobin mass over 100 days in active men. J Appl Physiol 2008: 104: 982-985.
7. Garvican LA, Martin DT, Clark SA, Schmidt WF, Gore CJ. Variability of erythropoietin response to sleeping at simulated altitude: a cycling case study. Int J Sports Physiol Perform 2007: 2: 327-331.
8. Garvican LA, Martin DT, McDonald W, Gore CJ. Seasonal variation of haemoglobin mass in internationally competitive female road cyclists. Eur J Appl Physiol 2010: doi: DOI: 10.1007/s00421-009-1349-2.
9. Gore CJ, Bourdon PC, Woolford SM, Ostler LM, Eastwood A, Scroop GC. Time and sample site dependency of the optimized co-rebreathing method. Med Sci Sports Exerc 2006: 38: 1187-1193.
10. Gore CJ, Clark SA, Saunders PU. Nonhematological mechanisms of improved sea-level performance after hypoxic exposure. Med Sci Sports Exerc 2007: 39: 1600-1609.
11. Gore CJ, Hopkins WG. Counterpoint: positive effects of intermittent hypoxia (live high:train low) on exercise performance are not mediated primarily by augmented red cell volume. J Appl Physiol 2005: 99: 2055-2057; discussion 2057-2058.
12. Gore CJ, Hopkins WG, Burge CM. Errors of measurement for blood volume parameters: a meta-analysis. J Appl Physiol 2005: 99: 1745-1758.
13. Hopkins WG, Marshall SW, Batterham AM, Hanin J. Progressive statistics for studies in sports medicine and exercise science. Med Sci Sports Exerc 2009: 41: 3-13.
14. Levine BD, Stray-Gundersen J. Point: positive effects of intermittent hypoxia (live high:train low) on exercise performance are mediated primarily by augmented red cell volume. J Appl Physiol 2005: 99: 2053-2055.
15. Levine BD, Stray-Gundersen J. Dose-response of altitude training: how much altitude is enough? Adv Exp Med Biol 2006: 588: 233-247.
16. Prommer N, Sottas PE, Schoch C, Schumacher YO, Schmidt W. Total hemoglobin mass - a new parameter to detect blood doping?Med Sci Sports Exerc 2008: 40: 2112-2118.
17. Prommer N, Thoma S, Quecke L, Gutekunst T, Völzke C, Wachsmuth N, Niess AM, Schmidt W. Oxygen transport in Kenyan runners. Med Sci Sports Exerc 2009: 41: S376: 2127.
18. Rice L, Ruiz W, Driscoll T, Whitley CE, Tapia R, Hachey DL, Gonzales GF, Alfrey CP. Neocytolysis on descent from altitude: a newly recognized mechanism for the control of red cell mass. Ann Intern Med 2001: 134: 652-656.
19. Robertson EY, Saunders PU, Pyne DB, Aughey RJ, Anson J, Gore CJ. Reproducibility of performance changes to simulated live high/train low altitude. Med Sci Sports Exerc 2010: 42(2): 394-401.
20. Rusko HK, Tikkanen HO, Peltonen JE. Altitude and endurance training. J Sports Sci 2004: 22: 928-944; discussion 945.
21. Saunders PU, Pyne DB, Gore CJ. Endurance training at altitude. High Alt Med Biol 2009: 10: 135-148.
22. Sawka MN, Muza SR, Young AR. Erythrocyte volume expansion and human performance. In: Fourcroy JL ed. Pharmacology, doping and sports: a scientific guide for athletes, coaches, physicians, scientists and administrators. New York, NY: Routledge, 2009: 125-134.
23. Schmidt W, Heinicke K, Rojas J, Manuel Gomez J, Serrato M, Mora M, Wolfarth B, Schmid A, Keul J. Blood volume and hemoglobin mass in endurance athletes from moderate altitude. Med Sci Sports Exerc 2002: 34: 1934-1940.
24. Schmidt W, Prommer N. The optimised CO-rebreathing method: a new tool to determine total haemoglobin mass routinely. Eur J Appl Physiol 2005: 95: 486-495.
25. Schumacher YO, Ahlgrim C, Ruthardt S, Pottgiesser T. Hemoglobin mass in an elite endurance athlete before, during, and after injury-related immobility. Clin J Sport Med 2008: 18: 172-173.
26. Shepley B, MacDougall JD, Cipriano N, Sutton JR, Tarnopolsky MA, Coates G. Physiological effects of tapering in highly trained athletes. J Appl Physiol 1992: 72: 706-711.
27. Wilber RL, Stray-Gundersen J, Levine BD. Effect of hypoxic "dose" on physiological responses and sea-level performance. Med Sci Sports Exerc 2007: 39: 1590-1599.