Effects of erythrocyte infusion on V̇O(2max) at high altitude

Journal of Applied Physiology

Volumn 81, Issue 1, 1996, Pages 252-259

  Young, Andrew J ^a   Sawka, Michael N ^b   Muza, Stephen R ^b   Boushel, Robert ^b   Lyons, Timothy ^b   Rock, Paul B ^b   Freund, Beau J ^b   Waters, Ray ^b   Cymerman, Allen ^b   Pandolf, Kent B ^b   Valeri, C Robert ^b  

^a U S ARMY RESEARCH INSTITUTE OF ENVIRONMENTAL MEDICINE   (United States)

^b NONE

Author keywords

blood doping; exercise; hypoxia; maximal oxygen uptake; oxygen transport

Indexed keywords

ADULT; ALTITUDE; ARTERIAL OXYGEN TENSION; ARTICLE; ATMOSPHERIC PRESSURE; CONTROLLED STUDY; ERYTHROCYTE TRANSFUSION; HUMAN; MALE; NORMAL HUMAN; OXYGEN CONSUMPTION; OXYGEN TRANSPORT; PRIORITY JOURNAL;

EID: 9344230352     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1996.81.1.252     Document Type: Article

References (23)

1. Buick, F. J., N. Gledhill, A. B. Froese, L. Spriet, and E. C. Meyers. Effect of induced erythrocythemia on aerobic work capacity. J. Appl. Physiol. 48: 636-642, 1980.
2. Fulco, C. S., and A. Cymerman. Human performance and acute hypoxia. In: Human Performance Physiology and Environmental Medicine at Terrestrial Extremes, edited by K. B. Pandolf, M. N. Sawka, and R. R. Gonzalez. Indianapolis, IN: Benchmark, 1988, p. 467-495.
3. Gardner, R. M., J. L. Hankinson, J. L. Clausen, R. O. Crapo, R. L. J. Johnson, and G. R. Epler. Standardization of spirometry-1987 update. Am. Rev. Respir. Dis. 136: 1285-1298, 1987.
4. Gledhill, N. Blood doping and related issues: a brief review. Med. Sci. Sports Exercise 14: 183-189, 1982.
5. Gledhill, N. The influence of altered blood volume and oxygen transport capacity on aerobic performance. In: Exercise and Sports Science Review, edited by R. L. Terjung. New York: Macmillan, 1985, p. 75-93.
6. Grover, R. F., J. V. Weil, and J. T. Reeves. Cardiovascular adaptation to exercise and high altitude. In: Exercise and Sports Science Review, edited by K. B. Pandolf. New York: Macmillan, 1986, vol. 14, p. 269-302.
7. Mitchell, J. H., B. J. Sproule, and C. B. Chapman. The physiological meaning of the maximal oxygen intake test. J. Clin. Invest. 37: 538-547, 1958.
8. Pace, N., E. L. Lozner, W. V. Consolazio, G. C. Pitts, and L. J. Pecora. The increase in hypoxia tolerance of normal men accompanying the polycythemia induced by transfusion of erythrocytes. Am. J. Physiol. 148: 152-163, 1947.
9. Richalet, J. P. The French scientific expedition to Numbur, autumn 1981. In: Progress in Clinical and Biological Research; Hypoxia, Exercise and Altitude, edited by J. R. Sutton, C. S. Houston, and N. L. Jones. New York: Liss, 1983, p. 189-195.
10. Robertson, R. J., R. Gilcher, K. F. Metz, C. J. Caspersen, T. G. Allison, R. A. Abbott, G. S. Skrinar, J. R. Krause, and P. A. Nixon. Hemoglobin concentration and aerobic work capacity in women following induced erythrocythemia. J. Appl. Physiol. 57: 568-575, 1984.
11. Robertson, R. J., R. Gilcher, K. F. Metz, C. J. Caspersen, T. G. Allison, R. A. Abbott, G. S. Skrinar, J. R. Krause, and P. A. Nixon. Effect of simulated altitude erythrocythemia in women on hemoglobin flow rate during exercise. J. Appl. Physiol. 64: 1644-1649, 1988.
12. Robertson, R. J., R. Gilcher, K. F. Metz, G. S. Skrinar, T. G. Allison, H. T. Bahnson, R. A. Abbott, R. Becker, and J. E. Falkel. Effect of induced erythrocythemia on hypoxia tolerance during physical exercise. J. Appl. Physiol. 53: 490-495, 1982.
13. Sawka, M. N., and A. J. Young. Acute polycythemia and human performance during exercise and exposure to extreme environments. In: Exercise and Sports Science Review, edited by K. B. Pandolf. Baltimore, MD: Williams & Wilkins, 1989, p. 265-293.
14. Sawka, M. N., A. J. Young, P. B. Rock, T. P. Lyons, R. Boushel, B. J. Fruend, S. R. Muza, A. Cymerman, R. C. Dennis, K. B. Pandolf and C. R. Valeri. Altitude acclimatization and blood volume: effects of exogenous erythrocyte expansion. J. Appl. Physiol. In press.
15. Sawka, M. N., A. J. Young, S. R. Muza, R. R. Gonzalez, and K. B. Pandolf. Erythrocyte reinfusion and maximal aerobic power: examination of modifying factors. J. Am. Med. Assoc. 257: 1496-1499, 1987.
16. Spriet, L. L. Blood doping and oxygen transport. In: Perspectives in Exercise Science and Sports Medicine. Ergogenics - Enhancement of Performance, edited by D. R. Lamb and M. H. Williams. Indianapolis, IN: Brown & Benchmark, 1991, vol. 4, p. 213-248.
17. Spriet, L. L., N. Gledhill, A. B. Froese, and D. L. Wilkes. Effect of graded erythrocythemia on cardiovascular and metabolic responses to exercise. J. Appl. Physiol. 61: 1942-1948, 1986.
18. Thomson, J. M., J. A. Stone, A. D. Ginsburg, and P. Hamilton. Oxygen transport during exercise following blood reinfusion. J. Appl. Physiol. 53: 1213-1219, 1982.
19. Valeri, C. R., L. E. Pivacek, A. D. Gray, G. P. Cassidy, M. E. Levy, R. C. Dennis, A. J. Melaragno, J. Neihoff, N. Yeston, C. P. Emerson, and M. D. Altschule. The safety and therapeutic effectiveness of human red cells stored at -80°C for as long as 21 years. Transfusion 29: 429-437, 1989.
20. Wagner, P. D., J. R. Sutton, J. T. Reeves, A. Cymerman, B. M. Groves, and M. K. Malconian, Operation Everest II: pulmonary gas exchange during a simulated ascent of Mt. Everest. J. Appl. Physiol. 63: 2348-2359, 1987.
21. West, J. R., S. Lahiri, M. B. Gill, J. S. Milledge, L. G. C. E. Pugh, and M. P. Ward. Arterial oxygen saturation during exercise at high altitude. J. Appl. Physiol. 17: 617-621, 1962.
22. Young, A. J. Energy substrate utilization during exercise in extreme environments. In: Exercise and Sports Science Review, edited by K. B. Pandolf and J. O. Holloszy. Baltimore, MD: Williams & Wilkins, 1990, p. 65-117.
23. Young, A. J., A. Cymerman, and R. L. Burse. The influence of cardiorespiratory fitness on the decrement in maximal aerobic power at high altitude. Eur. J. Appl. Physiol. Occup. Physiol. 54: 12-15, 1985.