Altitude acclimatization and blood volume: Effects of exogenous erythrocyte volume expansion

Journal of Applied Physiology

Volumn 81, Issue 2, 1996, Pages 636-642

  Sawka, Michael N ^a   Young, Andrew J ^b   Rock, Paul B ^b   Lyons, Timothy P ^b   Boushel, Robert ^b   Freund, Beau J ^b   Muza, Stephen R ^b   Cymerman, Allen ^b   Dennis, Richard C ^b   Pandolf, Kent B ^b   Valeri, C Robert ^b  

^a U S ARMY RESEARCH INSTITUTE OF ENVIRONMENTAL MEDICINE   (United States)

^b NONE

Author keywords

erythropoietin; hypoxia; mean arterial pressure; plasma protein; plasma volume

Indexed keywords

ADAPTATION; ADULT; ALKALOSIS; ALTITUDE ACCLIMATIZATION; ARTICLE; BLOOD VESSEL PERMEABILITY; BLOOD VOLUME; ERYTHROCYTE VOLUME; HEMATOCRIT; HUMAN; HUMAN EXPERIMENT; HYDROSTATIC PRESSURE; MALE; MEAN ARTERIAL PRESSURE; NORMAL HUMAN; OXYGEN BLOOD LEVEL; PLASMA VOLUME; PRIORITY JOURNAL; RETICULOCYTE;

EID: 9544257289     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1996.81.2.636     Document Type: Article

References (45)

1. Alexander, J. K., L. H. Hartley, M. Modelski, and R. F. Grover. Reduction of stroke volume during exercise in man following ascent to 3,100 m altitude. J. Appl. Physiol. 23: 849-858, 1967.
2. Barbashova, Z. I. Cellular level of adaptation. In: Handbook of Physiology. Adaptation to the Environment. Washington, DC: Am. Physiol. Soc., 1964, sect. 4, chapt. 4, p. 37-54.
3. Berglund, B., and B. Ekblom. Effect of recombinant human erythropoietin treatment on blood pressure and some hematological parameters in healthy men. J. Intern. Med. 229: 125-130, 1991.
4. Bozzani, C. E., R. M. Alippi, and M. A. Martinez. The inhibitory effect of relative polycythemia on erythropoietin production in response to hypoxic hypoxia. Acta Physiol. Latinoam. 21: 293-296, 1971.
5. Bunn, H. F. Pathophysiology of the anemias. In: Harrison's Principles of Internal Medicine, edited by K. J. Isselbacher, E. Braunwald, J. D. Wilson, J. B. Martin, A. S. Fauci, and D. L. Kasper. New York: McGraw-Hill, 1994, p. 1717-1721.
6. Eckardt, K.-U., U. Boutellier, A. Kurtz, M. Schopen, E. A. Koller, and C. Bauer. Rate of erythropoietin formation in humans in response to acute hypobaric hypoxia. J. Appl. Physiol. 66: 1785-1788, 1989.
7. Grover, R. F., J. V. Weil, and J. T. Reeves. Cardiovascular adaptations to exercise at high altitude. Exercise Sport Sci. Rev. 14: 269-302, 1986.
8. Gunga, H.-C., K. Kirsch, L. Rocker, and W. Schobersberger. Time course of erythropoietin, triiodothyronine, thyroxine, and thyroid-stimulating hormone at 2,315 m. J. Appl. Physiol. 76: 1068-1072, 1994.
9. Hannon, J. P., K. S. K. Chinn, and J. L. Shields. Effects of acute high-altitude exposure on body fluids. Federation Proc. 28: 1178-1184, 1969.
10. Hartley, L. H., J. K. Alexander, M. Modelski, and R. F. Grover. Subnormal cardiac output at rest and during exercise in residents at 3,100 m altitude. J. Appl. Physiol. 23: 839-848, 1967.
11. Hoyt, R. W., M. J. Durkot, V. A. Forte, L. J. Hubbard, L. A. Trad, and A. Cymerman. Hypobaric hypoxia (380 Torr) decreases intracellular and total body water in goats. J. Appl. Physiol. 71: 509-513, 1991.
12. Hoyt, R. W., and A. R. Honig. Body fluid and energy metabolism at high altitude. In: Handbook of Physiology. Environmental Physiology. Bethesda, MD: Am. Physiol. Soc., 1996, sect. 4, vol. V, chapt. 55, p. 1277-1289.
13. Jain, S. C., J. Bardhan, Y. V. Swamy, B. Krishna, and H. S. Nayar. Body fluid compartments in humans during acute high-altitude exposure. Aviat. Space Environ. Med. 51: 234-236, 1980.
14. Krzywicki, H. J., C. F. Consolazio, L. O. Matoush, H. L. Johnson, and R. A. Barnhart. Body composition changes during exposure to altitude. Federation Proc. 28: 1190-1194, 1969.
15. Longmuir, I. S. Adaptation to hypoxia. Adv. Exp. Med. Biol. 215: 249-254, 1987.
16. Miles, D. S., D. R. Bransford, and S. M. Horvath. Hypoxia effects on plasma volume shifts at rest, work, and recovery in supine posture. J. Appl. Physiol. 51: 148-153, 1981.
17. Miles, D. S., M. N. Sawka, R. M. Glaser, and J. S. Petrofski. Plasma volume shifts during progressive arm and leg exercise. J. Appl. Physiol. 54: 491-495, 1983.
18. Miller, M. E., M. Rorth, H. H. Parving, D. Howard, I. Reddington, C. R. Valeri, and F. Stohlman. pH effect on erythropoietin response to hypoxia. N. Engl. J. Med. 288: 706-710, 1973.
19. Moncada, S., R. M. J. Palmer, and E. A. Higgs. Nitric oxide: physiology, pathophysiology, and pharmacology. Physiol. Rev. 43: 109-142, 1991.
20. Myhre, L. G., D. B. Dill, F. G. Hall, and D. K. Brown. Blood volume changes during three-week residence at high altitude. Clin. Chem. 16: 7-14, 1970.
21. Nguyen, L. S., A. C. Villablanca, and J. C. Rutledge. Substance P increases microvascular permeability via nitric oxide-mediated convective pathways. Am. J. Physiol. 268 (Regulatory Integrative Comp. Physiol. 37): R1060-R1068, 1995.
22. Parving, H.-H. The effect of hypoxia and carbon monoxide exposure on plasma volume and capillary permeability to albumin. Scand. J. Clin. Invest. 30: 49-56, 1972.
23. Poter, D. L., and M. A. Goldberg. Regulation of erythropoietin. Exp. Hematol. 21: 399-404, 1993.
24. Pugh, L. G. C. E. Blood volume and haemoglobin concentration at altitudes above 14,000 ft (5,500 m). J. Physiol. Lond. 170: 344-354, 1964.
25. Ray, C. A., K. J. Cureton, and H. G. Ouzts. Postural specificity of cardiovascular adaptations to exercise training. J. Appl. Physiol. 69: 2202-2208, 1990.
26. Reeves, J. T., L. G. Moore, E. E. Wolfel, R. S. Mazzeo, A. Cymerman, and A. J. Young. Activation of the sympathoadrenal system at high altitude. In: High Altitude Medicine, edited by G. Veda. Matsumato, Japan: Sinshu Univ. Press, 1992, p. 10-23.
27. Richalet, J. P., A. Hornych, C. Rathat, J. Aumont, P. Larmignat, and P. Remy. Plasma prostaglandins, leukotrienes, and thromboxane in acute high altitude hypoxia. Respir. Physiol. 85: 205-215, 1991.
28. Sanchez, C., C. Merino, and M. Figallo. Simultaneous measurement of plasma volume and cell mass in polycythemia of high altitude. J. Appl. Physiol. 28: 775-778, 1970.
29. Sawka, M. N. Body fluid responses and hypohydration during exercise-heat stress. In: Human Performance Physiology and Environmental Medicine at Terrestrial Extremes, edited by K. B. Pandolf, M. N. Sawka, and R. R. Gonzalez. Indianapolis, IN: Cooper Publishing Group, 1988, p. 227-266.
30. Sawka, M. N., R. C. Dennis, R. R. Gonzalez, A. J. Young, S. M. Muza, J. W. Martin, C. B. Wenger, R. P. Francesconi, and C. R. Valeri. Influence of polycythemia on blood volume and thermoregulation during exercise-heat stress. J. Appl. Physiol. 62: 912-918, 1987.
31. Sawka, M. N., A. J. Young, K. B. Pandolf, R. C. Dennis, and C. R. Valeri. Erythrocyte, plasma, and blood volume of healthy young men. Med. Sci. Sports Exercise 24: 447-453, 1992.
32. 2H labeled water. Am. J. Clin. Nutr. 33: 2686-2693, 1980.
33. Siggaard-Andersen, J., F. B. Petersen, T. I. Hansen, and K. Mellemgaard. Plasma volume and vascular permeability during hypoxia and carbon monoxide exposure. Scand. J. Clin. Lab. Invest. Suppl. 103: 39-48, 1968.
34. Stamler, J. S., D. J. Singel, and J. Loscalzo. Biochemistry of nitric oxide and its redox-activated forms. Science Wash. DC 258: 1898-1902, 1992.
35. Stokke, K. T., K. Rootwelt, R. Wergeland, and J. R. Vale. Changes in plasma and red cell volumes during exposure to high altitude. Scand. J. Clin. Lab. Invest. 46, Suppl. 184: 113-117, 1986.
36. Surks, M. I. Metabolism of serum albumin in man during acute exposure to high altitude (14,100 feet). J. Clin. Invest. 45: 1442-1451, 1966.
37. Surks, M. I., K. K. Chinn, and L. R. Matoush. Alterations in body composition in man after acute exposure to high altitude. J. Appl. Physiol. 21: 1741-1746, 1966.
38. Valeri, C. R., L. E. Pivacek, A. D. Gray, G. P. Cassidy, M. E. Levy, R. C. Dennis, A. J. Melaragno, J. Neihoff, N. Yeston, C. P. Emerson, and M. D. Altschule. The safety and therapeutic effectiveness of human red cells stored at -80°C for as long as 21 years. Transfusion 29: 429-437, 1989.
39. Weil, J. V., G. Jamieson, D. W. Brown, and R. F. Grover. The red cell mass-arterial oxygen relationship in normal man. J. Clin. Invest. 47: 1627-1639, 1968.
40. Westergaard, H., S. Jarnum, R. Preisig, K. Ramsoe, J. Tauber, and N. Tygstrup. Degradation of albumin and IgG at high altitude. J. Appl. Physiol. 28: 728-732, 1970.
41. Winslow, R. M. High-altitude polycythemia. In: High Altitude and Man, edited by J. B. West and S. Lahiri. Bethesda, MD: Am. Physiol. Soc., 1984, p. 163-172.
42. Wolfel, E. E., B. M. Groves, G. A. Brooks, G. E. Butterfield, R. Mazzeo, L. G. Moore, J. R. Sutton, P. R. Bender, T. E. Dahms, R. E. McCullough, R. G. McCullough, S.-Y. Haung, S.-F. Sun, R. F. Grover, H. N. Hultgren, and J. T. Reeves. Oxygen transport during steady-state submaximal exercise in chronic hypoxia. J. Appl. Physiol. 70: 1129-1136, 1991.
43. 2max at high altitude. J. Appl. Physiol. 81: 252-259, 1996.
44. Young, A. J., M. N. Sawka, M. D. Quigley, B. S. Cadarette, P. D. Neufer, R. C. Dennis, and C. R. Valeri. Role of thermal factors on aerobic capacity improvements with endurance training. J. Appl. Physiol. 75: 49-54, 1993.
45. Young, A. J., and P. M. Young. Human acclimatization to high terrestrial altitude. In: Human Performance Physiology and Environmental Medicine at Terrestrial Extremes, edited by K. B. Pandolf, M. N. Sawka, and R. R. Gonzalez. Indianapolis, IN: Cooper Publishing Group, 1988, p. 497-543.