Triptolide preserves cognitive function and reduces neuropathology in a mouse model of Alzheimer's disease

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Cheng, Shaowu ^a   LeBlanc, Kyle J ^a   Li, Ling ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; INSULINASE; TRIPTOLIDE; AMYLOID PRECURSOR PROTEIN; DITERPENE; EPOXIDE; PHENANTHRENE DERIVATIVE; PRESENILIN 1;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG DOSE REDUCTION; DRUG EFFECT; DRUG MECHANISM; DRUG RESPONSE; FEMALE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LEARNING DISORDER; MEMORY DISORDER; MOUSE; NERVOUS SYSTEM INFLAMMATION; NEUROPATHOLOGY; NONHUMAN; PROTEIN DEGRADATION; SPATIAL MEMORY; STEADY STATE; ANIMAL; ANXIETY; BRAIN; COGNITION; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; HABITUATION; INFLAMMATION; MEMORY DISORDERS; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PROTEIN PROCESSING; TRANSGENIC MOUSE; UPREGULATION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANXIETY; BRAIN; COGNITION; DISEASE MODELS, ANIMAL; DITERPENES; EPOXY COMPOUNDS; HABITUATION, PSYCHOPHYSIOLOGIC; INFLAMMATION; MEMORY DISORDERS; MICE; MICE, TRANSGENIC; PHENANTHRENES; PRESENILIN-1; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEOLYSIS; UP-REGULATION;

EID: 84907515230     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0108845     Document Type: Article

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