Natural product triptolide mediates cancer cell death by triggering CDK7-dependent degradation of RNA polymerase II

Cancer Research

Volumn 72, Issue 20, 2012, Pages 5363-5373

  Manzo, Stefano Giustino ^a   Zhou, Zhao Li ^b   Wang, Ying Qing ^b   Marinello, Jessica ^a   He, Jin Xue ^b   Li, Yuan Chao ^b   Ding, Jian ^b   Capranico, Giovanni ^a   Miao, Ze Hong ^b  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 7; CYCLIN DEPENDENT KINASE INHIBITOR; NATURAL PRODUCT; PROTEASOME INHIBITOR; PROTEIN RPB1; RNA POLYMERASE II; SERINE; TRANSCRIPTION FACTOR; TRIPTOLIDE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG TARGETING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; UBIQUITINATION;

BASE SEQUENCE; BIOLOGICAL AGENTS; CELL DEATH; CELL LINE, TUMOR; CHROMATIN IMMUNOPRECIPITATION; CYCLIN-DEPENDENT KINASES; DITERPENES; DNA PRIMERS; EPOXY COMPOUNDS; HUMANS; NEOPLASMS; PHENANTHRENES; PHOSPHORYLATION; PROTEOLYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA POLYMERASE II;

EID: 84867569542     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-12-1006     Document Type: Article

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