Farnesyltransferase haplodeficiency reduces neuropathology and rescues cognitive function in a mouse model of Alzheimer disease

Journal of Biological Chemistry

Volumn 288, Issue 50, 2013, Pages 35952-35960

  Cheng, Shaowu ^a   Cao, Dongfeng ^a   Hottman, David A ^a   Yuan, LiLian ^a   Bergo, Martin O ^b   Li, Ling ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

COGNITIVE FUNCTIONS; FARNESYLTRANSFERASE; GERANYLGERANYLATION; LEARNING AND MEMORY; NEUROINFLAMMATION; PRECURSOR PROTEINS; PRENYLTRANSFERASES; SYNAPTIC PLASTICITY;

GLYCOPROTEINS; MAMMALS; NEURODEGENERATIVE DISEASES; PLANTS (BOTANY);

PROTEINS;

AMYLOID BETA PROTEIN; GERANYLGERANYLTRANSFERASE 1; PROTEIN FARNESYLTRANSFERASE; TRANSFERASE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASSOCIATION; COGNITION; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE MODEL; FEMALE; GENE DELETION; HAPLOINSUFFICIENCY; HETEROZYGOSITY; LEARNING DISORDER; MALE; MEMORY CONSOLIDATION; MEMORY DISORDER; MOUSE; NERVOUS SYSTEM INFLAMMATION; NEUROPATHOLOGY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FARNESYLATION; PROTEIN GERANYLGERANYLATION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; SPATIAL LEARNING; TRANSGENIC MOUSE;

ALZHEIMERS DISEASE; AMYLOID; ISOPRENOID; LEARNING AND MEMORY; NEUROINFLAMMATION; PROTEIN PRENYLATION; TRANSGENIC MICE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; BRAIN; COGNITION; DISEASE MODELS, ANIMAL; FARNESYLTRANSTRANSFERASE; GENE DELETION; MEMORY; MICE; MICE, TRANSGENIC; PROTEOLYSIS;

EID: 84890351522     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.503904     Document Type: Article

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