Oral administration of triptolide ameliorates the clinical signs of experimental autoimmune encephalomyelitis (EAE) by induction of HSP70 and stabilization of NF-κB/IκBα transcriptional complex

Journal of Neuroimmunology

Volumn 217, Issue 1-2, 2009, Pages 28-37

  Kizelsztein, Pablo ^a   Komarnytsky, Slavko ^a   Raskin, Ilya ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

EAE; Hsp70; Inflammation; NF B; Oral; Triptolide

Indexed keywords

HEAT SHOCK PROTEIN 70; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; TRIPTERYGIUM WILFORDII EXTRACT; TRIPTOLIDE;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DEMYELINATION; DRUG EFFICACY; FEMALE; IMMUNOMODULATION; IN VITRO STUDY; LYMPH NODE CELL; MACROPHAGE; MOUSE; NONHUMAN; PRIMARY PREVENTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RECURRENCE RISK;

ADMINISTRATION, ORAL; ANALYSIS OF VARIANCE; ANIMALS; CELL LINE, TRANSFORMED; CYTOKINES; CYTOPLASM; DISEASE MODELS, ANIMAL; DITERPENES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; EPOXY COMPOUNDS; HSP70 HEAT-SHOCK PROTEINS; I-KAPPA B PROTEINS; IMMUNOPRECIPITATION; IMMUNOSUPPRESSIVE AGENTS; LYMPH NODES; MACROPHAGES; MICE; MYELIN PROTEOLIPID PROTEIN; NF-KAPPA B; PEPTIDE FRAGMENTS; PHENANTHRENES; PHOSPHORYLATION; PHYTOTHERAPY; RNA, MESSENGER; SIGNAL TRANSDUCTION; TIME FACTORS; TRIPTERYGIUM; UP-REGULATION;

EID: 70449635134     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2009.08.017     Document Type: Article

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