Beta cell chromogranin B is partially segregated in distinct granules and can be released separately from insulin in response to stimulation

Diabetologia

Volumn 51, Issue 6, 2008, Pages 997-1007

  Giordano, T ^a,f   Brigatti, C ^a   Podini, P ^a   Bonifacio, E ^a,e   Meldolesi, J ^a,b,c,d   Malosio, M L ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^c National Institute of Neuroscience   (Italy)

^d Research Unit of Molecular Neuroscience   (Italy)

^e CENTER FOR REGENERATIVE THERAPIES DRESDEN   (Germany)

^f MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

Beta cell lines; Beta cells; Carbachol; Chromogranin B; INS 1E; Insulin; Ionomycin; Islets, dissociation of storage and secretion; Regulated secretion

Indexed keywords

CALCIUM ION; CARBACHOL; CHROMOGRANIN B; FORSKOLIN; GLUCOSE; INSULIN; IONOMYCIN; ISOBUTYLMETHYLXANTHINE;

ANIMAL CELL; ARTICLE; CELL FREE SYSTEM; CELL LINE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME LINKED IMMUNOSORBENT ASSAY; GOLGI COMPLEX; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOELECTRON MICROSCOPY; IMMUNOFLUORESCENCE; INSULIN RELEASE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SECRETION; RODENT; SECRETORY GRANULE; SENSITIVITY ANALYSIS; STIMULUS; THREE DIMENSIONAL IMAGING; TRANS GOLGI NETWORK;

1-METHYL-3-ISOBUTYLXANTHINE; ANIMALS; CARBACHOL; CELL LINE; CELL LINE, TUMOR; CHROMOGRANIN B; CYTOPLASMIC GRANULES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FORSKOLIN; GLUCOSE; IMAGE PROCESSING, COMPUTER-ASSISTED; INSULIN; INSULIN-SECRETING CELLS; IONOMYCIN; MICROSCOPY, IMMUNOELECTRON; RATS;

EID: 43049099615     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-008-0980-5     Document Type: Article

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