Flavonoid fraction of bergamot juice reduces LPS-induced inflammatory response through SIRT1-mediated NF-κB inhibition in THP-1 monocytes

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Risitano, Roberto ^a   Currò, Monica ^a   Cirmi, Santa ^a   Ferlazzo, Nadia ^a   Campiglia, Pietro ^b   Caccamo, Daniela ^a   Ientile, Riccardo ^a   Navarra, Michele ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF SALERNO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; FLAVONOID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; SIRTINOL; SIRTUIN 1; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; AUTACOID; CYTOKINE; PLANT EXTRACT;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; BERGAMOT JUICE; CITRUS BERGAMIA; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; FRUIT JUICE; GENE EXPRESSION; HUMAN; HUMAN CELL; MONOCYTE; PROTEIN ACETYLATION; RUTACEAE; ACETYLATION; CELL LINE; CELL SURVIVAL; CHEMISTRY; CITRUS; DRUG EFFECTS; ENZYME ACTIVATION; INFLAMMATION; METABOLISM; SIGNAL TRANSDUCTION;

ACETYLATION; CELL LINE; CELL SURVIVAL; CITRUS; CYTOKINES; ENZYME ACTIVATION; FLAVONOIDS; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MONOCYTES; NF-KAPPA B; PLANT EXTRACTS; SIGNAL TRANSDUCTION; SIRTUIN 1; TRANSCRIPTION FACTOR RELA;

EID: 84907426298     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0107431     Document Type: Article

References (43)

1. Karima R, Matsumoto S, Higashi H, Matsushima K (1999) The molecular pathogenesis of endotoxic shock and organ failure. Mol Med Today 5(3): 123-32.
2. Shacter E, Weitzman SA (2002) Chronic inflammation and cancer. Oncology (Williston Park) 16(2): 217-26, 229; discussion 230-2.
3. Manabe I (2011) Chronic inflammation links cardiovascular, metabolic and renal diseases. Circ J 75(12): 2739-48.
4. Prasad S, Sung B, Aggarwal BB (2012) Age-associated chronic diseases require age-old medicine: role of chronic inflammation. Prev Med 54 Suppl: S29-37.
5. Tripathi P, Aggarwal A (2006) NF-κB transcription factor: a key player in the generation of immune response. Current Science 90(4): 519-531.
6. Hayden MS, Ghosh S (2008) Shared principles in NF-kappaB signaling. Cell 132(3): 344-62.
7. Baeuerle PA, Baltimore D (1988) I kappa B: a specific inhibitor of the NF-kappa B transcription factor. Science 242(4878): 540-6.
8. Baldwin AS Jr (1996) The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 14: 649-83.
9. Karin M, Cao Y, Greten FR, Li ZW (2002) NF-kappaB in cancer: from innocent bystander to major culprit. Nat Rev Cancer 2(4): 301-10.
10. Nakanishi C, Toi M (2005) Nuclear factor-kappa B inhibitors as sensitizers to anticancer drugs. Nature Reviews Cancer 5(4): 297-309.
11. Kiernan R, Bres V, Ng RWM, Coudart MP, El Messaoudi S, et al. (2003) Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65. Journal of Biological Chemistry 278(4): 2758-2766.
12. Chen LF, Mu YJ, Greene WC (2002) Acetylation of ReIA at discrete sites regulates distinct nuclear functions of NF-kappa B. Embo Journal 21(23): 6539-6548.
13. Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, et al. (2003) Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425(6954): 191-196.
14. Grozinger CM, Chao ED, Blackwell HE, Moazed D, Schreiber SL (2001) Identification of a class of small molecule inhibitors of the sirtuin family of NADdependent deacetylases by phenotypic screening. Journal of Biological Chemistry 276(42): 38837-38843.
15. Trapp J, Jochum A, Meier R, Saunders L, Marshall B, et al. (2006) Adenosine mimetics as inhibitors of NAD(+)-dependent histone deacetylases, from kinase to sirtuin inhibition. Journal of Medicinal Chemistry 49(25): 7307-7316.
16. Warner TD, Giuliano F, Vojnovic I, Bukasa A, Mitchell JA, et al. (1999) Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis. Proc Natl Acad Sci U S A 96(13): 7563-7568.
17. Yamamoto Y, Gaynor RB (2001) Therapeutic potential of inhibition of the NF-kappa B pathway in the treatment of inflammation and cancer. Journal of Clinical Investigation 107(2): 135-142.
18. Harborne JB (1990) Role of Secondary Metabolites in Chemical Defense-Mechanisms in Plants. Ciba Foundation Symposia 154: 126-139.
19. Manach C, Scalbert A, Morand C, Remesy C, Jimenez L (2004) Polyphenols: food sources and bioavailability. American Journal of Clinical Nutrition 79(5): 727-747.
20. Bengmark S (2006) Impact of nutrition on ageing and disease. Current Opinion in Clinical Nutrition and Metabolic Care 9(1): 2-7.
21. Manach C, Mazur A, Scalbert A (2005) Polyphenols and prevention of cardiovascular diseases. Current Opinion in Lipidology 16(1): 77-84.
22. Kim DO, Lee KW, Lee HJ, Lee CY (2002) Vitamin C equivalent antioxidant capacity (VCEAC) of phenolic phytochemicals. Journal of Agricultural and Food Chemistry 50(13): 3713-3717.
23. Eberhardt MV, Lee CY, Liu RH (2000) Nutrition - Antioxidant activity of fresh apples. Nature 405(6789): 903-904.
24. Potapovich AI, Lulli D, Fidanza P, Kostyuk VA, De Luca C, et al. (2011) Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NF kappa B and AhR and EGFR-ERK pathway. Toxicology and Applied Pharmacology 255(2): 138-149.
25. Kostyuk VA, Potapovich AI, Suhan TO, de Luca C, Korkina LG (2011) Antioxidant and signal modulation properties of plant polyphenols in controlling vascular inflammation. European Journal of Pharmacology 658(2-3): 248-256.
26. Corasaniti MT, Maiuolo J, Maida S, Fratto V, Navarra M, et al. (2007) Cell signaling pathways in the mechanisms of neuroprotection afforded by bergamot essential oil against NMDA-induced cell death in vitro. British Journal of Pharmacology 151(4): 518-529.
27. Miceli N, Mondello MR, Monforte MT, Sdrafkakis V, Dugo P, et al. (2007) Hypolipidemic effects of Citrus bergamia Risso et Poiteau juice in rats fed a hypercholesterolemic diet. Journal of Agricultural and Food Chemistry 55(26): 10671-10677.
28. Mollace V, Sacco I, Janda E, Malara C, Ventrice D, et al. (2011) Hypolipemic and hypoglycaemic activity of bergamot polyphenols: From animal models to human studies. Fitoterapia 82(3): 309-316.
29. Delle Monache S, Sanita P, Trapasso E, Ursino MR, Dugo P, et al. (2013) Mechanisms Underlying the Anti-Tumoral Effects of Citrus bergamia Juice. Plos One 8(4).
30. Navarra M, Ursino MR, Ferlazzo N, Russo M, Schumacher U, et al. (2014) Effect of Citrus bergamia juice on human neuroblastoma cells in vitro and in metastatic xenograft models. Fitoterapia 95: 83-92.
31. Visalli G, Ferlazzo N, Cirmi S, Campiglia P, Gangemi S, et al. (2014) Bergamot Juice Extract Inhibits Proliferation by Inducing Apoptosis in Human Colon Cancer Cells. Anticancer Agents Med Chem 14 (9).
32. Sommella E, Pepe G, Pagano F, Tenore GC, Dugo P, et al. (2013) Ultra high performance liquid chromatography with ion-trap TOF-MS for the fast characterization of flavonoids in Citrus bergamia juice. J Sep Sci 36(20): 3351-5.
33. Sharif O, Bolshakov VN, Raines S, Newham P, Perkins ND (2007) Transcriptional profiling of the LPS induced NF-kappaB response in macrophages. BMC Immunol 8: 1.
34. Sakharwade SC, Sharma PK, Mukhopadhaya A (2013) Vibrio cholerae porin OmpU induces pro-inflammatory responses, but down-regulates LPS-mediated effects in RAW 264.7, THP-1 and human PBMCs. Plos One 8(9): e76583.
35. Kim D, Kim JY (2014) Anti-CD14 antibody reduces LPS responsiveness via TLR4 internalization in human monocytes. Mol Immunol 57(2): 210-5.
36. Chanput W, Mes J, Vreeburg RA, Savelkoul HF, Wichers HJ (2010) Transcription profiles of LPS-stimulated THP-1 monocytes and macrophages: a tool to study inflammation modulating effects of food-derived compounds. Food Funct 1(3): 254-61.
37. Schildberger A, Rossmanith E, Eichhorn T, Strassl K, Weber V (2013) Monocytes, peripheral blood mononuclear cells, and THP-1 cells exhibit different cytokine expression patterns following stimulation with lipopolysaccharide. Mediators Inflamm 2013: 697972.
38. Hegde PS, White IR, Debouck C (2004) Interplay of transcriptomics and proteomics. Drug Discov Today 9(2 Suppl): S53-6.
39. Chen LF, Greene WC (2003) Regulation of distinct biological activities of the NF-kappaB transcription factor complex by acetylation. J Mol Med (Berl) 81(9): 549-57.
40. Yao H, Rahman I (2012) Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence. Biochem Pharmacol 84(10): 1332-9.
41. Xie J, Zhang X, Zhang L (2013) Negative regulation of inflammation by SIRT1. Pharmacological Research 67(1): 60-7.
42. Middleton E Jr, Kandaswami C, Theoharides TC (2000) The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 52(4): 673-751.
43. Gonzalez R, Ballester I, Lopez-Posadas R, Suarez MD, Zarzuelo A, et al. (2011) Effects of flavonoids and other polyphenols on inflammation. Crit Rev Food Sci Nutr 51(4): 331-62.