Impact of nutrition on ageing and disease

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 9, Issue 1, 2006, Pages 2-7

  Bengmark, Stig ^a,b,c  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

Advanced glycation end products; Ageing; Chronic diseases; Inflammation; Lifestyle; Telomeres

Indexed keywords

ALPHA TOCOPHEROL; CYANOCOBALAMIN; FOLIC ACID; FRUCTOSE OLIGOSACCHARIDE; POLYPHENOL; PROBIOTIC AGENT; VITAMIN;

AGING; ALCOHOL CONSUMPTION; BIFIDOBACTERIUM LONGUM; CALORIC INTAKE; DAIRY PRODUCT; DIET; DIET RESTRICTION; DIET SUPPLEMENTATION; DNA REPAIR; EXERCISE; FISH; GENERAL ASPECTS OF DISEASE; GLYCATION; HUMAN; IMMUNE SYSTEM; IMMUNITY; INFLAMMATION; LIFESPAN; NERVOUS SYSTEM; NUTRITION; REVIEW; SMOKING; VASCULAR ENDOTHELIUM; VITAMIN SUPPLEMENTATION; AGED; IMMUNOLOGY; LIFESTYLE; METHODOLOGY; PHYSIOLOGY; PREVENTIVE MEDICINE;

AGED; AGING; DIET; DISEASE; HUMANS; LIFE STYLE; NUTRITION PHYSIOLOGY; PREVENTIVE MEDICINE;

EID: 33646247871     PISSN: 13631950     EISSN: 15353885     Source Type: Journal    
DOI: 10.1097/01.mco.0000171129.29278.26     Document Type: Review

References (49)

1. Bengmark S. Acute and 'chronic' phase response: a mother of disease. Clin Nutr 2004; 23:1256-1266.
2. The World Health Report 2002: reducing risks, promoting healthy lifestyle. Geneva: World Health Organization, 2002.
3. Heffler S, Smith S, Keehan S, et al. Health spending projections for 2002-2012. Health Aff (Millwood) Web Exclusives 2003; W3 (Suppl):54-65.
4. Adams JM, Whiter M. Biological ageing: a fundamental, biological link between socio-economic status and health. Eur J Public Health 2004; 14:331-334. Important report emphasizing the higher incidence of age-related chronic diseases in the under-privileged.
5. von Zglinicki T. Oxidative stress shortens telomeres. Trends Biochem Sci 2002; 27:339-344.
6. von Zglinicki T, Serra V, Lorenz M, et al. Short telomeres in patients with vascular dementia: an indicator of low antioxidative capacity and a possible prognostic factor. Lab Invest 2000; 80:1739-1747.
7. Cawthorn R, Smith K, O'Brien E, et al. Association between telomere length in blood and mortality in people aged 60 or older. Lancet 2003; 361:393-395.
8. Raj DS, Lim G, Levi M, et al. Advanced glycation end products and oxidative stress are increased in chronic allograft nephropathy. Am J Kidney Dis 2004; 43:154-160. Significant study of the role of AGEs in premature ageing.
9. Odetti P, Rossi S, Monacelli F, et al. Advanced glycation end products and bone loss during aging. Ann N Y Acad Sci 2005; 1043:710-717. Significant study of the role of AGEs in premature bone loss.
10. Mullarkey CJ, Edelstein D, Brownlee M. Free radical generation by early glycation products: a mechanism for accelerated atherogenesis in diabetes. Biochem Biophys Res Commun 1990; 173:932-939.
11. Pitsavos C, Panagiotakos DB, Menotti A, et al. Forty-year follow-up of coronary heart disease mortality and its predictors: the Corfu cohort of the seven countries study. Prev Cardiol 2003; 6:155-160.
12. Koizumi J, Shimizu M, Miyamoto S, et al. Risk evaluation of coronary heart disease and cerebrovascular disease by the Japan Atherosclerosis Society Guidelines 2002 using the cohort of the Holicos-PAT study. J Atheroscler Thromb 2005; 12:48-52.
13. Armstrong B, Doll R. Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices, Int J Cancer 1975; 15:617-631.
14. Darnton-Hill I, Nishida C, James WPT. A life course approach to diet, nutrition and the prevention of chronic diseases. Public Health Nutr 2004; 7:101-121. Documents the global epidemic of increasing obesity, diabetes and other chronic diseases, especially in developing and transitional economies, and in the less affluent of these.
15. Angus DC, Linde-Zwirble WT, Lidicker J, et al. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome and associated costs of care. Crit Care Med 2001; 29:1303-1310.
16. Angus DC, Wax RS. Epidemiology of sepsis: an update. Crit Care Med 2001; 29:109-116.
17. Knoops KT, De Groot LCPGM, Kromhout D, et al. Mediterranean diet, lifestyle factors and 10 year mortality in elderly European men and women. JAMA 2004; 292:1433-1439. Documents that in individuals aged 70-90 years, adherence to a Mediterranean diet and healthy lifestyle is associated with a more than 50% lower rate of all-cause and cause-specific mortality.
18. Rimm EB, Stampfer MJ. Diet, lifestyle and longevity: the next steps? JAMA 2004; 292:1490-1492. Important summary of recent observations in the US of healthy lifestyle-associated decline in incidence of chronic diseases.
19. Stampfer MJ, Hu FB, Manson JE, et al. Primary prevention of coronary heart disease in women through diet and lifestyle. N Engl J Med 2000; 343:16-22.
20. Hu FB, Manson JE, Stampfer MJ, et al. Diet, lifestyle and the risk of type 2 diabetes mellitus in women. N Engl J Med 2001; 345:790-797.
21. Platz EA, Willett WC, Colditz GA, et al. Proportion of colon cancer risk that might be preventable in a cohort of middle-aged US men. Cancer Causes Control 2000; 11:579-588.
22. Trichopoulou A, Costacou T, Barmia Ch. Trichopoulou D. Adherence to a Mediterranean diet and survival in a Greek population. N Engl J Med 2003; 348:2599-2608.
23. Kuhlmann MK, Levin NW. Interaction between nutrition and inflammation in hemodialysis patients. Contrib Nephrol 2005; 149:200-207. Significant review on the role of AGEs in development of other morbidity in patients with chronic kidney disease.
24. Haslbeck KM, Schleicher E, Bierhaus A, et al. The AGE/RAGE/NF-(kappa)B pathway may contribute to the pathogenesis of polyneuropathy in impaired glucose tolerance (IGT). Exp Clin Endocrinol Diabetes 2005; 113:288-291. Significant review on the role of AGEs in pathogenesis of polynephropathies.
25. Gliguem H, Birlouez-Aragon I. Effects of sterilization, packaging, and storage on vitamin C degradation, protein denaturation, and glycation in fortified milks. J Dairy Sci 2005; 88:891-899. Describes how sterilization, packing and storage of milk induces vitamin C degradation, protein denaturation, and production of AGEs.
26. Ahmed N, Mirshekar-Syahkal B, Kennish L, et al. Assay of advanced glycation end products in selected beverages and food by liquid chromatography with tandem mass spectrometric detection. Mol Nutr Food Res 2005; 49:691-699. Provides information regarding content of AGEs in some foods.
27. McCarty MF. The low-AGE content of low-fat vegan diets could benefit diabetics: though concurrent taurine supplementation may be needed to minimize endogenous AGE production. Med Hypotheses 2005; 64:394-398. Demonstrates the significant reduction in AGEs as a result of a low-fat diet and supplementation of taurine.
28. Vlassara H. Advanced glycation in health and disease: role of the modern environment. Ann N Y Acad Sci 2005; 1043:452-460. Review summarizing how dietary AGE restriction is associated with suppression of several immune defects, insulin resistance, and diabetic complications, whether genetically or diet induced, despite persistent diabetes.
29. Yan H, Harding JJ. Carnosine protects against the inactivation of esterase induced by glycation and a steroid. Biochim Biophys Acta 2005; 1741:120-126. Provides evidence for carnosine's role as an antiglycation compound.
30. Hipkiss AR. Glycation, ageing and carnosine: are carnivorous diets beneficial? Mech Ageing Dev 2005; 12 June [Epub ahead of print]. Summarizes the possible beneficial effects of carnosine and related structures on protein carbonyl stress, AGE formation, secondary diabetic complications and age-related neuropathology.
31. Wu CH, Yen GC. Inhibitory effect of naturally occurring flavonoids on the formation of advanced glycation endproducts. J Agric Food Chem 2005; 533:167-173. Demonstrates that the inhibitory capability of flavonoids against protein glycation is significantly related to the scavenging of free radicals derived from the glycoxidation process.
32. Kiho T, Usui S, Hirano K, et al. Tomato paste fraction inhibiting the formation of advanced glycation end-products. Biosci Biotechnol Biochem 2004; 68:200-205. Demonstrates that rutin, a tomato-derived antioxidant, significantly contributes to inhibiting the formation of AGEs.
33. Osawa T, Kato Y. Protective role of antioxidative food factors in oxidative stress caused by hyperglycemia. Ann N Y Acad Sci 2005; 1043:440-451. Discusses the preventive role of various antioxidants and natural cyclooxygenase-2 inhibitors, curcuminoids, flavonoids and glutathione, against oxidative stress, and prevention of diabetic complications.
34. Mocchegiani E, Malavolta M. NK and NKT cell functions in immunosenescence. Aging Cell 2004; 3:177-184. Discusses the role of neuroendocrine-immune network and nutritional factors, such as zinc, in maintaining natural killer and NKT cell functions in ageing.
35. Larbi A, Dupuis G, Douziech N, et al. Low-grade inflammation with aging has consequences for T-lymphocyte signaling. Ann N Y Acad Sci 2004; 1030:125-133. Demonstrates a link between ageing, T-lymphocyte membrane lipid rafts, immunesenescence, and low-grade inflammation.
36. Fulop T, Larbi A, Douziech N, et al. Signal transduction and functional changes in neutrophils with aging. Aging Cell 2004; 3:217-226. Discusses how neutrophil membrane lipid rafts and alterations in neutrophil functions and signal transduction that occur during aging may contribute to the significant increase in infections in old age.
37. van den Biggelaar AH, Huizinga TW, de Craen AJ, et al. Impaired innate immunity predicts frailty in old age: the Leiden 85-plus study. Exp Gerontol 2004; 39:1407-1414. Important study showing that a malfunctioning innate immune response predicts frailty in old age and is under specific (immuno) genetic control.
38. DeVeale B, Brummel T, Seroude L. Immunity and aging: the enemy within? Aging Cell 2004; 3:195-208. Review suggesting that the immune response has a positive effect on longevity, possibly by increasing fitness, and that immunity may be an ally early in life, but turns out to be an enemy as we age.
39. Caruso C, Candore G, Colonna-Romano G, et al. Inflammation and life-span. Science 2005; 307:208-209.
40. Grant AM, Avenell A, Campbell MK, et al. Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial. Lancet 2005; 365:1621-1628. Study demonstrating the limited effects of routine oral supplementation with calcium and vitamin D3, either alone or in combination, for the prevention of further fractures in previously mobile elderly people.
41. Porthouse J, Cockayne S, King C, et al. Randomised controlled trial of calcium and supplementation with cholecalciferol (vitamin D3) for prevention of fractures in primary care. BMJ 2005; 330:1003. Finds there is no evidence that calcium and vitamin D supplementation reduces the risk of clinical fractures in women with one or more risk factors for hip fracture.
42. Avenell A, Handoll HH. Nutritional supplementation for hip fracture aftercare in older people. Cochrane Database Syst Rev 2005; 2:CD001880. Cochrane review demonstrating there are no or limited effects of nutritional supplementation in the aftercare of hip fractures.
43. Manach C, Williamson G, Morand C, et al. Bioavailability and bioefficacy of polyphenols in humans. I: Review of 97 bioavailability studies. Am J Clin Nutr 2005; 81 (Suppl 1):230S-242S. Review of 97 studies on bioavailability of polyphenols.
44. Williamson G, Manach C. Bioavailability and bioefficacy of polyphenols in humans. II: Review of 93 intervention studies. Am J Clin Nutr 2005; 81 (Suppl 1):243S-255S. Important review showing that the in-vivo effects of flavonoids are less pronounced than in vitro and suggesting that the length of human intervention studies should be increased to more closely reflect the long-term dietary consumption of polyphenols.
45. Tucker KL, Hallfrisch J, Qiao N, et al. Baltimore Longitudinal Study of Aging. The combination of high fruit and vegetable and low saturated fat intakes is more protective against mortality in aging men than is either alone: the Baltimore Longitudinal Study of Aging. J Nutr 2005; 135:556-561. Important study demonstrating that combining a diet low in saturated fat with a high intake of plant-derived food is more protective than either regime alone.
46. Bunout D, Barrera G, Hirsch S, et al. Effects of a nutritional supplement on the immune response and cytokine production in free-living Chilean elderly. JPEN J Parenter Enteral Nutr 2004; 28:348-354. Demonstrates that a specific nutritional supplement containing a probiotic nutritional supplement increases innate immunity and protects against infections in elderly people.
47. Del Piano M, Ballare M, Montino F, et al. Clinical experience with probiotics in the elderly on total enteral nutrition. J Clin Gastroenterol 2004; 38 (Suppl):S111-S114. No statistically significant difference in episodes of fever or diarrhea, use of antibiotics, or BMI was observed between elderly supplied with probiotics and a control group.
48. Darmadi-Blackberry I, Wahlquist ML, Kouris-Blazos A, et al. Legumes: the most important dietary predictor of survival in older people of different ethnicities. Asia Pacific J Clin Nutr 2004; 13:217-220. A most interesting five-country study identifying legumes as dietary predictors of survival in older age.
49. Reeves MJ, Rafferty AP. Healthy lifestyle characteristics among adults in the United States, 2000. Arch Intern Med 2005; 165:854-857. A study which documents a surprisingly low adherence to a healthy lifestyle in a developed Western society.