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Volumn 2014, Issue , 2014, Pages

Autophagy, warburg, and warburg reverse effects in human cancer

Author keywords

[No Author keywords available]

Indexed keywords

ANAEROBIC GLYCOLYSIS; AUTOPHAGY; CANCER GROWTH; CARCINOGENESIS; CELL ENERGY; CELL METABOLISM; CELLULAR, SUBCELLULAR AND MOLECULAR BIOLOGICAL PHENOMENA AND FUNCTIONS; FIBROBLAST; GLUCOSE METABOLISM; HUMAN; METABOLIC REGULATION; MITOCHONDRIAL RESPIRATION; NONHUMAN; REVIEW; SIGNAL TRANSDUCTION; STROMA CELL; WARBURG EFFCT; WARBURG REVERSE EFFECT; BIOLOGICAL MODEL; GLYCOLYSIS; METABOLISM; NEOPLASM; PATHOLOGY;

EID: 84907380852     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2014/926729     Document Type: Review
Times cited : (57)

References (99)
  • 1
    • 0442323561 scopus 로고    scopus 로고
    • Autophagy: In sickness and in health
    • A. M. Cuervo, "Autophagy: in sickness and in health," Trends in Cell Biology, vol. 14, no. 2, pp. 70-77, 2004.
    • (2004) Trends in Cell Biology , vol.14 , Issue.2 , pp. 70-77
    • Cuervo, A.M.1
  • 2
    • 1842583789 scopus 로고    scopus 로고
    • Development by self-digestion: Molecular mechanisms and biological functions of autophagy
    • B. Levine and D. J. Klionsky, "Development by self-digestion: molecular mechanisms and biological functions of autophagy," Developmental Cell, vol. 6, no. 4, pp. 463-477, 2004.
    • (2004) Developmental Cell , vol.6 , Issue.4 , pp. 463-477
    • Levine, B.1    Klionsky, D.J.2
  • 5
    • 74849087878 scopus 로고    scopus 로고
    • The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
    • S. Pavlides, D. Whitaker-Menezes, R. Castello-Cros et al., "The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma," Cell Cycle, vol. 8, no. 23, pp. 3984-4001, 2009.
    • (2009) Cell Cycle , vol.8 , Issue.23 , pp. 3984-4001
    • Pavlides, S.1    Whitaker-Menezes, D.2    Castello-Cros, R.3
  • 6
    • 33745192802 scopus 로고    scopus 로고
    • Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
    • T. Hara, K. Nakamura, M. Matsui et al., "Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice," Nature, vol. 441, no. 7095, pp. 885-889, 2006.
    • (2006) Nature , vol.441 , Issue.7095 , pp. 885-889
    • Hara, T.1    Nakamura, K.2    Matsui, M.3
  • 7
    • 33847404337 scopus 로고    scopus 로고
    • Autophagy gene-dependent clearance of apoptotic cells during embryonic development
    • X. Qu, Z. Zou, Q. Sun et al., "Autophagy gene-dependent clearance of apoptotic cells during embryonic development," Cell, vol. 128, no. 5, pp. 931-946, 2007.
    • (2007) Cell , vol.128 , Issue.5 , pp. 931-946
    • Qu, X.1    Zou, Z.2    Sun, Q.3
  • 8
    • 33645512801 scopus 로고    scopus 로고
    • Bcl-2 inhibition of autophagy: A new route to cancer?
    • S. Pattingre and B. Levine, "Bcl-2 inhibition of autophagy: a new route to cancer?" Cancer Research, vol. 66, no. 6, pp. 2885-2888, 2006.
    • (2006) Cancer Research , vol.66 , Issue.6 , pp. 2885-2888
    • Pattingre, S.1    Levine, B.2
  • 9
    • 8344242220 scopus 로고    scopus 로고
    • Autophagy in health and disease: A double-edged sword
    • T. Shintani and D. J. Klionsky, "Autophagy in health and disease: a double-edged sword," Science, vol. 306, no. 5698, pp. 990-995, 2004.
    • (2004) Science , vol.306 , Issue.5698 , pp. 990-995
    • Shintani, T.1    Klionsky, D.J.2
  • 10
    • 23344446037 scopus 로고    scopus 로고
    • Autophagy
    • D. J. Klionsky, "Autophagy," Current Biology, vol. 15, no. 8, pp. 282-283, 2005.
    • (2005) Current Biology , vol.15 , Issue.8 , pp. 282-283
    • Klionsky, D.J.1
  • 11
    • 0034537290 scopus 로고    scopus 로고
    • Autophagy as a regulated pathway of cellular degradation
    • D. J. Klionsky and S. D. Emr, "Autophagy as a regulated pathway of cellular degradation," Science, vol. 290, no. 5497, pp. 1717-1721, 2000.
    • (2000) Science , vol.290 , Issue.5497 , pp. 1717-1721
    • Klionsky, D.J.1    Emr, S.D.2
  • 12
    • 27644493346 scopus 로고    scopus 로고
    • The pleiotropic role of autophagy: From protein metabolism to bactericide
    • N. Mizushima, "The pleiotropic role of autophagy: from protein metabolism to bactericide," Cell Death & Differentiation, vol. 12, no. 2, pp. 1535-1541, 2005.
    • (2005) Cell Death & Differentiation , vol.12 , Issue.2 , pp. 1535-1541
    • Mizushima, N.1
  • 13
    • 10744225487 scopus 로고    scopus 로고
    • A unified nomenclature for yeast autophagy-related genes
    • D. J. Klionsky, J. M. Cregg, W. A. Dunn Jr. et al., "A unified nomenclature for yeast autophagy-related genes," Developmental Cell, vol. 5, no. 4, pp. 539-545, 2003.
    • (2003) Developmental Cell , vol.5 , Issue.4 , pp. 539-545
    • Klionsky, D.J.1    Cregg, J.M.2    Dunn, W.A.3
  • 14
    • 0000906170 scopus 로고    scopus 로고
    • Induction of autophagy and inhibition of tumorigenesis by beclin 1
    • X. H. Liang, S. Jackson, M. Seaman et al., "Induction of autophagy and inhibition of tumorigenesis by beclin 1," Nature, vol. 402, no. 6762, pp. 672-676, 1999.
    • (1999) Nature , vol.402 , Issue.6762 , pp. 672-676
    • Liang, X.H.1    Jackson, S.2    Seaman, M.3
  • 15
    • 25144457455 scopus 로고    scopus 로고
    • Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
    • S. Pattingre, A. Tassa, X. Qu et al., "Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy," Cell, vol. 122, no. 6, pp. 927-939, 2005.
    • (2005) Cell , vol.122 , Issue.6 , pp. 927-939
    • Pattingre, S.1    Tassa, A.2    Qu, X.3
  • 16
    • 33745751085 scopus 로고    scopus 로고
    • Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG
    • C. Liang, P. Feng, B. Ku et al., "Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG," Nature Cell Biology, vol. 8, no. 7, pp. 688-698, 2006.
    • (2006) Nature Cell Biology , vol.8 , Issue.7 , pp. 688-698
    • Liang, C.1    Feng, P.2    Ku, B.3
  • 17
    • 0035809160 scopus 로고    scopus 로고
    • Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase y sorting in Saccharomyces cerevisiae
    • A. Kihara, T. Noda, N. Ishihara, and Y. Ohsumi, "Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase y sorting in Saccharomyces cerevisiae," Journal of Cell Biology, vol. 153, no. 3, pp. 519-530, 2001.
    • (2001) Journal of Cell Biology , vol.153 , Issue.3 , pp. 519-530
    • Kihara, A.1    Noda, T.2    Ishihara, N.3    Ohsumi, Y.4
  • 18
    • 72549095406 scopus 로고    scopus 로고
    • Regulation mechanisms and signaling pathways of autophagy
    • C. He and D. J. Klionsky, "Regulation mechanisms and signaling pathways of autophagy," Annual Review of Genetics, vol. 43, pp. 67-93, 2009.
    • (2009) Annual Review of Genetics , vol.43 , pp. 67-93
    • He, C.1    Klionsky, D.J.2
  • 19
    • 77955884684 scopus 로고    scopus 로고
    • Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins
    • E. Itakura and N. Mizushima, "Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins," Autophagy, vol. 6, no. 6, pp. 764-776, 2010.
    • (2010) Autophagy , vol.6 , Issue.6 , pp. 764-776
    • Itakura, E.1    Mizushima, N.2
  • 20
    • 41449102022 scopus 로고    scopus 로고
    • A novel mammalian trans-membrane protein reveals an alternative initiation pathway for autophagy
    • M. I. Vaccaro, A. Ropolo, D. Grasso, and J. L. Iovanna, "A novel mammalian trans-membrane protein reveals an alternative initiation pathway for autophagy," Autophagy, vol. 4, no. 3, pp. 388-390, 2008.
    • (2008) Autophagy , vol.4 , Issue.3 , pp. 388-390
    • Vaccaro, M.I.1    Ropolo, A.2    Grasso, D.3    Iovanna, J.L.4
  • 21
    • 77951214016 scopus 로고    scopus 로고
    • Mammalian autophagy: Core molecular machinery and signaling regulation
    • Z. Yang and D. J. Klionsky, "Mammalian autophagy: core molecular machinery and signaling regulation," Current Opinion in Cell Biology, vol. 22, no. 2, pp. 124-131, 2010.
    • (2010) Current Opinion in Cell Biology , vol.22 , Issue.2 , pp. 124-131
    • Yang, Z.1    Klionsky, D.J.2
  • 22
    • 34250891313 scopus 로고    scopus 로고
    • AMP-activated protein kinase: A universal regulator of autophagy?
    • M. Høyer-Hansen and M. Jäättelä, "AMP-activated protein kinase: a universal regulator of autophagy?" Autophagy, vol. 3, pp. 381-383, 2007.
    • (2007) Autophagy , vol.3 , pp. 381-383
    • Høyer-Hansen, M.1    Jäättelä, M.2
  • 23
    • 79952281400 scopus 로고    scopus 로고
    • Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1
    • M. Zheng, Y. Wang, X. Wu et al., "Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1," Nature Cell Biology, vol. 13, no. 3, pp. 263-272, 2011.
    • (2011) Nature Cell Biology , vol.13 , Issue.3 , pp. 263-272
    • Zheng, M.1    Wang, Y.2    Wu, X.3
  • 25
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • S. Wullschleger, R. Loewith, and M. N. Hall, "TOR signaling in growth and metabolism," Cell, vol. 124, no. 3, pp. 471-484, 2006.
    • (2006) Cell , vol.124 , Issue.3 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 26
    • 77951768486 scopus 로고    scopus 로고
    • Ragulator-rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
    • Y. Sancak, L. Bar-Peled, R. Zoncu, A. L. Markhard, S. Nada, and D. M. Sabatini, "Ragulator-rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids," Cell, vol. 141, no. 2, pp. 290-303, 2010.
    • (2010) Cell , vol.141 , Issue.2 , pp. 290-303
    • Sancak, Y.1    Bar-Peled, L.2    Zoncu, R.3    Markhard, A.L.4    Nada, S.5    Sabatini, D.M.6
  • 27
    • 42949139481 scopus 로고    scopus 로고
    • AMPK phosphorylation of raptor mediates a metabolic checkpoint
    • D. M. Gwinn, D. B. Shackelford, D. F. Egan et al., "AMPK phosphorylation of raptor mediates a metabolic checkpoint," Molecular Cell, vol. 30, no. 2, pp. 214-226, 2008.
    • (2008) Molecular Cell , vol.30 , Issue.2 , pp. 214-226
    • Gwinn, D.M.1    Shackelford, D.B.2    Egan, D.F.3
  • 28
    • 48249092267 scopus 로고    scopus 로고
    • Bcl-2 family members: Dual regulators of apoptosis and autophagy
    • B. Levine, S. Sinha, and G. Kroemer, "Bcl-2 family members: dual regulators of apoptosis and autophagy," Autophagy, vol. 4, no. 5, pp. 600-606, 2008.
    • (2008) Autophagy , vol.4 , Issue.5 , pp. 600-606
    • Levine, B.1    Sinha, S.2    Kroemer, G.3
  • 29
    • 33645520907 scopus 로고    scopus 로고
    • Autophagy signaling and the cogwheels of cancer
    • J. Botti, M. Djavaheri-Mergny, Y. Pilatte, and P. Codogno, "Autophagy signaling and the cogwheels of cancer," Autophagy, vol. 2, no. 2, pp. 67-73, 2006.
    • (2006) Autophagy , vol.2 , Issue.2 , pp. 67-73
    • Botti, J.1    Djavaheri-Mergny, M.2    Pilatte, Y.3    Codogno, P.4
  • 30
    • 77955015772 scopus 로고    scopus 로고
    • Calcium and energy: Making the cake and eating it too?
    • D. R. Green and R. Wang, "Calcium and energy: making the cake and eating it too?" Cell, vol. 142, no. 2, pp. 200-202, 2010.
    • (2010) Cell , vol.142 , Issue.2 , pp. 200-202
    • Green, D.R.1    Wang, R.2
  • 32
    • 33646503655 scopus 로고    scopus 로고
    • Autophagy by ARF: A Short Story
    • C. J. Sherr, "Autophagy by ARF: a Short Story," Molecular Cell, vol. 22, no. 4, pp. 436-437, 2006.
    • (2006) Molecular Cell , vol.22 , Issue.4 , pp. 436-437
    • Sherr, C.J.1
  • 33
    • 33846260837 scopus 로고    scopus 로고
    • DRAM links autophagy to p53 and programmed cell death
    • D. Crighton, S. Wilkinson, and K. M. Ryan, "DRAM links autophagy to p53 and programmed cell death," Autophagy, vol. 3, no. 1, pp. 72-74, 2007.
    • (2007) Autophagy , vol.3 , Issue.1 , pp. 72-74
    • Crighton, D.1    Wilkinson, S.2    Ryan, K.M.3
  • 34
    • 75149171923 scopus 로고    scopus 로고
    • Control of basal autophagy by calpain1 mediated cleavage of ATG5
    • H. G. Xia, L. Zhang, G. Chen et al., "Control of basal autophagy by calpain1 mediated cleavage of ATG5," Autophagy, vol. 6, no. 1, pp. 61-66, 2010.
    • (2010) Autophagy , vol.6 , Issue.1 , pp. 61-66
    • Xia, H.G.1    Zhang, L.2    Chen, G.3
  • 36
    • 20144381544 scopus 로고    scopus 로고
    • Essential roles of Atg5 and FADD in autophagic cell death: Dissection of autophagic cell death into vacuole formation and cell death
    • J. O. Pyo, M. H. Jang, Y. K. Kwon et al., "Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death," The Journal of Biological Chemistry, vol. 280, no. 21, pp. 20722-20729, 2005.
    • (2005) The Journal of Biological Chemistry , vol.280 , Issue.21 , pp. 20722-20729
    • Pyo, J.O.1    Jang, M.H.2    Kwon, Y.K.3
  • 37
    • 33645916698 scopus 로고    scopus 로고
    • Inositol and IP3 levels regulate autophagy: Biology and therapeutic speculations
    • S. Sarkar and D. C. Rubinsztein, "Inositol and IP3 levels regulate autophagy: biology and therapeutic speculations," Autophagy, vol. 2, no. 2, pp. 132-134, 2006.
    • (2006) Autophagy , vol.2 , Issue.2 , pp. 132-134
    • Sarkar, S.1    Rubinsztein, D.C.2
  • 38
    • 34248994604 scopus 로고    scopus 로고
    • Small molecules enhance autophagy and reduce toxicity in Huntington's disease models
    • S. Sarkar, E. O. Perlstein, S. Imarisio et al., "Small molecules enhance autophagy and reduce toxicity in Huntington's disease models," Nature Chemical Biology, vol. 3, no. 6, pp. 331-338, 2007.
    • (2007) Nature Chemical Biology , vol.3 , Issue.6 , pp. 331-338
    • Sarkar, S.1    Perlstein, E.O.2    Imarisio, S.3
  • 39
    • 77951221542 scopus 로고    scopus 로고
    • The role of the Atg1/ULK1 complex in autophagy regulation
    • N. Mizushima, "The role of the Atg1/ULK1 complex in autophagy regulation," Current Opinion in Cell Biology, vol. 22, no. 2, pp. 132-139, 2010.
    • (2010) Current Opinion in Cell Biology , vol.22 , Issue.2 , pp. 132-139
    • Mizushima, N.1
  • 40
    • 37549012209 scopus 로고    scopus 로고
    • The pancreatitis-induced vacuole membrane protein 1 triggers autophagy in mammalian cells
    • A. Ropolo, D. Grasso, R. Pardo et al., "The pancreatitis-induced vacuole membrane protein 1 triggers autophagy in mammalian cells," Journal of Biological Chemistry, vol. 282, no. 51, pp. 37124-37133, 2007.
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.51 , pp. 37124-37133
    • Ropolo, A.1    Grasso, D.2    Pardo, R.3
  • 41
    • 79953144994 scopus 로고    scopus 로고
    • Zymophagy, a novel selective autophagy pathway mediated by VMP1-USP9x-p62, prevents pancreatic cell death
    • D. Grasso, A. Ropolo, A. Lo Ré et al., "Zymophagy, a novel selective autophagy pathway mediated by VMP1-USP9x-p62, prevents pancreatic cell death," Journal of Biological Chemistry, vol. 286, no. 10, pp. 8308-8324, 2011.
    • (2011) Journal of Biological Chemistry , vol.286 , Issue.10 , pp. 8308-8324
    • Grasso, D.1    Ropolo, A.2    Lo Ré, A.3
  • 42
    • 84864108090 scopus 로고    scopus 로고
    • Novel AKT1-GLI3-VMP1 pathway mediates KRAS oncogene-induced autophagy in cancer cells
    • A. E. Lo Ré, M. G. Fernández-Barrena, L. L. Almada et al., "Novel AKT1-GLI3-VMP1 pathway mediates KRAS oncogene-induced autophagy in cancer cells," The Journal of Biological Chemistry, vol. 287, no. 30, pp. 25325-25334, 2012.
    • (2012) The Journal of Biological Chemistry , vol.287 , Issue.30 , pp. 25325-25334
    • Lo Ré, A.E.1    Fernández-Barrena, M.G.2    Almada, L.L.3
  • 44
    • 77953713630 scopus 로고    scopus 로고
    • C. elegans screen identifies autophagy genes specific to multicellular organisms
    • Y. Tian, Z. Li, W. Hu et al., "C. elegans screen identifies autophagy genes specific to multicellular organisms," Cell, vol. 141, no. 6, pp. 1042-1055, 2010.
    • (2010) Cell , vol.141 , Issue.6 , pp. 1042-1055
    • Tian, Y.1    Li, Z.2    Hu, W.3
  • 45
    • 75149186608 scopus 로고    scopus 로고
    • Autophagy dysfunction and ubiquitin-positive protein aggregates in Dictyostelium cells lacking Vmp1
    • J. Calvo-Garrido and R. Escalante, "Autophagy dysfunction and ubiquitin-positive protein aggregates in Dictyostelium cells lacking Vmp1," Autophagy, vol. 6, no. 1, pp. 100-109, 2010.
    • (2010) Autophagy , vol.6 , Issue.1 , pp. 100-109
    • Calvo-Garrido, J.1    Escalante, R.2
  • 46
    • 77951476722 scopus 로고    scopus 로고
    • Gemcitabine induces the VMP1-mediated autophagy pathway to promote apoptotic death in human pancreatic cancer cells
    • R. Pardo, A. Lo Ré, C. Archange et al., "Gemcitabine induces the VMP1-mediated autophagy pathway to promote apoptotic death in human pancreatic cancer cells," Pancreatology, vol. 10, no. 1, pp. 19-26, 2010.
    • (2010) Pancreatology , vol.10 , Issue.1 , pp. 19-26
    • Pardo, R.1    Lo Ré, A.2    Archange, C.3
  • 47
    • 39849109338 scopus 로고    scopus 로고
    • Autophagy fights disease through cellular self-digestion
    • N. Mizushima, B. Levine, A. M. Cuervo, and D. J. Klionsky, "Autophagy fights disease through cellular self-digestion," Nature, vol. 451, no. 7182, pp. 1069-1075, 2008.
    • (2008) Nature , vol.451 , Issue.7182 , pp. 1069-1075
    • Mizushima, N.1    Levine, B.2    Cuervo, A.M.3    Klionsky, D.J.4
  • 48
    • 48249156591 scopus 로고    scopus 로고
    • Autophagy: An emerging target for cancer therapy
    • M. Høyer-Hansen and M. Jäättelä, "Autophagy: an emerging target for cancer therapy," Autophagy, vol. 4, pp. 574-580, 2008.
    • (2008) Autophagy , vol.4 , pp. 574-580
    • Høyer-Hansen, M.1    Jäättelä, M.2
  • 49
    • 0036036626 scopus 로고    scopus 로고
    • Cellular autophagic capacity changes during azaserine-induced tumour progression in the rat pancreas: Up-regulation in all premalignant stages and down-regulation with loss of cycloheximide sensitivity of segregation along with malignant transformation
    • S. Tóth, K. Nagy, Z. Pálfia, and G. Réz, "Cellular autophagic capacity changes during azaserine-induced tumour progression in the rat pancreas: up-regulation in all premalignant stages and down-regulation with loss of cycloheximide sensitivity of segregation along with malignant transformation," Cell and Tissue Research, vol. 309, no. 3, pp. 409-416, 2002.
    • (2002) Cell and Tissue Research , vol.309 , Issue.3 , pp. 409-416
    • Tóth, S.1    Nagy, K.2    Pálfia, Z.3    Réz, G.4
  • 50
    • 9144240441 scopus 로고    scopus 로고
    • Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
    • X. Qu, J. Yu, G. Bhagat et al., "Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene," Journal of Clinical Investigation, vol. 112, no. 12, pp. 1809-1820, 2003.
    • (2003) Journal of Clinical Investigation , vol.112 , Issue.12 , pp. 1809-1820
    • Qu, X.1    Yu, J.2    Bhagat, G.3
  • 51
    • 34147193472 scopus 로고    scopus 로고
    • Cell biology: Autophagy and cancer
    • B. Levine, "Cell biology: autophagy and cancer," Nature, vol. 446, pp. 745-747, 2007.
    • (2007) Nature , vol.446 , pp. 745-747
    • Levine, B.1
  • 54
    • 80052589806 scopus 로고    scopus 로고
    • High mobility group box 1 (HMGB1) activates an autophagic response to oxidative stress
    • D. Tang, R. Kang, K. M. Livesey, H. J. Zeh III, and M. T. Lotze, "High mobility group box 1 (HMGB1) activates an autophagic response to oxidative stress," Antioxidants & Redox Signaling, vol. 15, no. 8, pp. 2185-2195, 2011.
    • (2011) Antioxidants & Redox Signaling , vol.15 , Issue.8 , pp. 2185-2195
    • Tang, D.1    Kang, R.2    Livesey, K.M.3    Zeh, H.J.4    Lotze, M.T.5
  • 55
    • 77956386515 scopus 로고    scopus 로고
    • Endogenous HMGB1 regulates autophagy
    • D. Tang, R. Kang, K. M. Livesey et al., "Endogenous HMGB1 regulates autophagy," Journal of Cell Biology, vol. 190, no. 5, pp. 881-892, 2010.
    • (2010) Journal of Cell Biology , vol.190 , Issue.5 , pp. 881-892
    • Tang, D.1    Kang, R.2    Livesey, K.M.3
  • 56
    • 80052590666 scopus 로고    scopus 로고
    • The receptor for advanced glycation end-products (RAGE) protects pancreatic tumor cells against oxidative injury
    • R. Kang, D. Tang, K. M. Livesey, N. E. Schapiro, M. T. Lotze, and H. J. Zeh, "The receptor for advanced glycation end-products (RAGE) protects pancreatic tumor cells against oxidative injury," Antioxidants and Redox Signaling, vol. 15, no. 8, pp. 2175-2184, 2011.
    • (2011) Antioxidants and Redox Signaling , vol.15 , Issue.8 , pp. 2175-2184
    • Kang, R.1    Tang, D.2    Livesey, K.M.3    Schapiro, N.E.4    Lotze, M.T.5    Zeh, H.J.6
  • 57
    • 74549157124 scopus 로고    scopus 로고
    • Mechanisms of ascorbate-induced cytotoxicity in pancreatic cancer
    • J. Du, S. M. Martin, M. Levine et al., "Mechanisms of ascorbate-induced cytotoxicity in pancreatic cancer," Clinical Cancer Research, vol. 16, no. 2, pp. 509-520, 2010.
    • (2010) Clinical Cancer Research , vol.16 , Issue.2 , pp. 509-520
    • Du, J.1    Martin, S.M.2    Levine, M.3
  • 58
    • 79959956124 scopus 로고    scopus 로고
    • Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism
    • M. Donadelli, I. Dando, T. Zaniboni et al., "Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism," Cell Death and Disease, vol. 2, no. 4, article e152, 2011.
    • (2011) Cell Death and Disease , vol.2 , Issue.4
    • Donadelli, M.1    Dando, I.2    Zaniboni, T.3
  • 59
    • 3042561471 scopus 로고    scopus 로고
    • Tumor hypoxia correlates with metastatic tumor growth of pancreatic cancer in an orthotopic murine model
    • P. Büchler, H. A. Reber, R. S. Lavey et al., "Tumor hypoxia correlates with metastatic tumor growth of pancreatic cancer in an orthotopic murine model," Journal of Surgical Research, vol. 120, no. 2, pp. 295-303, 2004.
    • (2004) Journal of Surgical Research , vol.120 , Issue.2 , pp. 295-303
    • Büchler, P.1    Reber, H.A.2    Lavey, R.S.3
  • 60
    • 0034327361 scopus 로고    scopus 로고
    • Remarkable tolerance of tumor cells to nutrient deprivation: Possible new biochemical target for cancer therapy
    • K. Izuishi, K. Kato, T. Ogura, T. Kinoshita, and H. Esumi, "Remarkable tolerance of tumor cells to nutrient deprivation: possible new biochemical target for cancer therapy," Cancer Research, vol. 60, no. 21, pp. 6201-6207, 2000.
    • (2000) Cancer Research , vol.60 , Issue.21 , pp. 6201-6207
    • Izuishi, K.1    Kato, K.2    Ogura, T.3    Kinoshita, T.4    Esumi, H.5
  • 61
    • 0037031895 scopus 로고    scopus 로고
    • Hypoxia and nitric oxide treatment confer tolerance to glucose starvation in a 5′-AMP-activated protein kinase-dependent manner
    • H. Esumi, K. Izuishi, K. Kato et al., "Hypoxia and nitric oxide treatment confer tolerance to glucose starvation in a 5′-AMP-activated protein kinase-dependent manner," Journal of Biological Chemistry, vol. 277, no. 36, pp. 32791-32798, 2002.
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.36 , pp. 32791-32798
    • Esumi, H.1    Izuishi, K.2    Kato, K.3
  • 62
    • 50149095124 scopus 로고    scopus 로고
    • Autophagy is activated in pancreatic cancer cells and correlates with poor patient outcome
    • S. Fujii, S. Mitsunaga, M. Yamazaki et al., "Autophagy is activated in pancreatic cancer cells and correlates with poor patient outcome," Cancer Science, vol. 99, no. 9, pp. 1813-1819, 2008.
    • (2008) Cancer Science , vol.99 , Issue.9 , pp. 1813-1819
    • Fujii, S.1    Mitsunaga, S.2    Yamazaki, M.3
  • 63
    • 45849100530 scopus 로고    scopus 로고
    • Inflaming gastrointestinal oncogenic programming
    • D. G. DeNardo, M. Johansson, and L. M. Coussens, "Inflaming gastrointestinal oncogenic programming," Cancer Cell, vol. 14, no. 1, pp. 7-9, 2008.
    • (2008) Cancer Cell , vol.14 , Issue.1 , pp. 7-9
    • DeNardo, D.G.1    Johansson, M.2    Coussens, L.M.3
  • 64
    • 44449097168 scopus 로고    scopus 로고
    • AGE-RAGE systemand carcinogenesis
    • R. Abe and S. Yamagishi, "AGE-RAGE systemand carcinogenesis," Current Pharmaceutical Design, vol. 14, no. 10, pp. 940-945, 2008.
    • (2008) Current Pharmaceutical Design , vol.14 , Issue.10 , pp. 940-945
    • Abe, R.1    Yamagishi, S.2
  • 65
    • 23044491967 scopus 로고    scopus 로고
    • S100P promotes pancreatic cancer growth, survival, and invasion
    • T. Arumugam, D. M. Simeone, K. Van Golen, and C. D. Logsdon, "S100P promotes pancreatic cancer growth, survival, and invasion," Clinical Cancer Research, vol. 11, no. 15, pp. 5356-5364, 2005.
    • (2005) Clinical Cancer Research , vol.11 , Issue.15 , pp. 5356-5364
    • Arumugam, T.1    Simeone, D.M.2    Van Golen, K.3    Logsdon, C.D.4
  • 66
    • 77949542302 scopus 로고    scopus 로고
    • The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival
    • R. Kang, D. Tang, N. E. Schapiro et al., "The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival," Cell Death and Differentiation, vol. 17, no. 4, pp. 666-676, 2010.
    • (2010) Cell Death and Differentiation , vol.17 , Issue.4 , pp. 666-676
    • Kang, R.1    Tang, D.2    Schapiro, N.E.3
  • 68
    • 38949119423 scopus 로고    scopus 로고
    • Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3
    • M. B. Azad, Y. Chen, E. S. Henson et al., "Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3," Autophagy, vol. 4, no. 2, pp. 195-204, 2008.
    • (2008) Autophagy , vol.4 , Issue.2 , pp. 195-204
    • Azad, M.B.1    Chen, Y.2    Henson, E.S.3
  • 69
    • 62849105988 scopus 로고    scopus 로고
    • The role of Bcl-2 family member BNIP3 in cell death and disease: NIPping at the heels of cell death
    • T. R. Burton and S. B. Gibson, "The role of Bcl-2 family member BNIP3 in cell death and disease: NIPping at the heels of cell death," Cell Death and Differentiation, vol. 16, no. 4, pp. 515-523, 2009.
    • (2009) Cell Death and Differentiation , vol.16 , Issue.4 , pp. 515-523
    • Burton, T.R.1    Gibson, S.B.2
  • 70
    • 3442888541 scopus 로고    scopus 로고
    • Silencing of the hypoxia-inducible cell death protein BNIP3 in pancreatic cancer
    • J. Okami, D. M. Simeone, and C. D. Logsdon, "Silencing of the hypoxia-inducible cell death protein BNIP3 in pancreatic cancer," Cancer Research, vol. 64, no. 15, pp. 5338-5346, 2004.
    • (2004) Cancer Research , vol.64 , Issue.15 , pp. 5338-5346
    • Okami, J.1    Simeone, D.M.2    Logsdon, C.D.3
  • 71
    • 34547120221 scopus 로고    scopus 로고
    • S100A4 contributes to the suppression of BNIP3 expression, chemoresistance, and inhibition of apoptosis in pancreatic cancer
    • P. C. Mahon, P. Baril, V. Bhakta et al., "S100A4 contributes to the suppression of BNIP3 expression, chemoresistance, and inhibition of apoptosis in pancreatic cancer," Cancer Research, vol. 67, no. 14, pp. 6786-6795, 2007.
    • (2007) Cancer Research , vol.67 , Issue.14 , pp. 6786-6795
    • Mahon, P.C.1    Baril, P.2    Bhakta, V.3
  • 72
    • 20444437669 scopus 로고    scopus 로고
    • Upregulation of BNIP3 by 5-aza-2′-deoxycytidine sensitizes pancreatic cancer cells to hypoxia-mediated cell death
    • T. Abe, M. Toyota, H. Suzuki et al., "Upregulation of BNIP3 by 5-aza-2′-deoxycytidine sensitizes pancreatic cancer cells to hypoxia-mediated cell death," Journal of Gastroenterology, vol. 40, no. 5, pp. 504-510, 2005.
    • (2005) Journal of Gastroenterology , vol.40 , Issue.5 , pp. 504-510
    • Abe, T.1    Toyota, M.2    Suzuki, H.3
  • 73
    • 0035661648 scopus 로고    scopus 로고
    • Cvt18/Gsa12 is required for cytoplasm-to-vacuole transport, pexophagy, and autophagy in Saccharomyces cerevisiae and Pichia pastoris
    • J. Guan, P. E. Stromhaug, M. D. George et al., "Cvt18/Gsa12 is required for cytoplasm-to-vacuole transport, pexophagy, and autophagy in Saccharomyces cerevisiae and Pichia pastoris," Molecular Biology of the Cell, vol. 12, no. 12, pp. 3821-3838, 2001.
    • (2001) Molecular Biology of the Cell , vol.12 , Issue.12 , pp. 3821-3838
    • Guan, J.1    Stromhaug, P.E.2    George, M.D.3
  • 74
    • 11244289333 scopus 로고    scopus 로고
    • WIPI-1α (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy
    • T. Proikas-Cezanne, S. Waddell, A. Gaugel, T. Frickey, A. Lupas, and A. Nordheim, "WIPI-1α (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy," Oncogene, vol. 23, no. 58, pp. 9314-9325, 2004.
    • (2004) Oncogene , vol.23 , Issue.58 , pp. 9314-9325
    • Proikas-Cezanne, T.1    Waddell, S.2    Gaugel, A.3    Frickey, T.4    Lupas, A.5    Nordheim, A.6
  • 75
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • O. Warburg, "On the origin of cancer cells," Science, vol. 123, no. 3191, pp. 309-314, 1956.
    • (1956) Science , vol.123 , Issue.3191 , pp. 309-314
    • Warburg, O.1
  • 77
    • 35448982216 scopus 로고    scopus 로고
    • Hypoxia, glucose metabolism and the Warburg's effect
    • R. Bartrons and J. Caro, "Hypoxia, glucose metabolism and the Warburg's effect," Journal of Bioenergetics and Biomembranes, vol. 39, no. 3, pp. 223-229, 2007.
    • (2007) Journal of Bioenergetics and Biomembranes , vol.39 , Issue.3 , pp. 223-229
    • Bartrons, R.1    Caro, J.2
  • 78
    • 77649187905 scopus 로고    scopus 로고
    • The Warburg effect and mitochondrial stability in cancer cells
    • V. Gogvadze, B. Zhivotovsky, and S. Orrenius, "The Warburg effect and mitochondrial stability in cancer cells," Molecular Aspects of Medicine, vol. 31, no. 1, pp. 60-74, 2010.
    • (2010) Molecular Aspects of Medicine , vol.31 , Issue.1 , pp. 60-74
    • Gogvadze, V.1    Zhivotovsky, B.2    Orrenius, S.3
  • 79
    • 83455228966 scopus 로고    scopus 로고
    • Cancer: A de-repression of a default survival program common to all cells?
    • M. Vincent, "Cancer: a de-repression of a default survival program common to all cells?" BioEssays, vol. 34, no. 1, pp. 72-82, 2012.
    • (2012) BioEssays , vol.34 , Issue.1 , pp. 72-82
    • Vincent, M.1
  • 81
    • 33745918951 scopus 로고    scopus 로고
    • TIGAR, a p53-inducible regulator of glycolysis and apoptosis
    • K. Bensaad, A. Tsuruta, M. A. Selak et al., "TIGAR, a p53-inducible regulator of glycolysis and apoptosis," Cell, vol. 126, no. 1, pp. 107-120, 2006.
    • (2006) Cell , vol.126 , Issue.1 , pp. 107-120
    • Bensaad, K.1    Tsuruta, A.2    Selak, M.A.3
  • 82
    • 84859261025 scopus 로고    scopus 로고
    • Mouse genetics suggests cell-context dependency for myc-regulated metabolic enzymes during tumorigenesis
    • L. M. Nilsson, T. Z. Plym Forshell, S. Rimpi et al., "Mouse genetics suggests cell-context dependency for myc-regulated metabolic enzymes during tumorigenesis," PLoS Genetics, vol. 8, no. 3, Article ID e1002573, 2012.
    • (2012) PLoS Genetics , vol.8 , Issue.3
    • Nilsson, L.M.1    Plym Forshell, T.Z.2    Rimpi, S.3
  • 83
    • 77954165461 scopus 로고    scopus 로고
    • Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: Implications for breast cancer and DCIS therapy with autophagy inhibitors
    • U. E. Martinez-Outschoorn, S. Pavlides, D. Whitaker-Menezes et al., "Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: implications for breast cancer and DCIS therapy with autophagy inhibitors," Cell Cycle, vol. 9, no. 12, pp. 2423-2433, 2010.
    • (2010) Cell Cycle , vol.9 , Issue.12 , pp. 2423-2433
    • Martinez-Outschoorn, U.E.1    Pavlides, S.2    Whitaker-Menezes, D.3
  • 84
    • 77957138161 scopus 로고    scopus 로고
    • Understanding the "lethal" drivers of tumor-stroma coevolution: Emerging role(s) for hypoxia, oxidative stress and autophagy/mitophagy in the tumor micro-environment
    • M. P. Lisanti, U. E. Martinez-Outschoorn, B. Chiavarina et al., "Understanding the "lethal" drivers of tumor-stroma coevolution: emerging role(s) for hypoxia, oxidative stress and autophagy/mitophagy in the tumor micro-environment," Cancer Biology and Therapy, vol. 10, no. 6, pp. 537-542, 2010.
    • (2010) Cancer Biology and Therapy , vol.10 , Issue.6 , pp. 537-542
    • Lisanti, M.P.1    Martinez-Outschoorn, U.E.2    Chiavarina, B.3
  • 85
    • 84873448216 scopus 로고    scopus 로고
    • A report of the James Watson lecture at Yale University
    • T. Smith-Vikos, "A report of the James Watson lecture at Yale University," The Yale Journal of Biology and Medicine, vol. 85, no. 3, pp. 417-419, 2012.
    • (2012) The Yale Journal of Biology and Medicine , vol.85 , Issue.3 , pp. 417-419
    • Smith-Vikos, T.1
  • 86
    • 84857975015 scopus 로고    scopus 로고
    • Metformin: Multi-faceted protection against cancer
    • S. del Barco, A. Vazquez-Martin, S. Cufí et al., "Metformin: multi-faceted protection against cancer," Oncotarget, vol. 2, no. 12, pp. 896-917, 2011.
    • (2011) Oncotarget , vol.2 , Issue.12 , pp. 896-917
    • Del Barco, S.1    Vazquez-Martin, A.2    Cufí, S.3
  • 87
    • 84055199818 scopus 로고    scopus 로고
    • Pyruvate kinase expression (PKM1 and PKM2) in cancer associated fibroblasts drives stromal nutrient production and tumor growth
    • B. Chiavarina, D. Whitaker-Menezes, U. E. Martinez-Outschoorn et al., "Pyruvate kinase expression (PKM1 and PKM2) in cancer associated fibroblasts drives stromal nutrient production and tumor growth," Cancer Biology and Therapy, vol. 12,no. 12, pp. 1101-1113, 2011.
    • (2011) Cancer Biology and Therapy , vol.12 , Issue.12 , pp. 1101-1113
    • Chiavarina, B.1    Whitaker-Menezes, D.2    Martinez-Outschoorn, U.E.3
  • 88
    • 84873624215 scopus 로고    scopus 로고
    • +-ATP synthase and the lipogenic switch: New core components of metabolic reprogramming in induced pluripotent stem (iPS) cells
    • +-ATP synthase and the lipogenic switch: new core components of metabolic reprogramming in induced pluripotent stem (iPS) cells," Cell Cycle, vol. 12, no. 2, pp. 207-218, 2013.
    • (2013) Cell Cycle , vol.12 , Issue.2 , pp. 207-218
    • Vazquez-Martin, A.1    Corominas-Faja, B.2    Cufi, S.3
  • 89
    • 84862014301 scopus 로고    scopus 로고
    • Autophagy mediates survival of pancreatic tumour-initiating cells in a hypoxic microenvironment
    • V. Rausch, L. Liu, A. Apel et al., "Autophagy mediates survival of pancreatic tumour-initiating cells in a hypoxic microenvironment," The Journal of Pathology, vol. 227, no. 3,pp. 325-335, 2012.
    • (2012) The Journal of Pathology , vol.227 , Issue.3 , pp. 325-335
    • Rausch, V.1    Liu, L.2    Apel, A.3
  • 90
    • 79951847989 scopus 로고    scopus 로고
    • Principles and current strategies for targeting autophagy for cancer treatment
    • R. K. Amaravadi, J. Lippincott-Schwartz, X. Yin et al., "Principles and current strategies for targeting autophagy for cancer treatment," Clinical Cancer Research, vol. 17, no. 4, pp. 654-666, 2011.
    • (2011) Clinical Cancer Research , vol.17 , Issue.4 , pp. 654-666
    • Amaravadi, R.K.1    Lippincott-Schwartz, J.2    Yin, X.3
  • 91
    • 84883613147 scopus 로고    scopus 로고
    • Metabolic interaction between cancer cells and stromal cells according to breast cancer molecular subtype
    • J. Choi, H. Kim do, W. H. Jung, and J. S. Koo, "Metabolic interaction between cancer cells and stromal cells according to breast cancer molecular subtype," Breast Cancer Research, vol. 15, no. 5, article R78, 2013.
    • (2013) Breast Cancer Research , vol.15 , Issue.5
    • Choi, J.1    Kim Do, H.2    Jung, W.H.3    Koo, J.S.4
  • 92
    • 84859562694 scopus 로고    scopus 로고
    • Targeting autophagy addiction in cancer
    • J. D. Mancias and A. C. Kimmelman, "Targeting autophagy addiction in cancer," Oncotarget, vol. 2, no. 12, pp. 1302-1306, 2011.
    • (2011) Oncotarget , vol.2 , Issue.12 , pp. 1302-1306
    • Mancias, J.D.1    Kimmelman, A.C.2
  • 93
    • 54949098894 scopus 로고    scopus 로고
    • Nucleoside analogs: Molecular mechanisms signaling cell death
    • B. Ewald, D. Sampath, and W. Plunkett, "Nucleoside analogs: molecular mechanisms signaling cell death," Oncogene, vol. 27, no. 50, pp. 6522-6537, 2008.
    • (2008) Oncogene , vol.27 , Issue.50 , pp. 6522-6537
    • Ewald, B.1    Sampath, D.2    Plunkett, W.3
  • 94
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase-AKT pathway in human cancer
    • I. Vivanco and C. L. Sawyers, "The phosphatidylinositol 3-kinase-AKT pathway in human cancer," Nature Reviews Cancer, vol. 2, no. 7, pp. 489-501, 2002.
    • (2002) Nature Reviews Cancer , vol.2 , Issue.7 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 95
    • 77955661981 scopus 로고    scopus 로고
    • Efficacy and tolerability of limited field radiotherapy with concurrent capecitabine in local advanced pancreatic cancer
    • A. S. N. Jackson, P. Jain, G. R. Watkins et al., "Efficacy and tolerability of limited field radiotherapy with concurrent capecitabine in local advanced pancreatic cancer," Clinical Oncology, vol. 22, no. 7, pp. 570-577, 2010.
    • (2010) Clinical Oncology , vol.22 , Issue.7 , pp. 570-577
    • Jackson, A.S.N.1    Jain, P.2    Watkins, G.R.3
  • 97
    • 77954771890 scopus 로고    scopus 로고
    • Randomized phase III trial comparing FOLFIRINOX (F: 5FU/leucovorin [LV], irinotecan [I], and oxaliplatin [O]) versus gemcitabine (G) as first-line treatment for metastatic pancreatic adenocarcinoma (MPA): Preplanned interim analysis results of the PRODIGE 4/ACCORD 11 trial
    • abstract 4010
    • T. Conroy, F. Desseigne, M. Ychoy et al., "Randomized phase III trial comparing FOLFIRINOX (F: 5FU/leucovorin [LV], irinotecan [I], and oxaliplatin [O]) versus gemcitabine (G) as first-line treatment for metastatic pancreatic adenocarcinoma (MPA): preplanned interim analysis results of the PRODIGE 4/ACCORD 11 trial," Journal of Clinical Oncology, vol. 28, supplement 15s, abstract 4010, 2010.
    • (2010) Journal of Clinical Oncology , vol.28
    • Conroy, T.1    Desseigne, F.2    Ychoy, M.3
  • 98
    • 79953688703 scopus 로고    scopus 로고
    • Use of irinotecan for treatment of small cell carcinoma of the prostate
    • W. Tung, Y. Wang, P. W. Gout, D. M. Liu, and M. Gleave, "Use of irinotecan for treatment of small cell carcinoma of the prostate," Prostate, vol. 71, no. 7, pp. 675-681, 2011.
    • (2011) Prostate , vol.71 , Issue.7 , pp. 675-681
    • Tung, W.1    Wang, Y.2    Gout, P.W.3    Liu, D.M.4    Gleave, M.5


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