A systems biology analysis of apoptosome formation and apoptosis execution supports allosteric procaspase-9 activation

Journal of Biological Chemistry

Volumn 289, Issue 38, 2014, Pages 26277-26289

  Würstle, Maximilian L ^a   Rehm, Markus ^a  

^a ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; CHEMICAL ACTIVATION; DIMERIZATION;

APOPTOSOMES; CASPASES; HOMODIMERIZATION; MATHEMATICAL SIMULATIONS; PROCASPASE; SYSTEMS BIOLOGY;

ACTIVATION ANALYSIS;

APOPTOSOME; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 3; CYTOCHROME C; DEOXYADENOSINE TRIPHOSPHATE; PROCASPASE 9; X LINKED INHIBITOR OF APOPTOSIS; APAF1 PROTEIN, HUMAN; CASP9 PROTEIN, HUMAN; CASPASE 9; PROTEIN BINDING; PROTEIN PRECURSOR;

ALLOSTERISM; APOPTOSIS; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL MEMBRANE PERMEABILITY; DIMERIZATION; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; HELA CELL LINE; HOMODIMERIZATION; HUMAN; MATHEMATICAL MODEL; OLIGOMERIZATION; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN CLEAVAGE; PROTEIN DEPLETION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SYSTEMS BIOLOGY; VALIDATION PROCESS; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; KINETICS; PHYSIOLOGY; PROTEIN MULTIMERIZATION;

ALLOSTERIC REGULATION; APOPTOSIS; APOPTOSOMES; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; CASPASE 9; CATALYTIC DOMAIN; COMPUTER SIMULATION; ENZYME ACTIVATION; HELA CELLS; HUMANS; KINETICS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN PRECURSORS; SYSTEMS BIOLOGY;

EID: 84907222764     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.590034     Document Type: Article

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