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Volumn 19, Issue 8, 2011, Pages 1074-1083

Crystal structure of full-length Apaf-1: How the death signal is relayed in the mitochondrial pathway of apoptosis

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; APOPTOSOME; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 9; CYTOCHROME C;

EID: 80051534863     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2011.05.013     Document Type: Article
Times cited : (94)

References (51)
  • 1
    • 0033597923 scopus 로고    scopus 로고
    • Regulation of apoptotic protease activating factor-1 oligomerization and apoptosis by the WD-40 repeat region
    • C. Adrain, E.A. Slee, M.T. Harte, and S.J. Martin Regulation of apoptotic protease activating factor-1 oligomerization and apoptosis by the WD-40 repeat region J. Biol. Chem. 274 1999 20855 20860
    • (1999) J. Biol. Chem. , vol.274 , pp. 20855-20860
    • Adrain, C.1    Slee, E.A.2    Harte, M.T.3    Martin, S.J.4
  • 2
    • 0036187036 scopus 로고    scopus 로고
    • Three-dimensional structure of the apoptosome: Implications for assembly, procaspase-9 binding, and activation
    • DOI 10.1016/S1097-2765(02)00442-2
    • D. Acehan, X. Jiang, D.G. Morgan, J.E. Heuser, X. Wang, and C.W. Akey Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation Mol. Cell 9 2002 423 432 (Pubitemid 34195566)
    • (2002) Molecular Cell , vol.9 , Issue.2 , pp. 423-432
    • Acehan, D.1    Jiang, X.2    Morgan, D.G.3    Heuser, J.E.4    Wang, X.5    Akey, C.W.6
  • 3
    • 33846236461 scopus 로고    scopus 로고
    • Calcium Blocks Formation of Apoptosome by Preventing Nucleotide Exchange in Apaf-1
    • DOI 10.1016/j.molcel.2006.12.013, PII S1097276506008719
    • Q. Bao, W. Lu, J.D. Rabinowitz, and Y. Shi Calcium blocks formation of apoptosome by preventing nucleotide exchange in Apaf-1 Mol. Cell 25 2007 181 192 (Pubitemid 46109608)
    • (2007) Molecular Cell , vol.25 , Issue.2 , pp. 181-192
    • Bao, Q.1    Lu, W.2    Rabinowitz, J.D.3    Shi, Y.4
  • 4
    • 33845501864 scopus 로고    scopus 로고
    • Apoptosome: A platform for the activation of initiator caspases
    • DOI 10.1038/sj.cdd.4402028, PII 4402028
    • Q. Bao, and Y. Shi Apoptosome: a platform for the activation of initiator caspases Cell Death Differ. 14 2007 56 65 (Pubitemid 44911894)
    • (2007) Cell Death and Differentiation , vol.14 , Issue.1 , pp. 56-65
    • Bao, Q.1    Shi, Y.2
  • 7
    • 37049014272 scopus 로고    scopus 로고
    • Version 1.2 of the crystallography and NMR system
    • A.T. Brunger Version 1.2 of the crystallography and NMR system Nat. Protoc. 2 2007 2728 2733
    • (2007) Nat. Protoc. , vol.2 , pp. 2728-2733
    • Brunger, A.T.1
  • 8
    • 0345731420 scopus 로고    scopus 로고
    • Chemical-Induced Apoptosis: Formation of the Apaf-1 Apoptosome
    • DOI 10.1081/DMR-120026497
    • K. Cain Chemical-induced apoptosis: formation of the Apaf-1 apoptosome Drug Metab. Rev. 35 2003 337 363 (Pubitemid 38018111)
    • (2003) Drug Metabolism Reviews , vol.35 , Issue.4 , pp. 337-363
    • Cain, K.1
  • 9
    • 59649103157 scopus 로고    scopus 로고
    • Wheel of Life, Wheel of Death: A mechanistic insight into signaling by STAND proteins
    • O. Danot, E. Marquenet, D. Vidal-Ingigliardi, and E. Richet Wheel of Life, Wheel of Death: a mechanistic insight into signaling by STAND proteins Structure 17 2009 172 182
    • (2009) Structure , vol.17 , pp. 172-182
    • Danot, O.1    Marquenet, E.2    Vidal-Ingigliardi, D.3    Richet, E.4
  • 10
    • 1542357606 scopus 로고    scopus 로고
    • Apoptosis pathways in cancer and cancer therapy
    • K.M. Debatin Apoptosis pathways in cancer and cancer therapy Cancer Immunol. Immunother. 53 2004 153 159
    • (2004) Cancer Immunol. Immunother. , vol.53 , pp. 153-159
    • Debatin, K.M.1
  • 13
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and apoptosis
    • D.R. Green, and J.C. Reed Mitochondria and apoptosis Science 281 1998 1309 1312 (Pubitemid 28406816)
    • (1998) Science , vol.281 , Issue.5381 , pp. 1309-1312
    • Green, D.R.1    Reed, J.C.2
  • 15
    • 0032509354 scopus 로고    scopus 로고
    • WD-40 repeat region regulates Apaf-1 self-association and procaspase-9 activation
    • DOI 10.1074/jbc.273.50.33489
    • Y. Hu, L. Ding, D.M. Spencer, and G. Núñez WD-40 repeat region regulates Apaf-1 self-association and procaspase-9 activation J. Biol. Chem. 273 1998 33489 33494 (Pubitemid 29005731)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.50 , pp. 33489-33494
    • Hu, Y.1    Ding, L.2    Spencer, D.M.3    Nunez, G.4
  • 16
    • 0038624558 scopus 로고    scopus 로고
    • NODS: Intracellular proteins involved in inflammation and apoptosis
    • DOI 10.1038/nri1086
    • N. Inohara, and G. Nuñez NODs: intracellular proteins involved in inflammation and apoptosis Nat. Rev. Immunol. 3 2003 371 382 (Pubitemid 37323197)
    • (2003) Nature Reviews Immunology , vol.3 , Issue.5 , pp. 371-382
    • Inohara, N.1    Nunez, G.2
  • 17
    • 0034613302 scopus 로고    scopus 로고
    • Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1
    • X. Jiang, and X. Wang Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1 J. Biol. Chem. 275 2000 31199 31203
    • (2000) J. Biol. Chem. , vol.275 , pp. 31199-31203
    • Jiang, X.1    Wang, X.2
  • 18
    • 0027879008 scopus 로고
    • Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants
    • W. Kabsch Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants J. Appl. Cryst. 26 1993 795 800
    • (1993) J. Appl. Cryst. , vol.26 , pp. 795-800
    • Kabsch, W.1
  • 21
    • 33845480548 scopus 로고    scopus 로고
    • Caspase function in programmed cell death
    • DOI 10.1038/sj.cdd.4402060, PII 4402060
    • S. Kumar Caspase function in programmed cell death Cell Death Differ. 14 2007 32 43 (Pubitemid 44911892)
    • (2007) Cell Death and Differentiation , vol.14 , Issue.1 , pp. 32-43
    • Kumar, S.1
  • 22
    • 4644247731 scopus 로고    scopus 로고
    • STAND, a class of P-loop NTPases including animal and plant regulators of programmed cell death: Multiple, complex domain architectures, unusual phyletic patterns, and evolution by horizontal gene transfer
    • DOI 10.1016/j.jmb.2004.08.023, PII S0022283604010010
    • D.D. Leipe, E.V. Koonin, and L. Aravind STAND, a class of P-loop NTPases including animal and plant regulators of programmed cell death: multiple, complex domain architectures, unusual phyletic patterns, and evolution by horizontal gene transfer J. Mol. Biol. 343 2004 1 28 (Pubitemid 39294573)
    • (2004) Journal of Molecular Biology , vol.343 , Issue.1 , pp. 1-28
    • Leipe, D.D.1    Koonin, E.V.2    Aravind, L.3
  • 23
    • 54249096028 scopus 로고    scopus 로고
    • Caspases in apoptosis and beyond
    • J. Li, and J. Yuan Caspases in apoptosis and beyond Oncogene 27 2008 6194 6206
    • (2008) Oncogene , vol.27 , pp. 6194-6206
    • Li, J.1    Yuan, J.2
  • 24
    • 0030715323 scopus 로고    scopus 로고
    • Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
    • P. Li, D. Nijhawan, I. Budihardjo, S.M. Srinivasula, M. Ahmad, E.S. Alnemri, and X. Wang Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade Cell 91 1997 479 489 (Pubitemid 27508237)
    • (1997) Cell , vol.91 , Issue.4 , pp. 479-489
    • Li, P.1    Nijhawan, D.2    Budihardjo, I.3    Srinivasula, S.M.4    Ahmad, M.5    Alnemri, E.S.6    Wang, X.7
  • 26
    • 0037459081 scopus 로고    scopus 로고
    • Mitochondria: Releasing power for life and unleashing the machineries of death
    • DOI 10.1016/S0092-8674(03)00116-8
    • D.D. Newmeyer, and S. Ferguson-Miller Mitochondria: releasing power for life and unleashing the machineries of death Cell 112 2003 481 490 (Pubitemid 36263081)
    • (2003) Cell , vol.112 , Issue.4 , pp. 481-490
    • Newmeyer, D.D.1    Ferguson-Miller, S.2
  • 28
    • 44349171085 scopus 로고    scopus 로고
    • The Nod-like receptor (NLR) family: A tale of similarities and differences
    • M. Proell, S.J. Riedl, J.H. Fritz, A.M. Rojas, and R. Schwarzenbacher The Nod-like receptor (NLR) family: a tale of similarities and differences PLoS One 3 2008 e2119
    • (2008) PLoS One , vol.3 , pp. 2119
    • Proell, M.1    Riedl, S.J.2    Fritz, J.H.3    Rojas, A.M.4    Schwarzenbacher, R.5
  • 29
    • 0034710942 scopus 로고    scopus 로고
    • Cytochrome c binding to Apaf-1: The effects of dATP and ionic strength
    • C. Purring-Koch, and G. McLendon Cytochrome c binding to Apaf-1: the effects of dATP and ionic strength Proc. Natl. Acad. Sci. USA 97 2000 11928 11931
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 11928-11931
    • Purring-Koch, C.1    McLendon, G.2
  • 30
    • 77951881456 scopus 로고    scopus 로고
    • Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4
    • S. Qi, Y. Pang, Q. Hu, Q. Liu, H. Li, Y. Zhou, T. He, Q. Liang, Y. Liu, and X. Yuan Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4 Cell 141 2010 446 457
    • (2010) Cell , vol.141 , pp. 446-457
    • Qi, S.1    Pang, Y.2    Hu, Q.3    Liu, Q.4    Li, H.5    Zhou, Y.6    He, T.7    Liang, Q.8    Liu, Y.9    Yuan, X.10
  • 31
    • 0033542482 scopus 로고    scopus 로고
    • Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1
    • H. Qin, S.M. Srinivasula, G. Wu, T. Fernandes-Alnemri, E.S. Alnemri, and Y. Shi Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1 Nature 399 1999 549 557
    • (1999) Nature , vol.399 , pp. 549-557
    • Qin, H.1    Srinivasula, S.M.2    Wu, G.3    Fernandes-Alnemri, T.4    Alnemri, E.S.5    Shi, Y.6
  • 32
    • 70450263353 scopus 로고    scopus 로고
    • A new model for the transition of APAF-1 from inactive monomer to caspase-activating apoptosome
    • T.F. Reubold, S. Wohlgemuth, and S. Eschenburg A new model for the transition of APAF-1 from inactive monomer to caspase-activating apoptosome J. Biol. Chem. 284 2009 32717 32724
    • (2009) J. Biol. Chem. , vol.284 , pp. 32717-32724
    • Reubold, T.F.1    Wohlgemuth, S.2    Eschenburg, S.3
  • 33
    • 17244368276 scopus 로고    scopus 로고
    • Structure of the apoptotic protease-activating factor 1 bound to ADP
    • DOI 10.1038/nature03465
    • S.J. Riedl, W. Li, Y. Chao, R. Schwarzenbacher, and Y. Shi Structure of the apoptotic protease-activating factor 1 bound to ADP Nature 434 2005 926 933 (Pubitemid 40559008)
    • (2005) Nature , vol.434 , Issue.7035 , pp. 926-933
    • Riedl, S.J.1    Li, W.2    Chao, Y.3    Schwarzenbacher, R.4    Shi, Y.5
  • 34
    • 34247345833 scopus 로고    scopus 로고
    • The apoptosome: Signalling platform of cell death
    • DOI 10.1038/nrm2153, PII NRM2153
    • S.J. Riedl, and G.S. Salvesen The apoptosome: signalling platform of cell death Nat. Rev. Mol. Cell Biol. 8 2007 405 413 (Pubitemid 46643237)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.5 , pp. 405-413
    • Riedl, S.J.1    Salvesen, G.S.2
  • 35
    • 0033580926 scopus 로고    scopus 로고
    • Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation
    • A. Saleh, S.M. Srinivasula, S. Acharya, R. Fishel, and E.S. Alnemri Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation J. Biol. Chem. 274 1999 17941 17945
    • (1999) J. Biol. Chem. , vol.274 , pp. 17941-17945
    • Saleh, A.1    Srinivasula, S.M.2    Acharya, S.3    Fishel, R.4    Alnemri, E.S.5
  • 37
    • 77950362382 scopus 로고    scopus 로고
    • The inflammasomes
    • K. Schroder, and J. Tschopp The inflammasomes Cell 140 2010 821 832
    • (2010) Cell , vol.140 , pp. 821-832
    • Schroder, K.1    Tschopp, J.2
  • 38
    • 77950793231 scopus 로고    scopus 로고
    • Experimental phasing with SHELXC/D/E: Combining chain tracing with density modification
    • G.M. Sheldrick Experimental phasing with SHELXC/D/E: combining chain tracing with density modification Acta Crystallogr. D Biol. Crystallogr. 66 2010 479 485
    • (2010) Acta Crystallogr. D Biol. Crystallogr. , vol.66 , pp. 479-485
    • Sheldrick, G.M.1
  • 39
    • 33750627440 scopus 로고    scopus 로고
    • Mechanical aspects of apoptosome assembly
    • DOI 10.1016/j.ceb.2006.09.006, PII S0955067406001517
    • Y. Shi Mechanical aspects of apoptosome assembly Curr. Opin. Cell Biol. 18 2006 677 684 (Pubitemid 44692474)
    • (2006) Current Opinion in Cell Biology , vol.18 , Issue.6 , pp. 677-684
    • Shi, Y.1
  • 40
    • 58149161238 scopus 로고    scopus 로고
    • Diversity of WD-repeat proteins
    • T.F. Smith Diversity of WD-repeat proteins Subcell. Biochem. 48 2008 20 30
    • (2008) Subcell. Biochem. , vol.48 , pp. 20-30
    • Smith, T.F.1
  • 42
    • 0032575750 scopus 로고    scopus 로고
    • Caspases: Enemies within
    • N.A. Thornberry, and Y. Lazebnik Caspases: enemies within Science 281 1998 1312 1316 (Pubitemid 28406817)
    • (1998) Science , vol.281 , Issue.5381 , pp. 1312-1316
    • Thornberry, N.A.1    Lazebnik, Y.2
  • 43
    • 0141557547 scopus 로고    scopus 로고
    • The Structure of Aip1p, a WD Repeat Protein That Regulates Cofilin-mediated Actin Depolymerization
    • DOI 10.1074/jbc.M302773200
    • W.C. Voegtli, A.Y. Madrona, and D.K. Wilson The structure of Aip1p, a WD repeat protein that regulates Cofilin-mediated actin depolymerization J. Biol. Chem. 278 2003 34373 34379 (Pubitemid 37553282)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.36 , pp. 34373-34379
    • Voegtli, W.C.1    Madrona, A.Y.2    Wilson, D.K.3
  • 44
    • 35948947822 scopus 로고    scopus 로고
    • AAA+ ATPases: Achieving diversity of function with conserved machinery
    • DOI 10.1111/j.1600-0854.2007.00642.x
    • S.R. White, and B. Lauring AAA+ ATPases: achieving diversity of function with conserved machinery Traffic 8 2007 1657 1667 (Pubitemid 350066678)
    • (2007) Traffic , vol.8 , Issue.12 , pp. 1657-1667
    • White, S.R.1    Lauring, B.2
  • 45
    • 38149113537 scopus 로고    scopus 로고
    • NLR proteins: Integral members of innate immunity and mediators of inflammatory diseases
    • J.M. Wilmanski, T. Petnicki-Ocwieja, and K.S. Kobayashi NLR proteins: integral members of innate immunity and mediators of inflammatory diseases J. Leukoc. Biol. 83 2008 13 30
    • (2008) J. Leukoc. Biol. , vol.83 , pp. 13-30
    • Wilmanski, J.M.1    Petnicki-Ocwieja, T.2    Kobayashi, K.S.3
  • 46
    • 27644483812 scopus 로고    scopus 로고
    • A structure of the human apoptosome at 12.8 A resolution provides insights into this cell death platform
    • DOI 10.1016/j.str.2005.09.006, PII S0969212605003497
    • X. Yu, D. Acehan, J.F. Ménétret, C.R. Booth, S.J. Ludtke, S.J. Riedl, Y. Shi, X. Wang, and C.W. Akey A structure of the human apoptosome at 12.8 A resolution provides insights into this cell death platform Structure 13 2005 1725 1735 (Pubitemid 41571836)
    • (2005) Structure , vol.13 , Issue.11 , pp. 1725-1735
    • Yu, X.1    Acehan, D.2    Menetret, J.-F.3    Booth, C.R.4    Ludtke, S.J.5    Riedl, S.J.6    Shi, Y.7    Wang, X.8    Akey, C.W.9
  • 47
    • 28944443033 scopus 로고    scopus 로고
    • Three-dimensional structure of a double apoptosome formed by the Drosophila apaf-1 related killer
    • DOI 10.1016/j.jmb.2005.10.040, PII S0022283605012842
    • X. Yu, L. Wang, D. Acehan, X. Wang, and C.W. Akey Three-dimensional structure of a double apoptosome formed by the Drosophila Apaf-1 related killer J. Mol. Biol. 355 2006 577 589 (Pubitemid 41785758)
    • (2006) Journal of Molecular Biology , vol.355 , Issue.3 , pp. 577-589
    • Yu, X.1    Wang, L.2    Acehan, D.3    Wang, X.4    Akey, C.W.5
  • 50
    • 0030745646 scopus 로고    scopus 로고
    • Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
    • DOI 10.1016/S0092-8674(00)80501-2
    • H. Zou, W.J. Henzel, X. Liu, A. Lutschg, and X. Wang Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3 Cell 90 1997 405 413 (Pubitemid 27347231)
    • (1997) Cell , vol.90 , Issue.3 , pp. 405-413
    • Zou, H.1    Henzel, W.J.2    Liu, X.3    Lutschg, A.4    Wang, X.5
  • 51
    • 0033596980 scopus 로고    scopus 로고
    • An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9
    • H. Zou, Y. Li, X. Liu, and X. Wang An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9 J. Biol. Chem. 274 1999 11549 11556
    • (1999) J. Biol. Chem. , vol.274 , pp. 11549-11556
    • Zou, H.1    Li, Y.2    Liu, X.3    Wang, X.4


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