Gambogic acid induced oxidative stress dependent caspase activation regulates both apoptosis and autophagy by targeting various key molecules (NF-κB, Beclin-1, p62 and NBR1) in human bladder cancer cells

Biochimica et Biophysica Acta - General Subjects

Volumn 1840, Issue 12, 2014, Pages 3374-3384

  Ishaq, Mohammad ^a   Khan, Mohammad Aslam ^a   Sharma, Kapil ^a   Sharma, Gaurav ^a   Dutta, Rajesh Kumar ^a   Majumdar, Sekhar ^a  

^a INSTITUTE OF MICROBIAL TECHNOLOGY   (India)

Author keywords

Apoptosis; Autophagy; Bladder cancer; Gambogic acid; p62

Indexed keywords

ADAPTOR PROTEIN; BECLIN 1; CASPASE; CASPASE 2; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; GAMBOGIC ACID; GLUCOSE REGULATED PROTEIN 78; HEAT SHOCK PROTEIN 90; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JANUS KINASE; NEIGHBOR OF BRCA1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN P62; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; AUTOPHAGY; BLADDER CANCER CELL LINE; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HYPERPOLARIZATION; MITOCHONDRIAL HYPERPOLARIZATION; OXIDATIVE STRESS; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; WESTERN BLOTTING;

EID: 84907212785     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2014.08.019     Document Type: Article

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