Regulator of G protein signaling 6 (RGS6) induces apoptosis via a mitochondrial-dependent pathway not involving its GTPase-activating protein activity

Journal of Biological Chemistry

Volumn 286, Issue 2, 2011, Pages 1409-1419

  Maity, Biswanath ^a   Yang, Jianqi ^a   Huang, Jie ^a   Askeland, Ryan W ^a   Bera, Soumen ^a   Fisher, Rory A ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-PROLIFERATIVE; APOPTOSIS; BREAST CANCER; BREAST CANCER CELLS; CANCER CELLS; CANCER RISK; CASPASE ACTIVATION; CASPASES; CELL-CYCLE ARREST; COLONY FORMATION; CYTOCHROME C; DOWN-REGULATION; DOXORUBICIN; EPITHELIAL CELLS; FEED FORWARD; G PROTEIN; G PROTEIN ACTIVATION; GROWTH SUPPRESSIONS; GTPASE-ACTIVATING PROTEIN; IN-CELL; INDUCED APOPTOSIS; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE EMBRYONIC FIBROBLASTS; OUTER MEMBRANE; POLY POLYMERASE; REACTIVE OXYGEN SPECIES; THERAPEUTIC TARGETS;

CELL CULTURE; CELL DEATH; CELL MEMBRANES; CHEMICAL ACTIVATION; ECOLOGY; FIBROBLASTS; GROWTH KINETICS; MITOCHONDRIA; OXYGEN; SIGNALING;

PROTEINS;

CASPASE 3; CASPASE 9; COMPLEMENTARY DNA; CYTOCHROME C; DOXORUBICIN; GUANOSINE TRIPHOSPHATASE; LIPOCORTIN 5; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL 2; PROTEIN P53; REACTIVE OXYGEN METABOLITE; RGS PROTEIN; RGS6 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BREAST CANCER; BREAST EPITHELIUM; CANCER INHIBITION; CELL CYCLE ARREST; CELL PERMEABILIZATION; CELL SURVIVAL; CELL TRANSFORMATION; CELL VIABILITY; CLONOGENIC ASSAY; COLONY FORMATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; EPITHELIUM CELL; FIBROBLAST; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; APOPTOSIS; BREAST NEOPLASMS; CARCINOMA, DUCTAL; CELL DIVISION; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; FEMALE; FIBROBLASTS; GENE EXPRESSION REGULATION, NEOPLASTIC; GTPASE-ACTIVATING PROTEINS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; REACTIVE OXYGEN SPECIES; RGS PROTEINS; SIGNAL TRANSDUCTION;

EID: 78651411488     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.186700     Document Type: Article

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