Pentoxifylline induces apoptosis in vitro in cutaneous T cell lymphoma (HuT-78) and enhances FasL mediated killing by upregulating Fas expression

Biochemical Pharmacology

Volumn 77, Issue 1, 2009, Pages 30-45

  Rishi, Loveena ^a   Gahlot, Satindra ^a   Kathania, Mahesh ^a   Majumdar, Sekhar ^a  

^a INSTITUTE OF MICROBIAL TECHNOLOGY   (India)

Author keywords

Apoptosis; Cutaneous T cell lymphoma; Fas; Pentoxifylline; ROI

Indexed keywords

CASPASE 3; CYTOCHROME C; FAS LIGAND; FLICE INHIBITORY PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PENTOXIFYLLINE; PROTEIN BCL XL; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL KILLING; CONTROLLED STUDY; CUTANEOUS T CELL LYMPHOMA; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ANTIGENS, CD95; APOPTOSIS; CELL LINE, TUMOR; CELLS, CULTURED; FAS LIGAND PROTEIN; GENE EXPRESSION REGULATION; HUMANS; LYMPHOMA, T-CELL, CUTANEOUS; PENTOXIFYLLINE; SKIN NEOPLASMS; UP-REGULATION;

EID: 56649099051     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2008.09.018     Document Type: Article

References (45)

1. Michel L., Dupuy A., Jean-Louis F., Sors A., Poupon J., Viguier M., et al. Arsenic trioxide induces apoptosis of cutaneous T cell lymphoma cells: evidence for a partially caspase-independent pathway and potentiation by ascorbic acid (vitamin C). J Invest Dermatol 121 (2003) 881-893
2. Zhang C.L., Kamarashev J., Qin J.Z., Burg G., Dummer R., and Dobbeling U. Expression of apoptosis regulators in cutaneous T-cell lymphoma (CTCL) cells. J Pathol 200 (2003) 249-254
3. Mann B.S., Johnson J.R., He K., Sridhara R., Abraham S., Booth B.P., et al. Vorinostat for treatment of cutaneous manifestations of advanced primary cutaneous T-cell lymphoma. Clin Cancer Res 13 (2007) 2318-2322
4. Contassot E., Kerl K., Roques S., Shane R., Gaide O., Dupuis M., et al. Resistance to FasL and tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in Sezary syndrome T-cells associated with impaired death receptor and FLICE-inhibitory protein expression. Blood 111 (2008) 4780-4787
5. O'Connell M.A., Cleere R., Long A., O'Neill L.A., and Kelleher D. Cellular proliferation and activation of NF kappa B are induced by autocrine production of tumor necrosis factor alpha in the human T lymphoma line HuT 78. J Biol Chem 270 (1995) 7399-7404
6. Giri D.K., and Aggarwal B.B. Constitutive activation of NF-kappaB causes resistance to apoptosis in human cutaneous T cell lymphoma HuT-78 cells. Autocrine role of tumor necrosis factor and reactive oxygen intermediates. J Biol Chem 273 (1998) 14008-14014
7. Ashikawa K., Majumdar S., Banerjee S., Bharti A.C., Shishodia S., and Aggarwal B.B. Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation. J Immunol 169 (2002) 6490-6497
8. Shishodia S., and Aggarwal B.B. Nuclear factor-kappaB activation: a question of life or death. J Biochem Mol Biol 35 (2002) 28-40
9. Sors A., Jean-Louis F., Pellet C., Laroche L., Dubertret L., Courtois G., et al. Down-regulating constitutive activation of the NF-kappaB canonical pathway overcomes the resistance of cutaneous T-cell lymphoma to apoptosis. Blood 107 (2006) 2354-2363
10. Burstein E., and Duckett C.S. Dying for NF-kappaB? Control of cell death by transcriptional regulation of the apoptotic machinery. Curr Opin Cell Biol 15 (2003) 732-737
11. Lima V., Brito G.A., Cunha F.Q., Reboucas C.G., Falcao B.A., Augusto R.F., et al. Effects of the tumour necrosis factor-alpha inhibitors pentoxifylline and thalidomide in short-term experimental oral mucositis in hamsters. Eur J Oral Sci 113 (2005) 210-217
12. Bellas R.E., Lee J.S., and Sonenshein G.E. Expression of a constitutive NF-kappa B-like activity is essential for proliferation of cultured bovine vascular smooth muscle cells. J Clin Invest 96 (1995) 2521-2527
13. Wang W., Tam W.F., Hughes C.C., Rath S., and Sen R. c-Rel is a target of pentoxifylline-mediated inhibition of T lymphocyte activation. Immunity 6 (1997) 165-174
14. Jimenez J.L., Punzon C., Navarro J., Munoz-Fernandez M.A., and Fresno M. Phosphodiesterase 4 inhibitors prevent cytokine secretion by T lymphocytes by inhibiting nuclear factor-kappaB and nuclear factor of activated T cells activation. J Pharmacol Exp Ther 299 (2001) 753-759
15. Rauko P., Sedlak J., Duraj J., Szekeres M.F., and Novotny L. Pentoxifylline stimulates drug-induced apoptosis in leukemic cells. Neoplasma 45 (1998) 296-300
16. Alas S., Bonavida B., and Emmanouilides C. Potentiation of fludarabine cytotoxicity on non-Hodgkin's lymphoma by pentoxifylline and rituximab. Anticancer Res 20 (2000) 2961-2966
17. Lerma-Diaz J.M., Hernandez-Flores G., Dominguez-Rodriguez J.R., Ortiz-Lazareno P.C., Gomez-Contreras P., Cervantes-Munguia R., et al. In vivo and in vitro sensitization of leukemic cells to adriamycin-induced apoptosis by pentoxifylline. Involvement of caspase cascades and IkappaBalpha phosphorylation. Immunol Lett 103 (2006) 149-158
18. Waldeck W., Strunz A.M., Muller G., Hotz-Wagenblatt A., Wijenne J., Langowski J., et al. Induced and repressed genes after irradiation sensitizing by pentoxyphylline. Int J Cancer 120 (2007) 1198-1207
19. Rishi L., Dhiman R., Raje M., and Majumdar S. Nitric oxide induces apoptosis in cutaneous T cell lymphoma (HuT-78) by downregulating constitutive NF-kappaB. Biochim Biophys Acta 1770 (2007) 1230-1239
20. Blaszczyk A., and Skolimowski J. Apoptosis and cytotoxicity caused by ethoxyquin salts in human lymphocytes in vitro. Food Chem 105 (2007) 1159-1163
21. Herrmann M., Lorenz H.M., Voll R., Grunke M., Woith W., and Kalden J.R. A rapid and simple method for the isolation of apoptotic DNA fragments. Nucleic Acids Res 22 (1994) 5506-5507
22. Liu M.J., Yue P.Y., Wang Z., and Wong R.N. Methyl protodioscin induces G2/M arrest and apoptosis in K562 cells with the hyperpolarization of mitochondria. Cancer Lett 224 (2005) 229-241
23. Miyoshi N., Nakamura Y., Ueda Y., Abe M., Ozawa Y., Uchida K., et al. Dietary ginger constituents, galanals A and B, are potent apoptosis inducers in human T lymphoma Jurkat cells. Cancer Lett 199 (2003) 113-119
24. Majumdar S., and Aggarwal B.B. Adenosine suppresses activation of nuclear factor-kappaB selectively induced by tumor necrosis factor in different cell types. Oncogene 22 (2003) 1206-1218
25. Dhiman R., Kathania M., Raje M., and Majumdar S. Inhibition of bfl-1/A1 by siRNA inhibits mycobacterial growth in THP-1 cells by enhancing phagosomal acidification. Biochim Biophys Acta 1780 (2008) 733-742
26. Raje C.I., Kumar S., Harle A., Nanda J.S., and Raje M. The macrophage cell surface glyceraldehyde-3-phosphate dehydrogenase is a novel transferrin receptor. J Biol Chem 282 (2007) 3252-3261
27. Walz C., Crowley B.J., Hudon H.E., Gramlich J.L., Neuberg D.S., Podar K., et al. Activated Jak2 with the V617F point mutation promotes G1/S phase transition. J Biol Chem 281 (2006) 18177-18183
28. Xu Y., Kim S.O., Li Y., and Han J. Autophagy contributes to caspase-independent macrophage cell death. J Biol Chem 281 (2006) 19179-19187
29. Longley D.B., Wilson T.R., McEwan M., Allen W.L., McDermott U., Galligan L., et al. c-FLIP inhibits chemotherapy-induced colorectal cancer cell death. Oncogene 25 (2006) 838-848
30. Braun F.K., Fecker L.F., Schwarz C., Walden P., Assaf C., Durkop H., et al. Blockade of death receptor-mediated pathways early in the signaling cascade coincides with distinct apoptosis resistance in cutaneous T-cell lymphoma cells. J Invest Dermatol 127 (2007) 2425-2437
31. SundarRaj S., Mukhopadhyay D., and Karande A.A. Glycodelin A triggers mitochondrial stress and apoptosis in T cells by a mechanism distinct and independent of TCR signaling. Mol Immunol 45 (2008) 2391-2400
32. Chung H.K., Yi Y.W., Jung N.C., Kim D., Suh J.M., Kim H., et al. Gadd45gamma expression is reduced in anaplastic thyroid cancer and its reexpression results in apoptosis. J Clin Endocrinol Metab 88 (2003) 3913-3920
33. Tolomeo M., Dusonchet L., Meli M., Grimaudo S., D'Alessandro N., Papoff G., et al. The CD95/CD95 ligand system is not the major effector in anticancer drug-mediated apoptosis. Cell Death Differ 5 (1998) 735-742
34. Izban K.F., Ergin M., Qin J.Z., Martinez R.L., Pooley R.J., Saeed S., et al. Constitutive expression of NF-kappa B is a characteristic feature of mycosis fungoides: implications for apoptosis resistance and pathogenesis. Hum Pathol 31 (2000) 1482-1490
35. Jazirehi A.R., Vega M.I., Chatterjee D., Goodglick L., and Bonavida B. Inhibition of the Raf-MEK1/2-ERK1/2 signaling pathway, Bcl-xL down-regulation, and chemosensitization of non-Hodgkin's lymphoma B cells by Rituximab. Cancer Res 64 (2004) 7117-7126
36. Kim R., Ohi Y., Inoue H., and Toge T. Taxotere activates transcription factor AP-1 in association with apoptotic cell death in gastric cancer cell lines. Anticancer Res 19 (1999) 5399-5405
37. Li X., and Sun A.Y. Paraquat induced activation of transcription factor AP-1 and apoptosis in PC12 cells. J Neural Transm 106 (1999) 1-21
38. Zhang X., Zhang L., Yang H., Huang X., Otu H., Libermann T.A., et al. c-Fos as a proapoptotic agent in TRAIL-induced apoptosis in prostate cancer cells. Cancer Res 67 (2007) 9425-9434
39. Kang H.S., and Choi I. Protein phosphatase 2A modulates the proliferation of human multiple myeloma cells via regulation of the production of reactive oxygen intermediates and anti-apoptotic factors. Cell Immunol 213 (2001) 34-44
40. Kinoshita H., Yoshikawa H., Shiiki K., Hamada Y., Nakajima Y., and Tasaka K. Cisplatin (CDDP) sensitizes human osteosarcoma cell to Fas/CD95-mediated apoptosis by down-regulating FLIP-L expression. Int J Cancer 88 (2000) 986-991
41. Zhang C., Hazarika P., Ni X., Weidner D.A., and Duvic M. Induction of apoptosis by bexarotene in cutaneous T-cell lymphoma cells: relevance to mechanism of therapeutic action. Clin Cancer Res 8 (2002) 1234-1240
42. Olsen E.A. Interferon in the treatment of cutaneous T-cell lymphoma. Dermatol Ther 16 (2003) 311-321
43. Rook A.H., Kuzel T.M., and Olsen E.A. Cytokine therapy of cutaneous T-cell lymphoma: interferons, interleukin-12, and interleukin-2. Hematol Oncol Clin N Am 17 (2003) 1435-1448 ix
44. Senturk G.B., and Sahi{cyrillic, ukrainian}n S. Extracorporeal photochemotherapy in the treatment of cutaneous T-cell lymphoma. Turk J Cancer 33 (2003) 23-26
45. Ni X., Zhang C., Talpur R., and Duvic M. Resistance to activation-induced cell death and bystander cytotoxicity via the Fas/Fas ligand pathway are implicated in the pathogenesis of cutaneous T cell lymphomas. J Invest Dermatol 124 (2005) 741-750