Death receptors 4 and 5 activate Nox1 NADPH oxidase through riboflavin kinase to induce reactive oxygen species-mediated apoptotic cell death

Journal of Biological Chemistry

Volumn 287, Issue 5, 2012, Pages 3313-3325

  Park, Kyung Jin ^a   Lee, Chang Han ^a   Kim, Aeyung ^a   Jeong, Ki Jun ^b   Kim, Chul Ho ^c   Kim, Yong Sung ^a  

^a Ajou University   (South Korea)

^b Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^c Ajou University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOTIC CELL DEATH; BINDING ASSAYS; C-JUN N-TERMINAL KINASE; CYTOSOLIC; DEATH DOMAIN; DEATH-RECEPTOR; NADPH OXIDASE; REACTIVE OXYGEN; REACTIVE OXYGEN SPECIES; SIGNALING COMPLEX; SUPEROXIDE ANIONS; TUMOR CELLS; TUMOR NECROSIS FACTORS;

CELL MEMBRANES; CHEMICAL ACTIVATION; ENZYME ACTIVITY; OXYGEN; TUMORS;

CELL DEATH;

CASPASE 3; CASPASE 8; DEATH RECEPTOR 4; DEATH RECEPTOR 5; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NOXA1 PROTEIN; NOXO1 PROTEIN; PROTEIN; PROTEIN VARIANT; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; RECOMBINANT PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; RIBOFLAVIN KINASE; STRESS ACTIVATED PROTEIN KINASE; SUPEROXIDE; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED DEATH DOMAIN PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BINDING ASSAY; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN SUBUNIT; SIGNAL TRANSDUCTION;

APOPTOSIS; GENE KNOCKDOWN TECHNIQUES; HELA CELLS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; NADPH OXIDASE; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); RAC1 GTP-BINDING PROTEIN; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; SUPEROXIDES; TNF RECEPTOR-ASSOCIATED DEATH DOMAIN PROTEIN; TNF RECEPTOR-ASSOCIATED FACTOR 2;

EID: 84863012720     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.309021     Document Type: Article

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