-
1
-
-
66949128922
-
Meta-Analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 93 randomised trials and 17,346 patients
-
P ignon JP, le Maitre A, Maillard E and Bourhis J: Meta-Analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 93 randomised trials and 17,346 patients. Radiother Oncol 92: 4-14, 2009.
-
(2009)
Radiother Oncol
, vol.92
, pp. 4-14
-
-
Pignon, J.P.1
Le Maitre, A.2
Maillard, E.3
Bourhis, J.4
-
2
-
-
84877621050
-
Treatment of stage III non-small cell lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidencebased clinical practice guidelines
-
Ramnath N, Dilling TJ, Harris LJ, et al: Treatment of stage III non-small cell lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidencebased clinical practice guidelines. Chest 143: ES314-eS340, 2013.
-
(2013)
Chest
, vol.143
, pp. eS314-eS340
-
-
Ramnath, N.1
Dilling, T.J.2
Harris, L.J.3
-
3
-
-
84903154832
-
Concomitant chemotherapy and radiation for the treatment of advanced-stage endometrial cancer
-
Wilkinson-Ryan I, Binder PS, Pourabolghasem S, et al: Concomitant chemotherapy and radiation for the treatment of advanced-stage endometrial cancer. Gynecol Oncol 134: 24-28, 2014.
-
(2014)
Gynecol Oncol
, vol.134
, pp. 24-28
-
-
Wilkinson-Ryan, I.1
Binder, P.S.2
Pourabolghasem, S.3
-
4
-
-
0037169358
-
Apoptosis: A link between cancer genetics and chemotherapy
-
Johnstone RW, Ruefli AA and Lowe SW: Apoptosis: A link between cancer genetics and chemotherapy. Cell 108: 153-164, 2002.
-
(2002)
Cell
, vol.108
, pp. 153-164
-
-
Johnstone, R.W.1
Ruefli, A.A.2
Lowe, S.W.3
-
5
-
-
30544434832
-
Targeting molecular determinants of tumor chemo-radioresistance
-
Milas L, Raju U, Liao Z and Ajani J: Targeting molecular determinants of tumor chemo-radioresistance. Semin Oncol 32: S78-S81, 2005.
-
(2005)
Semin Oncol
, vol.32
, pp. S78-S81
-
-
Milas, L.1
Raju, U.2
Liao, Z.3
Ajani, J.4
-
6
-
-
56349158694
-
Current state-of-Yhe-Art for concurrent chemoradiation
-
Bernier J: Current state-of-Yhe-Art for concurrent chemoradiation. Semin Radiat Oncol 19: 3-10, 2009.
-
(2009)
Semin Radiat Oncol
, vol.19
, pp. 3-10
-
-
Bernier, J.1
-
7
-
-
84897972454
-
Current challenges and future perspectives of radiotherapy for locally advanced breast cancer
-
Ghiam AF, Spayne J and Lee J: Current challenges and future perspectives of radiotherapy for locally advanced breast cancer. Curr Opin Support Palliat Care 8: 46-52, 2014.
-
(2014)
Curr Opin Support Palliat Care
, vol.8
, pp. 46-52
-
-
Ghiam, A.F.1
Spayne, J.2
Lee, J.3
-
8
-
-
0033761072
-
Growth arrest and cell death in the breast tumor cell in response to ionizing radiation and chemotherapeutic agents which induce DNA damage
-
Gewirtz DA: Growth arrest and cell death in the breast tumor cell in response to ionizing radiation and chemotherapeutic agents which induce DNA damage. Breast Cancer Res Treat 62: 223-235, 2000.
-
(2000)
Breast Cancer Res Treat
, vol.62
, pp. 223-235
-
-
Gewirtz, D.A.1
-
10
-
-
84874050842
-
Molecular targets and mechanisms of radiosensitization using DNA damage response pathways
-
Raleigh DR and Haas-Kogan DA: Molecular targets and mechanisms of radiosensitization using DNA damage response pathways. Future Oncol 9: 219-233, 2013.
-
(2013)
Future Oncol
, vol.9
, pp. 219-233
-
-
Raleigh, D.R.1
Haas-Kogan, D.A.2
-
11
-
-
0043163868
-
EGFR family signaling and its association with breast cancer development and resistance to chemotherapy (Review)
-
Navolanic PM, Steelman LS and McCubrey JA: EGFR family signaling and its association with breast cancer development and resistance to chemotherapy (Review). Int J Oncol 22: 237-252, 2003.
-
(2003)
Int J Oncol
, vol.22
, pp. 237-252
-
-
Navolanic, P.M.1
Steelman, L.S.2
McCubrey, J.A.3
-
12
-
-
33751328082
-
ErbB receptors: New insights on mechanisms and biology
-
L inggi B and Carpenter G: ErbB receptors: New insights on mechanisms and biology. Trends Cell Biol 16: 649-656, 2006.
-
(2006)
Trends Cell Biol
, vol.16
, pp. 649-656
-
-
Linggi, B.1
Carpenter, G.2
-
13
-
-
84896091512
-
ERBB receptors: From oncogene discovery to basic science to mechanism-based cancer therapeutics
-
Arteaga Carlos L and Engelman Jeffrey A: ERBB receptors: From oncogene discovery to basic science to mechanism-based cancer therapeutics. Cancer Cell 25: 282-303, 2014.
-
(2014)
Cancer Cell
, vol.25
, pp. 282-303
-
-
Arteaga, C.L.1
Engelman, J.A.2
-
14
-
-
84861516765
-
Intrinsic and acquired resistance to HER2-Yargeted therapies in HER2 gene-Amplified breast cancer: Mechanisms and clinical implications
-
Rexer BN and Arteaga CL: Intrinsic and acquired resistance to HER2-Yargeted therapies in HER2 gene-Amplified breast cancer: Mechanisms and clinical implications. Crit Rev Oncog 17: 1-16, 2012.
-
(2012)
Crit Rev Oncog
, vol.17
, pp. 1-16
-
-
Rexer, B.N.1
Arteaga, C.L.2
-
15
-
-
34147190965
-
Radiation-induced cell signaling: Inside-out and outside-in
-
V alerie K, Yacoub A, Hagan MP, et al: Radiation-induced cell signaling: Inside-out and outside-in. Mol Cancer Ther 6: 789-801, 2007.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 789-801
-
-
Valerie, K.1
Yacoub, A.2
Hagan, M.P.3
-
17
-
-
50349092591
-
Activation of epidermal growth factor receptor and its downstream signaling pathway by nitric oxide in response to ionizing radiation
-
L ee H-C, An S, Lee H, et al: Activation of epidermal growth factor receptor and its downstream signaling pathway by nitric oxide in response to ionizing radiation. Mol Cancer Res 6: 996-1002, 2008.
-
(2008)
Mol Cancer Res
, vol.6
, pp. 996-1002
-
-
Lee, H.-C.1
An, S.2
Lee, H.3
-
18
-
-
84891356953
-
Radiation-induced dimer formation of EGFR: Implications for the radiosensitizing effect of cetuximab
-
Kiyozuka M, Akimoto T, Fukutome M, Motegi A and Mitsuhashi N: Radiation-induced dimer formation of EGFR: Implications for the radiosensitizing effect of cetuximab. Anticancer Res 33: 4337-4346, 2013.
-
(2013)
Anticancer Res
, vol.33
, pp. 4337-4346
-
-
Kiyozuka, M.1
Akimoto, T.2
Fukutome, M.3
Motegi, A.4
Mitsuhashi, N.5
-
19
-
-
84939873145
-
A novel function of HER2/Neu in the activation of G2/M checkpoint in response to [gamma]-irradiation
-
June 9, (Epub ahead of print)
-
Y an Y, Hein AL, Greer PM, et al: A novel function of HER2/Neu in the activation of G2/M checkpoint in response to [gamma]-irradiation. Oncogene: June 9, 2014 (Epub ahead of print). doi: 10.1038/onc.2014.167.
-
(2014)
Oncogene
-
-
Yan, Y.1
Hein, A.L.2
Greer, P.M.3
-
20
-
-
0036184190
-
Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo
-
Meng TC, Fukada T and Tonks NK: Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo. Mol Cell 9: 387-399, 2002.
-
(2002)
Mol Cell
, vol.9
, pp. 387-399
-
-
Meng, T.C.1
Fukada, T.2
Tonks, N.K.3
-
21
-
-
0035872421
-
Ionizing radiation-induced, mitochondriadependent generation of reactive oxygen/nitrogen
-
L each JK, Van Tuyle G, Lin PS, Schmidt-Ullrich R and Mikkelsen RB: Ionizing radiation-induced, mitochondriadependent generation of reactive oxygen/nitrogen. Cancer Res 61: 3894-3901, 2001.
-
(2001)
Cancer Res
, vol.61
, pp. 3894-3901
-
-
Leach, J.K.1
Van Tuyle, G.2
Lin, P.S.3
Schmidt-Ullrich, R.4
Mikkelsen, R.B.5
-
22
-
-
0842304926
-
Radiosensitization by Pan ErbB Inhibitor CI-1033 in vitro and in vivo
-
Nyati MK, Maheshwari D, Hanasoge S, et al: Radiosensitization by Pan ErbB Inhibitor CI-1033 in vitro and in vivo. Clin Cancer Res 10: 691-700, 2004.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 691-700
-
-
Nyati, M.K.1
Maheshwari, D.2
Hanasoge, S.3
-
23
-
-
3242686392
-
Sensitization of breast cancer cells to radiation by trastuzumab
-
L iang K, Lu Y, Jin W, Ang KK, Milas L and Fan Z: Sensitization of breast cancer cells to radiation by trastuzumab. Mol Cancer Ther 2: 1113-1120, 2003.
-
(2003)
Mol Cancer Ther
, vol.2
, pp. 1113-1120
-
-
Liang, K.1
Lu, Y.2
Jin, W.3
Ang, K.K.4
Milas, L.5
Fan, Z.6
-
24
-
-
43949128408
-
EGFR tyrosine kinase inhibition radiosensitizes and induces apoptosis in malignant glioma and childhood ependymoma xenografts
-
Geoerger B, Gaspar N, Opolon P, et al: EGFR tyrosine kinase inhibition radiosensitizes and induces apoptosis in malignant glioma and childhood ependymoma xenografts. Int J Cancer 123: 209-216, 2008.
-
(2008)
Int J Cancer
, vol.123
, pp. 209-216
-
-
Geoerger, B.1
Gaspar, N.2
Opolon, P.3
-
25
-
-
24744449739
-
Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase
-
Dittmann K, Mayer C, Fehrenbacher B, et al: Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase. J Biol Chem 280: 31182-31189, 2005.
-
(2005)
J Biol Chem
, vol.280
, pp. 31182-31189
-
-
Dittmann, K.1
Mayer, C.2
Fehrenbacher, B.3
-
26
-
-
28444453967
-
Inhibition of radiationinduced EGFR nuclear import by C225 (Cetuximab) suppresses DNA-PK activity
-
Dittmann K, Mayer C and Rodemann HP: Inhibition of radiationinduced EGFR nuclear import by C225 (Cetuximab) suppresses DNA-PK activity. Radiother Oncol 76: 157-161, 2005.
-
(2005)
Radiother Oncol
, vol.76
, pp. 157-161
-
-
Dittmann, K.1
Mayer, C.2
Rodemann, H.P.3
-
27
-
-
0141757460
-
MAPK pathways in radiation responses
-
Dent P, Yacoub A, Fisher PB, Hagan MP and Grant S: MAPK pathways in radiation responses. Oncogene 22: 5885-5896, 2003.
-
(2003)
Oncogene
, vol.22
, pp. 5885-5896
-
-
Dent, P.1
Yacoub, A.2
Fisher, P.B.3
Hagan, M.P.4
Grant, S.5
-
28
-
-
0034526814
-
Cisplatin-induced response of c-jun N-Yerminal kinase 1 and extracellular signal-regulated protein kinases 1 and 2 in a series of cisplatin-resistant ovarian carcinoma cell lines
-
Cui W, Yazlovitskaya EM, Mayo MS, Pelling JC and Persons DL: Cisplatin-induced response of c-jun N-Yerminal kinase 1 and extracellular signal-regulated protein kinases 1 and 2 in a series of cisplatin-resistant ovarian carcinoma cell lines. Mol Carcinog 29: 219-228, 2000.
-
(2000)
Mol Carcinog
, vol.29
, pp. 219-228
-
-
Cui, W.1
Yazlovitskaya, E.M.2
Mayo, M.S.3
Pelling, J.C.4
Persons, D.L.5
-
29
-
-
0033613944
-
Mitogen-Activated protein kinase kinase 2 activation is essential for progression through the G2/M checkpoint arrest in cells exposed to ionizing radiation
-
Abbott DW and Holt JT: Mitogen-Activated protein kinase kinase 2 activation is essential for progression through the G2/M checkpoint arrest in cells exposed to ionizing radiation. J Biol Chem 274: 2732-2742, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 2732-2742
-
-
Abbott, D.W.1
Holt, J.T.2
-
30
-
-
0037066686
-
ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53
-
Tang D, Wu D, Hirao A, et al: ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53. J Biol Chem 277: 12710-12717, 2002.
-
(2002)
J Biol Chem
, vol.277
, pp. 12710-12717
-
-
Tang, D.1
Wu, D.2
Hirao, A.3
-
31
-
-
34447537796
-
Irradiation-induced G2/M checkpoint response requires ERK1/2 activation
-
Y an Y, Black CP and Cowan KH: Irradiation-induced G2/M checkpoint response requires ERK1/2 activation. Oncogene 26: 4689-4698, 2007.
-
(2007)
Oncogene
, vol.26
, pp. 4689-4698
-
-
Yan, Y.1
Black, C.P.2
Cowan, K.H.3
-
32
-
-
84890487369
-
Mitogen-Activated protein kinases and their role in radiation response
-
Munshi A and Ramesh R: Mitogen-Activated protein kinases and their role in radiation response. Genes Cancer 4: 401-408, 2013.
-
(2013)
Genes Cancer
, vol.4
, pp. 401-408
-
-
Munshi, A.1
Ramesh, R.2
-
33
-
-
0034618369
-
MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-X(L), and Mcl-1 and promotes survival of human pancreatic cancer cells
-
Boucher MJ, Morisset J, Vachon PH, Reed JC, Laine J and Rivard N: MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-X(L), and Mcl-1 and promotes survival of human pancreatic cancer cells. J Cell Biochem 79: 355-369, 2000.
-
(2000)
J Cell Biochem
, vol.79
, pp. 355-369
-
-
Boucher, M.J.1
Morisset, J.2
Vachon, P.H.3
Reed, J.C.4
Laine, J.5
Rivard, N.6
-
34
-
-
0035809182
-
Matrix attachment regulates Fas-induced apoptosis in endothelial cells: A role for c-flip and implications for anoikis
-
Aoudjit F and Vuori K: Matrix attachment regulates Fas-induced apoptosis in endothelial cells: A role for c-flip and implications for anoikis. J Cell Biol 152: 633-643, 2001.
-
(2001)
J Cell Biol
, vol.152
, pp. 633-643
-
-
Aoudjit, F.1
Vuori, K.2
-
35
-
-
0035794191
-
Epidermal growth factor receptor-dependent control of keratinocyte survival and Bcl-xL expression through a MEK-dependent pathway
-
Jost M, Huggett TM, Kari C, Boise LH and Rodeck U: Epidermal growth factor receptor-dependent control of keratinocyte survival and Bcl-xL expression through a MEK-dependent pathway. J Biol Chem 276: 6320-6326, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 6320-6326
-
-
Jost, M.1
Huggett, T.M.2
Kari, C.3
Boise, L.H.4
Rodeck, U.5
-
36
-
-
0032698075
-
Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
-
Bonni A, Brunet A, West AE, Datta SR, Takasu MA and Greenberg ME: Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science 286: 1358-1362, 1999.
-
(1999)
Science
, vol.286
, pp. 1358-1362
-
-
Bonni, A.1
Brunet, A.2
West, A.E.3
Datta, S.R.4
Takasu, M.A.5
Greenberg, M.E.6
-
37
-
-
34547405738
-
Contrasting roles of neuronal Msk1 and Rsk2 in Bad phosphorylation and feedback regulation of Erk signalling
-
Clark CJ, McDade DM, O'Shaughnessy CT and Morris BJ: Contrasting roles of neuronal Msk1 and Rsk2 in Bad phosphorylation and feedback regulation of Erk signalling. J Neurochem 102: 1024-1034, 2007.
-
(2007)
J Neurochem
, vol.102
, pp. 1024-1034
-
-
Clark, C.J.1
McDade, D.M.2
O'Shaughnessy, C.T.3
Morris, B.J.4
-
38
-
-
34250892541
-
ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL
-
Ewings KE, Hadfield-Moorhouse K, Wiggins CM, et al: ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL. Embo J 26: 2856-2867, 2007.
-
(2007)
Embo J
, vol.26
, pp. 2856-2867
-
-
Ewings, K.E.1
Hadfield-Moorhouse, K.2
Wiggins, C.M.3
-
39
-
-
0038726089
-
Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK
-
Allan LA, Morrice N, Brady S, Magee G, Pathak S and Clarke P R: Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK. Nat Cell Biol 5: 647-654, 2003.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 647-654
-
-
Allan, L.A.1
Morrice, N.2
Brady, S.3
Magee, G.4
Pathak, S.5
Clarke P, R.6
-
40
-
-
0032982539
-
Correlation between gamma-ray-induced G2 arrest and radioresistance in two human cancer cells
-
Tamamoto T, Ohnishi K, Takahashi A, et al: Correlation between gamma-ray-induced G2 arrest and radioresistance in two human cancer cells. Int J Radiat Oncol Biol Phys 44: 905-909, 1999.
-
(1999)
Int J Radiat Oncol Biol Phys
, vol.44
, pp. 905-909
-
-
Tamamoto, T.1
Ohnishi, K.2
Takahashi, A.3
-
41
-
-
0142061926
-
Lovastatin causes sensitization of HeLa cells to ionizing radiation-induced apoptosis by the abrogation of G2 blockage
-
Fritz G, Brachetti C and Kaina B: Lovastatin causes sensitization of HeLa cells to ionizing radiation-induced apoptosis by the abrogation of G2 blockage. Int J Radiat Biol 79: 601-610, 2003.
-
(2003)
Int J Radiat Biol
, vol.79
, pp. 601-610
-
-
Fritz, G.1
Brachetti, C.2
Kaina, B.3
-
42
-
-
48549098149
-
Gamma-irradiation-induced DNA damage checkpoint activation involves feedback regulation between extracellular signal-regulated kinase 1/2 and BRCA1
-
Y an Y, Black CP, Cao PT, et al: Gamma-irradiation-induced DNA damage checkpoint activation involves feedback regulation between extracellular signal-regulated kinase 1/2 and BRCA1. Cancer Res 68: 5113-5121, 2008.
-
(2008)
Cancer Res
, vol.68
, pp. 5113-5121
-
-
Yan, Y.1
Black, C.P.2
Cao, P.T.3
-
43
-
-
0037382902
-
Epidermal growth factor and ionizing radiation up-regulate the DNA repair genes XRCC1 and ERCC1 in DU145 and LNCaP prostate carcinoma through MAPK signaling
-
Y acoub A, McKinstry R, Hinman D, Chung T, Dent P and Hagan MP: Epidermal growth factor and ionizing radiation up-regulate the DNA repair genes XRCC1 and ERCC1 in DU145 and LNCaP prostate carcinoma through MAPK signaling. Radiat Res 159: 439-452, 2003.
-
(2003)
Radiat Res
, vol.159
, pp. 439-452
-
-
Yacoub, A.1
McKinstry, R.2
Hinman, D.3
Chung, T.4
Dent, P.5
Hagan, M.P.6
-
44
-
-
66149094649
-
Pro-survival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double-strand break repair in human glioma cells
-
Golding SE, Morgan RN, Adams BR, Hawkins AJ, Povirk LF and Valerie K: Pro-survival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double-strand break repair in human glioma cells. Cancer Biol Ther 8: 730-738, 2009.
-
(2009)
Cancer Biol Ther
, vol.8
, pp. 730-738
-
-
Golding, S.E.1
Morgan, R.N.2
Adams, B.R.3
Hawkins, A.J.4
Povirk, L.F.5
Valerie, K.6
-
45
-
-
84868667376
-
Inhibition of ERK activation enhances the repair of double-stranded breaks via non-homologous end joining by increasing DNA-PKcs activation
-
Wei F, Yan J, Tang D, et al: Inhibition of ERK activation enhances the repair of double-stranded breaks via non-homologous end joining by increasing DNA-PKcs activation. Biochim Biophys Acta 1833: 90-100, 2013.
-
(2013)
Biochim Biophys Acta
, vol.1833
, pp. 90-100
-
-
Wei, F.1
Yan, J.2
Tang, D.3
-
46
-
-
35649007784
-
PARP-1 activation in the ERK signaling pathway
-
Cohen-Armon M: PARP-1 activation in the ERK signaling pathway. Trends Pharmacol Sci 28: 556-560, 2007.
-
(2007)
Trends Pharmacol Sci
, vol.28
, pp. 556-560
-
-
Cohen-Armon, M.1
-
47
-
-
33846362869
-
DNA-independent PARP-1 activation by phosphorylated ERK2 increases Elk1 activity: A link to histone acetylation
-
Cohen-Armon M, Visochek L, Rozensal D, et al: DNA-independent PARP-1 activation by phosphorylated ERK2 increases Elk1 activity: A link to histone acetylation. Mol Cell 25: 297-308, 2007.
-
(2007)
Mol Cell
, vol.25
, pp. 297-308
-
-
Cohen-Armon, M.1
Visochek, L.2
Rozensal, D.3
-
48
-
-
33847066413
-
Extracellular signal-related kinase positively regulates ataxia telangiectasia mutated, homologous recombination repair, and the DNA damage response
-
Golding SE, Rosenberg E, Neill S, Dent P, Povirk LF and Valerie K: Extracellular signal-related kinase positively regulates ataxia telangiectasia mutated, homologous recombination repair, and the DNA damage response. Cancer Res 67: 1046-1053, 2007.
-
(2007)
Cancer Res
, vol.67
, pp. 1046-1053
-
-
Golding, S.E.1
Rosenberg, E.2
Neill, S.3
Dent, P.4
Povirk, L.F.5
Valerie, K.6
-
49
-
-
84859513105
-
RAC1 GTPase plays an important role in gamma-irradiation induced G2/M checkpoint activation
-
Y an Y, Greer PM, Cao PT, Kolb RH and Cowan KH: RAC1 GTPase plays an important role in gamma-irradiation induced G2/M checkpoint activation. Breast Cancer Res 14: R60, 2012.
-
(2012)
Breast Cancer Res
, vol.14
, pp. R60
-
-
Yan, Y.1
Greer, P.M.2
Cao, P.T.3
Kolb, R.H.4
Cowan, K.H.5
-
50
-
-
0028605310
-
The signaling pathway coupling epidermal growth factor receptors to activation of p21ras
-
S asaoka T, Langlois WJ, Leitner JW, Draznin B and Olefsky JM: The signaling pathway coupling epidermal growth factor receptors to activation of p21ras. J Biol Chem 269: 32621-32625, 1994.
-
(1994)
J Biol Chem
, vol.269
, pp. 32621-32625
-
-
Sasaoka, T.1
Langlois, W.J.2
Leitner, J.W.3
Draznin, B.4
Olefsky, J.M.5
-
51
-
-
0028000009
-
Activation of the Ras signalling pathway in human breast cancer cells overexpressing erbB-2
-
Janes PW, Daly RJ, deFazio A and Sutherland RL: Activation of the Ras signalling pathway in human breast cancer cells overexpressing erbB-2. Oncogene 9: 3601-3608, 1994.
-
(1994)
Oncogene
, vol.9
, pp. 3601-3608
-
-
Janes, P.W.1
Daly, R.J.2
DeFazio, A.3
Sutherland, R.L.4
-
52
-
-
0032815618
-
Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-Activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death
-
Dent P, Reardon DB, Park JS, et al: Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-Activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death. Mol Biol Cell 10: 2493-2506, 1999.
-
(1999)
Mol Biol Cell
, vol.10
, pp. 2493-2506
-
-
Dent, P.1
Reardon, D.B.2
Park, J.S.3
-
53
-
-
0034029550
-
Ionizing radiation-induced mitogen-Activated protein (MAP) kinase activation in DU145 prostate carcinoma cells: MAP kinase inhibition enhances radiation-induced cell killing and G2/M-phase arrest
-
Hagan M, Wang L, Hanley JR, Park JS and Dent P: Ionizing radiation-induced mitogen-Activated protein (MAP) kinase activation in DU145 prostate carcinoma cells: MAP kinase inhibition enhances radiation-induced cell killing and G2/M-phase arrest. Radiat Res 153: 371-383, 2000.
-
(2000)
Radiat Res
, vol.153
, pp. 371-383
-
-
Hagan, M.1
Wang, L.2
Hanley, J.R.3
Park, J.S.4
Dent, P.5
-
54
-
-
84896401739
-
Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway
-
P olivka J Jr and Janku F: Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway. Pharmacol Ther 142: 164-175, 2014.
-
(2014)
Pharmacol Ther
, vol.142
, pp. 164-175
-
-
Polivka, J.1
Janku, F.2
-
55
-
-
0035936023
-
The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change
-
Y amaguchi H and Wang HG: The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change. Oncogene 20: 7779-7786, 2001.
-
(2001)
Oncogene
, vol.20
, pp. 7779-7786
-
-
Yamaguchi, H.1
Wang, H.G.2
-
56
-
-
2442681877
-
Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils
-
Gardai SJ, Hildeman DA, Frankel SK, et al: Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils. J Biol Chem 279: 21085-21095, 2004.
-
(2004)
J Biol Chem
, vol.279
, pp. 21085-21095
-
-
Gardai, S.J.1
Hildeman, D.A.2
Frankel, S.K.3
-
57
-
-
33644865025
-
Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function
-
Qi XJ, Wildey GM and Howe PH: Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function. J Biol Chem 281: 813-823, 2006.
-
(2006)
J Biol Chem
, vol.281
, pp. 813-823
-
-
Qi, X.J.1
Wildey, G.M.2
Howe, P.H.3
-
58
-
-
0037385088
-
Inactivation of the forkhead transcription factor FoxO3 is essential for PKB-mediated survival of hematopoietic progenitor cells by kit ligand
-
Engström M, Karlsson R and Jönsson J-I: Inactivation of the forkhead transcription factor FoxO3 is essential for PKB-mediated survival of hematopoietic progenitor cells by kit ligand. Exp Hematol 31: 316-323, 2003.
-
(2003)
Exp Hematol
, vol.31
, pp. 316-323
-
-
Engström, M.1
Karlsson, R.2
Jönsson, J.-I.3
-
59
-
-
33749346063
-
Ionizing radiation activates expression of FOXO3a, Fas ligand, and Bim, and induces cell apoptosis
-
Y ang JY, Xia W and Hu MC: Ionizing radiation activates expression of FOXO3a, Fas ligand, and Bim, and induces cell apoptosis. Int J Oncol 29: 643-648, 2006.
-
(2006)
Int J Oncol
, vol.29
, pp. 643-648
-
-
Yang, J.Y.1
Xia, W.2
Hu, M.C.3
-
60
-
-
33847077943
-
FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells
-
Obexer P, Geiger K, Ambros PF, Meister B and Ausserlechner MJ: FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells. Cell Death Differ 14: 534-547, 2007.
-
(2007)
Cell Death Differ
, vol.14
, pp. 534-547
-
-
Obexer, P.1
Geiger, K.2
Ambros, P.F.3
Meister, B.4
Ausserlechner, M.J.5
-
61
-
-
35649004861
-
Akt phosphorylates MstI and prevents its proteolytic activation, blocking FOXO3 phosphorylation and nuclear translocation
-
Jang S-W, Yang S-J, Srinivasan S and Ye K: Akt phosphorylates MstI and prevents its proteolytic activation, blocking FOXO3 phosphorylation and nuclear translocation. J Biol Chem 282: 30836-30844, 2007.
-
(2007)
J Biol Chem
, vol.282
, pp. 30836-30844
-
-
Jang, S.-W.1
Yang, S.-J.2
Srinivasan, S.3
Ye, K.4
-
62
-
-
0033517189
-
NF-kappaB activation by tumour necrosis factor requires the Akt serine-Yhreonine kinase
-
Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM and Donner DB: NF-kappaB activation by tumour necrosis factor requires the Akt serine-Yhreonine kinase. Nature 401: 82-85, 1999.
-
(1999)
Nature
, vol.401
, pp. 82-85
-
-
Ozes, O.N.1
Mayo, L.D.2
Gustin, J.A.3
Pfeffer, S.R.4
Pfeffer, L.M.5
Donner, D.B.6
-
63
-
-
1242317030
-
Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP)
-
Dan HC, Sun M, Kaneko S, et al: Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP). J Biol Chem 279: 5405-5412, 2004.
-
(2004)
J Biol Chem
, vol.279
, pp. 5405-5412
-
-
Dan, H.C.1
Sun, M.2
Kaneko, S.3
-
64
-
-
33745307617
-
Ras,PI(3)K and mTOR signalling controls tumour cell growth
-
S haw RJ and Cantley LC: Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature 441: 424-430, 2006.
-
(2006)
Nature
, vol.441
, pp. 424-430
-
-
Shaw, R.J.1
Cantley, L.C.2
-
66
-
-
34247161742
-
Temporal onset of hypoxia and oxidative stress after pulmonary irradiation
-
Fleckenstein K, Zgonjanin L, Chen L, et al: Temporal onset of hypoxia and oxidative stress after pulmonary irradiation. Int J Radiat Oncol Biol Phys 68: 196-204, 2007.
-
(2007)
Int J Radiat Oncol Biol Phys
, vol.68
, pp. 196-204
-
-
Fleckenstein, K.1
Zgonjanin, L.2
Chen, L.3
-
67
-
-
84900821472
-
Apoptotic cell death under hypoxia
-
S endoel A and Hengartner MO: Apoptotic cell death under hypoxia. Physiology 29: 168-176, 2014.
-
(2014)
Physiology
, vol.29
, pp. 168-176
-
-
Sendoel, A.1
Hengartner, M.O.2
-
68
-
-
0035900197
-
Caspase-3 activation induced by inhibition of mitochondrial complex I is facilitated by glycogen synthase kinase-3β and attenuated by lithium
-
King TD, Bijur GN and Jope RS: Caspase-3 activation induced by inhibition of mitochondrial complex I is facilitated by glycogen synthase kinase-3β and attenuated by lithium. Brain Res 919: 106-114, 2001.
-
(2001)
Brain Res
, vol.919
, pp. 106-114
-
-
King, T.D.1
Bijur, G.N.2
Jope, R.S.3
-
69
-
-
0036830441
-
Enhanced glycogen synthase kinase-3β activity mediates hypoxia-induced apoptosis of vascular smooth muscle cells and is prevented by glucose transport and metabolism
-
L oberg RD, Vesely E and Brosius FC: Enhanced glycogen synthase kinase-3β activity mediates hypoxia-induced apoptosis of vascular smooth muscle cells and is prevented by glucose transport and metabolism. J Biol Chem 277: 41667-41673, 2002.
-
(2002)
J Biol Chem
, vol.277
, pp. 41667-41673
-
-
Loberg, R.D.1
Vesely, E.2
Brosius, F.C.3
-
70
-
-
51049105757
-
Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair
-
Toulany M, Kehlbach R, Florczak U, et al: Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair. Mol Cancer Ther 7: 1772-1781, 2008.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 1772-1781
-
-
Toulany, M.1
Kehlbach, R.2
Florczak, U.3
-
71
-
-
0028302018
-
ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor
-
S oltoff SP, Carraway KL III, Prigent SA, Gullick WG and Cantley LC: ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor. Int J Radiat Biol 14: 3550-3558, 1994.
-
(1994)
Int J Radiat Biol
, vol.14
, pp. 3550-3558
-
-
Soltoff, S.P.1
Carraway, K.L.2
Prigent, S.A.3
Gullick, W.G.4
Cantley, L.C.5
-
73
-
-
34548058584
-
Stimulated PI3K-AKT signaling mediated through ligand or radiationinduced EGFR depends indirectly, but not directly, on constitutive K-Ras activity
-
Toulany M, Baumann M and Rodemann HP: Stimulated PI3K-AKT signaling mediated through ligand or radiationinduced EGFR depends indirectly, but not directly, on constitutive K-Ras activity. Mol Cancer Res 5: 863-872, 2007.
-
(2007)
Mol Cancer Res
, vol.5
, pp. 863-872
-
-
Toulany, M.1
Baumann, M.2
Rodemann, H.P.3
-
74
-
-
81855194075
-
K-RAS(V12) induces autocrine production of EGFR ligands and mediates radioresistance through EGFR-dependent Akt signaling and activation of DNA-PKcs
-
Minjgee M, Toulany M, Kehlbach R, Giehl K and Rodemann HP: K-RAS(V12) induces autocrine production of EGFR ligands and mediates radioresistance through EGFR-dependent Akt signaling and activation of DNA-PKcs. Int J Radiat Oncol Biol Phys 81: 1506-1514, 2011.
-
(2011)
Int J Radiat Oncol Biol Phys
, vol.81
, pp. 1506-1514
-
-
Minjgee, M.1
Toulany, M.2
Kehlbach, R.3
Giehl, K.4
Rodemann, H.P.5
-
75
-
-
84864018780
-
Akt promotes postirradiation survival of human tumor cells through initiation, progression, and termination of DNA-PKcs-dependent DNA double-strand break repair
-
Toulany M, Lee K-J, Fattah KR, et al: Akt promotes postirradiation survival of human tumor cells through initiation, progression, and termination of DNA-PKcs-dependent DNA double-strand break repair. Mol Cancer Res 10: 945-957, 2012.
-
(2012)
Mol Cancer Res
, vol.10
, pp. 945-957
-
-
Toulany, M.1
Lee, K.-J.2
Fattah, K.R.3
-
76
-
-
84898810931
-
The influence of AKT isoforms on radiation sensitivity and DNA repair in colon cancer cell lines
-
S ahlberg SH, Gustafsson AS, Pendekanti PN, Glimelius B and Stenerlow B: The influence of AKT isoforms on radiation sensitivity and DNA repair in colon cancer cell lines. Tumour Biol 35: 3525-3534, 2014.
-
(2014)
Tumour Biol
, vol.35
, pp. 3525-3534
-
-
Sahlberg, S.H.1
Gustafsson, A.S.2
Pendekanti, P.N.3
Glimelius, B.4
Stenerlow, B.5
-
77
-
-
79955578793
-
Targeting the AKT/GSK3β/cyclin D1/Cdk4 survival signaling pathway for eradication of tumor radioresistance acquired by fractionated radiotherapy
-
S himura T, Kakuda S, Ochiai Y, Kuwahara Y, Takai Y and Fukumoto M: Targeting the AKT/GSK3β/cyclin D1/Cdk4 survival signaling pathway for eradication of tumor radioresistance acquired by fractionated radiotherapy. Int J Radiat Oncol Biol Phys 80: 540-548, 2011.
-
(2011)
Int J Radiat Oncol Biol Phys
, vol.80
, pp. 540-548
-
-
Shimura, T.1
Kakuda, S.2
Ochiai, Y.3
Kuwahara, Y.4
Takai, Y.5
Fukumoto, M.6
-
78
-
-
24744452428
-
Selective inhibition of Ras, phosphoinositide 3 kinase, and Akt isoforms increases the radiosensitivity of human carcinoma cell lines
-
Kim IA, Bae SS, Fernandes A, et al: Selective inhibition of Ras, phosphoinositide 3 kinase, and Akt isoforms increases the radiosensitivity of human carcinoma cell lines. Cancer Res 65: 7902-7910, 2005.
-
(2005)
Cancer Res
, vol.65
, pp. 7902-7910
-
-
Kim, I.A.1
Bae, S.S.2
Fernandes, A.3
-
79
-
-
0037030519
-
Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cells
-
Contessa JN, Hampton J, Lammering G, et al: Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cells. Oncogene 21: 4032-4041, 2002.
-
(2002)
Oncogene
, vol.21
, pp. 4032-4041
-
-
Contessa, J.N.1
Hampton, J.2
Lammering, G.3
-
80
-
-
0026318356
-
Participation of p53 protein in the cellular response to DNA damage
-
Kastan MB, Onyekwere O, Sidransky D, Vogelstein B and Craig RW: Participation of p53 protein in the cellular response to DNA damage. Cancer Res 51: 6304-6311, 1991.
-
(1991)
Cancer Res
, vol.51
, pp. 6304-6311
-
-
Kastan, M.B.1
Onyekwere, O.2
Sidransky, D.3
Vogelstein, B.4
Craig, R.W.5
-
81
-
-
0036718590
-
MEK/ERK pathway protects ionizing radiation-induced loss of mitochondrial membrane potential and cell death in lymphocytic leukemia cells
-
S honai T, Adachi M, Sakata K, et al: MEK/ERK pathway protects ionizing radiation-induced loss of mitochondrial membrane potential and cell death in lymphocytic leukemia cells. Cell Death Differ 9: 963-971, 2002.
-
(2002)
Cell Death Differ
, vol.9
, pp. 963-971
-
-
Shonai, T.1
Adachi, M.2
Sakata, K.3
-
82
-
-
0038485982
-
PKC epsilon-mediated ERK1/2 activation involved in radiation-induced cell death in NIH3T3 cells
-
L ee YJ, Soh JW, Jeoung DI, et al: PKC epsilon-mediated ERK1/2 activation involved in radiation-induced cell death in NIH3T3 cells. Biochim Biophys Acta 1593: 219-229, 2003.
-
(2003)
Biochim Biophys Acta
, vol.1593
, pp. 219-229
-
-
Lee, Y.J.1
Soh, J.W.2
Jeoung, D.I.3
-
83
-
-
84883479608
-
Radiosensitivity enhancement of human hepatocellular carcinoma cell line SMMC-7721 by sorafenib through the MEK/ERK signal pathway
-
Dai X-F, Ding J, Zhang R-G, Ren J-H, Ma C-MC and Wu G: Radiosensitivity enhancement of human hepatocellular carcinoma cell line SMMC-7721 by sorafenib through the MEK/ERK signal pathway. Int J Radiat Biol 89: 1, 2013.
-
(2013)
Int J Radiat Biol
, vol.89
, pp. 1
-
-
Dai, X.-F.1
Ding, J.2
Zhang, R.-G.3
Ren, J.-H.4
Ma, C.-M.C.5
Wu, G.6
-
86
-
-
14044258346
-
G2 damage checkpoints: What is the turn-on?
-
O'Connell MJ and Cimprich KA: G2 damage checkpoints: What is the turn-on? J Cell Sci 118: 1-6, 2005.
-
(2005)
J Cell Sci
, vol.118
, pp. 1-6
-
-
O'Connell, M.J.1
Cimprich, K.A.2
-
88
-
-
0028296168
-
Ionizing radiation induces rapid tyrosine phosphorylation of p34cdc2
-
Kharbanda S, Saleem A, Datta R, Yuan ZM, Weichselbaum R and Kufe D: Ionizing radiation induces rapid tyrosine phosphorylation of p34cdc2. Cancer Res 54: 1412-1414, 1994.
-
(1994)
Cancer Res
, vol.54
, pp. 1412-1414
-
-
Kharbanda, S.1
Saleem, A.2
Datta, R.3
Yuan, Z.M.4
Weichselbaum, R.5
Kufe, D.6
-
89
-
-
0031034628
-
Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast
-
Rhind N, Furnari B and Russell P: Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast. Genes Dev 11: 504-511, 1997.
-
(1997)
Genes Dev
, vol.11
, pp. 504-511
-
-
Rhind, N.1
Furnari, B.2
Russell, P.3
-
90
-
-
0031035528
-
Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation
-
O'Connell MJ, Raleigh JM, Verkade HM and Nurse P: Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation. Embo J 16: 545-554, 1997.
-
(1997)
Embo J
, vol.16
, pp. 545-554
-
-
O'Connell, M.J.1
Raleigh, J.M.2
Verkade, H.M.3
Nurse, P.4
-
91
-
-
0026035524
-
Mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2
-
L undgren K, Walworth N, Booher R, Dembski M, Kirschner M and Beach D: Mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2. Cell 64: 1111-1122, 1991.
-
(1991)
Cell
, vol.64
, pp. 1111-1122
-
-
Lundgren, K.1
Walworth, N.2
Booher, R.3
Dembski, M.4
Kirschner, M.5
Beach, D.6
-
92
-
-
0026611530
-
P107wee1 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15
-
P arker LL, Atherton-Fessler S and Piwnica-Worms H: P107wee1 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15. Proc Natl Acad Sci US A 89: 2917-2921, 1992.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 2917-2921
-
-
Parker, L.L.1
Atherton-Fessler, S.2
Piwnica-Worms, H.3
-
93
-
-
0037804567
-
Dual phosphorylation controls Cdc25 phosphatases and mitotic entry
-
Bulavin DV, Higashimoto Y, Demidenko ZN, et al: Dual phosphorylation controls Cdc25 phosphatases and mitotic entry. Nat Cell Biol 5: 545-551, 2003.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 545-551
-
-
Bulavin, D.V.1
Higashimoto, Y.2
Demidenko, Z.N.3
-
94
-
-
9244251125
-
Cell-cycle checkpoints and cancer
-
Kastan MB and Bartek J: Cell-cycle checkpoints and cancer. Nature 432: 316-323, 2004.
-
(2004)
Nature
, vol.432
, pp. 316-323
-
-
Kastan, M.B.1
Bartek, J.2
-
95
-
-
0034753336
-
Computational approach for determining the spectrum of DNA damage induced by ionizing radiation
-
Nikjoo H, O'Neill P, Wilson WE and Goodhead DT: Computational approach for determining the spectrum of DNA damage induced by ionizing radiation. Radiat Res 156: 577-583, 2001.
-
(2001)
Radiat Res
, vol.156
, pp. 577-583
-
-
Nikjoo, H.1
O'Neill, P.2
Wilson, W.E.3
Goodhead, D.T.4
-
96
-
-
84863680357
-
Typical cell signaling response to ionizing radiation: DNA damage and extranuclear damage
-
Y u H: Typical cell signaling response to ionizing radiation: DNA damage and extranuclear damage. Chin J Cancer Res 24: 83-89, 2012.
-
(2012)
Chin J Cancer Res
, vol.24
, pp. 83-89
-
-
Yu, H.1
-
97
-
-
0028222686
-
DNA damage as the cause of ionizing radiationinduced gene activation
-
Ward JF: DNA damage as the cause of ionizing radiationinduced gene activation. Radiat Res 138: S85-S88, 1994.
-
(1994)
Radiat Res
, vol.138
, pp. S85-S88
-
-
Ward, J.F.1
-
98
-
-
84905707030
-
Repair of ionizing radiation-induced DNA damage and risk of second cancer in childhood cancer survivors
-
Apr 19, Epub ahead of print
-
Haddy N, Tartier L, Koscielny S, et al: Repair of ionizing radiation-induced DNA damage and risk of second cancer in childhood cancer survivors. Carcinogenesis: Apr 19, 2014 (Epub ahead of print).
-
(2014)
Carcinogenesis
-
-
Haddy, N.1
Tartier, L.2
Koscielny, S.3
-
99
-
-
84891622264
-
Targeting DNA doublestrand break signalling and repair: Recent advances in cancer therapy
-
Huhn D, Bolck HA and Sartori AA: Targeting DNA doublestrand break signalling and repair: Recent advances in cancer therapy. Swiss Med Wkly 143: W13837, 2013.
-
(2013)
Swiss Med Wkly
, vol.143
, pp. w13837
-
-
Huhn, D.1
Bolck, H.A.2
Sartori, A.A.3
-
100
-
-
84898471903
-
Targeting DNA damage response in cancer therapy
-
Hosoya N and Miyagawa K: Targeting DNA damage response in cancer therapy. Cancer Sci 105: 370-388, 2014.
-
(2014)
Cancer Sci
, vol.105
, pp. 370-388
-
-
Hosoya, N.1
Miyagawa, K.2
-
101
-
-
84880586724
-
DNA repair mechanisms in dividing and non-dividing cells
-
Iyama T and Wilson Iii DM: DNA repair mechanisms in dividing and non-dividing cells. DNA Repair 12: 620-636, 2013.
-
(2013)
DNA Repair
, vol.12
, pp. 620-636
-
-
Iyama, T.1
Wilson, D.M.2
|