K-RAS(V12) induces autocrine production of EGFR ligands and mediates radioresistance through EGFR-dependent Akt signaling and activation of DNA-PKcs

International Journal of Radiation Oncology Biology Physics

Volumn 81, Issue 5, 2011, Pages 1506-1514

  Minjgee, Minjmaa ^a   Toulany, Mahmoud ^a   Kehlbach, Rainer ^a   Giehl, Klaudia ^b   Rodemann, H Peter ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

DNA PKcs; EGFR ligands; K RAS mutation; Radiation resistance

Indexed keywords

AMPHIREGULIN; CATALYTIC SUBUNITS; CONDITIONED MEDIUM; DNA DAMAGES; DNA-DEPENDENT PROTEIN KINASE; DNA-PKCS; DOUBLE-STRAND BREAKS; EMPTY VECTOR; EPIDERMAL GROWTH FACTOR RECEPTORS; HEAD-AND-NECK CANCER; K-RAS MUTATION; MOLECULAR MECHANISM; NEUTRALIZING ANTIBODIES; OVER-EXPRESSION; PARENTAL CELLS; POSTIRRADIATION; RADIATION RESISTANCE; RADIATION-INDUCED; RADIORESISTANCE; TRANSFECTED CELLS; TRANSFORMING GROWTH FACTORS; TUMOR CELLS; WILD TYPES;

ANTIBODIES; BIOACTIVITY; CELLS; DNA; ENZYMES; PEPTIDES; PHOSPHORYLATION; REPAIR; TUMORS;

LIGANDS;

AMPHIREGULIN; DNA; DOUBLE STRANDED DNA; EPIDERMAL GROWTH FACTOR RECEPTOR; K RAS PROTEIN; K RAS PROTEIN V12; NEUTRALIZING ANTIBODY; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE; PROTEIN KINASE B; TRANSFORMING GROWTH FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CONTROLLED STUDY; DEPLETION; DNA DAMAGE; DNA REPAIR; ENZYME ACTIVE SITE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; RADIOSENSITIVITY; SURVIVAL; TUMOR CELL; WILD TYPE;

ANTIBODIES, MONOCLONAL; CELL LINE, TUMOR; CELL SURVIVAL; CULTURE MEDIA, CONDITIONED; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA-ACTIVATED PROTEIN KINASE; GENES, RAS; GLYCOPROTEINS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; MUTATION; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS P21(RAS); RADIATION TOLERANCE; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TRANSFECTION; TRANSFORMING GROWTH FACTOR ALPHA;

EID: 81855194075     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2011.05.057     Document Type: Article

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