-
1
-
-
70349599428
-
The G2 DNA damage checkpoint: Could this ancient regulator be the Achilles heel of cancer?
-
Kuntz K, O'Connell MJ. The G2 DNA damage checkpoint: could this ancient regulator be the Achilles heel of cancer? Cancer Biol Ther 2009; 8: 1433-1439.
-
(2009)
Cancer Biol Ther
, vol.8
, pp. 1433-1439
-
-
Kuntz, K.1
O'Connell, M.J.2
-
2
-
-
0026318356
-
Participation of p53 protein in the cellular response to DNA damage
-
Kastan MB, Onyekwere O, Sidransky D, Vogelstein B, Craig RW. Participation of p53 protein in the cellular response to DNA damage. Cancer Res 1991; 51: 6304-6311.
-
(1991)
Cancer Res
, vol.51
, pp. 6304-6311
-
-
Kastan, M.B.1
Onyekwere, O.2
Sidransky, D.3
Vogelstein, B.4
Craig, R.W.5
-
3
-
-
0842287638
-
DNA damage tumor suppressor genes and genomic instability
-
Motoyama N, Naka K. DNA damage tumor suppressor genes and genomic instability. Curr Opin Genet Dev 2004; 14: 11.
-
(2004)
Curr Opin Genet Dev
, vol.14
, pp. 11
-
-
Motoyama, N.1
Naka, K.2
-
5
-
-
0031034628
-
Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast
-
Rhind N, Furnari B, Russell P. Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast. Genes Dev 1997; 11: 504-511.
-
(1997)
Genes Dev
, vol.11
, pp. 504-511
-
-
Rhind, N.1
Furnari, B.2
Russell, P.3
-
6
-
-
0028296168
-
Ionizing radiation induces rapid tyrosine phosphorylation of p34cdc2
-
Kharbanda S, Saleem A, Datta R, Yuan ZM, Weichselbaum R, Kufe D. Ionizing radiation induces rapid tyrosine phosphorylation of p34cdc2. Cancer Res 1994; 54: 1412-1414.
-
(1994)
Cancer Res
, vol.54
, pp. 1412-1414
-
-
Kharbanda, S.1
Saleem, A.2
Datta, R.3
Yuan, Z.M.4
Weichselbaum, R.5
Kufe, D.6
-
7
-
-
0031035528
-
Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation
-
O'Connell MJ, Raleigh JM, Verkade HM, Nurse P. Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation. EMBO J 1997; 16: 545-554.
-
(1997)
EMBO J
, vol.16
, pp. 545-554
-
-
O'Connell, M.J.1
Raleigh, J.M.2
Verkade, H.M.3
Nurse, P.4
-
8
-
-
0026035524
-
Mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2
-
Lundgren K, Walworth N, Booher R, Dembski M, Kirschner M, Beach D. Mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2. Cell 1991; 64: 1111-1122.
-
(1991)
Cell
, vol.64
, pp. 1111-1122
-
-
Lundgren, K.1
Walworth, N.2
Booher, R.3
Dembski, M.4
Kirschner, M.5
Beach, D.6
-
9
-
-
0026611530
-
P107wee1 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15
-
Parker LL, Atherton-Fessler S, Piwnica-Worms H. P107wee1 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15. Proc Natl Acad Sci USA 1992; 89: 2917-2921.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 2917-2921
-
-
Parker, L.L.1
Atherton-Fessler, S.2
Piwnica-Worms, H.3
-
10
-
-
0037804567
-
Dual phosphorylation controls Cdc25 phosphatases and mitotic entry
-
Bulavin DV, Higashimoto Y, Demidenko ZN, Meek S, Graves P, Phillips C et al. Dual phosphorylation controls Cdc25 phosphatases and mitotic entry. Nat Cell Biol 2003; 5: 545-551.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 545-551
-
-
Bulavin, D.V.1
Higashimoto, Y.2
Demidenko, Z.N.3
Meek, S.4
Graves, P.5
Phillips, C.6
-
11
-
-
9244251125
-
Cell-cycle checkpoints and cancer
-
Kastan MB, Bartek J. Cell-cycle checkpoints and cancer. Nature 2004; 432: 316-323.
-
(2004)
Nature
, vol.432
, pp. 316-323
-
-
Kastan, M.B.1
Bartek, J.2
-
12
-
-
0141613756
-
Phosphorylation of serine 10 in histone H3, what for?
-
Prigent C, Dimitrov S. Phosphorylation of serine 10 in histone H3, what for? J Cell Sci 2003; 116: 3677-3685.
-
(2003)
J Cell Sci
, vol.116
, pp. 3677-3685
-
-
Prigent, C.1
Dimitrov, S.2
-
13
-
-
4444349390
-
Analyzing cell cycle checkpoints after ionizing radiation
-
Xu B, Kastan MB. Analyzing cell cycle checkpoints after ionizing radiation. Methods Mol Biol 2004; 281: 283-292.
-
(2004)
Methods Mol Biol
, vol.281
, pp. 283-292
-
-
Xu, B.1
Kastan, M.B.2
-
14
-
-
0030828073
-
Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation
-
Hendzel MJ, Wei Y, Mancini MA, Van Hooser A, Ranalli T, Brinkley BR et al. Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation. Chromosoma 1997; 106: 348-360.
-
(1997)
Chromosoma
, vol.106
, pp. 348-360
-
-
Hendzel, M.J.1
Wei, Y.2
Mancini, M.A.3
Van Hooser, A.4
Ranalli, T.5
Brinkley, B.R.6
-
15
-
-
0345299208
-
Phosphorylation-induced rearrangement of the histone H3 NH2-terminal domain during mitotic chromosome condensation
-
Sauve DM, Anderson HJ, Ray JM, James WM, Roberge M. Phosphorylation-induced rearrangement of the histone H3 NH2-terminal domain during mitotic chromosome condensation. J Cell Biol 1999; 145: 225-235.
-
(1999)
J Cell Biol
, vol.145
, pp. 225-235
-
-
Sauve, D.M.1
Anderson, H.J.2
Ray, J.M.3
James, W.M.4
Roberge, M.5
-
16
-
-
0036146085
-
Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation
-
Xu B, Kim ST, Lim DS, Kastan MB. Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation. Mol Cell Biol 2002; 22: 1049-1059.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 1049-1059
-
-
Xu, B.1
Kim, S.T.2
Lim, D.S.3
Kastan, M.B.4
-
17
-
-
34447537796
-
Irradiation-induced G2/M checkpoint response requires ERK1/2 activation
-
Yan Y, Black CP, Cowan KH. Irradiation-induced G2/M checkpoint response requires ERK1/2 activation. Oncogene 2007; 26: 4689-4698.
-
(2007)
Oncogene
, vol.26
, pp. 4689-4698
-
-
Yan, Y.1
Black, C.P.2
Cowan, K.H.3
-
18
-
-
0043163868
-
EGFR family signaling and its association with breast cancer development and resistance to chemotherapy
-
Review
-
Navolanic PM, Steelman LS, McCubrey JA. EGFR family signaling and its association with breast cancer development and resistance to chemotherapy (Review). Int J Oncol 2003; 22: 237-252.
-
(2003)
Int J Oncol
, vol.22
, pp. 237-252
-
-
Navolanic, P.M.1
Steelman, L.S.2
McCubrey, J.A.3
-
19
-
-
33747878462
-
Current strategies in overcoming resistance of cancer cells to apoptosis melanoma as a model
-
Kwang WJ (ed) Academic Press: New York, NY
-
Hersey P, Zhuang L, Zhang XD. Current strategies in overcoming resistance of cancer cells to apoptosis melanoma as a model. In: Kwang WJ (ed) International Review of Cytology Vol. 251. Academic Press: New York, NY, 2006, pp 131-158.
-
(2006)
International Review of Cytology
, vol.251
, pp. 131-158
-
-
Hersey, P.1
Zhuang, L.2
Zhang, X.D.3
-
20
-
-
84896735708
-
Signaling cross-talk in the resistance to HER family receptor targeted therapy
-
Yamaguchi H, Chang SS, Hsu JL, Hung MC. Signaling cross-talk in the resistance to HER family receptor targeted therapy. Oncogene 2013; 33: 1073-1081.
-
(2013)
Oncogene
, vol.33
, pp. 1073-1081
-
-
Yamaguchi, H.1
Chang, S.S.2
Hsu, J.L.3
Hung, M.C.4
-
21
-
-
0034618369
-
MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-X(L), and Mcl-1 and promotes survival of human pancreatic cancer cells
-
Boucher MJ, Morisset J, Vachon PH, Reed JC, Laine J, Rivard N. MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-X(L), and Mcl-1 and promotes survival of human pancreatic cancer cells. J Cell Biochem 2000; 79: 355-369.
-
(2000)
J Cell Biochem
, vol.79
, pp. 355-369
-
-
Boucher, M.J.1
Morisset, J.2
Vachon, P.H.3
Reed, J.C.4
Laine, J.5
Rivard, N.6
-
22
-
-
0033613944
-
Mitogen-activated protein kinase kinase 2 activation is essential for progression through the G2/M checkpoint arrest in cells exposed to ionizing radiation
-
Abbott DW, Holt JT. Mitogen-activated protein kinase kinase 2 activation is essential for progression through the G2/M checkpoint arrest in cells exposed to ionizing radiation. J Biol Chem 1999; 274: 2732-2742.
-
(1999)
J Biol Chem
, vol.274
, pp. 2732-2742
-
-
Abbott, D.W.1
Holt, J.T.2
-
23
-
-
0037066686
-
ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53
-
Tang D, Wu D, Hirao A, Lahti JM, Liu L, Mazza B et al. ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53. J Biol Chem 2002; 277: 12710-12717.
-
(2002)
J Biol Chem
, vol.277
, pp. 12710-12717
-
-
Tang, D.1
Wu, D.2
Hirao, A.3
Lahti, J.M.4
Liu, L.5
Mazza, B.6
-
24
-
-
84869206966
-
ERK1/2 signaling plays an important role in topoisomerase II poison-induced G2/M checkpoint activation
-
Kolb RH, Greer PM, Cao PT, Cowan KH, Yan Y. ERK1/2 signaling plays an important role in topoisomerase II poison-induced G2/M checkpoint activation. PLoS ONE 2012; 7: e50281.
-
(2012)
PLoS ONE
, vol.7
, pp. e50281
-
-
Kolb, R.H.1
Greer, P.M.2
Cao, P.T.3
Cowan, K.H.4
Yan, Y.5
-
25
-
-
18844376884
-
BRCA1-mediated G2/M cell cycle arrest requires ERK1/2 kinase activation
-
Yan Y, Spieker RS, Kim M, Stoeger SM, Cowan KH. BRCA1-mediated G2/M cell cycle arrest requires ERK1/2 kinase activation. Oncogene 2005; 24: 3285-3296.
-
(2005)
Oncogene
, vol.24
, pp. 3285-3296
-
-
Yan, Y.1
Spieker, R.S.2
Kim, M.3
Stoeger, S.M.4
Cowan, K.H.5
-
26
-
-
84859513105
-
RAC1 GTPase plays an important role in gamma-irradiation induced G2/M checkpoint activation
-
Yan Y, Greer PM, Cao PT, Kolb RH, Cowan KH. RAC1 GTPase plays an important role in gamma-irradiation induced G2/M checkpoint activation. Breast Cancer Res 2012; 14 : R60.
-
(2012)
Breast Cancer Res
, vol.14
, pp. R60
-
-
Yan, Y.1
Greer, P.M.2
Cao, P.T.3
Kolb, R.H.4
Cowan, K.H.5
-
27
-
-
0037031908
-
BRCA1-induced apoptosis involves inactivation of ERK1/2 activities
-
Yan Y, Haas JP, Kim M, Sgagias MK, Cowan KH. BRCA1-induced apoptosis involves inactivation of ERK1/2 activities. J Biol Chem 2002; 277: 33422-33430.
-
(2002)
J Biol Chem
, vol.277
, pp. 33422-33430
-
-
Yan, Y.1
Haas, J.P.2
Kim, M.3
Sgagias, M.K.4
Cowan, K.H.5
-
28
-
-
33751328082
-
ErbB receptors: New insights on mechanisms and biology
-
Linggi B, Carpenter G. ErbB receptors: new insights on mechanisms and biology. Trends Cell Biol 2006; 16: 649-656.
-
(2006)
Trends Cell Biol
, vol.16
, pp. 649-656
-
-
Linggi, B.1
Carpenter, G.2
-
29
-
-
84861516765
-
Intrinsic and acquired resistance to HER2-targeted therapies in HER2 gene-amplified breast cancer: Mechanisms and clinical implications
-
Rexer BN, Arteaga CL. Intrinsic and acquired resistance to HER2-targeted therapies in HER2 gene-amplified breast cancer: mechanisms and clinical implications. Crit Rev Oncogen 2012; 17: 1-16.
-
(2012)
Crit Rev Oncogen
, vol.17
, pp. 1-16
-
-
Rexer, B.N.1
Arteaga, C.L.2
-
30
-
-
84861495556
-
Therapeutic targeting of the epidermal growth factor receptor in human cancer
-
Dhomen NS, Mariadason J, Tebbutt N, Scott AM. Therapeutic targeting of the epidermal growth factor receptor in human cancer. Crit Rev Oncogen 2012; 17: 31-50.
-
(2012)
Crit Rev Oncogen
, vol.17
, pp. 31-50
-
-
Dhomen, N.S.1
Mariadason, J.2
Tebbutt, N.3
Scott, A.M.4
-
31
-
-
17844372539
-
Critical update and emerging trends in epidermal growth factor receptor targeting in cancer
-
Baselga J, Arteaga CL. Critical update and emerging trends in epidermal growth factor receptor targeting in cancer. J Clin Oncol 2005; 23: 2445-2459.
-
(2005)
J Clin Oncol
, vol.23
, pp. 2445-2459
-
-
Baselga, J.1
Arteaga, C.L.2
-
33
-
-
50349092591
-
Activation of epidermal growth factor receptor and its downstream signaling pathway by nitric oxide in response to ionizing radiation
-
Lee H-C, An S, Lee H, Woo S-H, Jin H-O, Seo S-K et al. Activation of epidermal growth factor receptor and its downstream signaling pathway by nitric oxide in response to ionizing radiation. Mol Cancer Res 2008; 6: 996-1002.
-
(2008)
Mol Cancer Res
, vol.6
, pp. 996-1002
-
-
Lee, H.-C.1
An, S.2
Lee, H.3
Woo, S.-H.4
Jin, H.-O.5
Seo, S.-K.6
-
34
-
-
84891356953
-
Radiation-induced dimer formation of EGFR: Implications for the radiosensitizing effect of cetuximab
-
Kiyozuka M, Akimoto T, Fukutome M, Motegi A, Mitsuhashi N. Radiation-induced dimer formation of EGFR: implications for the radiosensitizing effect of cetuximab. Anticancer Res 2013; 33: 4337-4346.
-
(2013)
Anticancer Res
, vol.33
, pp. 4337-4346
-
-
Kiyozuka, M.1
Akimoto, T.2
Fukutome, M.3
Motegi, A.4
Mitsuhashi, N.5
-
35
-
-
0842304926
-
Radiosensitization by Pan ErbB inhibitor CI-1033 in vitro and in vivo
-
Nyati MK, Maheshwari D, Hanasoge S, Sreekumar A, Rynkiewicz SD, Chinnaiyan AM et al. Radiosensitization by Pan ErbB inhibitor CI-1033 in vitro and in vivo. Clin Cancer Res 2004; 10: 691-700.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 691-700
-
-
Nyati, M.K.1
Maheshwari, D.2
Hanasoge, S.3
Sreekumar, A.4
Rynkiewicz, S.D.5
Chinnaiyan, A.M.6
-
36
-
-
3242686392
-
Sensitization of breast cancer cells to radiation by trastuzumab
-
Liang K, Lu Y, Jin W, Ang KK, Milas L, Fan Z. Sensitization of breast cancer cells to radiation by trastuzumab. Mol Cancer Therap 2003; 2: 1113-1120.
-
(2003)
Mol Cancer Therap
, vol.2
, pp. 1113-1120
-
-
Liang, K.1
Lu, Y.2
Jin, W.3
Ang, K.K.4
Milas, L.5
Fan, Z.6
-
37
-
-
43949128408
-
EGFR tyrosine kinase inhibition radiosensitizes and induces apoptosis in malignant glioma and childhood ependymoma xenografts
-
Geoerger B, Gaspar N, Opolon P, Morizet J, Devanz P, Lecluse Y et al. EGFR tyrosine kinase inhibition radiosensitizes and induces apoptosis in malignant glioma and childhood ependymoma xenografts. Int J Cancer 2008; 123: 209-216.
-
(2008)
Int J Cancer
, vol.123
, pp. 209-216
-
-
Geoerger, B.1
Gaspar, N.2
Opolon, P.3
Morizet, J.4
Devanz, P.5
Lecluse, Y.6
-
38
-
-
77953408213
-
The expression patterns of ER, PR, HER2, CK5/6, EGFR, Ki-67 and AR by immunohistochemical analysis in breast cancer cell lines
-
Subik K, Lee JF, Baxter L, Strzepek T, Costello D, Crowley P et al. The expression patterns of ER, PR, HER2, CK5/6, EGFR, Ki-67 and AR by immunohistochemical analysis in breast cancer cell lines. Breast Cancer (Auckl) 2010; 4: 35-41.
-
(2010)
Breast Cancer (Auckl)
, vol.4
, pp. 35-41
-
-
Subik, K.1
Lee, J.F.2
Baxter, L.3
Strzepek, T.4
Costello, D.5
Crowley, P.6
-
39
-
-
63749131243
-
Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2
-
Reinhardt HC, Yaffe MB. Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2. Curr Opin Cell Biol 2009; 21: 245-255.
-
(2009)
Curr Opin Cell Biol
, vol.21
, pp. 245-255
-
-
Reinhardt, H.C.1
Yaffe, M.B.2
-
40
-
-
0035032649
-
Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation
-
Xu B, Kim S, Kastan MB. Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation. Mol Cell Biol 2001; 21: 3445-3450.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 3445-3450
-
-
Xu, B.1
Kim, S.2
Kastan, M.B.3
-
42
-
-
0028968949
-
Tyrosine kinase inhibition: An approach to drug development
-
Levitzki A, Gazit A. Tyrosine kinase inhibition: an approach to drug development. Science 1995; 267: 1782-1788.
-
(1995)
Science
, vol.267
, pp. 1782-1788
-
-
Levitzki, A.1
Gazit, A.2
-
43
-
-
84896091512
-
ERBB receptors: From oncogene discovery to basic science to mechanism-based cancer therapeutics
-
Arteaga Carlos L, Engelman Jeffrey A. ERBB receptors: from oncogene discovery to basic science to mechanism-based cancer therapeutics. Cancer Cell 2014; 25: 282-303.
-
(2014)
Cancer Cell
, vol.25
, pp. 282-303
-
-
Arteaga Carlos, L.1
Engelman Jeffrey, A.2
-
44
-
-
35448955219
-
Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor
-
Jani JP, Finn RS, Campbell M, Coleman KG, Connell RD, Currier N et al. Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor. Cancer Res 2007; 67: 9887-9893.
-
(2007)
Cancer Res
, vol.67
, pp. 9887-9893
-
-
Jani, J.P.1
Finn, R.S.2
Campbell, M.3
Coleman, K.G.4
Connell, R.D.5
Currier, N.6
-
45
-
-
77955170847
-
Protein phosphatase 2A has an essential role in the activation of gamma-irradiation-induced G2/M checkpoint response
-
Yan Y, Cao PT, Greer PM, Nagengast ES, Kolb RH, Mumby MC et al. Protein phosphatase 2A has an essential role in the activation of gamma-irradiation-induced G2/M checkpoint response. Oncogene 2010; 29: 4317-4329.
-
(2010)
Oncogene
, vol.29
, pp. 4317-4329
-
-
Yan, Y.1
Cao, P.T.2
Greer, P.M.3
Nagengast, E.S.4
Kolb, R.H.5
Mumby, M.C.6
-
46
-
-
0037421969
-
ErbB-2 signaling is involved in regulating PSA secretion in androgen-independent human prostate cancer LNCaP C-81 cells
-
Lee MS, Igawa T, Yuan TC, Zhang XQ, Lin FF, Lin MF. ErbB-2 signaling is involved in regulating PSA secretion in androgen-independent human prostate cancer LNCaP C-81 cells. Oncogene 2003; 22: 781-796.
-
(2003)
Oncogene
, vol.22
, pp. 781-796
-
-
Lee, M.S.1
Igawa, T.2
Yuan, T.C.3
Zhang, X.Q.4
Lin, F.F.5
Lin, M.F.6
-
47
-
-
0030772168
-
Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation
-
Schmidt-Ullrich RK, Mikkelsen RB, Dent P, Todd DG, Valerie K, Kavanagh BD et al. Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation. Oncogene 1997; 15: 1191-1197.
-
(1997)
Oncogene
, vol.15
, pp. 1191-1197
-
-
Schmidt-Ullrich, R.K.1
Mikkelsen, R.B.2
Dent, P.3
Todd, D.G.4
Valerie, K.5
Kavanagh, B.D.6
-
48
-
-
0036184190
-
Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo
-
Meng TC, Fukada T, Tonks NK. Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo. Mol Cell 2002; 9: 387-399.
-
(2002)
Mol Cell
, vol.9
, pp. 387-399
-
-
Meng, T.C.1
Fukada, T.2
Tonks, N.K.3
-
49
-
-
0035872421
-
Ionizing radiation-induced, mitochondria-dependent generation of reactive oxygen/nitrogen
-
Leach JK, Van Tuyle G, Lin PS, Schmidt-Ullrich R, Mikkelsen RB. Ionizing radiation-induced, mitochondria-dependent generation of reactive oxygen/nitrogen. Cancer Res 2001; 61: 3894-3901.
-
(2001)
Cancer Res
, vol.61
, pp. 3894-3901
-
-
Leach, J.K.1
Van Tuyle, G.2
Lin, P.S.3
Schmidt-Ullrich, R.4
Mikkelsen, R.B.5
-
50
-
-
84863230465
-
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR
-
Prahallad A, Sun C, Huang S, Di Nicolantonio F, Salazar R, Zecchin D et al. Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. Nature 2012; 483: 100-103.
-
(2012)
Nature
, vol.483
, pp. 100-103
-
-
Prahallad, A.1
Sun, C.2
Huang, S.3
Di Nicolantonio, F.4
Salazar, R.5
Zecchin, D.6
-
51
-
-
84863596086
-
MEK inhibition leads to PI3K/AKT activation by relieving a negative feedback on ERBB receptors
-
Turke AB, Song Y, Costa C, Cook R, Arteaga CL, Asara JM et al. MEK inhibition leads to PI3K/AKT activation by relieving a negative feedback on ERBB receptors. Cancer Res 2012; 72: 3228-3237.
-
(2012)
Cancer Res
, vol.72
, pp. 3228-3237
-
-
Turke, A.B.1
Song, Y.2
Costa, C.3
Cook, R.4
Arteaga, C.L.5
Asara, J.M.6
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