C-terminal domain small phosphatase 1 and MAP kinase reciprocally control REST stability and neuronal differentiation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 37, 2014, Pages E3929-E3936

  Nesti, Edmund ^a   Corson, Glen M ^a   McCleskey, Maxwell ^a   Oyer, Jon A ^a,b   Mandel, Gail ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA TRANSDUCIN REPEAT CONTAINING PROTEIN; CHROMATIN; CTDSP1 PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR; GREEN FLUORESCENT PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NIMA-INTERACTING PEPTIDYLPROLYL ISOMERASE; NUCLEAR PROTEIN; PEPTIDE; PEPTIDYLPROLYL ISOMERASE; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOSERINE; PROTEIN BINDING; RAS PROTEIN; RE1-SILENCING TRANSCRIPTION FACTOR; REPRESSOR PROTEIN;

ANIMAL; CELL DIFFERENTIATION; CHICKEN; CHROMATIN; CYTOLOGY; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; MOUSE; MUTATION; NERVE CELL; PC12 CELL LINE; PHOSPHORYLATION; PROTEIN DEGRADATION; PROTEIN STABILITY; RAT; SIGNAL TRANSDUCTION;

ANIMALS; BETA-TRANSDUCIN REPEAT-CONTAINING PROTEINS; CELL DIFFERENTIATION; CHICKENS; CHROMATIN; EPIDERMAL GROWTH FACTOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GREEN FLUORESCENT PROTEINS; HEK293 CELLS; HUMANS; MAP KINASE SIGNALING SYSTEM; MICE; MUTATION; NEURONS; NUCLEAR PROTEINS; PC12 CELLS; PEPTIDES; PEPTIDYLPROLYL ISOMERASE; PHOSPHOPROTEIN PHOSPHATASES; PHOSPHORYLATION; PHOSPHOSERINE; PROTEIN BINDING; PROTEIN STABILITY; PROTEOLYSIS; RAS PROTEINS; RATS; REPRESSOR PROTEINS;

EID: 84907187884     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1414770111     Document Type: Article

References (46)

1. Chong JA, et al. (1995) REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell 80(6):949-957.
2. Schoenherr CJ, Anderson D.J. (1995) The neuron-restrictive silencer factor (NRSF): A coordinate repressor of multiple neuron-specific genes. Science 267(5202):1360-1363.
3. Ballas N, Grunseich C, Lu D.D., Speh JC, Mandel G. (2005) REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis. Cell 121(4): 645-657.
4. Bruce AW, et al. (2004) Genome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genes. Proc Natl Acad Sci USA 101(28):10458-10463.
5. Conaco C, Otto S, Han J.J., Mandel G. (2006) Reciprocal actions of REST and a microRNA promote neuronal identity. Proc Natl Acad Sci USA 103(7):2422-2427.
6. Mortazavi A, Leeper Thompson EC, Garcia ST, Myers RM, Wold B. (2006) Comparative genomics modeling of the NRSF/REST repressor network: From single conserved sites to genome-wide repertoire. Genome Res 16(10):1208-1221.
7. Otto SJ, et al. (2007) A new binding motif for the transcriptional repressor REST uncovers large gene networks devoted to neuronal functions. J Neurosci 27(25): 6729-6739.
8. Ballas N, et al. (2001) Regulation of neuronal traits by a novel transcriptional complex. Neuron 31(3):353-365.
9. Kojima T, Murai K, Naruse Y., Takahashi N, Mori N. (2001) Cell-type non-selective transcription of mouse and human genes encoding neural-restrictive silencer factor. Brain Res Mol Brain Res 90(2):174-186.
10. Guardavaccaro D, et al. (2008) Control of chromosome stability by the beta-TrCP-REST-Mad2 axis. Nature 452(7185):365-369.
11. Westbrook TF, et al. (2008) SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation. Nature 452(7185):370-374.
12. Kaneko N, Hwang JY, Gertner M, Pontarelli F., Zukin R.S. (2014) Casein kinase 1 suppresses activation of REST in insulted hippocampal neurons and halts ischemia-induced neuronal death. J Neurosci 34(17):6030-6039.
13. Bersten DC, Wright JA, McCarthy P.J., Whitelaw M.L. (2014) Regulation of the neuronal transcription factor NPAS4 by REST and microRNAs. Biochim Biophys Acta 1839(1):13-24.
14. Lu PJ, Zhou XZ, Liou Y.C., Noel JP, Lu K.P. (2002) Critical role of WW domain phos-phorylation in regulating phosphoserine binding activity and Pin1 function. J Biol Chem 277(4):2381-2384.
15. Ley R, Balmanno K, Hadfield K., Weston C, Cook S.J. (2003) Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim. J Biol Chem 278(21):18811-18816.
16. Khokhlatchev A, et al. (1997) Reconstitution of mitogen-activated protein kinase phosphorylation cascades in bacteria. Efficient synthesis of active protein kinases. J Biol Chem 272(17):11057-11062.
17. Xu Be, Wilsbacher JL, Collisson T, Cobb M.H. (1999) The N-terminal ERK-binding site of MEK1 is required for efficient feedback phosphorylation by ERK2 in vitro and ERK activation in vivo. J Biol Chem 274(48):34029-34035.
18. Samuels IS, et al. (2008) Deletion of ERK2 mitogen-activated protein kinase identifies its key roles in cortical neurogenesis and cognitive function. J Neurosci 28(27):6983-6995.
19. R HR, Kim H, Noh K., Kim Y.J. (2014) The diverse roles of RNA polymerase II C-terminal domain phosphatase SCP1. BMB Rep 47(4):192-196.
20. Feng Y, et al. (2010) Arabidopsis SCP1-like small phosphatases differentially de-phosphorylate RNA polymerase II C-terminal domain. Biochem Biophys Res Commun 397(2):355-360.
21. Zhang Y, et al. (2006) Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1. Mol Cell 24(5):759-770.
22. Visvanathan J, Lee S, Lee B., Lee JW, Lee S.K. (2007) The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development. Genes Dev 21(7):744-749.
23. Ballas N, Mandel G. (2005) The many faces of REST oversee epigenetic programming of neuronal genes. Curr Opin Neurobiol 15(5):500-506.
24. Li S, et al. (2014) RAS/ERK signaling controls proneural genetic programs in cortical development and gliomagenesis. J Neurosci 34(6):2169-2190.
25. Satoh Y, et al. (2011) Deletion of ERK1 and ERK2 in the CNS causes cortical abnormalities and neonatal lethality: Erk1 deficiency enhances the impairment of neuro-genesis in Erk2-deficient mice. J Neurosci 31(3):1149-1155.
26. Mandel G, et al. (2011) Repressor element 1 silencing transcription factor (REST) controls radial migration and temporal neuronal specification during neocortical development. Proc Natl Acad Sci USA 108(40):16789-16794.
27. Gao Z, et al. (2011) The master negative regulator REST/NRSF controls adult neuro-genesis by restraining the neurogenic program in quiescent stem cells. J Neurosci 31(26):9772-9786.
28. Lu T, et al. (2014) REST and stress resistance in ageing and Alzheimer's disease. Nature 507(7493):448-454.
29. Pekar O, et al. (2012) EHD2 shuttles to the nucleus and represses transcription. Biochem J 444(3):383-394.
30. Le Gallic L, Virgilio L, Cohen P., Biteau B, Mavrothalassitis G. (2004) ERF nuclear shuttling, a continuous monitor of Erk activity that links it to cell cycle progression. Mol Cell Biol 24(3):1206-1218.
31. Shimojo M (2008) Huntingtin regulates RE1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) nuclear trafficking indirectly through a complex with REST/NRSF-interacting LIM domain protein (RILP) and dynactin p150 Glued. J Biol Chem 283(50):34880-34886.
32. Zuccato C, et al. (2003) Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes. Nat Genet 35(1):76-83.
33. Yeo M, et al. (2005) Small CTD phosphatases function in silencing neuronal gene expression. Science 307(5709):596-600.
34. Yeo M, Lin PS, Dahmus M.E., Gill G.N. (2003) A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. J Biol Chem 278(28):26078-26085.
35. Bernis C, et al. (2007) Pin1 stabilizes Emi1 during G2 phase by preventing its association with SCF(betatrcp). EMBO Rep 8(1):91-98.
36. Hamdane M, et al. (2006) Pin1 allows for differential Tau dephosphorylation in neuronal cells. Mol Cell Neurosci 32(1-2):155-160.
37. Nakamura K, et al. (2012) Prolyl isomerase Pin1 regulates neuronal differentiation via β-catenin. Mol Cell Biol 32(15):2966-2978.
38. Matsuda T, Cepko C.L. (2004) Electroporation and RNA interference in the rodent retina in vivo and in vitro. Proc Natl Acad Sci USA 101(1):16-22.
39. Jin J, et al. (2003) SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. Genes Dev 17(24):3062-3074.
40. Jin J, Ang XL, Shirogane T, Wade Harper J (2005) Identification of substrates for F-box proteins. Methods Enzymol 399:287-309.
41. Winkler KE, Swenson KI, Kornbluth S, Means A.R. (2000) Requirement of the prolyl isomerase Pin1 for the replication checkpoint. Science 287(5458):1644-1647.
42. Stukenberg PT, Kirschner M.W. (2001) Pin1 acts catalytically to promote a conformational change in Cdc25. Mol Cell 7(5):1071-1083.
43. Reynolds BA, Weiss S. (1992) Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 255(5052): 1707-1710.
44. Nesti E, Everill B, Morielli A.D. (2004) Endocytosis as a mechanism for tyrosine kinase-dependent suppression of a voltage-gated potassium channel. Mol Biol Cell 15(9): 4073-4088.
45. Hattan D, Nesti E, Cachero T.G., Morielli A.D. (2002) Tyrosine phosphorylation of Kv1.2 modulates its interaction with the actin-binding protein cortactin. J Biol Chem 277(41):38596-38606.
46. Li Y, Takahashi M, Stork P.J. (2013) Ras-mutant cancer cells display B-Raf binding to Ras that activates extracellular signal-regulated kinase and is inhibited by protein kinase A phosphorylation. J Biol Chem 288(38):27646-27657.