Repressor element 1 silencing transcription factor (REST) controls radial migration and temporal neuronal specification during neocortical development

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 40, 2011, Pages 16789-16794

  Mandel, Gail ^a,d   Fiondella, Christopher G ^c   Covey, Matthew V ^b   Lu, Diane D ^a   LoTurco, Joseph J ^c   Ballas, Nurit ^b  

^a Stony Brook University   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c UNIVERSITY OF CONNECTICUT   (United States)

^d OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

In utero electroporation; Neuronal cell fate; Neuronal differentiation

Indexed keywords

DOUBLECORTIN; REPRESSOR ELEMENT 1 SILENCING TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL FATE; CELL MIGRATION; GENE OVEREXPRESSION; HETEROTOPIA; MOLECULAR MECHANICS; MOUSE; NEOCORTEX; NERVE CELL; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL LINE; CELL MOVEMENT; CHROMATIN IMMUNOPRECIPITATION; DNA PRIMERS; DNA, COMPLEMENTARY; ELECTROPORATION; GENETIC VECTORS; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; MICROTUBULE-ASSOCIATED PROTEINS; NEOCORTEX; NERVE TISSUE PROTEINS; NEUROGENESIS; NEUROPEPTIDES; REPRESSOR PROTEINS;

EID: 80053651936     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1113486108     Document Type: Article

References (30)

1. Qian X, et al. (2000) Timing of CNS cell generation: A programmed sequence of neuron and glial cell production from isolated murine cortical stem cells. Neuron 28:69-80.
2. Okano H, Temple S (2009) Cell types to order: Temporal specification of CNS stem cells. Curr Opin Neurobiol 19:112-119.
3. Edlund T, Jessell TM (1999) Progression from extrinsic to intrinsic signaling in cell fate specification: A view from the nervous system. Cell 96:211-224. (Pubitemid 29059351)
4. Gupta A, Tsai LH, Wynshaw-Boris A (2002) Life is a journey: A genetic look at neocortical development. Nat Rev Genet 3:342-355. (Pubitemid 34506716)
5. Hsieh J, Gage FH (2004) Epigenetic control of neural stem cell fate. Curr Opin Genet Dev 14:461-469. (Pubitemid 39360292)
6. Miller FD, Gauthier AS (2007) Timing is everything: Making neurons versus glia in the developing cortex. Neuron 54:357-369. (Pubitemid 46659814)
7. Schoenherr CJ, Anderson DJ (1995) The neuron-restrictive silencer factor (NRSF): A coordinate repressor of multiple neuron-specific genes. Science 267:1360-1363.
8. Otto SJ, et al. (2007) A new binding motif for the transcriptional repressor REST uncovers large gene networks devoted to neuronal functions. J Neurosci 27:6729-6739. (Pubitemid 46983428)
9. Chong JA, et al. (1995) REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell 80:949-957.
10. Bruce AW, et al. (2004) Genome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genes. Proc Natl Acad Sci USA 101:10458-10463. (Pubitemid 38924947)
11. Johnson DS, Mortazavi A, Myers RM, Wold B (2007) Genome-wide mapping of in vivo protein-DNA interactions. Science 316:1497-1502. (Pubitemid 46906620)
12. Ballas N, Grunseich C, Lu DD, Speh JC, Mandel G (2005) REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis. Cell 121:645-657. (Pubitemid 40720016)
13. Lunyak VV, et al. (2002) Corepressor-dependent silencing of chromosomal regions encoding neuronal genes. Science 298:1747-1752. (Pubitemid 35404110)
14. Ballas N, Mandel G (2005) The many faces of REST oversee epigenetic programming of neuronal genes. Curr Opin Neurobiol 15:500-506. (Pubitemid 41394393)
15. Westbrook TF, et al. (2008) SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation. Nature 452:370-374. (Pubitemid 351430796)
16. Chen ZF, Paquette AJ, Anderson DJ (1998) NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis. Nat Genet 20:136-142. (Pubitemid 28455445)
17. Paquette AJ, Perez SE, Anderson DJ (2000) Constitutive expression of the neuron-restrictive silencer factor (NRSF)/REST in differentiating neurons disrupts neuronal gene expression and causes axon pathfinding errors in vivo. Proc Natl Acad Sci USA 97:12318-12323.
18. Ballas N, et al. (2001) Regulation of neuronal traits by a novel transcriptional complex. Neuron 31:353-365. (Pubitemid 32778556)
19. Yamada Y, Aoki H, Kunisada T, Hara A (2010) Rest promotes the early differentiation of mouse ESCs but is not required for their maintenance. Cell Stem Cell 6:10-15.
20. Bai J, et al. (2003) RNAi reveals doublecortin is required for radial migration in rat neocortex. Nat Neurosci 6:1277-1283. (Pubitemid 37485121)
21. Gao Z, et al. (2011) The master negative regulator REST/NRSF controls adult neurogenesis by restraining the neurogenic program in quiescent stem cells. J Neurosci 31:9772-9786.
22. Kohyama J, et al. (2010) BMP-induced REST regulates the establishment and maintenance of astrocytic identity. J Cell Biol 189:159-170.
23. Morrow T, Song MR, Ghosh A (2001) Sequential specification of neurons and glia by developmentally regulated extracellular factors. Development 128:3585-3594. (Pubitemid 32962725)
24. Conaco C, Otto S, Han JJ, Mandel G (2006) Reciprocal actions of REST and a microRNA promote neuronal identity. Proc Natl Acad Sci USA 103:2422-2427. (Pubitemid 43271685)
25. Ross SE, Greenberg ME, Stiles CD (2003) Basic helix-loop-helix factors in cortical development. Neuron 39:13-25. (Pubitemid 36830945)
26. Li X, Jin P (2010) Roles of small regulatory RNAs in determining neuronal identity. Nat Rev Neurosci 11:329-338.
27. Tomita K, Moriyoshi K, Nakanishi S, Guillemot F, Kageyama R (2000) Mammalian achaete-scute and atonal homologs regulate neuronal versus glial fate determination in the central nervous system. EMBO J 19:5460-5472.
28. Nieto M, Schuurmans C, Britz O, Guillemot F (2001) Neural bHLH genes control the neuronal versus glial fate decision in cortical progenitors. Neuron 29:401-413. (Pubitemid 32206479)
29. Cheng LC, Pastrana E, Tavazoie M, Doetsch F (2009) miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche. Nat Neurosci 12:399-408.
30. Bittman KS, LoTurco JJ (1999) Differential regulation of connexin 26 and 43 in murine neocortical precursors. Cereb Cortex 9:188-195. (Pubitemid 29174200)