Cell-type non-selective transcription of mouse and human genes encoding neural-restrictive silencer factor

Molecular Brain Research

Volumn 90, Issue 2, 2001, Pages 174-186

  Kojima, Takuya ^a,b   Murai, Kiyohito ^a,c   Naruse, Yoshihisa ^a   Takahashi, Naoki ^b   Mori, Nozomu ^a,b,c  

^a NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

^b NARA INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Gene regulation; Neural restrictive silencer factor; Neuron; RE1 silencing transcription factor; Transcripton

Indexed keywords

DNA BINDING PROTEIN; HISTONE DEACETYLASE; NEURAL RESTRICTIVE SILENCER FACTOR; PROTEIN CO REPRESSING ELEMENT 1 SILENCING TRANSCRIPTION FACTOR; PROTEIN MSIN3; REPRESSING ELEMENT 1 SILENCING TRANSCRIPTION FACTOR; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL LINE; CELL SPECIFICITY; CELL TYPE; CHROMATIN STRUCTURE; CONTROLLED STUDY; DNA FLANKING REGION; DNA RESPONSIVE ELEMENT; DNA SEQUENCE; DNA TRANSCRIPTION; EXON; GENE ACTIVITY; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMAN; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN STABILITY; RAT; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

3T3 CELLS; 5' UNTRANSLATED REGIONS; ANIMALS; BASE SEQUENCE; EXONS; GENE EXPRESSION REGULATION; GLIOMA; HUMANS; INTRONS; MICE; MOLECULAR SEQUENCE DATA; NEUROBLASTOMA; NEURONS; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; REPRESSOR PROTEINS; SP1 TRANSCRIPTION FACTOR; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 0035919182     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(01)00107-3     Document Type: Article

References (50)

1. Lineages and transcription factors in the specification of vertebrate primary sensory neurons
2. Cell lineage determination and the control of neuronal identity in the neural crest
3. CoREST: A functional corepressor required for regulation of neural-specific gene expression
4. Single-stranded DNA-binding proteins and neuron-restrictive silencer factor participate in cell-specific transcriptional control of the NMDAR1 gene
5. The neuron-restrictive silencer element: A dual enhancer/silencer crucial for patterned expression of a nicotinic receptor gene in the brain
6. NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis
7. REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons
8. POU domain genes are differentially expressed in the early stages after lineage commitment of the PNS-derived stem cell line, RT4-AC
9. The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex
10. Transcriptional repression by REST: Recruitment of Sin3A and histone deacetylase to neuronal genes
11. Targeted disruption of mammalian hairy and enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects
12. Neuron-specific expression of the human dopamine beta-hydroxylase gene requires both the cAMP-response element and a silencer region
13. Identification of a negative regulatory element in the 5′-flanking region of the human dopamine beta-hydroxylase gene
14. Two rat homologues of Drosophila achaete-scute specifically expressed in neuronal precursors
15. bHLH transcription factors and mammalian neuronal differentiation
16. Silencer elements modulate the expression of the gene for the neuron-glia cell adhesion molecule Ng-CAM
17. Tissue-specific expression of the L1 cell adhesion molecule is modulated by the neural restrictive silencer element
18. 2+ channel alpha 1B gene promoter activity in NS20Y cells
19. Differential regulation by multiple promoters of the gene encoding the neuron-restrictive silencer factor
20. Silencing the type II sodium channel gene: A model for neural-specific gene regulation
21. POU family transcription factors in sensory neurons
22. Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein
23. Identification of a functional silencer element involved in neuron-specific expression of the synapsin I gene
24. Cholinergic neuron-specific expression of the human choline acetyltransferase gene is controlled by silencer elements
25. Cell type-specific regulation of choline acetyltransferase gene expression, Role of the neuron-restrictive silencer element and cholinergic-specific enhancer sequences
26. Expression of the rat m4 muscarinic acetylcholine receptor gene is regulated by the neuron-restrictive silencer element/repressor element 1
27. Neuron-targeted gene transfer by adenovirus carrying neural-restrictive silencer element
28. A cell type-preferred silencer element that controls the neural-specific expression of the SCG10 gene
29. + channel genes binds a factor present in nonneuronal cells but not in neuronal cells
30. Neural restrictive silencer factor recruits mSin3 and histone deacetylase complex to repress neuron-specific target genes
31. Neuronal expression of zinc finger transcription factor REST/NRSF/XBR gene
32. Neuron-specific splicing of zinc finger transcription factor REST/NRSF/XBR is frequent in neuroblastomas and conserved in human, mouse and rat
33. Constitutive expression of the neuron-restrictive silencer factor (NRSF)/REST in differentiating neurons disrupts neuronal gene expression and causes axon pathfinding errors in vivo
34. Neuronal-specific gene expression - The interaction of both positive and negative transcriptional regulators
35. Alternatively spliced transcripts of the Drosophila tramtrack gene encode zinc finger proteins with distinct DNA binding specificities
36. Transcriptional repression by neuron-restrictive silencer factor is mediated via the Sin3-histone deacetylase complex
37. I. Neuron-specific gene expression of synapsin, Major role of a negative regulatory mechanism
38. The neuron-restrictive silencer factor (NRSF): A coordinate repressor of multiple neuron-specific genes
39. Silencing is golden: Negative regulation in the control of neuronal gene transcription
40. Identification of potential target genes for the neuron-restrictive silencer factor
41. Protein kinase A regulates cholinergic gene expression in PC12 cells: REST4 silences the silencing activity of neuron-restrictive silencer factor/REST
42. Silencer-mediated repression and non-mediated activation of BDNF and c-fos gene promoters in primary glial or neuronal cells
43. PHYL acts to down-regulate TTK88, a transcriptional repressor of neuronal cell fates, by a SINA-dependent mechanism
44. A single zinc finger motif in the silencing factor REST represses the neural-specific type II sodium channel promoter
45. Biological activity and modular structure of RE-1-silencing transcription factor (REST), a repressor of neuronal genes
46. Brain-derived neurotrophic factor expression in vivo is under the control of neuron-restrictive silencer element
47. Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: Implications for olfactory neuronal development
48. Png-1, a nervous system-specific zinc finger gene, identifies regions containing postmitotic neurons during mammalian embryonic development
49. Neural specific expression of the m4 muscarinic acetylcholine receptor gene is mediated by a RE1/NRSE-type silencing element