SCFβ-TRCP controls oncogenic transformation and neural differentiation through REST degradation

Nature

Volumn 452, Issue 7185, 2008, Pages 370-374

  Westbrook, Thomas F ^a,d   Hu, Guang ^a   Ang, Xiaolu L ^b   Mulligan, Peter ^b   Pavlova, Natalya N ^a   Liang, Anthony ^a   Leng, Yumei ^a   Maehr, Rene ^c   Shi, Yang ^b   Harper, J Wade ^b   Elledge, Stephen J ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Harvard University   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

F BOX PROTEIN; PROTEIN SCF BETA TRCP; SKP1 CULL F BOX PROTEIN; TRANSCRIPTION FACTOR REL; UBIQUITIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; BETA TRANSDUCIN REPEAT CONTAINING PROTEIN; BTRC PROTEIN, HUMAN; RE1 SILENCING TRANSCRIPTION FACTOR; RE1-SILENCING TRANSCRIPTION FACTOR; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR; UBIQUITIN PROTEIN LIGASE;

CANCER; DEGRADATION; ENZYME ACTIVITY; GENE EXPRESSION; HOMINID; NERVOUS SYSTEM; PROTEIN; RNA; TRANSFORMATION; TUMOR;

ARTICLE; CARCINOGENESIS; CELL DIFFERENTIATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RNA INTERFERENCE; UBIQUITINATION; ANIMAL; CELL TRANSFORMATION; CYTOLOGY; ENZYME SPECIFICITY; GENETICS; METABOLISM; MOUSE; NERVE CELL; NUCLEOTIDE SEQUENCE; PATHOLOGY; PHOSPHORYLATION; PROTEIN PROCESSING; TUMOR CELL LINE;

ANIMALS; BETA-TRANSDUCIN REPEAT-CONTAINING PROTEINS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; CONSERVED SEQUENCE; HUMANS; MICE; NEURONS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; REPRESSOR PROTEINS; RNA INTERFERENCE; SKP CULLIN F-BOX PROTEIN LIGASES; SUBSTRATE SPECIFICITY; TRANSCRIPTION FACTORS; UBIQUITIN;

EID: 41149119961     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature06780     Document Type: Article

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