Ras-mutant cancer cells display B-Raf binding to ras that activates extracellular signal-regulated kinase and is inhibited by protein kinase a phosphorylation

Journal of Biological Chemistry

Volumn 288, Issue 38, 2013, Pages 27646-27657

  Li, Yanping ^a   Takahashi, Maho ^a   Stork, Philip J S ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER CELL LINES; EXTRACELLULAR SIGNAL-REGULATED KINASE; LUNG CANCER CELLS; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE; PROTEIN KINASE A; RELATIVE CONTRIBUTION; SMALL G PROTEINS;

CELL CULTURE; CELLS; DERMATOLOGY; ONCOLOGY; PHOSPHORYLATION; PROTEINS;

ENZYMES;

ADAPTOR PROTEIN; B RAF KINASE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; EPIDERMAL GROWTH FACTOR; ISOPROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; PLATELET DERIVED GROWTH FACTOR; RAS PROTEIN; SERINE; SERINE 259; SERINE 365; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CELL PROLIFERATION; GENE MUTATION; HUMAN; HUMAN CELL; LUNG CANCER; MELANOMA CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

B-RAF; C-RAF; ERK; MAP KINASES (MAPKS); PROTEIN KINASE A (PKA); RAF; RAS;

CELL LINE, TUMOR; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; LUNG NEOPLASMS; MUTATION; ONCOGENE PROTEIN P21(RAS); PHOSPHORYLATION; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS B-RAF; PROTO-ONCOGENE PROTEINS C-RAF; SIGNAL TRANSDUCTION;

EID: 84884561095     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.463067     Document Type: Article

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