Human urinary biomarkers of dioxin exposure: Analysis by metabolomics and biologically driven data dimensionality reduction

Toxicology Letters

Volumn 230, Issue 2, 2014, Pages 234-243

  Jeanneret, Fabienne ^a   Boccard, Julien ^b   Badoud, Flavia ^a   Sorg, Olivier ^a   Tonoli, David ^a   Pelclova, Daniela ^c   Vlckova, Stepanka ^c   Rutledge, Douglas N ^b   Samer, Caroline F ^a,d   Hochstrasser, Denis ^a,d   Saurat, Jean Hilaire ^a   Rudaz, Serge ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b Université Paris Saclay   (France)

^c CHARLES UNIVERSITY   (Czech Republic)

^d GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

Biomarkers; Dimensionality reduction; Dioxin; Extreme phenotype; Steroidomics; Toxicity

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ANDROGEN RECEPTOR; AROMATIC HYDROCARBON RECEPTOR; BILE ACID; BIOLOGICAL MARKER; CELL NUCLEUS RECEPTOR; CHOLESTEROL 7ALPHA MONOOXYGENASE; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; DIOXIN; DRUG METABOLITE; ESTROGEN RECEPTOR; FARNESOID X RECEPTOR; LIVER X RECEPTOR; STEROL ELEMENT BINDING PROTEIN 2; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CZECH (PEOPLE); HUMAN; LIVER INJURY; METABOLOMICS; OCCUPATIONAL EXPOSURE; OXIDATIVE STRESS; PHENOTYPE; QUADRUPOLE MASS SPECTROMETRY; SHORT HETERODIMER PARTNER; TIME OF FLIGHT MASS SPECTROMETRY; TOXICITY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; URINALYSIS; ANALYSIS; DATA MINING; DRUG EFFECTS; ENVIRONMENTAL MONITORING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER; METABOLISM; PROCEDURES; URINE;

BIOLOGICAL MARKERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DATA MINING; ENVIRONMENTAL MONITORING; HUMANS; LIVER; METABOLOMICS; OCCUPATIONAL EXPOSURE; OXIDATIVE STRESS; TETRACHLORODIBENZODIOXIN;

EID: 84907166901     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2013.10.031     Document Type: Article

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